65 results about "Repair processes" patented technology

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention belongs to the field of biomedical materials and manufacturing thereof, and discloses a composite 3D printing stent with a time sequence regulation blood vessel and bone tissue regeneration function as well as a preparation method and application of the composite 3D printing stent. The method comprises the following steps: respectively loading an osteogenesis inducer and a vascular induced differentiation agent into two carrier materials with different degradation rates, and carrying out 3D printing and gel coating modification according to a reverse sequence of a physiological repair process of carrying out vascularization first and then carrying out osteogenesis to form a composite 3D printing stent of which the inner layer is loaded with the osteogenesis inducer and the outer layer is loaded with the vascular induced differentiation agent. After the composite 3D printing stent is implanted into a body, according to different degradation rates of the composite material, the repair and regeneration process of vascularization and osteogenesis is realized in a manner of degrading the gel coating and degrading the 3D printing stent, and the composite 3D printing stent has good living compatibility, biological activity and mechanical properties, and has good application prospects. The material can be used as a biomedical material for repairing or treating bone defects or self-repairing, and has a good application prospect in treatment and self-repairing of bone defects.

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention discloses an application of a DHA-RXR-PPAR signal channel in promotion of postoperative recovery of hysteromyoma after HIFU (high intensity focused ultrasound). Clinical sample metabolic spectrum analysis and in-vitro cell function experiments are combined, and research proves that the differential metabolite DHA drives macrophage metabolism reprogramming through an RXR-PPAR signal axis, so that the macrophage is promoted to be transformed into an anti-inflammatory and phagocytosis-promoting repair phenotype, the absorption and repair process of the HIFU postoperative hysteromyoma is accelerated, and the treatment effect of the HIFU postoperative hysteromyoma is improved. A new intervention target spot (RXR-PPAR gamma axis) and a new potential medicine are provided for HIFU (high intensity focused ultrasound) postoperative rehabilitation.

The present invention belongs to the field of biomedicine. Disclosed are a collagen peptide, a composition and the use thereof. Specifically disclosed are a type 21 recombinant humanized collagen peptide (ColpepA1 21) and a composition thereof, and the use of a collagen material in anti-aging treatments, skin care and wound repair. The recombinant collagen of the present invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of skin, reduce fine lines and wrinkles, improve the firmness and elasticity of skin, thereby significantly promoting key biological reactions in the wound healing process. Further disclosed in the present invention is a composite collagen material, which can effectively promote wound healing and cell regeneration, and alleviate oxidative damage.

The present application belongs to the technical field of medical operation auxiliary, and particularly relates to a precise tension control method and system for aortic repair operation. By acquiring the edge information and repair displacement of the repair area, the present application can not only evaluate the feasibility of the repair operation, but also obtain multiple executable repair plans through simulation calculation, so that the doctor can pre-plan the best repair scheme before the operation is implemented, greatly improving the success rate and safety of the operation. At the same time, the tension parameters in the repair process can be monitored in real time during the operation, ensuring that the repair process is carried out within a safe range, preventing the repair area from being stretched or compressed excessively, avoiding surgical risks, and through precise control of tension and optimization of repair plans, the operation time is shortened, the operation efficiency is improved, and the postoperative recovery time and complication risk of the patient are reduced.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

This invention relates to the field of facial acne repair technology, and more particularly to a computer vision-based system and method for assessing facial acne atrophic scars. The system includes: analyzing the intensity of facial pollution behaviors caused by the patient's daily activities based on patient daily behavior data and scar location distribution data; predicting the patient's risk of stress response in the scar area under future environmental conditions by combining environmental status data with epidermal morphology data of the patient's facial acne atrophic scar area; assessing the risk of scar recovery deterioration during the patient's scar repair process based on the results of the facial pollution behavior intensity analysis and the predicted risk of stress response in the scar area; and providing early warning for medical follow-up examinations based on the results of the scar recovery deterioration risk assessment. This system can accurately assess the state of acne atrophic scars, dynamically monitor the risk of recovery deterioration, and promptly trigger follow-up examination warnings, effectively improving the scar repair effect and the accuracy of medical intervention.

The present disclosure relates to the field of medical and healthcare instruments, specifically relates to an pelvic floor muscle repair device that includes a body and a variable diameter structure sleeved around the body, wherein the body is a strip-shaped structure, and the variable diameter structure is connected to the body and configured to change a diameter of the body. The present disclosure can choose bodies with different diameters according to a user's situation, and gradually reduce an overall diameter of the body as a repair process progresses to better suit the user, and also can reduce production costs and be convenient storage.

The invention relates to the field of biological medicine, in particular to a composition for repairing skin mucosa. The composition takes the cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser (PO3H2) and the vitamin B12 as active ingredients, the repair process of skin mucosa is remarkably promoted, including acceleration of epithelial cell migration, enhancement of barrier protein expression, inhibition of inflammatory response and promotion of wound healing, and compared with a traditional skin mucosa repair agent, the composition has higher repair efficiency and better treatment effect.

The application relates to the technical field of medical intelligent decision-making, in particular to a repair process monitoring method of absorbable biomaterials; the application realizes real-time collection of state parameters such as temperature, pH value, stress, strain and conductivity of the absorbable biomaterials through skin patch sensors and implantable biocompatible sensors, and can accurately identify different stages of the repair process in combination with data processing and analysis, can effectively optimize the repair process, improve the repair effect, and avoid potential problems caused by inaccurate repair progress; the application adopts multi-sensor data collection and efficient data fusion technology, accurately masters the degradation process of the repair material and the tissue repair condition through multi-dimensional monitoring, timely discovers abnormal degradation or local instability of the repair material, and ensures that the degradation process of the repair material is accurately controlled, and the repair effect is maximally ensured.

The present application relates to the field of biological medicine, and particularly relates to a composition for skin mucosa repair. The composition takes a cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser(PO3H2) and vitamin B12 as active ingredients, significantly promotes the repair process of skin mucosa, including accelerating epithelial cell migration, enhancing barrier protein expression, inhibiting inflammatory reaction and promoting wound healing, and has higher repair efficiency and better treatment effect compared with traditional skin mucosa repair agents.

The present invention belongs to the technical field of healthcare instruments, and specifically relates to a pelvic floor muscle repair apparatus. The apparatus comprises a repair body and a diameter-varying structure. The repair body is in the shape of a strip, the diameter-varying structure is connected to the repair body, and the diameter-varying structure is configured to change the diameter of the repair body. The present application allows for the selection of repair bodies of different diameters on the basis of the situations of users and also enables the overall diameter of the repair body to be gradually reduced as the repair process proceeds, so as to be better suitable for the users. The present application also offers the advantages of reducing production costs and facilitating storage.

The invention relates to the technical field of oral biomedical materials, in particular to an oral restoration membrane material and a preparation method thereof. In order to improve the antibacterial performance of the oral cavity repairing film, the prepared oral cavity repairing film material adopts a multi-layer composite film structure, a back film in contact with an external oral cavity environment is made of a film prepared from PLGA, and gelatin-based hydrogel with an antibacterial function is used as an inner layer material of the oral cavity repairing film inside, so that the antibacterial performance of the oral cavity repairing film is improved, and the antibacterial performance of the oral cavity repairing film is improved. The porphyromonas gingivalis prepared from porphyromonas gingivalis, which contains thiophene and imidazole groups, and can generate antibacterial activity on common periodontal pathogenic bacteria, so that the alveolar bone can be prevented from being invaded by the porphyromonas gingivalis in the repairing process, and the repairing process is accelerated.

The invention discloses a preparation method of a 3D printing PEEK network stent for repairing large-scale defects of lower jawbone, and belongs to the field of biomedical engineering and mouth rehabilitation, and the preparation method comprises the following steps: reversely deducing the elastic modulus required by the stent in a specific area according to local stress distribution by introducing a mechanical calculation formula, further optimizing the microstructure of the stent, and obtaining the 3D printing PEEK network stent for repairing the large-scale defects of the lower jawbone. And the stent can dynamically meet the growth requirement of bone tissues in the whole repair process, so that the regeneration of endogenous bones and blood vessels is effectively promoted.

The invention provides a surgical data processing method, system and equipment. According to the method, firstly, the area meeting the repair condition can be accurately locked, such as the part, needing hyaluronic acid repair, of the face, the operation is targeted, and normal tissue is not affected, and secondly, the repair point location and the repair amount are determined according to the plane and three-dimensional data of the repair area. For example, according to the three-dimensional structure of the face, the use amount of hyaluronic acid at each point position is accurately calculated, traditional operation based on experience is avoided, the situation that hyaluronic acid is injected excessively or insufficiently is reduced, the risks of face swelling, poor repairing effect and the like are reduced, and the naturalness of the repairing effect and the success rate of an operation are improved; and finally, determining a repairing sequence according to the positions of the repairing point positions and dynamically labeling. The doctors operate in sequence, the operation efficiency is improved, the doctors can conveniently control the repair progress and dosage in real time and adjust in time through dynamic labeling, the repair process is more accurate and safer, better plastic surgery experience is brought to patients, and plastic surgery medical technology development is promoted.

The application discloses arginase 2 inhibiting peptides and application thereof in wound healing. The arginase 2 inhibiting peptide has an amino acid sequence as shown in SEQ ID No. 1 or a mutant sequence thereof. It is found through research of the application at a cell level and in a mouse skin wound model that MUT4-short peptide and MUT5-short peptide can effectively improve the viability and migration ability of keratinocytes under high-sugar conditions in vitro and in a metabolic abnormality model in vivo, reduce the intracellular reactive oxygen level, and promote the repair process of skin wounds, wherein the MUT4-short peptide shows more significant in promoting the recovery of cell functions and accelerating wound healing, and has a good application prospect in promoting skin wound healing, especially in the treatment of difficult-to-heal wounds related to metabolic diseases such as diabetes.

The invention discloses a preparation technology of a silk protein bone nail with a porous structure and biological activity, and particularly relates to the technical field of biomedical engineering.The preparation technology comprises the following steps that S1, a silk protein raw material is provided, and a regenerated silk protein solution is prepared through degumming, dissolving and purifying treatment; s2, uniformly mixing the silk protein solution obtained in the step S1 with a pore-foaming agent to prepare mixed slurry with proper viscosity; and S3, transferring the mixed slurry obtained in the step S2 into three-dimensional printing equipment, and performing extrusion printing according to a preset bone nail three-dimensional model. According to the preparation technology of the silk protein bone nail with the porous structure and the biological activity, the silk protein bone nail with the mutually-communicated porous structure is prepared through the synergistic effect of the three-dimensional printing technology and the pore-foaming agent, and the overall porosity is 60%-85%. The porous structure effectively improves the problem of poor connectivity of pore channels formed by traditional methods such as salt dissolution pore forming and the like, and is beneficial to cell migration, blood vessel ingrowth and nutrient substance transmission, so that the bone defect repair process is accelerated.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.

The invention discloses Mxene / Zn nano coating modified CF / PEEK as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, pretreating a CF / PEEK stent; s2, sulfonating the surface of the CF / PEEK stent; s3, a PEI-TA adhesive layer is constructed; s4, a CF / PEEK-MXene material is prepared; and S5, preparing the CF / PEEK-MXene coated Zn material. Through the synergistic effect of promoting osteogenesis and angiogenesis, the MXene / Zn nano-coating modified CF / PEEK stent can effectively solve the problem of mismatch of multiple biological interfaces of mechanical support-nutrition transport-cell recruitment in large-section bearing bone defect repair. The gradient mechanical adaptation characteristic of the stent can provide stable mechanical support, meanwhile, good mechanical matching with surrounding bone tissues is achieved, and the stress shielding effect is avoided. And the blood vessel-osteogenesis coupling activity ensures that the collection of cells, the transportation of nutrition and the formation of new bones can be orderly carried out in the bone repair process, so that the success rate of large-section bearing bone defect repair is greatly improved.

The utility model discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof, the engineering construction composite artificial bone comprises a bioactive material and a mechanical support bracket, the bioactive material is used as a main body, the mechanical support bracket is contained in the bioactive material, and the bioactive material and the mechanical support bracket are tightly combined to form an artificial bone tissue complex. The mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. According to the utility model, the osseointegration performance and the mechanical property of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

The invention discloses a BBB repairing agent evaluation method and system based on an ischemia reperfusion injury model, and relates to the technical field of biologication.The method comprises the following specific steps that the ischemia reperfusion injury model is built, and a sample is collected, specifically, an animal ischemia reperfusion injury model is built, and experimental animals are divided into an experimental group and a control group; brain tissue and blood samples of the two groups of animals are collected at a plurality of preset time nodes, and behavioral evaluation is carried out at the same time to obtain score data; according to the method, the deep learning model fused with the dynamic attention mechanism is constructed, the weights of different time nodes and different modal data on BBB repair effect evaluation after ischemia reperfusion injury can be automatically identified, the problems that early signals are ignored and key time node evaluation is deviated due to fixed static data weights in a traditional evaluation method are solved, and the accuracy of BBB repair effect evaluation is improved. The model can flexibly adjust the weight of each modal data according to the dynamic change characteristics of the BBB repair process, and a more reliable basis is provided for research, development and application of a repair agent.

This invention provides a tissue repair and filling composite gel, its preparation method, and its application, relating to the field of biomedical materials technology. The composite gel is mainly prepared by freeze-thaw physical cross-linking of hyaluronic acid and biodegradable microspheres, wherein: the hyaluronic acid has a molecular weight of 800,000 to 3,000,000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair and filling composite gel of this application consists of a hyaluronic acid matrix with a porous three-dimensional network structure obtained by freeze-thaw physical cross-linking and uniformly dispersed hydroxyapatite microspheres. During the filling and repair process, the hyaluronic acid provides an immediate filling effect, while the hydroxyapatite microspheres stimulate collagen regeneration. This tissue repair and filling composite gel effectively alleviates the technical problems of poor safety associated with existing hyaluronic acid gels obtained by cross-linking agents for in vivo filling, and the inconvenience of injecting regenerated microsphere fillers.

A method for treating muscular dystrophy of a subject comprising administrating a N-formyl peptide receptor (FPR) agonist to the subject and compositions therefore. An FPR agonist may be used to target the FPR2-mediated pro-resolving pathway, thus facilitating the clearance of inflammation, reducing inflammatory response, enhancing repair processes, enhancing regenerative capacity in muscles, and otherwise improving prognosis of muscular dystrophy.

The invention relates to the technical field of facial acne repair, in particular to a facial acne depressed scar evaluation system and method based on computer vision, and the method comprises the steps: analyzing the intensity of facial pollution behaviors caused by the daily behaviors of a patient based on the daily behavior data and scar position distribution data of the patient; predicting the stress reaction risk of the scar area of the patient in the future environment by combining the environment state data and the epidermis form data of the acne depressed scar area on the face of the patient; based on the facial pollution behavior intensity analysis result and the cicatrix area stress response risk prediction result, the cicatrix recovery deterioration risk in the cicatrix repair process of the patient is evaluated; performing medical review early warning on the patient according to the cicatrix recovery deterioration risk assessment result; the acne depressed scar state can be accurately evaluated, the recovery deterioration risk is dynamically monitored, reexamination early warning is triggered in time, and the scar repair effect and the medical intervention accuracy are effectively improved.

The invention belongs to the technical field of lung in-vitro repair monitoring, and particularly relates to an in-vitro lung culture environment monitoring system and method based on lung repair. According to the method, various physiological condition parameters, such as oxygen concentration, carbon dioxide concentration, temperature, humidity and nutrient solution content, of the lung sample under in-vitro culture are monitored and regulated in real time, accurate control over the lung sample repairing process is achieved, and the lung sample repairing accuracy is improved by summarizing the damage amount and the repairing amount of the lung sample. And reliable data support is provided for the repair progress of the lung sample. Meanwhile, according to the repairing condition of the lung sample, the perfusion amount of each physiological condition parameter is dynamically adjusted, the repairing efficiency and success rate of the lung sample are effectively improved, the perfusion amount of each physiological condition parameter is optimized and adjusted for the lung sample in a normal state and a risk state, and the repairing efficiency of the lung sample is improved. It is ensured that the lung sample is repaired in the optimal environment, so that the in-vitro repairing quality and repairing speed of the lung sample are improved.

The invention discloses a three-dimensional patch for esophageal hiatus hernia repair, and relates to the technical field of human life necessities. A three-dimensional patch for esophageal hiatus hernia repair comprises a patch body and an esophagus lower end connecting piece, the esophagus lower end connecting piece is in a U shape and is connected and sewn with the lower end of an esophagus, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is made of a silk collagen material, and the silk collagen material has the slow absorbable characteristic; the patch body is gradually degraded into carbon dioxide and water within about two years, the process is matched with the natural repairing process of esophageal pore tissue, meanwhile, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is matched with the U-shaped esophageal lower end connecting piece, the complex anatomical structure of the esophageal pore and surrounding tissue can be precisely matched, and the repairing effect is good. The arc-shaped end conforms to the bending form of the connecting part of the esophagus and the stomach, and the U-shaped esophagus lower end connecting piece is attached to the diaphragm radian around the esophageal crack hole, so that the patch is tightly attached to the tissue, and the repairing effect is improved.