Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Single-sided adhesive hydrogel adhesive as well as preparation method and application thereof

A hydrogel adhesive and hydrogel technology, which can be used in applications, surgical adhesives, surgery, etc., can solve the problems of poor physical interface adhesion, easy to fall off, and poor tissue adhesion and anti-tissue adhesion effect.

Active Publication Date: 2022-04-12
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
View PDF11 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the purpose of this application is to provide a single-sided adhesive hydrogel adhesive and its preparation method and application, aiming to solve the problem of the existing physical barrier materials for reducing postoperative tissue adhesion. Poor tissue adhesion effect and poor physical interface adhesion, easy to fall off

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Single-sided adhesive hydrogel adhesive as well as preparation method and application thereof
  • Single-sided adhesive hydrogel adhesive as well as preparation method and application thereof
  • Single-sided adhesive hydrogel adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] The present invention also provides a method for preparing a single-sided adhesive hydrogel adhesive, comprising the steps of:

[0046] S1, dissolving anionic monomers, cationic monomers, crosslinking agents, photoinitiators, and coupling agents in an aqueous solution to obtain a mixed solution;

[0047] S2, subjecting the mixed solution to ultraviolet light cross-linking and curing treatment, and then drying to obtain a hydrogel body;

[0048] S3. Spraying a surfactant on one side of the hydrogel body to obtain a single-sided bonding hydrogel adhesive.

[0049] In some embodiments, in the mixed solution in step S1, by weight, 10-15 parts of anionic monomer, 10-15 parts of cationic monomer, 0.5-1 part of photoinitiator, and 0.25-1 part of crosslinking agent , 0.5-3 parts of coupling agent, 100 parts of water.

[0050] In some embodiments, in the step of ultraviolet light cross-linking curing treatment in step S2, the curing temperature is 20-30° C., and the curing tim...

Embodiment 1

[0061] Get the reaction raw material of following parts by weight:

[0062] 15 parts of acrylic acid, 15 parts of (3-methacrylamide) propyl trimethyl ammonium chloride, 1 part of acrylic acid-N-succinimide, photoinitiator 2-hydroxy-4-(2-hydroxyethoxy base)-1 part of 2-methylpropiophenone, 0.5 part of cross-linking agent polyethylene glycol diacrylate (Mn=2000), 100 parts of deionized water, and 0.05 part of DMPC.

[0063] Acrylic acid, (3-methacrylamido) propyltrimethylammonium chloride, acrylic acid-N-succinimide, photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2- Mix and dissolve methylpropiophenone and cross-linking agent polyethylene glycol diacrylate (Mn=2000) (0.5wt%) in deionized water, mix evenly and centrifuge to remove bubbles, slowly pour into the mold, and seal under ultraviolet light Under the condition of 25°C in the curing box, the airtight reaction was carried out for 0.5h. The released hydrogel material evaporated most of the solvent at room temperature and drie...

Embodiment 2

[0066] Use single-sided adhesive hydrogel adhesives for adhering damaged tissue:

[0067] Cut length, width and thickness of 10mm * 10mm * 0.1mm single-sided adhesive hydrogel adhesive (the single-sided adhesive hydrogel adhesive made in embodiment 1), adhere to the wound surface and be coated with PBS aqueous solution ( pH 7.4) of the Achilles tendon tissue, after pressing for 5 seconds, the adhesion and sealing of the single-sided adhesive hydrogel adhesive to the biological tissue can be realized.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a single-sided adhesive hydrogel adhesive, which comprises a hydrogel body and a surfactant sprayed on the single side surface of the hydrogel body, and the hydrogel body comprises the following components in parts by weight: 10-15 parts of anionic monomer, 10-15 parts of cationic monomer, 0.5-1 part of photoinitiator and 0.25-1 part of cross-linking agent, 0.5-3 parts by weight of a coupling agent and 100 parts by weight of water; the weight part of the surface active agent is 0.01 to 0.05. According to the invention, the anionic monomer and the cationic monomer are mixed, the photoinitiator, the cross-linking agent and the coupling agent are added to form a polyelectrolyte hydrogel adhesive film, and the hydrogel body is subjected to single-side surface physical treatment by using the biocompatible surfactant, so that the long-term stable adhesion effect with the achilles tendon tissue interface can be realized; repair of damaged tissues is promoted, and postoperative adhesion existing in the achilles tendon repair process is effectively avoided.

Description

technical field [0001] The invention relates to the technical field of adhesives, in particular to a single-sided adhesive hydrogel adhesive and a preparation method and application thereof. Background technique [0002] Tendons are dense connective tissues that connect muscles to bones and transmit force from muscles to bones. Tendons are prone to spontaneous or traumatic rupture during long-term overuse, causing tendon diseases, resulting in tendon pain and motor dysfunction, which seriously affect the quality of life of patients. Injured tendons (especially the Achilles tendon, tendon cuff, and tibialis posterior) are usually treated surgically or conservatively, which has the characteristics of high incidence, easy recurrence, and long treatment cycle, which poses a great challenge to the treatment of tendon diseases . In addition, damaged tendon tissue has low cell density and cell activity, and the imbalance of endogenous healing and exogenous healing during the reco...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L24/08A61L24/06A61L24/04A61L24/00C08F220/06C08F220/60C08F222/20C08F220/36
Inventor 刘吉张俊陈兴梅
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com