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Dysosma versipellis extract, medicine composite containing extract as well as preparation method and application thereof

A technology of lotus extract and star anise lotus, applied in the field of star anise lotus extract, can solve the problems of high toxicity of drugs and no inhibitory effect, and achieve the effects of small side effects, clear effect and advanced technology

Inactive Publication Date: 2013-03-13
四川省自然资源科学研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dichloromethane extracts, except the star anise, did not show inhibitory effect due to the toxicity of the drug itself
However, there is no relevant report on the preparation of total lignans and total flavonoids from the effective parts of star anise lotus into medicine or disinfection products

Method used

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  • Dysosma versipellis extract, medicine composite containing extract as well as preparation method and application thereof
  • Dysosma versipellis extract, medicine composite containing extract as well as preparation method and application thereof
  • Dysosma versipellis extract, medicine composite containing extract as well as preparation method and application thereof

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preparation example Construction

[0025] The preparation method step of star anise lotus extract of the present invention is as follows:

[0026] A, take star anise lotus as raw material, take ethanol as extraction solvent, obtain extract a after the extract is concentrated;

[0027] B, extract a is washed with ethyl acetate, filtered, and the filtrate is concentrated to obtain extract b;

[0028] C, the extract b is heated and reflux washed with a mixed organic solvent, filtered, and the filtrate is concentrated to obtain the extract c;

[0029] D. The extract c is dried and pulverized to obtain the star anise lotus extract.

[0030] The key of the invention lies in the adoption of mixed organic solvent extraction, which reduces the impurity content in the extract and increases the content ratio of active ingredients in the extract.

[0031] The mixed organic solvent is a mixed solvent of a low-polarity organic solvent and a medium-polarity organic solvent, wherein the low-polarity organic solvent is at lea...

Embodiment 1 8

[0033] The preparation of embodiment 1 star anise lotus extract

[0034] (1) 10KG of star anise lotus, crushed into 20 meshes, percolated with 95% ethanol to recover ethanol.

[0035] (2) The extract is washed and filtered with ethyl acetate, and the solvent is recovered from the filtrate; the extract is washed with a mixed organic solvent (ethyl acetate:cyclohexane=2:1) ​​and heated to reflux, and filtered.

[0036] (3) The solvent was recovered from the filtrate, and the extract was dried and pulverized to obtain 522 g of star anise lotus extract A. The content of podophyllotoxin in the extract was 33.2% and that of kaempferol was 4.5% as determined by HPLC. The total flavonoid content was 10.8% measured by UV spectrophotometry.

Embodiment 2 8

[0037] The preparation of embodiment 2 star anise lotus extract

[0038] (1) 1KG of star anise lotus, crushed into 10 meshes, percolated with 95% ethanol to recover ethanol.

[0039] (2) The extract is washed and filtered with ethyl acetate, and the solvent is recovered from the filtrate; the extract is washed with a mixed organic solvent (petroleum ether: acetone = 1:1) under reflux, and filtered.

[0040] (3) The solvent was recovered from the filtrate, and the extract was dried and pulverized to obtain 41 g of star anise lotus extract. As determined by HPLC, the content of podophyllotoxin in the extract was 49.5%, and the content of kaempferol was 3.1%. The total flavonoid content was measured by ultraviolet spectrophotometry to be 8.7%.

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Abstract

The invention relates to a dysosma versipellis extract, a medicine composite containing the extract as well as a preparation method and application thereof. The dysosma versipellis extract with specific chemical components contains active components, such as general lignans, general flavones and the like; and the impurities of the extract are reduced, and contents of effective components are high. The dysosma versipellis extract comprises the following components in percentage by weight: 20-50 percent of podophyllotoxin, 3-8 percent of kaempferol and 8-15 percent of general flavones. The dysosma versipellis extract is high in contents of the effective components and low in impurities; and the dysosma versipellis extract or the medicine composite containing the extract is obvious in effect and low in side effects during skin sterilization and treatment in verruca acuminate. Compared with the prior art, the preparation method has the advantages of advanced process, high production, high practicability, relatively low cost and low environment pollution.

Description

technical field [0001] The invention relates to star anise lotus extract, a pharmaceutical composition containing the extract, its preparation method and application. Background technique [0002] The octagonal lotus is distributed in mountainous areas with an altitude of 300-1500 meters in the southeast of Tibet, west of Sichuan, Qinling, and south of the Huaihe River. It is known that there are distributions in Hubei, Hunan, Henan, Sichuan, Jiangxi, Anhui, Zhejiang, Guangdong, Guangxi, Yunnan, Guizhou, and Shanxi provinces, but the distribution in each area is not much. Star anise is a genus endemic to my country, with about 12 species and 1 variety. Over the years, the phenomenon of people digging indiscriminately has been very serious. At present, several plants in this genus have been listed as rare and endangered plants under the national third-level protection. [0003] Plants of the star anise genus generally contain aromatic tetrahydronaphthalene lignans such as p...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61P31/02A61P31/20
Inventor 熊铁一罗禹秦小波王玉杨楠杨适
Owner 四川省自然资源科学研究院
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