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Method for measuring amoxicillin content of amoxicilin sodium and clavulanate potassium

A technology of potassium amoxicillin sodium clavulanate and potassium clavulanate, which is applied in the field of medicine and biology, can solve inaccurate measurement, cannot eliminate the interference of potassium clavulanate, and cannot effectively control amoxicillin sodium clavulanate potassium A Moxicillin content and other issues, to achieve the effect of simple method and accurate measurement results

Inactive Publication Date: 2015-01-07
SICHUAN PHARMA
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Problems solved by technology

[0004] At present, there are few reports on the determination of the content of amoxicillin and clavulanic acid combined preparations. The relevant reported determination methods cannot eliminate the interference of clavulanate potassium, which makes the measurement inaccurate and cannot effectively control the concentration of amoxicillin sodium and clavulanate potassium. Amoxicillin content of

Method used

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Embodiment 1

[0018] A method for measuring the amoxicillin content of amoxicillin sodium and clavulanate potassium, using a phosphate buffer solution of pH=4.0-7.0 to put an equal volume of amoxicillin sodium and clavulanate potassium stock solution in the wavelength range of 200-400nm Spectrophotometric scanning was carried out to confirm the different absorption wavelengths of clavulanate potassium and amoxicillin to eliminate the absorption interference of clavulanate potassium.

[0019] Also included is the preparation process prior to confirming the elimination of wavelengths that interfere with clavulanate potassium absorption:

[0020] Weigh an appropriate amount of amoxicillin sodium and place it in a volumetric flask to obtain a 0.5 mg / ml amoxicillin sodium stock solution; use the same method to prepare a 0.5 mg / ml potassium clavulanate stock solution.

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Abstract

The invention provides a method for measuring amoxicillin content of amoxicilin sodium and clavulanate potassium. The interference of clavulanate potassium can be eliminated in an environment with certain pH values and in a certain wavelength range, and the measurement result can be accurate; and the method is simple and convenient and can provide support for controlling the acceptable quality of the amoxicilin sodium and clavulanate potassium in production.

Description

[0001] technical field [0002] The invention relates to the field of medical biology, in particular to a method for determining the amoxicillin content of amoxicillin sodium clavulanate potassium. Background technique [0003] Amoxicillin Sodium Clavulanate Potassium is a compound preparation composed of β-lactam inhibitor clavulanate potassium and semi-synthetic penicillin Amoxicillin. Amoxicillin is a bactericidal broad-spectrum antibiotic, and potassium clavulanate is an irreversible broad-spectrum β-lactamase inhibitor, which can effectively inhibit the β-lactamase produced by drug-resistant bacteria. Satisfactory curative effect has been achieved clinically. [0004] At present, there are few reports on the determination of the content of amoxicillin and clavulanic acid combined preparations. The relevant reported determination methods cannot eliminate the interference of clavulanate potassium, which makes the measurement inaccurate and cannot effectively control the ...

Claims

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Application Information

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IPC IPC(8): G01N21/33
Inventor 王强张静文刘萍
Owner SICHUAN PHARMA
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