A pharmaceutical composition for treating mammary gland hyperplasia and its preparation method, preparation and application
A technology of mammary gland hyperplasia and composition, which is applied in the field of medicine, can solve the problems of long course of disease, large adverse reactions, and easy recurrence, and achieve the effects of small toxic and side effects, good safety, and improved curative effect
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[0022] The preparation method of the pharmaceutical composition for the treatment of mammary gland hyperplasia described in the present invention comprises pretreatment, extraction, posttreatment steps, specifically comprises:
[0023] A. Pretreatment: crush and sieve the raw material Periplaneta americana with the formula ratio to obtain material a for later use; at the same time, cut the raw materials Moutan Cortex, Prunella vulgaris, Bupleurum, Sanleng and Curcuma zedoary into slices or segments and mix them to obtain Material b is reserved;
[0024] B. Extraction:
[0025] 1) adding ethanol solution to material a to extract and concentrate to obtain extract c;
[0026] 2) adding ethanol solution to material b to extract and concentrate to obtain extract d;
[0027] C. Post-processing: crush and sieve the extract c and extract d respectively, and mix them uniformly to obtain a pharmaceutical composition for treating mammary gland hyperplasia disease with the target substa...
Embodiment 1
[0049] The formula is 100 parts of Periplaneta americana; 60 parts of Cortex Moutan; 200 parts of Prunella vulgaris; 80 parts of Bupleurum; 150 parts of Sanleng;
[0050] (1) The preparation of the Periplaneta americana extract, the method and steps are as described above, and it is set aside.
[0051] (2) The preparation method of Moutan Cortex, Prunella vulgaris, Bupleurum, Sanleng, and Curcuma five-flavor herbal medicine extract:
[0052] a. Pre-treatment: Take the five medicinal materials of Moutan bark, Prunella vulgaris, Bupleurum, Sanleng, and Zedoary, remove impurities, slice or segment;
[0053] b. Extraction: take the slices of medicinal herbs cut in a, extract twice with 70% ethanol, add 6 times the amount of 70% ethanol for the first time, soak at room temperature for half an hour, then heat and reflux for 2 hours; 3 times the amount of 70% ethanol, heated to reflux for extraction for 1 hour. The extracts were collected, combined, and filtered to obtain an ethano...
Embodiment 2
[0058] The formula is 100 parts of Periplaneta americana; 150 parts of Cortex Moutan; 90 parts of Prunella vulgaris; 30 parts of Bupleurum; 60 parts of Sanleng;
[0059] (1) The preparation of the Periplaneta americana extract, the method and steps are as described above, and it is set aside.
[0060] (2) Preparation method of Moutan Cortex, Prunella vulgaris, Bupleurum, Sanleng, and Curcuma five-flavor herbal medicine extract
[0061] a. Pre-treatment: Take the five medicinal materials of Moutan bark, Prunella vulgaris, Bupleurum, Sanleng, and Zedoary, remove impurities, slice or segment;
[0062] b. Extraction: take the slices of medicinal herbs cut in a, extract them with 80% ethanol for 3 times, add 8 times the amount of 80% ethanol for the first time, soak at room temperature for half an hour, then heat and reflux for 3 hours; 5 times the amount of 80% ethanol, heated to reflux for extraction for 2 hours. The extracts were collected, combined, and filtered to obtain an ...
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