1442 results about "Human Mammary Glands" patented technology

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

An apparatus for ultrasonic mammography includes: an array of ultrasonic transducers and signal processing means for converting the output of the transducer array into three dimensional renderings of anatomical features; and, an applicator device having a first side conformable to the contour of the transducer array and a second side configured to accept the breast, the applicator device further containing a quantity of fluid sufficient to surround and stabilize the breast during examination without substantially altering the breast from its natural shape.

A method for using computer-aided diagnosis (CAD) for digital tomosynthesis mammograms (DTM) including retrieving a DTM image file having a plurality of DTM image slices; applying a three-dimensional gradient field analysis to the DTM image file to detect lesion candidates; identifying a volume of interest and locating its center at a location of high gradient convergence; segmenting the volume of interest by a three dimensional region growing method; extracting one or more three dimensional object characteristics from the object corresponding to the volume of interest, the three dimensional object characteristics being one of a morphological feature, a gray level feature, or a texture feature; and invoking a classifier to determine if the object corresponding to the volume of interest is a breast cancer lesion or normal breast tissue.

The invention provides a method for detecting an X-ray mammary gland lesion image based on feature pyramid network under transfer learning. The method comprises the steps: 1, establishing a source domain data set and a target domain data set; 2, establishing a deformable convolution residual network layer by a deformable convolution and extended residual network module; 3, establishing a multi-scale feature extraction sub-network based on a feature pyramid structure through a feature map up-sampling and feature fusion method in combination with a deformable convolution residual network layer;4, establishing a deformable pooling sub-network sensitive to the focus position; 5, establishing a post-processing network layer to optimize a prediction result and a loss function; and 6, migratingthe training model to a small sample molybdenum target X-ray mammary gland focus detection task so as to improve the detection precision of the network model on the focus in the small sample image. According to the method, a transfer learning strategy is combined to realize focus image processing in a small sample medical image.

Cyclin D1 is one of the targets of beta-catenin in breast cancer cells. Transactivation of beta-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, high beta-catenin activity significantly correlated with poor prognosis of the patients and is a strong and independent prognostic factor in breast cancer (p<0.001). Moreover, by multivariate analyses, the inventors found that activated beta-catenin is a strong prognostic factor which provided additional and independent predictive information on patients survival rate even when other prognostic factors, including lymph node metastasis, tumor size, estrogen receptor and progesterone receptor status, were taken into account (p<0.001). This invention demonstrates that beta-catenin is involved in breast cancer formation and / or progression and may serve as a target for breast cancer therapy.

Methods and systems are provided for the noninvasive measurement of the subepithelial impedance of the breast and for assessing the risk that a substantially asymptomatic female patient will develop or be at substantially increased risk of developing proliferative or pre-cancerous changes in the breast, or may be at subsequent risk for the development of pre-cancerous or cancerous changes. A plurality of electrodes are used to measure subepithelial impedance of parenchymal breast tissue of a patient at one or more locations and at least one frequency, particularly moderately high frequencies. The risk of developing breast cancer is assessed according to measured and expected or estimated values of subepithelial impedance for the patient and according to one or more experienced-based algorithms. Devices for practicing the disclosed methods are also provided.

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and / or treatment of diseases, particularly breast cancer.

The invention provides traditional Chinese medicine for treating breast diseases, which is formed by mixing Chinese angelica, red paeony root, peach kernels, red flower, salvia miltiorrhiza, zedoary turmeric oil, rhizoma corydalis, szechuan lovage rhizome, lumbricus, pangolin scales, uniflower swisscentaury root, fritillaria thunbergii, spina gleditsiae, cowherb seeds, angelica root, mongolian snakegourd root, concha ostreae, pericarpium citri reticulatae viride, nutgrass galingale rhizome, tangerine seeds, radix bupleuri, dandelion, rhizoma pleionis, fructus forsythiae, astragalus root, codonopsis pilosula, liquorice, frankincense, myrrh, poria cocos and oldenlandia diffusa. The traditional Chinese medicine has the effects of invigorating Qi and enriching the blood, invigorating the blood circulation and softening the hard lumps, activating the meridians and detoxicating, soothing the depressed livers and regulating the flow of Qi, softening and resolving the hard lumps, invigorating the spleens and reducing the phlegm, strengthening the healthy energy and eliminating the pathogenic factors and can be used for treating hyperplasia of mammary gland, acute or chronic mastitis, breast fibroadenoma, intraductal papilloma, breast lump, breast scrofula, breast carbuncle and breast cancer.

The invention discloses a deep residual network-based semantic mammary gland molybdenum target image lump segmentation method. The method comprises the following steps of: labelling pixel categories of lumps and normal tissues corresponding to a collected mammary gland molybdenum target image so as to generate label images, and dividing the mammary gland molybdenum target image and the corresponding label images into training samples and test samples; preprocessing the training samples to form a training data set; constructing a deep residual network, and training the network by utilizing thetraining data set, so as to obtain a deep residual network training model; after a to-be-segmented mammary gland molybdenum target image lump is preprocessed, carrying out binary classification and post-processing on a pixel of the to-be-segmented mammary gland molybdenum target image by utilizing the deep residual network training model, and outputting lump segmentation image to realize semanticsegmentation of the mammary gland molybdenum target image lump. The method is capable of effectively improving the automatic and intelligent levels of mammary gland molybdenum target image lump segmentation, and can be applied to the technical field of assisting radiologists to carry out medical diagnosis.

X-ray mammography has been the standard for breast cancer screening for three decades, but offers poor statistical reliability; it also requires a radiologist for interpretation, employs ionizing radiation, and is expensive. The combination of multiple independent tests, performed effectively at the same time and co-registered, can produce substantially more reliable detection performance than that of the individual tests. The multi-sensor approach offers greatly improved reliability for detection of early breast tumors, with few false positives, and also can be designed to support machine decision, thus enabling screening by general practitioners and clinicians; it avoids ionizing radiation, and can ultimately be relatively inexpensive.

An image processing apparatus includes: an image obtaining device which obtains a breast image obtained by radiography of a breast; a mammary gland region extracting device which extracts a mammary gland region from the breast image; a local region setting device which sets a plurality of local regions around pixels belonging to the extracted mammary gland region; a local contrast value calculating device which calculates a plurality of local contrast values in a local regions, for each of the set plurality of local regions; and an image processing device which applies image processing to the breast image on the basis of the calculated plurality of local contrast values. Thus, considering a contrast between a mammary gland and a fat region, a stable image processing result can be obtained while enhancing viewability of a local mammary gland structure and a lesion.

A system and method for performing quantitative lesion analysis in molecular breast imaging (MBI) using the opposing images of a slightly compressed breast that are obtained from the dual-head gamma camera. The method uses the shape of the pixel intensity profiles through each tumor to determine tumor diameter. Also, the method uses a thickness of the compressed breast and the attenuation of gamma rays in soft tissue to determine the depth of the tumor from the collimator face of the detector head. Further still, the method uses the measured tumor diameter and measurements of counts in the tumor and background breast region to determine relative radiotracer uptake or tumor-to-background ratio (T / B ratio).

The invention provides novel compositions, methods and uses, for the diagnosis, prognosis, prediction, prevention and aid in treatment of malignant neoplasia such as breast cancer, ovarian cancer, gastric cancer, colon cancer, esophageal cancer, mesenchymal cancer, bladder cancer or non-small cell lung cancer. Genes that are chromosomally amplified in breast tissue of breast cancer patients are disclosed. Further disclosed are chromosomally amplified genes and non-amplified genes that correlate to Taxane resistance, Taxane benefit or adverse Taxane reaction, which can be used as an aid to make therapy dicisions.

The invention relates to the field of medical image processing and pattern recognition, and provides a computer-assisted lump detecting method based on a mammary gland magnetic resonance image. The computer-assisted lump detecting method based on the mammary gland magnetic resonance image aims at solving the problems that in the prior art, the lump partition effect is not good, and the accuracy, the sensitivity and the specificity in a classification test are not high. The computer-assisted lump detecting method includes the following steps: S1, extracting an interest area from the mammary gland magnetic resonance image; S2, extracting an initial lump area from the interest area in a separated mode, and determining the contour line of the initial lump area; S3, calculating the weight distribution of characteristic parameters of the initial lump area; S4, selecting the characteristic parameters, with the weight coefficients larger than a standard weight coefficient, of the initial lump area, and carrying out training classifying to obtain optimized characteristic parameters; S5, inputting the optimized characteristic parameters into a classifier, analyzing the optimized characteristic parameters with a support vector machine classification method, determining a final lump area, and displaying the final lump area for a user. The detecting method has the good lump partition effect, the accuracy, the sensitivity and the specificity in the classification test are effectively improved, the detecting result serves as a second opinion to be provided for a radiologist, and the misdiagnosis rate and the missed diagnosis rate of the radiologist can be effectively reduced.

Methods, systems, and apparatuses for automatically identifying glandular regions and tubule regions in a breast tissue sample are provided. An image of breast tissue is analyzed to detect nuclei and lumen candidates, identify tumor nuclei and true lumen from the candidates, and group tumor nuclei with neighboring tumor nuclei and lumina to define tubule glandular regions and non-tubule glandular regions of the image. Learnt supervised classifiers, such as random forest classifiers, can be applied to identify and classify the tumor nuclei and true lumina. Graph-cut methods can be applied to group the tumor nuclei and lumina and to define the tubule glandular regions and non-tubule glandular regions. The analysis can be applied to whole slide images and can resolve tubule areas with multiple layers of nuclei.

The invention relates to the field of livestock breeding technology, which specifically relates to a forage for sow during lactation period, and the forage is prepared by the following raw materials by weight: 70-80 parts of corn, 20-25 parts of bean cakes, 20-25 parts of millet bran, 15-18 parts of wheat bran, 12-15 parts of pea residues, 10-12 parts of dried white radish, 5-8 parts of black sesame, 3-4 parts of pig heat powder, 6-8 parts of vegetable sponge of luffa, 4-5 parts of fish meals, 2-3 parts of stone flour, 1-2 parts of shell powder, 5-6 parts of laver powder, 8-10 parts of purslane, 1-2 parts of radix Rhapontici, 2-3 parts of cape jasmine, 1-2 parts of pitch, 1-2 parts of Akebia stems, a proper amount of salts and 4-5 parts of feeding promoting agents. The prepared sow forage has balanced and comprehensive nutrition, and can satisfy each nutrition demand of postpartum sow, radix Rhapontici, cape jasmine, pitch, Akebia stems and other Chinese herbal medicine components can free mammary gland, increase milk yield, and the pigling fed by the sow which eats the forage has high survival rate, strong physique and red and bright hair.

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

The invention is directed toward a micro-endoscope assembly for the removal of tissue and cells from breast ducts comprising a cylindrical guide tube with a beveled distal end defining an internal cylindrical passageway and a first smaller cylindrical tube eccentrically formed in the cylindrical passageway of a smaller diameter than the tube internal cylindrical passageway and adapted to receive and guide an endoscope with a handle assembly wherein the smaller cylindrical tube together with an inner wall surface of the cylindrical guide tube forms a second passageway. A second conduit of a smaller diameter than the smaller cylindrical tube is mounted in the second passageway to divide the second passageway into two separate divided sections and is of sufficient diameter to receive a laser fiber and a micro-endoscope is mounted in the smaller cylindrical tube and a laser is mounted in the second cylindrical tube in the second passageway. The assembly is inserted into a mammary duct and the interior of the duct is viewed until an abnormality is determined in the duct. The tissue and cells from the abnormality area are dislodged, irrigated and aspirated through a suction channel to a removable collection device.

The invention relates to the technical field of medical image processing, and aims to provide a dynamic ultrasonic breast nodule real-time segmentation and recognition method based on deep learning. The method comprises the following steps: collecting ultrasonic mammary gland images and videos with nodules and case data with operative pathology results, constructing a data set, constructing a static image nodule segmentation network, and training the static image nodule segmentation model on an original image; predicting an intermediate frame nodule probability by using an LSTM layer, constructing a video dynamic segmentation network, and training a dynamic segmentation model; constructing a benign and malignant identification network structure by using a basic network, and training a benign and malignant identification model; and outputting nodule position information in real time, using the benign and malignant recognition model for recognizing benign and malignant nodules of each frame, and outputting the number of output nodules and the comprehensive benign and malignant probability after examination is finished. Information incompleteness of a single image can be avoided, error detection is reduced, missing small nodules are reduced, and the nodule benign and malignant identification accuracy is improved.

The invention relates to pueraria breast enlargement tea which comprises raw materials of, by weight, 50 parts of pueraria, 10 parts to 20 parts of motherwort, 10 parts to 20 parts of angelica, 10 parts to 10 parts of dogwood, 10 parts to 20 parts of papayas, 10 parts to 20 parts of wolfberry fruits, 10 parts to 20 parts of rehmannia glutinosa, 10 parts to 20 parts of Danshen roots, 10 parts to 20 parts of Chinese taxillus twing, 10 parts to 20 parts of king solomonseal rhizome, 10 parts to 20 parts of milkvetch roots, 10 parts to 20 parts of China dodder, 10 parts to 20 parts of albizia flowers, 10 parts to 20 parts of nutgrass galingale rhizome, 10 parts to 20 parts of white peony roots, 10 parts to 20 parts of poria, 10 parts to 20 parts of turmeric root-tuber, 10 parts to 20 parts of mongolian snakegourd roots, 10 parts to 20 parts of Chinese yam and 10 parts to 20 parts of largehead atractylodes rhizome. The pueraria breast enlargement tea has a function of stimulating pituitary secretion, and stimulates ovaries to secrete large numbers of female hormone and progestational hormone, so that the development of mammary gland and follicles is promoted, breasts are enlarged and strong, the estrogen level is adjusted, rubbish in bodies is cleaned, and accordingly, various healthcare functions of improving circulation, promoting breast development, reducing fat, losing weight, regulating blood pressure and the like are provided.

The invention relates to a plaster used for treating rheumatism, rheumatoid disease and various hyperosteogeny, which consists of 35 kinds of Chinese medicine materials, including nux vomica, unprocessed radix aconiti, unprocessed wild aconite, clematis chinensis, Chuanmugua, radix cyathulae, common culbmoss herb, Chuanduan, divaricate sapshnikovia root, cassia twig and ephedra, etc. The plaster has the functions of eliminating dampness, dispelling cold, activateing collaterals, promoting blood circulation by removing blood stasis, reducing swelling and resolving masses. Therefore, the plaster has the good effects on rheumatism, rheumatoid disease, prolapse of lumbar intervertebral disc, cervical spondylosis, gonarthritis, hyperosteogeny and hyperplasia of mammary glands and no toxicity and side effects. In addition, curative effect is quick, the course of treatment is short and cure rate is high.

Provided are methods of suppressing growth of hormone refractory breast tumors by contacting tumor cells with an ErbB3 inhibitor, preferably an anti-ErbB3 antibody. Also provided are methods for treating hormone refractory breast cancer in a patient by administering to the patient an inhibitor of heregulin binding to ErbB3 or to ErbB2 / ErbB3 heterodimer, which inhibitor is an anti-ErbB3 antibody or an anti-ErbB2 antibody. The treatment methods can further comprise selecting a patient having a hormone refractory breast cancer and then administering the inhibitor to the patient. The treatment methods may also comprise administering an estrogen receptor antagonist, or an aromatase inhibitor to the patent and may at further comprise administering to the patient at least one additional anti-cancer agent that is not an ErbB3 inhibitor, an estrogen receptor antagonist, or an aromatase inhibitor to the patient in combination with the ErbB3 inhibitor.

The invention relates to the technical field of ultrasonic imaging equipment, and in particular, relates to an ultrasonic transducer scanning system. The ultrasonic transducer scanning system comprises a mechanical arm, a storage unit, a path generating unit and a control device. The tail end of the mechanical arm is equipped with an ultrasonic transducer, so that the ultrasonic transducer can move and scan on the surface of target parts, which needs to be inspected, of an inspecting object. The storage unit stores reference cross-section images corresponding to different target parts. The path generating unit generates moving path information according to the initial cross-section images collected by the ultrasonic transducer and the reference cross-section images; the control device controls the mechanical arm and the ultrasonic transducer to do motion scanning to obtain target cross-section images according to the moving path information. The invention also provides a scanning method and an ultrasonic imaging device, for example, when mammary gland examination is performed, a transducer module is moved onto patient breasts for scanning through a support arm. The ultrasonic transducer scanning system can automatically obtain the target cross-section images of the target parts which needs to be inspected, has high degree of automation, and greatly improves the imaging efficiency.

Provided are systems using compression devices for a mammography unit, and methods of using the same, for example, in conjunction with imaging of a patient's breast. The instant mammography units can comprise at least one x-ray transparent inflatable chamber for containing a fluid. When fluid is introduced into the chamber, at least one surface of the chamber expands, breast motion is limited, and the breast and its vasculature are compressed. Fluid may also be released from the chamber, and as the chamber deflates, blood flow to the breast is restored, producing Korotkoff sounds that may be detected by a sound detection device. The detected sounds may be used to assist a radiologist in identifying regions of interest on a mammogram, and additionally or alternatively may be used to a enhance a computer-assisted detection (CAD) process by contributing an additional data parameter.

The invention provides an MRI image-based axillary lymph gland metastasis prediction system and relates to the technical field of computer aided diagnosis. The system comprises an input module, an area-of-interest extraction module, a lump segmentation module, a sub-visualization module, a feature extraction module, a feature dimensionality reduction module, a classification and diagnosis module,and an output module. The input module receives a to-be-diagnosed mammary gland DCE-MR image sequence input by a user. The area-of-interest extraction module extracts an area of interest from the mammary gland DCE-MR image sequence. The lump segmentation module segments a lump in the area of interest. The sub-visualization module carries out the visual display on each segmented image and extractsthe edge of a focus. The feature extraction module extracts relevant feature values according to the lump information and transmits the relevant feature values to the feature dimensionality reductionmodule. The feature dimensionality reduction module carries out feature dimensionality reduction on an extracted feature set. The classification and diagnosis module inputs each lump feature value into a classifier. After that, the automatic classification and recognition is carried out by a computer for judging whether a lymph gland has already been transferred or not. The output module displaysa transfer prediction result and a transfer probability. According to the invention, the accurate segmentation of breast lesions can be realized. The accurate diagnosis of mammary axillary lymph glandmetastasis can be effectively assisted.

The computer aided method of predicting mammary cancer risk includes the following steps: partitioning the mammary gland tissue area in X-ray image regularly into small areas and calculating the density characteristic value of the small areas; selecting the initial suspicious small areas with the preset density characteristic value for further research; judging the final suspicious small areas based on the information in the corresponding areas and the adjacent areas on two frames of images; and judging the near term mammary cancer risk of the testee based on the existence of the marked final suspicious small areas and predicting the mammary cancer position in case of existing final suspicious small areas. The present invention has high objectivity, high accuracy and high effectiveness in predicting mammary cancer risk.

The invention discloses a breast tumor partition method. The breast tumor partition method includes the steps of building a coupled framework of classifications and biased field correcting of breast tissue nuclear magnetic resonance images, enhancing the breast areas and the peripheral areas, and partitioning the breast tumor images in cooperation with the shape prior. By means of the breast tumor partition method, biased field information is fused into classification models, the biased field information and the classification models are combined to be the unified framework, and the classifications and a corrected biased field of the breast tumor nuclear magnetic resonance images are solved with the fast energy minimization method at the same time, and use information of each other in the model evolution process for finally achieving accurate solving of the classifications and the corrected biased field; the shapes of blood vessels and tumors are analyzed, differences of the blood vessels and the tumors in shape are caught, the shape prior is built through parameters such as the characteristic values and the characteristic vectors, and the level set driving force based on the shapes is built and combined with a level set method based on local information, so that a level set overcomes the interference of a tubular structure during evolution and only captures the breast tumor area.

The invention relates to a dairy cattle feed additive containing selenium-enriched yeast, iron-enriched yeast and zinc-enriched yeast. The dairy cattle feed additive comprises selenium-enriched yeast powder, iron-enriched yeast powder, zinc-enriched yeast powder, mycotoxin adsorbent, compound vitamin, compound probiotics and a biological antioxidant. The dairy cattle feed additive is reasonable in formula, contains various organic microelements and probiotics and is balanced in nutrition, antibiotics are not added, the number of somatic cells in milk can be effectively reduced, the occurring rate of recessive mastitis of dairy cattle is reduced, a good developmental mechanism of a mammary gland system is maintained, milk yield and milk quality are improved, white muscle disease of the dairy cattle can be prevented, the requirements of vast farmers at present can be met, and the dairy cattle feed additive is suitable for development of green healthy cultivation and production of pollution-free ruminant products.

The invention discloses an early-stage breast cancer nondestructive screening and imaging system, which mainly comprises circular gears, an annular ultrasonic array, a bowl-shaped annular shell, ultrasonic coupling liquid, a protective film, a horn antenna, a waveguide tube, a microwave generator, a frequency divider, a data acquisition circuit, a preprocessing circuit, a stepping motor, a driver, a digital I / O card, a computer and a display. The working process of the system is that: detected mammary glands are radiated by pulse microwaves to generate thermo-acoustic signals which are received by the annular ultrasonic array and are finally acquired by the computer; the driver drives the annular ultrasonic array to rotate to a next position around detected biological tissues; and the steps of acquisition and rotation are repeated until the thermo-acoustic signals of enough positions are received, and the computer re-establishes three-dimensional thermo-acoustic images of the detectedtissues. The early-stage breast cancer nondestructive screening and imaging system can quickly and nondestructively realize the three-dimensional thermo-acoustic imaging of the detected mammary glands to provide one of important bases for the diagnosis of early-stage breast cancer.