The invention discloses an injection for preventing and treating
delirium of ICU (
intensive care unit) critical and
cancer postoperative patients as well as a preparation method and application of the injection, and belongs to the technical field of pharmaceutical preparations. The injection is prepared from the following components in percentage by weight: 0.001 to 0.5 percent of
melatonin receptor stimulant, 530 percent of oil for injection, 0.55 percent of
phospholipid, 00.5 percent of co-
emulsion, 0.55 percent of isoosmotic adjusting agent, 0.011.0 percent of pH (Potential of
Hydrogen) adjusting agent and the balance of water for injection, and the pH is 5.010.0. The preparation process comprises the steps of
oil phase preparation, water phase preparation, emulsification, high-pressure homogenization, sterilization and the like. The average particle size (D50) of the injection is 100350nm, the content of large
emulsion particles with the particle size of 5 microns is 0-0.05%, the release rate within one hour is not lower than 80%, and the main
drug content within 24 months of validity is not lower than 90%. According to the invention, the
drug treatment
accessibility of existing ICU severe illness and
cancer postoperative
delirium is realized. The product takes effect quickly after administration, can realize smooth transition from short-term injection administration to
oral administration in a
recovery phase after ICU / severe illness operation, and has a remarkable clinical compliance
advantage.