Composition of starwort sulphonic acid or vitriolic acid polyoses ester total phenolic glycoside and method of preparing the same and antiviral application
A technology of sulfonic acid polysaccharide ester and sulfuric acid polysaccharide, applied in botany equipment and methods, antiviral agents, applications, etc.
Inactive Publication Date: 2008-01-23
朱耕新
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[0006] But it has not been seen to extract and isolate sulfated polysaccharide esters or sulfonic acid polysaccharide esters and their salts from plants of the genus so far, and phenols, especially with total flavonoids including apigenin, with carbon glycosidic bonds or / and oxygen glycosidic bonds. The formed molecular weight distribution is below 50,000, but it is mainly a type of total phenolic glycosides with a molecular weight distribution below 4,000, which is reported as a broad-spectrum antiviral drug application
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[0025] One), the preparation method of composition comprises following three kinds:
[0026] 1. Its first preparation method: wash the silt and crush the fresh grass or dried fresh grass of chickweed or other plants of the genus Chickweed, extract the aqueous solution, and obtain the liquid after sedimentation, centrifugation or filtration of the aqueous solution A; Liquid A is passed through the pre-treated macroporous resin column to absorb the composition of the composition, wash the column with water, wash the column with hot distilled water after heating the macroporous resin column to clean impurities, and collect the outflow deep Brown distilled water, then elute from the resin column with a lower alcohol with a concentration below 59% after heating, and collect the eluted brown-red or dark brown-red solution, recover the brown-red or dark brown-red solution after ethanol Combine with the collected dark brown water, concentrate until the specific gravity reaches about 0...
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Abstract
The invention relates to a kind of natural medicine of broad spectrum antibiotic. At present, the broad spectrum antibiotic medicine with high effect and safety is at shortage all round the world. The invention is intended to extract laminarinsulphate or sulphonic acid sugar ester or sulphosalts from plant chickweed or other chickweed plant with two resin adsorption methods or a water extraction and alcohol precipition method. The spectrum antibiotic in the invention is distributed under 50,000 in the formula weight formed by carbon glycosidic bond and/or oxide glycosidic bond with phenol, especially the total flavones comprising apigenin. However, the invention mainly acts as total phenolic glycoside with the formula weight under 4,000. Besides, the invention can form brownish compound with the total flavones comprising apigenin and the glycosidic ingredients without sulfur element, so as to be applied as broad spectrum antibiotic drug. Therefore, the compound in the invention can be applied to cure ADIS virus, hepatitis virus, influenza virus and parainfluenza virus comprising SARS, adenovirus, verruca acuminate virus, enterovirus, mumps virus, herpes simplex virus, herpes zoster virus and varicella. No toxic effect has been found in the application. What is more, the invention can be made into 10 sorts of formulation, disinfector and health-improving products.
Description
1. Technical field: [0001] The present invention relates to sulfated polysaccharide esters or sulfonic acid polysaccharide esters and salts thereof extracted from chickweed plants or other plants of the genus Chickweed, which can be combined with phenols, especially total flavonoids including apigenin with carbon glycosidic bonds or The molecular weight distribution formed by / and oxygen glycosidic bonds is below 50,000, but it is mainly a type of total phenolic glycosides with a molecular weight distribution below 4,000, formed with total flavonoids including apigenin and their glycosides without sulfur The brown-yellow composition is used as a broad-spectrum antiviral drug. [0002] Among them, the ratio of the total phenolic components of chickweed polysaccharide sulfate or the total phenolic components of chickweed polysaccharide sulfonate to the total flavonoids including apigenin and its glycosides without sulfur element is 9.0-9.8 The ratio is 1.0 to 0.2. 2. Backgro...
Claims
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IPC IPC(8): A61K36/36A61K31/737A61K31/715A61P31/14A61P31/16A61P31/18A61P31/22A61P31/12A01N65/00A61P1/00
Inventor 朱耕新曾毅李泽琳钱裕盛
Owner 朱耕新
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