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Biodegradable and absorbable hemostasis composition

A technology of biodegradation and composition, applied in the direction of drug combination, absorbent pads, blood diseases, etc., can solve the problem of not seeing hyaluronic acid, etc., and achieve the effect of promoting the formation of blood clots

Inactive Publication Date: 2015-04-29
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] There is no report on the compatibility of hyaluronic acid and starch with hyaluronic acid, chitosan and starch

Method used

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  • Biodegradable and absorbable hemostasis composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1: Hemostatic Composition

[0066] 1. Composition: 5g sodium hyaluronate, 10g carboxymethyl chitosan and 85g carboxymethyl starch.

[0067] 2. Preparation method:

[0068] Take carboxymethyl starch, sodium hyaluronate and carboxymethyl chitosan according to the proportioning ratio, then dissolve it in 10L water, stir well (concentration g / ml is respectively 0.85%, 0.05%, 0.1%), and use Freeze-dry in a vacuum freeze dryer for 24 hours (set freezing temperature -15°C, vacuum degree o.8pa), grind the freeze-dried composite film into powder and pass through a 35-mesh sieve, and then sterilize by irradiation to obtain sterile biodegradable hemostatic powder.

Embodiment 2

[0069] Example 2: Hemostatic Composition

[0070] 1. Composition: 5g sodium hyaluronate, 5g carboxymethyl chitosan and 90g carboxymethyl starch.

[0071] 2. Preparation method:

[0072] Take carboxymethyl starch, sodium hyaluronate and carboxymethyl chitosan according to the proportion, dissolve them in 10L water, stir evenly (concentration g / ml is respectively 0.05%, 0.05%, 0.9%), and freeze-dry in vacuum Machine freeze-drying for 24 hours (set freezing temperature -20°C, vacuum degree o.5pa), grind the freeze-dried composite film into powder, pass through a 35-mesh sieve, and then sterilize by irradiation to obtain a sterile biodegradable hemostatic powder .

Embodiment 3

[0073] Example 3: Hemostatic Composition

[0074] 1. Composition: 40g sodium hyaluronate and 60g carboxymethyl starch.

[0075] 2. Preparation method:

[0076] Take sodium hyaluronate and carboxymethyl starch according to the proportioning ratio, dissolve them in 10L water (concentration g / ml is 0.6%, 0.4% respectively), stir evenly, dry by spray drying method, and then irradiate and sterilize to obtain Bacterial biodegradable hemostatic powder.

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Abstract

The invention relates to a biodegradable and absorbable hemostasis composition. The hemostasis composition is prepared from hyaluronic acid and modified starch or hyaluronic acid, chitosan and modified starch. The hemostasis composition is capable of stopping bleeding rapidly and has the effect superior to that of the prior art.

Description

technical field [0001] The invention relates to a hemostatic composition, in particular to a biodegradable and absorbable hemostatic composition. Background technique [0002] Hemorrhage is the first cause of death in war wounds and the second cause of death in trauma. Hemorrhage is also the main cause of death in the operating room of trauma patients. Rapid and effective control of bleeding can significantly reduce deaths due to bleeding. Currently commonly used biodegradable hemostatic materials mainly include the following: [0003] (1) Fibrin glue [0004] Fibrin glue mainly uses mammalian or human blood-related components as raw materials, extracts high-concentration fibrinogen as a matrix, and adds thrombin that can convert it into fibrin, as well as calcium ions and aprotinin to form fibrin. glue. The hemostatic effect is mainly the third stage of coagulation in the body where thrombin activates fibrinogen replication. In recent years, the fibrin sealant has been...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/14A61P7/04A61L15/28A61L15/44A61K31/718A61K31/722
CPCA61L26/0052A61L26/009A61L2400/04C08L3/04C08L5/08A61L24/0052
Inventor 翟晖殷瑞贤李次会李湘杰张国强
Owner BEIJING DATSING BIO TECH
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