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Antiseptic composition of mezlocillin

A mezlocillin and drug technology, applied in the field of antibiotic compound drugs, can solve problems such as drug resistance and curative effect decline

Inactive Publication Date: 2004-03-31
周宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the problem of decreased curative effect caused by drug-resistant bacteria producing β-lactamase, and provides an antibacterial combination drug for inhibiting β-lactamase
To protect mezlocillin from being destroyed by β-lactamase produced by bacteria, and enhance its curative effect, to solve the problem of bacterial resistance to mezlocillin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Under aseptic and clean conditions, 10 kilograms of mezlocillin sodium (calculated as mezlocillin) and 1 kilogram of potassium clavulanate (calculated as active acid) are mixed, and the powder injection preparation process is operated to prepare this product. Invented 10,000 powder injections.

Embodiment 2

[0035] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of mezlocillin sodium (calculated as mezlocillin) and 20 kilograms of potassium clavulanate (calculated as active acid) are mixed, and the powder injection preparation process is operated to prepare this product. Invented 10,000 powder injections.

Embodiment 3

[0036] Embodiment 3: under sterile and clean conditions, 10 kilograms of mezlocillin sodium (calculated as mezlocillin) and 2 kilograms of clavulanic acid potassium (calculated as active acid) are mixed, and are operated by the freeze-dried powder injection preparation process procedure, Prepare 10000 powder injections of the present invention.

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PUM

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Abstract

An antibiotic composition of meloxine, which is composed of meloxine andª‰-lactamase inhibitor at the weight ratio of 1-10í†10-1 based on the amount of active acids. meloxine is in the form of the alkali salt of meloxine or in the form of its free acid and solubility promoter; theª‰-lactamase inhibitor is clavulanic acid or tazobactam or their derivatives. Besides mixing and preparing beforehand,the composition could be prepared by mixing meloxine andª‰-lactamase inhibitor proportionally in clinical applications, then is administered, ormeloxine andª‰-lactamase inhibitor are administered independently. meloxine andª‰-lactamase inhibitor are synergetic, which could solve the problem of meloxine resistance in clinical applications.

Description

technical field [0001] The invention relates to an antibiotic compound drug for inhibiting β-lactamase produced by bacteria, specifically a compound preparation composed of a semi-synthetic penicillin antibiotic-mezlocillin and a β-lactamase inhibitor. Background technique [0002] Semi-synthetic penicillin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. Mezlocillin is a semi-synthetic Penicillium antibiotic commonly used in clinical practice. It is effective against G+ bacteria including Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter , Citrobacter, Serratia, Acinetobacter, and Gram-positive cocci sensitive t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61P31/04
Inventor 周宇
Owner 周宇
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