The present disclosure relates to the treatment of a
skin condition in a subject, including but not limited to one or more of
luminosity, brightness,
skin pore size,
skin pore count,
sebum production, sebum composition, overall skin quality,
eyelid laxity, fine lines under the eye, fine lines on the face, laxity on the face, perioral rhytids,
moderate to severe facial folds and wrinkles such as nasolabial folds,
moderate to severe facial wrinkles such as smile lines or marionette lines, age-related midface contour deficiencies, dorsal hand to correct volume deficit, glabellar lines, correction of facila depressions, either due to injury or age-related, perioral wrinkles, lip commissures, crow's feet, facial rhytides, and
forehead wrinkles, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins. Also provided are compositions for use in the treatment of a skin condition in a subject, including but not limited to
hyperhidrosis, comprising a first composition and a second composition, wherein (a) the first composition comprises
Spongilla; and (b) the second composition comprises one or more botulinum toxins. Also provided are kits, including kits for the treatment of a skin condition in a subject including but not limited to
hyperhidrosis, comprising a first composition and a second composition, wherein the first composition comprises
Spongilla, and the second composition comprises one or more botulinum toxins.