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Application of bryophyllum, extract and medicinal preparation of bryophyllum

A technology of rooting and pharmaceutical preparations, applied in the field of medicine, can solve the problems of complex causes, large prescriptions, and unconfirmed curative effects, and achieve good drug effects

Inactive Publication Date: 2014-10-22
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have different mechanisms of action, but due to the complex causes of MCI or AD, their efficacy is not ideal
In addition, many researchers treat MCI and dementia with traditional Chinese medicine compound preparations. Invigorate the kidney and improve intelligence; Chen et al. use astragalus, psoraleae, cistanche, Polygonum multiflorum, Yizhiren, turmeric, medlar, calamus, leech, salvia miltiorrhiza, Chuanxiong, pinellia, licorice, etc. to invigorate the kidney and eliminate phlegm Removing blood stasis, etc. These traditional Chinese medicine compound prescriptions have more medicinal flavors, a large number of prescriptions, and do not use expensive medicinal materials, and the curative effect has not been clearly proven, which is not conducive to long-term use by patients

Method used

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  • Application of bryophyllum, extract and medicinal preparation of bryophyllum
  • Application of bryophyllum, extract and medicinal preparation of bryophyllum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A kind of ethanol extract of Rhizoma floridae can be prepared by the following method:

[0056] 1) Take 1 kg of fresh root, stem and leaf of ground-rooting plants, add 95% ethanol with a weight ratio of 4 times, soak for 1 to 2 days, crush, then extract and soak with 95% ethanol for 3 days, and collect the extract , recover ethanol under reduced pressure, and freeze-dry the concentrated solution to obtain the ethanol extract of Rhizoma Rhizome.

[0057] 2) Take 1 kg of the fresh whole plant of Rhizoma chinensis, crush it, add 95% ethanol with a weight ratio of 5 times to reflux for extraction twice, collect the extract, recover the ethanol under reduced pressure, and freeze-dry the concentrated solution to obtain the ethanol extract of Rhizoma radicis.

[0058] 3) Take 1 kg of the fresh plant of the root plant, freeze-dry it, crush it, add 95% ethanol with a weight ratio of 6 times, and extract it under reflux for 4 times, collect the extract, recover the ethanol under...

Embodiment 2

[0063] A kind of methanol extract of terrestrial root is obtained by the following method. Take 1 kg of fresh product of any part of root, stem and leaf of terrestrial root, pulverize it, add methanol to reflux for extraction twice, collect the extract, recover ethanol under reduced pressure, concentrate Freeze-dry to obtain the methanol extract of Rhizoma Rhizome.

[0064] In the above preparation method, the drying method is any one of freeze drying, vacuum drying, spray drying and microwave drying. Drying methods include, but are not limited to, reduced pressure drying, freeze drying, spray drying, and microwave drying.

[0065] A medicinal preparation containing the extract of Rhizoma chinensis, which is used alone and prepared by adding pharmaceutically acceptable auxiliary materials. Wherein the type of preparation can be a pharmaceutical preparation applicable to any route of administration, and any method known in pharmacy can be used to prepare the Rhizome root extra...

Embodiment 3

[0068] A kind of root petroleum ether extract obtained by the following method:

[0069] 1) According to the method for preparing the ethanol extract of Rhizoma Rhizome in Example 1, the concentrated solution of the ethanol extract of Rhizoma Rhizome was obtained, extracted with petroleum ether, recovered petroleum ether, and dried.

[0070] 2) According to the method for preparing the methanol extract of Rhizoma Rhizome in Example 2, obtain a dried sample of the methanol extract of Rhizoma Rhizome, add 4 to 20 times of water to suspend, extract with petroleum ether, recover the petroleum ether, and dry it.

[0071] 3) According to the method for preparing the ethanol extract of Rhizoma Rhizome in Example 1, obtain a dried sample of the ethanol extract of Rhizoma Rhizome, extract with petroleum ether under reflux, recover the petroleum ether, and dry it.

[0072] In the above preparation method, the drying method is any one of freeze drying, vacuum drying, spray drying and mic...

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Abstract

The invention discloses an application of bryophyllum, an extract and a medicinal preparation of the bryophyllum. A preparation method of the extract of the bryophyllum comprises the following steps: extracting a random fresh part of the complete plant or roots, stems and leaves of the bryophyllum, crushing the fresh part, adding 4-6 times amount of an extraction solvent, carrying out reflux extraction for 2-4 times, dipping or extracting, collecting an extraction solution, drying the extraction solution to obtain the extract of the bryophyllum, wherein the extraction solvent is methyl alcohol, 95% ethyl alcohol or petroleum ether; the medicine preparation is a preparation which is prepared by independently using the extract of the bryophyllum and subsequently adding pharmaceutically acceptable medicine carriers. The bryophyllum, the bryophyllum extract and the medicine preparation of the bryophyllum can be used as medicines for treating senile dementia and mild cognitive impairment and are especially remarkable in treatment effect on Alzheimer disease.

Description

technical field [0001] The invention relates to the field of medicines, and specifically refers to the application of the ground root and its extract and pharmaceutical preparation. Background technique [0002] Dementia is a progressive degeneration of cognitive function caused by brain injury or disease. The degree of degeneration is much higher than the progress of normal aging, especially affecting memory, attention, language, problem-solving ability, etc., serious Sometimes it is impossible to distinguish between people and things. Among them, Alzheimer's disease (Alzheimer's disease, AD) is the main type of dementia, and dementia also includes vascular dementia (vascular dementia, VD), mixed dementia and other types. Alzheimer's disease (AD) mainly occurs in middle-aged and elderly people. It is a central nervous degenerative disease characterized by progressive cognitive dysfunction and behavioral impairment. Once it occurs, it is difficult to reverse, and clinical t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P25/28
Inventor 张磊杨薇白筱璐余悦田兴军雷玲胡竟一吴瑕周静李兴平曾军秀唐丽燕李东晓
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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