The invention discloses a medicine used for nursing and treating a burn due to invasion of interior by toxic fire and a preparation method of the medicine. Various raw materials of the medicine comprise houttuynia cordata, tartary buckwheat, chinaroot greenbrier, basil, rhizoma bolbostemmae, calamint, shrub althea flower, japanese violet herb or root, willow branch, centella, air-plant herb, veined liparis, hypericum ascyron, folium agaves america nae, tree beautyberry root and leaf, cacumen biotae, lalang grass rhizome, involucrate balanophora, cactus, chinese elm bark, capitate knotweed herb, cynanchum thesioides, menispennaceae, madder, siberian walking fern, umbrellaleaf, peach laurel root, pseudostellaria maximowicziana, dwarf lilyturf root, changium smyrnioides, bighead atractylodes rhizome, ficus formosana root and liquorice. The medicine used for nursing and treating the burn due to invasion of interior by toxic fire has the beneficial effects that detoxication, inflammation diminishing, cool blooding and hemostasis are taken as main treatment principles, blood activation for stopping pain is realized, and the burn due to invasion of interior by toxic fire is nursed and treated; and the medicine used for nursing and treating the burn due to invasion of interior by toxic fire realizes treatment based on syndrome differentiation, has strong targeting and obvious curative effect, can resist to infection, prevent the surface of a wound from diffusing and improve cytothesis and skin healing capability, is low in cost and simple in production process and can be easily accepted by a patient.