Freckle dispelling composition

A composition and freckle removal technology, applied in the field of freckle removal compositions, can solve the problem of difficulty in obtaining freckle removal effect, etc., and achieve the effects of outstanding freckle removal effect, changing skin color, and good penetration performance

Inactive Publication Date: 2020-06-05
斑敏痘(广东)皮肤研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult for the freckle-removing products on the market to obtain outstanding freckle-removing effects.

Method used

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  • Freckle dispelling composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Tyrosinase inhibition experiment

[0033] Tyrosinase can catalyze L-dopa to generate dopachrome, which has an absorption maximum at 475 nm. The specific operation is based on references (Ding Xiaomei, He Shansheng, Wang Li, Li Jian, Li Guiling. Inhibition and antioxidant properties of spirulina polysaccharides on tyrosinase [J]. Chinese Journal of Food Science, 2019, 19(10): 86-92.) The method provided:

[0034] (1) Prepare samples 1-4 to be tested, and the specific active substances and mass ratios are as follows:

[0035] ;

[0036] (2) Take 0.1 mL of tyrosinogenase solution, mix with 0.9 mL of PBS solution (pH 6.8), and temporarily store at 0°C. Weigh 0.1g, 0.3g, 0.5g, 0.7g, 0.9g, 1.0g, 1.1g, 1.3g, 1.5g, 2.0g, 2.5g of the samples to be tested, dissolve them in DMSO (dimethyl sulfoxide), and set Contain to 25mL volumetric flask, and make different doses of inhibitors. Accurately pipette a certain amount of 0.5mmol / LL-dopa solution and place in a wa...

Embodiment 2

[0038] Example 2 In vitro transdermal absorption experiment

[0039] The diffusion cell method is a conventional transdermal absorption experiment. It installs the isolated human or animal skin on the diffusion cell, regularly collects the receiving liquid, uses an appropriate analytical method to measure the content of active ingredients, and calculates the transdermal rate to evaluate the chemical absorption. permeability characteristics of the substance. References for specific operations (Liang Leyi, Cai Huixian, Deng Jingru, Huang Xiangxing, Wen Xiaoting, Lu Xiuxia. Preparation and pharmacodynamics of magnolia oil microemulsion gel [J]. Chinese Journal of New Drugs, 2019, 28(23): 2899-2908. ) provided by the method:

[0040] (1) Treatment of isolated skin: Healthy SD rats (180-220) g were taken, anesthetized with anhydrous ether, and their abdominal hair was shaved immediately. After the hair was shaved, they were killed by dislocation, and the abdominal skin was cut and...

Embodiment 3

[0048] A freckle-removing essence, comprising the following components in mass percentage:

[0049] 1,3-propanediol 5%, PEG / PPG-17 / 6 copolymer 2%, 1,2-pentanediol 5%, PPG-24-glyceryl polyether-24 1%, xanthan gum 0.05%, polyacrylic acid Sodium grafted starch 0.1%, sodium hyaluronate 0.02%, sodium polyglutamate 0.01%, ammonium acryloyldimethyltaurate / VP copolymer 0.2%, p-hydroxyacetophenone 0.15%, troxerutin 0.5%, salicylic acid 0.5%, Baiwei extract 70%, glyceryl polyether-26 balance.

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Abstract

The invention provides a freckle dispelling composition. The freckle dispelling composition comprises the active components of troxerutin, a radix cynanchi atrati extract, salicylic acid and 4-Butyl-resorcinol. Experiments prove that the active components can achieve the basal layer of skin, and can effectively act on melanocyte; through efficacy test and assessment, after freckle dispelling essence of the embodiment of the invention is used for 1 week, 4 weeks and 8 weeks, individual typology angle values present gradual upward trend, which has notable statistics significance. After the product is used, the individual typology angle values are increased, which indicates that the freckle dispelling essence provided by the embodiment of the invention can notably change the skin color, and has the effect of dispelling freckle. The freckle dispelling composition provided by the invention is found to be free from irritation to skin, is free from additional addition water and is high in active matter content.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a freckle removing composition. Background technique [0002] Melanin, a major determinant of skin color, protects the skin from absorption of 50% to 75% of ultraviolet (UV) radiation and scavenges reactive oxygen species (ROS). Tyrosinase, a copper-containing monooxygenase, is a key regulatory enzyme that catalyzes melanin synthesis in melanocytes. The main role of this enzyme is to hydroxylate L-tyrosine to 3,4-dihydroxyphenylalanine (L-DOPA) and subsequently oxidize L-DOPA to dopaquinone. Dopaquinone is a highly active compound that can spontaneously polymerize to form melanin. However, excess production of melanin in the skin can lead to hyperpigmentation. Therefore, tyrosinase inhibitors are becoming more and more important in cosmetics and pharmaceuticals as whitening agents and in the treatment of pigmentation disorders such as melasma, moles and the like. [0003] Human skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9728A61K8/60A61K8/368A61K8/34A61Q19/02
CPCA61K8/9728A61K8/602A61K8/368A61K8/347A61Q19/02A61K2800/782A61K2800/592
Inventor 陈建波
Owner 斑敏痘(广东)皮肤研究院
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