125 results about "Repair processes" patented technology

The invention relates to the field of biological medicines, in particular to a facial anti-aging collagen peptide, a composition and an application of the facial anti-aging collagen peptide, and particularly relates to a 21-type recombinant humanized collagen peptide (ColpepA1 21) and an application of a composition of the 21-type recombinant humanized collagen peptide in anti-aging treatment and skin care. The recombinant collagen provided by the invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of the skin, reduce fine lines and wrinkles, and improve the compactness and elasticity of the skin.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses functional injection type bionic hydrogel for promoting bone healing and a preparation method thereof, and relates to the technical field of medical instruments. The hydrogel has good functional characteristics, is a biomimetic material prepared on the basis of methacrylated gelatin, and aims to regulate and control the degradation rate, the drug release mechanism and diversified synergistic treatment and promote bone repair and regeneration; according to the hydrogel, matching of the degradation rate and the bone regeneration rate is achieved through reasonable matching, stem cell osteogenic differentiation and angiogenesis are promoted, ultrasonic controlled-release drug release and synergistic controlled-release of active factors are achieved, inflammation is reduced, and the bone repair process is promoted; the calcium phosphate bone cement provides biocompatibility and bone conductivity, and the nano clay releases active ions to improve the microenvironment and promote bone repair; in addition, the magnetic nanoparticles and a static magnetic field have synergistic interaction, the bone healing process is further accelerated, and treatment effect monitoring is enhanced through magnetic resonance imaging.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention relates to the technical field of hydrogel, in particular to mussel mucoprotein loaded extracellular vesicle hydrogel as well as a preparation method and application thereof. The hydrogel is prepared by adopting a mode of combining human umbilical cord mesenchymal stem cell exosome Exo and mussel mucoprotein MAP; the method has the following advantages: 1, the wound repair effect is improved: the biological activity of the exosome Exo and the adhesion performance of the mussel mucin MAP are utilized to jointly promote the wound repair process, so that the repair effect is improved; 2, the adhesion performance is enhanced: the strong adhesion of the mussel adhesive protein MAP is utilized to ensure that the hydrogel can be tightly attached to the wound surface in a wet environment, and the dressing is prevented from falling off and infection risk; and 3, multifunctionality is realized: the composite hydrogel not only has the basic functions of promoting healing, resisting bacteria and the like, but also can transmit genetic information through exosome Exo, so that tissue regeneration and skin barrier repair are further promoted.

The invention discloses injectable hydrogel with a myocardial tissue repairing function as well as a preparation method and application of the injectable hydrogel, and relates to the technical field of medical materials. The preparation method of the injectable hydrogel comprises the following steps: carrying out a reaction on deferoxamine and DSPE-PEG-NHS, so as to obtain DSPE-PEG-DFO; the preparation method comprises the following steps: wrapping carvedilol with DSPE-PEG-DFO under the hydrophilic and hydrophobic action, so as to obtain a drug-loaded nano-micelle; the preparation method comprises the following steps: reacting a polymer containing amino or hydroxyl with methacrylic anhydride to obtain a methylacryloyl modified polymer; reacting the carboxyl-containing polymer with cysteamine hydrochloride to obtain a sulfydryl modified polymer; mixing the drug-loaded nano-micelle, the methylacryloyl modified polymer and the sulfydryl modified polymer, and reacting under ultraviolet radiation to obtain the injectable hydrogel. The hydrogel disclosed by the invention is good in biocompatibility, can release deferoxamine and carvedilol in a ladder manner, is matched with a myocardial repair process, and realizes a function of repairing damaged myocardial tissues.

The invention discloses a pre-stretched hydrogel nerve conduit for promoting directional growth of nerves and a preparation method of the pre-stretched hydrogel nerve conduit, and belongs to the field of preparation of multifunctional hydrogel biomedical materials. The preparation method of the nerve conduit comprises the following preparation steps: preparing a polyvinyl alcohol solution, adding gelatin into the polyvinyl alcohol solution, stirring to enable the gelatin to be completely dissolved in the polyvinyl alcohol solution to prepare a mixed solution, putting the mixed solution into a mold, gelatinizing for a certain time, and performing circulating freezing-melting cross-linking to obtain the nerve conduit. And soaking in a sodium chloride / borax solution, and circularly stretching the hydrogel to obtain the pre-stretched hydrogel nerve conduit. The inside of the pre-stretched hydrogel nerve conduit has a three-dimensional network porous structure, and the inside of the pre-stretched hydrogel nerve conduit is of a porous structure, so that nutrient substance transfer and metabolite discharge in the nerve repair process are facilitated. The surface of the pre-stretched hydrogel nerve conduit is provided with a topological structure for promoting growth of nerve cells, and the nerve cells are guided to grow directionally in the repairing process. Besides, the pre-stretched hydrogel nerve conduit has excellent biocompatibility and adjustable mechanical properties, can be used for bridging operations after peripheral nerve injury, and is gradually degraded and absorbed by organisms in the nerve regeneration process. The nerve conduit provided by the invention shows wide application potential in the field of biomedicine, and can efficiently promote repair and regeneration of human tissues such as nerves and blood vessels.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention belongs to the field of biomedical materials and manufacturing thereof, and discloses a composite 3D printing stent with a time sequence regulation blood vessel and bone tissue regeneration function as well as a preparation method and application of the composite 3D printing stent. The method comprises the following steps: respectively loading an osteogenesis inducer and a vascular induced differentiation agent into two carrier materials with different degradation rates, and carrying out 3D printing and gel coating modification according to a reverse sequence of a physiological repair process of carrying out vascularization first and then carrying out osteogenesis to form a composite 3D printing stent of which the inner layer is loaded with the osteogenesis inducer and the outer layer is loaded with the vascular induced differentiation agent. After the composite 3D printing stent is implanted into a body, according to different degradation rates of the composite material, the repair and regeneration process of vascularization and osteogenesis is realized in a manner of degrading the gel coating and degrading the 3D printing stent, and the composite 3D printing stent has good living compatibility, biological activity and mechanical properties, and has good application prospects. The material can be used as a biomedical material for repairing or treating bone defects or self-repairing, and has a good application prospect in treatment and self-repairing of bone defects.

The invention relates to a preparation method of a 3D printing porous degradable metal GBR film, and belongs to the field of biological material additive manufacturing. A preparation method of a 3D printing porous degradable metal GBR film comprises the following steps that S1, CT scanning is conducted on an alveolar bone of a bone defect repair implementation object, and a scanning entity prototype of the personalized GBR film is obtained through a reverse engineering technology; s2, selecting a lattice structure which is connected with nodes and has a symmetrical property as a basic filling unit for constructing the porous GBR membrane; s3, performing unit cell self-adaptive filling design on the scanning entity prototype of the personalized GBR membrane to form a porous GBR membrane model; s4, correcting the grids of the porous GBR membrane model by using printing post-processing software; and S5, preparing the porous degradable metal GBR film by adopting degradable biological metal powder through a 3D printing technology. By providing the personalized GBR film, the oral cavity structure of a patient can be better adapted. The porous GBR membrane is beneficial to migration and growth of bone cells and accelerates the repair process of bone defects.

The invention discloses an effect and application of RNA (Ribonucleic Acid) binding protein in skeletal muscle injury repair, and relates to the technical field of new application of medicines. A large number of experiments show that the RNA binding protein ARPP21 is up-regulated in the repair process after skeletal muscle injury. After the ARPP21 is knocked out, the repair capability of the mouse after skeletal muscle injury is weakened, and myoblast differentiation is inhibited. And when the ARPP21 is over-expressed, early migration of mouse myoblast differentiation can be promoted. Therefore, the ARPP21 plays an important regulating role in regeneration and repair after the skeletal muscle injury, can be used for preparing a medicine for regeneration and repair after the skeletal muscle injury, and provides a new clue and strategy for rehabilitation treatment after the skeletal muscle injury.

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention relates to an impression for repairing a complete denture, the complete denture and a preparation method. The impression terminator capable of being used for controlling the thickness of the impression material is designed by adopting computer modeling software, and the thickness of the impression material is limited by designing a bulge structure which is matched with the shape of an intraoral mucosa and has a certain thickness on an individual tray tissue surface, so that the intraoral impression of a patient has uniform thickness; the preparation precision of the edentulous jaw final impression is ensured; meanwhile, the individual tray and the diagnosis denture are designed into an integrated structure, so that a doctor can be assisted in acquiring the occlusion relation of a patient while the edentulous jaw final impression is acquired, the two steps of preparing the final impression and recording the jaw position relation in the traditional process are combined into one step, the clinical process is simplified, and the working efficiency is improved. And the experience dependence and the technical sensitivity of the operation process are reduced, so that the accuracy of the two key steps in the edentulous jaw repair process is improved.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention discloses an application of a DHA-RXR-PPAR signal channel in promotion of postoperative recovery of hysteromyoma after HIFU (high intensity focused ultrasound). Clinical sample metabolic spectrum analysis and in-vitro cell function experiments are combined, and research proves that the differential metabolite DHA drives macrophage metabolism reprogramming through an RXR-PPAR signal axis, so that the macrophage is promoted to be transformed into an anti-inflammatory and phagocytosis-promoting repair phenotype, the absorption and repair process of the HIFU postoperative hysteromyoma is accelerated, and the treatment effect of the HIFU postoperative hysteromyoma is improved. A new intervention target spot (RXR-PPAR gamma axis) and a new potential medicine are provided for HIFU (high intensity focused ultrasound) postoperative rehabilitation.

The invention relates to the technical field of medical intelligent decision making, in particular to a multi-parameter sensing and repairing process monitoring method for an absorbable biological material. State parameters such as the temperature, the pH value, the stress, the strain and the conductivity of the absorbable biological material are collected in real time through the skin patch sensor and the implantable biocompatible sensor, different stages of the repair process can be accurately recognized in combination with data processing and analysis, the repair process can be effectively optimized, the repair effect can be improved, and the repair cost can be reduced. A potential problem caused by an inaccurate repairing process is avoided; multi-sensor data acquisition and efficient data fusion technologies are adopted, the degradation process and tissue repair conditions of the repair material are accurately mastered through multi-dimensional monitoring, the conditions of abnormal degradation or local instability and the like of the repair material are found in time, it is ensured that the degradation process of the repair material is accurately controlled, and the repair effect is guaranteed to the maximum extent.

The present invention belongs to the field of biomedicine. Disclosed are a collagen peptide, a composition and the use thereof. Specifically disclosed are a type 21 recombinant humanized collagen peptide (ColpepA1 21) and a composition thereof, and the use of a collagen material in anti-aging treatments, skin care and wound repair. The recombinant collagen of the present invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of skin, reduce fine lines and wrinkles, improve the firmness and elasticity of skin, thereby significantly promoting key biological reactions in the wound healing process. Further disclosed in the present invention is a composite collagen material, which can effectively promote wound healing and cell regeneration, and alleviate oxidative damage.

The present application belongs to the technical field of medical operation auxiliary, and particularly relates to a precise tension control method and system for aortic repair operation. By acquiring the edge information and repair displacement of the repair area, the present application can not only evaluate the feasibility of the repair operation, but also obtain multiple executable repair plans through simulation calculation, so that the doctor can pre-plan the best repair scheme before the operation is implemented, greatly improving the success rate and safety of the operation. At the same time, the tension parameters in the repair process can be monitored in real time during the operation, ensuring that the repair process is carried out within a safe range, preventing the repair area from being stretched or compressed excessively, avoiding surgical risks, and through precise control of tension and optimization of repair plans, the operation time is shortened, the operation efficiency is improved, and the postoperative recovery time and complication risk of the patient are reduced.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The invention designs and develops an acoustic excitation antibacterial fiber wound repair material containing barium titanate (BTO) and liquid metal (GaIn) composite material, which is an ultrasonic response biological material, and is used for resisting wound bacterial infection. The invention also provides a preparation method of the material. The preparation method comprises the following steps: firstly, respectively constructing the BTO / GaIn composite material and the PLGA film, and loading the BTO / GaIn composite material on the PLGA film through surface spin coating. Under the ultrasonic action, the BTO / GaIn composite material can generate sufficient reactive oxygen species (ROS) to replace traditional antibiotic treatment to resist bacterial infection, and meanwhile, the regeneration of the wound surface is promoted in the repairing process. The material has excellent biocompatibility, relatively low cytotoxicity and lasting antibacterial performance, and can effectively resist microbial infection lacking of dressings in skin repair.

This invention relates to the field of facial acne repair technology, and more particularly to a computer vision-based system and method for assessing facial acne atrophic scars. The system includes: analyzing the intensity of facial pollution behaviors caused by the patient's daily activities based on patient daily behavior data and scar location distribution data; predicting the patient's risk of stress response in the scar area under future environmental conditions by combining environmental status data with epidermal morphology data of the patient's facial acne atrophic scar area; assessing the risk of scar recovery deterioration during the patient's scar repair process based on the results of the facial pollution behavior intensity analysis and the predicted risk of stress response in the scar area; and providing early warning for medical follow-up examinations based on the results of the scar recovery deterioration risk assessment. This system can accurately assess the state of acne atrophic scars, dynamically monitor the risk of recovery deterioration, and promptly trigger follow-up examination warnings, effectively improving the scar repair effect and the accuracy of medical intervention.

1. The name of the product of this design: Dental implant restoration anti-accidental swallowing tool. 2. Purpose of this product design: A tool to prevent the abutment from slipping into the oral cavity when removing the abutment during dental implant restoration. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present disclosure relates to the field of medical and healthcare instruments, specifically relates to an pelvic floor muscle repair device that includes a body and a variable diameter structure sleeved around the body, wherein the body is a strip-shaped structure, and the variable diameter structure is connected to the body and configured to change a diameter of the body. The present disclosure can choose bodies with different diameters according to a user's situation, and gradually reduce an overall diameter of the body as a repair process progresses to better suit the user, and also can reduce production costs and be convenient storage.

The invention relates to the field of biological medicine, in particular to a composition for repairing skin mucosa. The composition takes the cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser (PO3H2) and the vitamin B12 as active ingredients, the repair process of skin mucosa is remarkably promoted, including acceleration of epithelial cell migration, enhancement of barrier protein expression, inhibition of inflammatory response and promotion of wound healing, and compared with a traditional skin mucosa repair agent, the composition has higher repair efficiency and better treatment effect.

The invention discloses bacteriophage composite hydrogel as well as a preparation method and application thereof in promoting alveolar bone repair, and belongs to the field of biomedical materials. The preparation method comprises the following steps: mixing methacrylated gelatin, a photoinitiator, a genetically engineered bacteriophage and a lytic bacteriophage, and carrying out self-assembly under an illumination condition, wherein the genetically engineered bacteriophage is a double-display bacteriophage for displaying stem cell adhesion peptide and SDF1 mimic peptide on the surface of the same bacteriophage. The double-display bacteriophage in the bacteriophage composite hydrogel can maintain the functions of natural peptide for a long time, and the lytic bacteriophage kills bacterial infection in the repairing process in a green and side-effect-free manner in the repairing and regeneration process of the alveolar bone induced by the double-display bacteriophage, so that the repairing efficiency of the alveolar bone is improved. The invention provides a novel multifunctional phage composite hydrogel material for clinical repair of alveolar bones.

The application relates to the technical field of medical intelligent decision-making, in particular to a repair process monitoring method of absorbable biomaterials; the application realizes real-time collection of state parameters such as temperature, pH value, stress, strain and conductivity of the absorbable biomaterials through skin patch sensors and implantable biocompatible sensors, and can accurately identify different stages of the repair process in combination with data processing and analysis, can effectively optimize the repair process, improve the repair effect, and avoid potential problems caused by inaccurate repair progress; the application adopts multi-sensor data collection and efficient data fusion technology, accurately masters the degradation process of the repair material and the tissue repair condition through multi-dimensional monitoring, timely discovers abnormal degradation or local instability of the repair material, and ensures that the degradation process of the repair material is accurately controlled, and the repair effect is maximally ensured.

A cell repair-promoting extracellular vesicle, formed by silicate-induced stem cell secretion, helps express anti-inflammatory, tissue regeneration, and cell repair indicator factors, accelerating cell growth in wound tissue and the wound repair process.

The invention relates to application of a TEAD family transcription factor gene or a carrier containing the TEAD family transcription factor gene in preparation of a medicine for treating skin injury. The vector containing the TEAD family transcription factor gene is transfected into the damaged skin tissue, so that the yield of exosomes in the skin tissue can be remarkably increased, and the skin injury repair process is promoted. The method is not only suitable for multiple types of skin injury repair processes, but also has important potential value in biomedical research and clinical application such as nerve injury repair, metabolic regulation and tumor microenvironment regulation and control.

The present application relates to the field of biological medicine, and particularly relates to a composition for skin mucosa repair. The composition takes a cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser(PO3H2) and vitamin B12 as active ingredients, significantly promotes the repair process of skin mucosa, including accelerating epithelial cell migration, enhancing barrier protein expression, inhibiting inflammatory reaction and promoting wound healing, and has higher repair efficiency and better treatment effect compared with traditional skin mucosa repair agents.