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Amoxicillin and clavulanate potassium preparations and preparation method thereof

A technology of amoxicillin-clavulanate potassium and clavulanate potassium, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of reducing drug efficacy, reducing the content of amoxicillin active ingredients, shortening the Process and other issues, to achieve rapid effect, high bioavailability, fast absorption effect

Inactive Publication Date: 2019-07-26
葵花药业集团北京药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the above-mentioned disclosed patents, the inventive method shortens the technological process, reduces the production cycle and the exposure time of the drug in the air, ensures the stability of the drug, and further improves the quality of the product. However, in the preparation process, the use of a Moxicillin and trehalose are dissolved in buffer and granulated by evaporation, which reduces the active ingredient content of amoxicillin and reduces the efficacy of the drug

Method used

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  • Amoxicillin and clavulanate potassium preparations and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1 (preparation of dropping pill) (best)

[0042] Prepare according to the preparation method of the dropping pill in the above-mentioned preparation method, take polyethylene glycol 4000 468.75g and put it in the chemical material tank, turn on the heating system of the chemical material tank, adjust the temperature to 55 ° C, after the polyethylene glycol is completely melted, Open the stirring paddle of the chemical material tank, slowly add potassium clavulanate 31.25g and amoxicillin 125g, when the medicinal liquid becomes a molten liquid state, adjust the temperature control system of the dropping pill machine so that the temperature of the dripper of the dropping pill machine is heated and Keep it at 55°C, cool the temperature of the condensing agent and keep it at 3°C, put the medicine liquid in the dripping tank of the dropping pill machine, drop it into the simethicone oil through the dripper, and drop the shrinkage formed drops from the outlet of the...

Embodiment 2

[0044]Prepare according to the preparation method of the dripping pill in the above preparation method, take polyethylene glycol 6000 650g and put it in the chemical material tank, turn on the heating system of the chemical material tank, adjust the temperature to 75 ° C, after the polyethylene glycol is completely melted, turn on the Slowly add 30g of potassium clavulanate and 100g of amoxicillin to the stirring paddle of the chemical material tank. When the medicine liquid becomes a molten liquid state, adjust the temperature control system of the dropping pill machine so that the temperature of the dripper of the dropping pill machine is heated and kept at 75°C, the temperature of the condensing agent is cooled and kept at -1°C, the liquid medicine is placed in the dropping tank of the dropping pill machine, dripped into the simethicone oil through the dripper, and the shrinkage-shaped dropping pills are discharged from the outlet of the dropping pill machine Take it out, re...

Embodiment 3

[0046] Prepare according to the preparation method of the dripping pill in the above preparation method, take 10000765g of polyethylene glycol and put it in the chemical tank, turn on the heating system of the chemical tank, adjust the temperature to 75°C, and turn on the chemical tank after the polyethylene glycol is completely melted. Slowly add 33g of potassium clavulanate and 120g of amoxicillin to the stirring paddle of the material tank. When the liquid medicine is in a molten state, adjust the temperature control system of the dropping pill machine so that the dripper temperature of the dropping pill machine is heated and kept at 65 ℃, the temperature of the condensing agent is cooled and kept at 0 ℃, the liquid medicine is placed in the dripping tank of the dropping pill machine, dripped into the simethicone oil through the dripper, and the shrinkage-shaped dropping pills are taken out from the outlet of the dropping pill machine. Remove the surface condensing agent, dr...

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Abstract

The invention relates to amoxicillin and clavulanate potassium preparations and preparation method thereof. Amoxicillin and clavulanate potassium can be prepared into two preparations including that amoxicillin and clavulanate potassium are mixed and dissolved with a certain amount of water-soluble matrixes and then prepared into dropping pills through dropping pill preparation technology; or, amoxicillin and additives are micro-ground and uniformly mixed, then clavulanate potassium is dissolved in a certain amount of water into binding agent, and through spraying granulation, the materials are prepared into granules. The amoxicillin and clavulanate potassium preparations prepared through the methods above have the advantages of being simple in production, high in bioavailability, rapid inabsorption and effects and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to amoxicillin-clavulanate potassium preparation and a preparation method thereof. Background technique [0002] Amoxicillin, also known as amoxycillin or amoxicillin, is the most commonly used semi-synthetic penicillin broad-spectrum β-lactam antibiotics. It is a white powder and is one of the most widely used oral semi-synthetic penicillins. one. [0003] Potassium clavulanate is a white or light yellow crystalline powder, which is ineffective when used alone. It is often used in combination with penicillins to overcome the drug resistance caused by microorganisms producing β-lactamase and improve the curative effect. [0004] The combined use of amoxicillin and potassium clavulanate is suitable for lower respiratory tract infections, otitis media, sinusitis, and beta-lactamase gold produced by microorganisms caused by Haemophilus influenzae and Moraxella catarrhalis...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/16A61K47/10A61K47/38A61K31/43A61K31/424A61P31/04
CPCA61K9/1652A61K9/2031A61K31/424A61K31/43A61P31/04A61K2300/00
Inventor 李洪建关彦斌马帅
Owner 葵花药业集团北京药物研究院有限公司
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