87 results about "Repair processes" patented technology

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses injectable hydrogel with a myocardial tissue repairing function as well as a preparation method and application of the injectable hydrogel, and relates to the technical field of medical materials. The preparation method of the injectable hydrogel comprises the following steps: carrying out a reaction on deferoxamine and DSPE-PEG-NHS, so as to obtain DSPE-PEG-DFO; the preparation method comprises the following steps: wrapping carvedilol with DSPE-PEG-DFO under the hydrophilic and hydrophobic action, so as to obtain a drug-loaded nano-micelle; the preparation method comprises the following steps: reacting a polymer containing amino or hydroxyl with methacrylic anhydride to obtain a methylacryloyl modified polymer; reacting the carboxyl-containing polymer with cysteamine hydrochloride to obtain a sulfydryl modified polymer; mixing the drug-loaded nano-micelle, the methylacryloyl modified polymer and the sulfydryl modified polymer, and reacting under ultraviolet radiation to obtain the injectable hydrogel. The hydrogel disclosed by the invention is good in biocompatibility, can release deferoxamine and carvedilol in a ladder manner, is matched with a myocardial repair process, and realizes a function of repairing damaged myocardial tissues.

The invention discloses a pre-stretched hydrogel nerve conduit for promoting directional growth of nerves and a preparation method of the pre-stretched hydrogel nerve conduit, and belongs to the field of preparation of multifunctional hydrogel biomedical materials. The preparation method of the nerve conduit comprises the following preparation steps: preparing a polyvinyl alcohol solution, adding gelatin into the polyvinyl alcohol solution, stirring to enable the gelatin to be completely dissolved in the polyvinyl alcohol solution to prepare a mixed solution, putting the mixed solution into a mold, gelatinizing for a certain time, and performing circulating freezing-melting cross-linking to obtain the nerve conduit. And soaking in a sodium chloride / borax solution, and circularly stretching the hydrogel to obtain the pre-stretched hydrogel nerve conduit. The inside of the pre-stretched hydrogel nerve conduit has a three-dimensional network porous structure, and the inside of the pre-stretched hydrogel nerve conduit is of a porous structure, so that nutrient substance transfer and metabolite discharge in the nerve repair process are facilitated. The surface of the pre-stretched hydrogel nerve conduit is provided with a topological structure for promoting growth of nerve cells, and the nerve cells are guided to grow directionally in the repairing process. Besides, the pre-stretched hydrogel nerve conduit has excellent biocompatibility and adjustable mechanical properties, can be used for bridging operations after peripheral nerve injury, and is gradually degraded and absorbed by organisms in the nerve regeneration process. The nerve conduit provided by the invention shows wide application potential in the field of biomedicine, and can efficiently promote repair and regeneration of human tissues such as nerves and blood vessels.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention belongs to the field of biomedical materials and manufacturing thereof, and discloses a composite 3D printing stent with a time sequence regulation blood vessel and bone tissue regeneration function as well as a preparation method and application of the composite 3D printing stent. The method comprises the following steps: respectively loading an osteogenesis inducer and a vascular induced differentiation agent into two carrier materials with different degradation rates, and carrying out 3D printing and gel coating modification according to a reverse sequence of a physiological repair process of carrying out vascularization first and then carrying out osteogenesis to form a composite 3D printing stent of which the inner layer is loaded with the osteogenesis inducer and the outer layer is loaded with the vascular induced differentiation agent. After the composite 3D printing stent is implanted into a body, according to different degradation rates of the composite material, the repair and regeneration process of vascularization and osteogenesis is realized in a manner of degrading the gel coating and degrading the 3D printing stent, and the composite 3D printing stent has good living compatibility, biological activity and mechanical properties, and has good application prospects. The material can be used as a biomedical material for repairing or treating bone defects or self-repairing, and has a good application prospect in treatment and self-repairing of bone defects.

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention discloses an application of a DHA-RXR-PPAR signal channel in promotion of postoperative recovery of hysteromyoma after HIFU (high intensity focused ultrasound). Clinical sample metabolic spectrum analysis and in-vitro cell function experiments are combined, and research proves that the differential metabolite DHA drives macrophage metabolism reprogramming through an RXR-PPAR signal axis, so that the macrophage is promoted to be transformed into an anti-inflammatory and phagocytosis-promoting repair phenotype, the absorption and repair process of the HIFU postoperative hysteromyoma is accelerated, and the treatment effect of the HIFU postoperative hysteromyoma is improved. A new intervention target spot (RXR-PPAR gamma axis) and a new potential medicine are provided for HIFU (high intensity focused ultrasound) postoperative rehabilitation.

The invention relates to the technical field of medical intelligent decision making, in particular to a multi-parameter sensing and repairing process monitoring method for an absorbable biological material. State parameters such as the temperature, the pH value, the stress, the strain and the conductivity of the absorbable biological material are collected in real time through the skin patch sensor and the implantable biocompatible sensor, different stages of the repair process can be accurately recognized in combination with data processing and analysis, the repair process can be effectively optimized, the repair effect can be improved, and the repair cost can be reduced. A potential problem caused by an inaccurate repairing process is avoided; multi-sensor data acquisition and efficient data fusion technologies are adopted, the degradation process and tissue repair conditions of the repair material are accurately mastered through multi-dimensional monitoring, the conditions of abnormal degradation or local instability and the like of the repair material are found in time, it is ensured that the degradation process of the repair material is accurately controlled, and the repair effect is guaranteed to the maximum extent.

The present invention belongs to the field of biomedicine. Disclosed are a collagen peptide, a composition and the use thereof. Specifically disclosed are a type 21 recombinant humanized collagen peptide (ColpepA1 21) and a composition thereof, and the use of a collagen material in anti-aging treatments, skin care and wound repair. The recombinant collagen of the present invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of skin, reduce fine lines and wrinkles, improve the firmness and elasticity of skin, thereby significantly promoting key biological reactions in the wound healing process. Further disclosed in the present invention is a composite collagen material, which can effectively promote wound healing and cell regeneration, and alleviate oxidative damage.

The present application belongs to the technical field of medical operation auxiliary, and particularly relates to a precise tension control method and system for aortic repair operation. By acquiring the edge information and repair displacement of the repair area, the present application can not only evaluate the feasibility of the repair operation, but also obtain multiple executable repair plans through simulation calculation, so that the doctor can pre-plan the best repair scheme before the operation is implemented, greatly improving the success rate and safety of the operation. At the same time, the tension parameters in the repair process can be monitored in real time during the operation, ensuring that the repair process is carried out within a safe range, preventing the repair area from being stretched or compressed excessively, avoiding surgical risks, and through precise control of tension and optimization of repair plans, the operation time is shortened, the operation efficiency is improved, and the postoperative recovery time and complication risk of the patient are reduced.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

This invention relates to the field of facial acne repair technology, and more particularly to a computer vision-based system and method for assessing facial acne atrophic scars. The system includes: analyzing the intensity of facial pollution behaviors caused by the patient's daily activities based on patient daily behavior data and scar location distribution data; predicting the patient's risk of stress response in the scar area under future environmental conditions by combining environmental status data with epidermal morphology data of the patient's facial acne atrophic scar area; assessing the risk of scar recovery deterioration during the patient's scar repair process based on the results of the facial pollution behavior intensity analysis and the predicted risk of stress response in the scar area; and providing early warning for medical follow-up examinations based on the results of the scar recovery deterioration risk assessment. This system can accurately assess the state of acne atrophic scars, dynamically monitor the risk of recovery deterioration, and promptly trigger follow-up examination warnings, effectively improving the scar repair effect and the accuracy of medical intervention.

1. The name of the product of this design: Dental implant restoration anti-accidental swallowing tool. 2. Purpose of this product design: A tool to prevent the abutment from slipping into the oral cavity when removing the abutment during dental implant restoration. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present disclosure relates to the field of medical and healthcare instruments, specifically relates to an pelvic floor muscle repair device that includes a body and a variable diameter structure sleeved around the body, wherein the body is a strip-shaped structure, and the variable diameter structure is connected to the body and configured to change a diameter of the body. The present disclosure can choose bodies with different diameters according to a user's situation, and gradually reduce an overall diameter of the body as a repair process progresses to better suit the user, and also can reduce production costs and be convenient storage.

The invention relates to the field of biological medicine, in particular to a composition for repairing skin mucosa. The composition takes the cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser (PO3H2) and the vitamin B12 as active ingredients, the repair process of skin mucosa is remarkably promoted, including acceleration of epithelial cell migration, enhancement of barrier protein expression, inhibition of inflammatory response and promotion of wound healing, and compared with a traditional skin mucosa repair agent, the composition has higher repair efficiency and better treatment effect.

The application relates to the technical field of medical intelligent decision-making, in particular to a repair process monitoring method of absorbable biomaterials; the application realizes real-time collection of state parameters such as temperature, pH value, stress, strain and conductivity of the absorbable biomaterials through skin patch sensors and implantable biocompatible sensors, and can accurately identify different stages of the repair process in combination with data processing and analysis, can effectively optimize the repair process, improve the repair effect, and avoid potential problems caused by inaccurate repair progress; the application adopts multi-sensor data collection and efficient data fusion technology, accurately masters the degradation process of the repair material and the tissue repair condition through multi-dimensional monitoring, timely discovers abnormal degradation or local instability of the repair material, and ensures that the degradation process of the repair material is accurately controlled, and the repair effect is maximally ensured.

The invention relates to application of a TEAD family transcription factor gene or a carrier containing the TEAD family transcription factor gene in preparation of a medicine for treating skin injury. The vector containing the TEAD family transcription factor gene is transfected into the damaged skin tissue, so that the yield of exosomes in the skin tissue can be remarkably increased, and the skin injury repair process is promoted. The method is not only suitable for multiple types of skin injury repair processes, but also has important potential value in biomedical research and clinical application such as nerve injury repair, metabolic regulation and tumor microenvironment regulation and control.

The present application relates to the field of biological medicine, and particularly relates to a composition for skin mucosa repair. The composition takes a cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser(PO3H2) and vitamin B12 as active ingredients, significantly promotes the repair process of skin mucosa, including accelerating epithelial cell migration, enhancing barrier protein expression, inhibiting inflammatory reaction and promoting wound healing, and has higher repair efficiency and better treatment effect compared with traditional skin mucosa repair agents.

The present invention belongs to the technical field of healthcare instruments, and specifically relates to a pelvic floor muscle repair apparatus. The apparatus comprises a repair body and a diameter-varying structure. The repair body is in the shape of a strip, the diameter-varying structure is connected to the repair body, and the diameter-varying structure is configured to change the diameter of the repair body. The present application allows for the selection of repair bodies of different diameters on the basis of the situations of users and also enables the overall diameter of the repair body to be gradually reduced as the repair process proceeds, so as to be better suitable for the users. The present application also offers the advantages of reducing production costs and facilitating storage.

The invention relates to the technical field of oral biomedical materials, in particular to an oral restoration membrane material and a preparation method thereof. In order to improve the antibacterial performance of the oral cavity repairing film, the prepared oral cavity repairing film material adopts a multi-layer composite film structure, a back film in contact with an external oral cavity environment is made of a film prepared from PLGA, and gelatin-based hydrogel with an antibacterial function is used as an inner layer material of the oral cavity repairing film inside, so that the antibacterial performance of the oral cavity repairing film is improved, and the antibacterial performance of the oral cavity repairing film is improved. The porphyromonas gingivalis prepared from porphyromonas gingivalis, which contains thiophene and imidazole groups, and can generate antibacterial activity on common periodontal pathogenic bacteria, so that the alveolar bone can be prevented from being invaded by the porphyromonas gingivalis in the repairing process, and the repairing process is accelerated.

The invention discloses a preparation method of a 3D printing PEEK network stent for repairing large-scale defects of lower jawbone, and belongs to the field of biomedical engineering and mouth rehabilitation, and the preparation method comprises the following steps: reversely deducing the elastic modulus required by the stent in a specific area according to local stress distribution by introducing a mechanical calculation formula, further optimizing the microstructure of the stent, and obtaining the 3D printing PEEK network stent for repairing the large-scale defects of the lower jawbone. And the stent can dynamically meet the growth requirement of bone tissues in the whole repair process, so that the regeneration of endogenous bones and blood vessels is effectively promoted.

The invention provides a surgical data processing method, system and equipment. According to the method, firstly, the area meeting the repair condition can be accurately locked, such as the part, needing hyaluronic acid repair, of the face, the operation is targeted, and normal tissue is not affected, and secondly, the repair point location and the repair amount are determined according to the plane and three-dimensional data of the repair area. For example, according to the three-dimensional structure of the face, the use amount of hyaluronic acid at each point position is accurately calculated, traditional operation based on experience is avoided, the situation that hyaluronic acid is injected excessively or insufficiently is reduced, the risks of face swelling, poor repairing effect and the like are reduced, and the naturalness of the repairing effect and the success rate of an operation are improved; and finally, determining a repairing sequence according to the positions of the repairing point positions and dynamically labeling. The doctors operate in sequence, the operation efficiency is improved, the doctors can conveniently control the repair progress and dosage in real time and adjust in time through dynamic labeling, the repair process is more accurate and safer, better plastic surgery experience is brought to patients, and plastic surgery medical technology development is promoted.

The present application discloses a photocurable 3D printed bioceramic osteochondrium scaffold, which relates to the technical field of tissue repair materials. The scaffold includes a cartilage repair layer and a subchondral bone repair layer formed of the same material. The cartilage repair layer has a porous structure with a first aperture of 100-1000 μm, and the subchondral bone repair layer has a porous structure with a second aperture of 300-1000 μm. The cartilage repair layer and the subchondral bone repair layer are interlaced at the junction to form a pore structure with a third aperture of 50-300 μm; the third aperture is smaller than the first aperture and the second aperture. The osteochondrium scaffold of the present invention can ensure that bone marrow blood carries bioactive substances such as bone marrow mesenchymal stem cells and growth factors to penetrate into the cartilage defect site, and at the same time can hinder the vascular invasion of the subchondral bone repair layer and prevent the calcification of the cartilage layer; the subchondral bone repair layer provides sufficient support for the repair of the cartilage layer during the repair process.

The application discloses arginase 2 inhibiting peptides and application thereof in wound healing. The arginase 2 inhibiting peptide has an amino acid sequence as shown in SEQ ID No. 1 or a mutant sequence thereof. It is found through research of the application at a cell level and in a mouse skin wound model that MUT4-short peptide and MUT5-short peptide can effectively improve the viability and migration ability of keratinocytes under high-sugar conditions in vitro and in a metabolic abnormality model in vivo, reduce the intracellular reactive oxygen level, and promote the repair process of skin wounds, wherein the MUT4-short peptide shows more significant in promoting the recovery of cell functions and accelerating wound healing, and has a good application prospect in promoting skin wound healing, especially in the treatment of difficult-to-heal wounds related to metabolic diseases such as diabetes.

The invention discloses a preparation technology of a silk protein bone nail with a porous structure and biological activity, and particularly relates to the technical field of biomedical engineering.The preparation technology comprises the following steps that S1, a silk protein raw material is provided, and a regenerated silk protein solution is prepared through degumming, dissolving and purifying treatment; s2, uniformly mixing the silk protein solution obtained in the step S1 with a pore-foaming agent to prepare mixed slurry with proper viscosity; and S3, transferring the mixed slurry obtained in the step S2 into three-dimensional printing equipment, and performing extrusion printing according to a preset bone nail three-dimensional model. According to the preparation technology of the silk protein bone nail with the porous structure and the biological activity, the silk protein bone nail with the mutually-communicated porous structure is prepared through the synergistic effect of the three-dimensional printing technology and the pore-foaming agent, and the overall porosity is 60%-85%. The porous structure effectively improves the problem of poor connectivity of pore channels formed by traditional methods such as salt dissolution pore forming and the like, and is beneficial to cell migration, blood vessel ingrowth and nutrient substance transmission, so that the bone defect repair process is accelerated.

The present invention relates to the technical field of biomedical materials, and in particular to a degradable thermosensitive hydrogel composite calcium-silicon-based bone cement and a preparation method and application thereof, wherein the bone cement is composed of the following weight ratios: modified calcium silicate system: 70-100 parts; thermosensitive hydrogel: 5-30 parts; growth factor: 1-5 parts. The present application achieves excellent injectability and anti-collapse of bone cement, as well as mechanical properties matching human cancellous bone, and effectively shortens the curing time by integrating biocompatible components with thermosensitive hydrogel technology. In addition, the addition of growth factors significantly accelerates the repair and regeneration process of bone tissue, thereby greatly improving the repair effect of bone defects. Thus, the problems of mechanical property mismatch, long curing time, complex preparation process and growth factor application problems in the prior art are solved, affecting the surgical effect and the process of bone tissue repair.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.