The invention provides freckle removal cream and a preparation method. The freckle removal cream is prepared from 0.01%-0.1% of radix scutellariae extract, 0.005%-1% of radix glycyrrhizae extract, 0.005%-0.2% of grape seed extract, 0.0005%-0.001% of coenzyme, 2%-8% of olive fruit oil, 0.05%-1% of tocopheryl acetate, 2%-7% of arbutin, 2%-7% of magnesium ascorbyl phosphate, 1%-4% of Jojoba oil, 2%-8% of isopropyl palmitate, 2%-8% of glycerin, 2%-5% of cyclomethicone, 3%-9% of propylene glycol, 2%-7% of glyceryl stearate, 0.1%-0.5% of imidazolidinyl urea, 0.1%-0.4% of methylparaben, 0.05%-0.14% of propylparaben, 2%-5% of stearic acid, 2%-6% of stearyl alcohol, 2%-6% of potassium C9-15 alkyl phosphate, 0.1%-1% of essence and the balance of deionized water. The freckle removal cream has no sideeffect and can retard activity of melanophores and nurse the skin.