96results about How to "Promotes significant proliferation" patented technology

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

In order to cause effective function when a system adopting a conventional settlement card is shifted to a system adopting a settlement card of IC card type and to enable a significant contribution to proliferation of the settlement card of IC card type, when a person who has input authentication data is authenticated as a user of a card by an authentication section, transaction data read by a magnetic stripe reader and transaction authentication data read by a memory reader are transmitted to a host server from transaction terminal equipment. The host server conducts a transaction through use of the transaction data and the transaction authentication data, both being output from the transaction terminal equipment. When the transaction is conducted, a memory writer writes data into memory of the card or rewrites data recorded in the memory.

The invention discloses a maca functional beverage and a preparation method thereof. The maca functional beverage contains maca, citric acid and water. The preparation method comprises the following steps of crushing maca into fine powder, mixing the maca fine powder and other raw materials, and carrying out homogenization treatment on the mixture. The maca functional beverage has high biologically-active substance content, is conducive to direct absorption of functional and nutritive components by drinkers, realizes complete combination of maca functionality, naturality and safety and is a novel health food and drink having a plurality of functions.

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

The invention provides a compound with the structure shown in a formula I, a preparation method of the compound, and an application of the compound as a tyrosine kinase and / or serine-threonine kinase inhibitor. The compound has a good inhibitory action on the activity of multiple kinases, and has an obvious inhibitory effect on tyrosine kinase and / or serine-threonine kinase in biochemical level and cell level in vitro (P is less than 0.05), and the half inhibitory concentration (IC50) for c-Met kinase is commonly below 10<-6>mol / L; and the compound also has an obvious inhibitory effect on proliferation of multiple tumor cells (P is less than 0.05), and the IC50 is respectively below 10<-5>mol / L. The compound with the structure shown in the formula I can be applied to preparing medicines for treating diseases related to protein kinase in organisms. The formula I is shown in the specification.

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

The preparation process of water soluble chitosan includes the following steps: a) stoving and crushing clean crab shell and soaking in acid solution; b) washing, boiling in alkali solution and washing to neutrality; c) dissolving chitin in alkali and heating to obtain chitosan; d) washing and stoving chitosan, dissolving in acetic acid solution, and hydrolyzing with excessive hydrogen peroxide; and e) vacuum concentration, suction filtering, and neutralizing with alkali solution to obtain water soluble chitosan. The present invention has the advantages of simple technological process, low production cost, safe product without side effect, and excellent physiological activity and health care effect of the product.

The invention relates to a composite prebiotic beverage, which comprises the following raw materials in parts by weight: 40-70 parts of high-purity fructo-oligosaccharides with a weight content of more than 95%, 10-20 parts of stachyose with a weight content of more than 80%, galacto-oligosaccharides 10~25, xylooligosaccharide 3~10; its preparation method includes the following steps: in the purification workshop, the temperature below 25 ℃, the environment below 30% humidity, the above raw materials are mixed according to the proportion, and then bottled or bagged in the clean workshop Add water and fruit juice to the compound prebiotic solid beverage, or add water directly, and after filling the prepared beverage, sterilize to obtain the compound prebiotic liquid beverage. Beneficial effects of the invention: it is beneficial to improve the balance of intestinal probiotic flora. Regular consumption can quickly achieve the good effects of two-way regulation of intestinal tract, nourishing intestinal tract and detoxification, restores intestinal function, and is beneficial to health.

The invention relates to a probiotic solid beverage. The probiotic solid beverage comprises the following components in percentage by weight: 2-10% of lactic acid bacteria powder, 30-50% of fructo-oligosaccharide, 5-15% of xylooligosaccharide, 10-20% of maltodextrin, 5-20% of erythritol and 5-15% of pomegranate fruit powder. According to the probiotic solid beverage disclosed by the invention, thefructo-oligosaccharide has obvious proliferation effect on beneficial bacteria of bifidobacterium lactis, lactobacilli and lactobacillus rhamnosus in gastrointestinal tracts of human bodies; the probiotics are bacteria beneficial to human, can maintain bacterial colonies balanced in the intestinal tracts, can assist in eliminating diarrhea, and can stop constipation; and the fructo-oligosaccharide and the probiotic powder are in collocation for eating, so that diarrhea can be eliminated, constipation can also be stopped, and the fructo-oligosaccharide and the probiotic powder jointly have theeffect of two-way regulation on the intestinal tracts.

The invention discloses Chinese herb tea and a preparation method of the Chinese herb tea. The Chinese herb tea is mainly prepared from the following raw materials in parts by weight: 60-100 parts of white granulated sugar, 10-20 parts of grass jelly, 3-10 parts of freeze-dried grosvener siraitia, 1-6 parts of stachyose, 0.5-2 parts of plumeria rubra, 0.5-2 parts of common lophatherum herb, 0.5-2 parts of honeysuckle flower, 0.3-1 part of common self-heal fruit-spike, 0.3-1 part of lalang grass rhizome, 0.2-1 part of coix seed, 0.2-1 part of chrysanthemum, 0.1-0.5 part of microcos leaf and 0.1-0.5 part of indian buead. The preparation method comprises the steps of performing extraction, rough filtration, fine filtration, ultra-filtration, blending, canning and sterilization on the raw materials to prepare the Chinese herb tea. A product disclosed by the invention has the food therapy effects of clearing heat and reducing internal heat, and invigorating the spleen and eliminating dampness, and is faint scent in smell and sweet and refreshing in taste; especially, stachyose is added, and has very significant proliferation effects on effective microbial communities such as bifidobacterium and lactobacillus in the gastrointestinal tract of a human body, promotes the natural proliferation of bifidus factors, rapidly improves the gastrointestinal internal environments of the human body, and regulates the gastrointestinal microflora balancing functions.

The invention belongs to the technical field of preparation of probiotic products, and particularly relates to a preparation method of Bifidobacterium microcapsules, which comprises the following steps: 1. preparing a composite bacterial suspension; 2. dissolving a wall material; and 3. preparing the composite microcapsules. The invention provides a novel method for preparing Bifidobacterium powder microcapsules, removes the film-forming reaction of chitosan, and lowers the production cost. According to the invention, the Bifidobacterium is embedded into an enteric material isolate the outside air, so that the Bifidobacterium microcapsules are hardly dissolved in gastric acid and slowly release in the intestinal tract; and after the Bifidobacterium microcapsules are digested by the intestinal tract, the bioavailability is enhanced, and the survival rate is higher than the document report.

The invention provides an anti-helicobacter-pylori probiotic composition, which comprises fructo-oligosaccharide, stachyose, orange juice powder, glucose, yam powder, maltodextrin and lactobacillus dry powder. The probiotic composition provided by the invention can inhibit the growth of helicobacter pylori so as to relieve the occurrence of gastric ulcer and stomachache.

The invention relates to a method for extracting and purifying neutral pseudo-ginseng polysaccharide, a research and an application for pharmacological activity for promoting cell proliferation. The pseudo-ginseng waste residue of the notoginsenoside extracted in the production process is taken as a raw material, a water extract and alcohol precipitation method is adopted for acquiring crude pseudo-ginseng polysaccharide and the DEAE Sepharose Fast Flow anion exchange chromatography is adopted for purifying the crude pseudo-ginseng polysaccharide so as to acquire five components: neutral pseudo-ginseng polysaccharide PNPS I and acidic pseudo-ginseng polysaccharide PNPS II, PNPS III, PNPS IV and PNPS V five samples. The research on the influence of the pseudo-ginseng polysaccharide on human periodontal ligament stem cell, mice osteoblast and human skin epidermis cell in vitro proliferation proves that the neutral pseudo-ginseng polysaccharide PNPS I is effective in boosting the periodontal ligament stem cell, mice osteoblast and human skin epidermis cell in vitro proliferation and the neutral pseudo-ginseng polysaccharide PNPS I can be used as an important drug intermediate for developing a new drug and a natural raw material for a functional healthcare food and also can be used as an active raw material of the household chemicals.

The invention belongs to the field of medical technology and relates to preparation and application of a series of curcumin analogues. The curcumin analogues have structures as shown in the formula I, formula II and formula III, wherein R, R1 and R2 are as mentioned in the specification. Pharmaceutically acceptable salt and solvate of the curcumin analogues and a medicine containing the curcumin analogues or the pharmaceutically acceptable salt used as active components can be used in treatment of cancer. The curcumin analogues and the pharmaceutically acceptable salt have a good anticancer activity. A preparation method of the curcumin analogues is simple and feasible and is easy to operate.

The invention discloses the application of astragalin in preparation of anti-ovarian-senescence medicaments. Astragalin can treat various ovarian failure diseases, and has a remarkable effect on polycystic ovarian syndrome, dysfunctional uterine bleeding, premature ovarian failure or climacteric syndrome and the like. According to the invention, astragalin is prepared into oral medicaments, percutaneous medicaments or parenteral medicaments for treating ovarian failure diseases.

The invention discloses a 2,7-naphthyridine derivative and a preparation method and application thereof. The derivative is a compound with a structure represented by the formula I, or a pharmaceutically acceptable equivalent or salt thereof. The compound represented by the formula has a good inhibiting effect against various kinase activities. Half inhibitory concentrations of the compound against kinases such as c-Met, KDR, c-kit, and the like are generally lower than 10<-7>mol.L<-1>. Also, according to the embodiment of the invention, the compound with the structure of the formula I has an inhibiting effect against the proliferation of various tumor cells. The formula I is represented as the following.

The invention belonging to the cell biology and pharmacology technical field relates to the purpose of a Chinese traditional medicine monomeric compound, in particularly to the new purpose of a protocatechuic acid in the aspect of promoting the external proliferation and induction-differentiation of a nerve stem cell. The invention is characterized in the application of producing medicine to treat the neurodegenerative diseases by nerve stem cell transplantation, in the application of producing neurenergen and cell differential agent for restoring damaged nerve tissues and reconstructing nerve functions, and in the application of constructing high efficient medical screening model to initially screen and appraise the efficacy of medicine. The invention confirms the new phamacoloic activity of the protocatechuic acid, providing material basis with regard to prevention effect of the Chinese traditional medicine, and providing reference for the development of new medicine with independent intellectual property rights.

In order to cause effective function when a system adopting a conventional settlement card is shifted to a system adopting a settlement card of IC card type and to enable a significant contribution to proliferation of the settlement card of IC card type, when a person who has input authentication data is authenticated as a user of a card by an authentication section, transaction data read by a magnetic stripe reader and transaction authentication data read by a memory reader are transmitted to a host server from transaction terminal equipment. The host server conducts a transaction through use of the transaction data and the transaction authentication data, both being output from the transaction terminal equipment. When the transaction is conducted, a memory writer writes data into memory of the card or rewrites data recorded in the memory.

The invention discloses an application of catalpol in preparing ovarian aging resisting medicaments. The catalpol can treat various ovarian aging diseases, and particularly has obvious effects on polycystic ovarian syndrome, dysfunctional uterine bleeding, premature ovarian failure or menopause syndrome and the like. According to the application, the catalpol is prepared into oral medicaments, transdermal medicaments or injections for treating ovarian failure diseases.

The invention belongs to the technical field of food production, and particularly relates to a liver protecting formula food containing oligopeptides and a preparing method thereof. The liver protecting formula food is prepared from 25%-35% of the soy protein oligopeptides, 18%-22% of polysaccharopeptide, 25%-35% of the goat milk protein oligopeptides, 8%-13% of sodium alga acid, 3%-6% of taurine, 3%-5% of stachyose and 0.05%-0.1% of vitamin B-complexes. The formula is characterized in that the micro-molecule oligopeptides can be rapidly absorbed, nutritional ingredients required by the livers can be rapidly supplemented, liver nutrients can be intensified, injured liver cells can be assisted to be repaired, liver-cell regeneration can be promoted, organism immunity can be improved, the resistant capacity of the livers can be enhanced, absorbing of harmful elements in the body can be further inhibited, and alexipharmic burdens of the livers can be reduced; meanwhile, lipid and cholesterol in the body can be assisted to be removed, accumulation of fat in the livers can be prevented, chemical liver injuries such as fatty livers and liver cirrhosis can be effectively prevented, and the liver protecting formula food is safe and free of any toxic and side effect.

The invention relates to pyrimidine derivate as shown in a formula I, and pharmaceutically acceptable salt, hydrate, solvate and prodrug of the pyrimidine derivate. The invention also relates to a compound which is shown in the formula 1 and has high inhibitive capability to c-Met kinase, and relates to a compound and pharmaceutically acceptable salt and hydrate thereof, a preparation method of the compound, a pharmaceutical composition containing the compound, and application of the compound.

The invention discloses a probiotic solid beverage. The probiotic solid beverage comprises raw materials, auxiliary materials and probiotic powder, wherein the raw materials comprise the components in grams by weight: 1.2 grams of fructo-oligosaccharide and 0.6 grams of stachyose; the auxiliary materials comprise the following raw materials in grams by weight of 0.1 gram of yeast powder and 0.1 gram of strawberry powder; and the probiotic powder comprises 20 hundred millions of bifidobacterium animalis, 80 hundred millions of bifidobacterium lactis and 80 hundred millions of lactobacillus rhamnosus. The probiotic solid beverage can maintain bacterial colony in intestinal tracts balanced, can facilitate elimination of diarrhoea, can stop constipation, has favorable two-way regulation effect on the intestinal tracts, and is good in mouth feel. The water activity of other raw materials in the probiotic solid beverage is controlled to 0.05 or below, and the activity time of probiotics can be prolonged.

The invention provides a compound with the structure shown in a formula I, a preparation method of the compound, and an application of the compound as a tyrosine kinase and / or serine-threonine kinase inhibitor. The compound has a good inhibitory action on the activity of multiple kinases, and has an obvious inhibitory effect on tyrosine kinase and / or serine-threonine kinase in biochemical level and cell level in vitro (P is less than 0.05), and the half inhibitory concentration (IC50) for c-Met kinase is commonly below 10<-6>mol / L; and the compound also has an obvious inhibitory effect on proliferation of multiple tumor cells (P is less than 0.05), and the IC50 is respectively below 10<-5>mol / L. The compound with the structure shown in the formula I can be applied to preparing medicines for treating diseases related to protein kinase in organisms. The formula I is shown in the specification.

The invention discloses an application of oxyresveratrol in preparing an ovary aging resistant medicine. The oxyresveratrol has significant treatment effects on various ovary aging diseases such as polycystic ovarian syndrome, dysfunctional uterine bleeding, premature ovarian failure and climacteric syndrome. The oxyresveratrol is prepared into the oral, transdermal or injection medicine for treating the ovary aging diseases.

The invention discloses a stachyose effervescent tablet and a preparation method thereof. The stachyose effervescent tablet is characterized by comprising the following constituents by weight: 5 to 15 percent of stachyose, 60 to 68 percent of a disintegrant, 15 to 20 percent of a sweetening agent, 2 to 4 percent of an adhesive, 2 to 5 percent of a lubricating agent, 0.55 to 1.1 percent of an algefacient, and 0.1 to 0.2 percent of essence. The preparation method comprises the following steps: mixing the stachyose, the disintegrant, the sweetening agent, the adhesive, the lubricating agent, the algefacient and the essence according to the ratio after screening the raw materials through a 80-mesh screen, performing forced air drying on the raw materials for 4 h, then screening the raw materials to perform granulating, feeding lactobacillus plantarum powder into the raw materials, performing tabletting in conditions that the relative humidity is 35 to 45 percent and the temperature is 15 to 20 DEG C, performing drying at 36 to 38 DEG C, and then obtaining the stachyose effervescent tablet finished products after package. The stachyose effervescent tablet has the advantages that the stachyose effervescent tablet not only is high in disintegration speed, but also contains stachyose prebiotics and lactobacillus plantarum probiotics, and the foaming capacity is 12 mL / g.

The invention discloses application of luteolin in preparation of ovarian senescence resistance medicines. The luteolin has obvious effects in treatment of multiple ovarian regression diseases such as polycystic ovarian syndrome, dysfunctional uterine bleeding, premature ovary failure or climacteric syndrome. The luteolin is prepared into oral medicines, transdermal delivery medicines or injection medicines for treating the ovarian regression diseases.

The invention belonging to the cell biology and pharmacology technical field relates to the purpose of a Chinese traditional medicine monomeric compound, in particularly to the new purpose of a protocatechuic acid in the aspect of promoting the external proliferation and induction-differentiation of a nerve stem cell. The invention is characterized in the application of producing medicine to treat the neurodegenerative diseases by nerve stem cell transplantation, in the application of producing neurenergen and cell differential agent for restoring damaged nerve tissues and reconstructing nerve functions, and in the application of constructing high efficient medical screening model to initially screen and appraise the efficacy of medicine. The invention confirms the new phamacoloic activity of the protocatechuic acid, providing material basis with regard to prevention effect of the Chinese traditional medicine, and providing reference for the development of new medicine with independent intellectual property rights.

The invention discloses moderate stomach-nourishing type ancient-prescription herbal tea and belongs to the technical field of tea drinking. The moderate stomach-nourishing type ancient-prescription herbal tea is prepared from the following raw materials in parts by weight: 8-20 parts of coix seeds, 10-16 parts of Poria cocos, 2-8 parts of stachyose, 8-30 parts of lalang grass rhizomes, 5-10 parts of grosvener siraitia, 8-24 parts of common lophatherum herb, 20-30 parts of chrysanthemum and 4-12 parts of tea leaves. The moderate stomach-nourishing type ancient-prescription herbal tea is prepared by a process method comprising the steps of selecting clearly, washing, extracting, blending, sterilizing and packaging. The moderate stomach-nourishing type ancient-prescription herbal tea takes the coix seeds, the Poria cocos and the stachyose, and the lalang grass rhizomes, the grosvener siraitia, the common lophatherum herb and the chrysanthemum, which have a plurality of health functions, as the raw materials and has the effects of preventing internal heat and coordinating intestines and stomach; the formula is moderate and is not cold and has the effects of clearing heat and expelling dampness, purging intense heat and relieving restlessness, tonifying spleen and eliminating summer heat, dispelling stomach cold and the like, so that the moderate stomach-nourishing type ancient-prescription herbal tea is suitable for people of all ages and both sexes to drink; and phenomena that almost tea capable of clearing away and lowering heat is tea which is obtained through grinding and sieving, without crushing, excessive coarse crushing or excessive crushing, and the size is not uniform so that heavy metal easily exceeds standards are avoided.