Preparation method of high purity Ceftizoxime

A ceftizoxime sodium, high-purity technology, applied in the field of medicine, can solve the problems of drug purity not meeting the requirements, improper production process control, etc., and achieve the effect of high yield

Active Publication Date: 2012-11-28
SUZHOU ERYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In some cases, the purity of the drug did not meet the requirements due to improper control of the production process

Method used

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  • Preparation method of high purity Ceftizoxime

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Embodiment Construction

[0025] Accurately weigh 10g of Ceftizoxime Sodium bulk drug with a purity of 95%. Add the solution containing ceftizoxime sodium into a fixed bed filled with D001 type strongly acidic styrene-based cation exchange resin, continue the exchange until the pH value is 3.5, and then use 10% hydrochloric acid aqueous solution as the eluent to elute, collect The eluate was concentrated under reduced pressure.

[0026] Then use 1M sodium carbonate aqueous solution to adjust the pH value to 7 when the temperature is raised to 65 degrees, and filter out the insoluble matter while it is hot.

[0027] Raise the temperature to 80°C, keep it for 30 minutes, add 120% volume of absolute ethanol, slowly lower the temperature, when the temperature drops to 10°C, crystals are precipitated, and after standing overnight, crystals are obtained, and after drying, 9.7 g of ceftizoxime sodium is obtained. The yield is 97%.

[0028] The high-performance liquid phase checks that the purity is 99.7%, a...

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Abstract

The invention relates to a preparation method of high purity Ceftizoxime. The method comprises the following steps of: (1) conducting adsorption on Ceftizoxime with a strong-acid ion exchange resin, then carrying out elution, collecting the elution solution, and performing pressure reduced concentration so as to obtain Ceftizoxime acid; (2) performing neutralization with an alkali sodium salt aqueous solution, and implementing filtration to remove insoluble matters to obtain a Ceftizoxime aqueous solution; and (3) adding a proper amount of ethanol into the aqueous solution, controlling the temperature and carrying out recrystallization, thus obtaining high purity Ceftizoxime.

Description

technical field [0001] The invention relates to a preparation method of high-purity ceftizoxime sodium, which belongs to the technical field of medicine. Background technique [0002] Ceftizoxime sodium was first developed by Japan Fujisawa Pharmaceutical Co., Ltd., and was first listed in Japan in 1982. Its English name is: Ceftizoxime, its molecular formula is: C13H13N5O5S2, and its chemical name is: (6r,7R)-7-[ (Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido]-8-oxo-5-thia-1-aminobicyclo[4.2.0]octane -2-ene-2-carboxylic acid sodium salt, the structural formula is: [0003] [0004] Ceftizoxime sodium belongs to the third-generation cephalosporin, which has a broad-spectrum antibacterial effect and is effective against broad-spectrum β-lactamase (including penicillinase and cephalosporinase) produced by various Gram-positive and Gram-negative bacteria. )Stablize. Ceftizoxime sodium has a strong antibacterial effect on Escherichia coli, Klebsiella pneumoniae, and P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/20C07D501/12
Inventor 陈洋洋陈学文
Owner SUZHOU ERYE PHARMA CO LTD
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