43 results about "Repair processes" patented technology

The invention belongs to the field of biomedical materials and manufacturing thereof, and discloses a composite 3D printing stent with a time sequence regulation blood vessel and bone tissue regeneration function as well as a preparation method and application of the composite 3D printing stent. The method comprises the following steps: respectively loading an osteogenesis inducer and a vascular induced differentiation agent into two carrier materials with different degradation rates, and carrying out 3D printing and gel coating modification according to a reverse sequence of a physiological repair process of carrying out vascularization first and then carrying out osteogenesis to form a composite 3D printing stent of which the inner layer is loaded with the osteogenesis inducer and the outer layer is loaded with the vascular induced differentiation agent. After the composite 3D printing stent is implanted into a body, according to different degradation rates of the composite material, the repair and regeneration process of vascularization and osteogenesis is realized in a manner of degrading the gel coating and degrading the 3D printing stent, and the composite 3D printing stent has good living compatibility, biological activity and mechanical properties, and has good application prospects. The material can be used as a biomedical material for repairing or treating bone defects or self-repairing, and has a good application prospect in treatment and self-repairing of bone defects.

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention discloses an application of a DHA-RXR-PPAR signal channel in promotion of postoperative recovery of hysteromyoma after HIFU (high intensity focused ultrasound). Clinical sample metabolic spectrum analysis and in-vitro cell function experiments are combined, and research proves that the differential metabolite DHA drives macrophage metabolism reprogramming through an RXR-PPAR signal axis, so that the macrophage is promoted to be transformed into an anti-inflammatory and phagocytosis-promoting repair phenotype, the absorption and repair process of the HIFU postoperative hysteromyoma is accelerated, and the treatment effect of the HIFU postoperative hysteromyoma is improved. A new intervention target spot (RXR-PPAR gamma axis) and a new potential medicine are provided for HIFU (high intensity focused ultrasound) postoperative rehabilitation.

The present invention belongs to the field of biomedicine. Disclosed are a collagen peptide, a composition and the use thereof. Specifically disclosed are a type 21 recombinant humanized collagen peptide (ColpepA1 21) and a composition thereof, and the use of a collagen material in anti-aging treatments, skin care and wound repair. The recombinant collagen of the present invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of skin, reduce fine lines and wrinkles, improve the firmness and elasticity of skin, thereby significantly promoting key biological reactions in the wound healing process. Further disclosed in the present invention is a composite collagen material, which can effectively promote wound healing and cell regeneration, and alleviate oxidative damage.

The present application belongs to the technical field of medical operation auxiliary, and particularly relates to a precise tension control method and system for aortic repair operation. By acquiring the edge information and repair displacement of the repair area, the present application can not only evaluate the feasibility of the repair operation, but also obtain multiple executable repair plans through simulation calculation, so that the doctor can pre-plan the best repair scheme before the operation is implemented, greatly improving the success rate and safety of the operation. At the same time, the tension parameters in the repair process can be monitored in real time during the operation, ensuring that the repair process is carried out within a safe range, preventing the repair area from being stretched or compressed excessively, avoiding surgical risks, and through precise control of tension and optimization of repair plans, the operation time is shortened, the operation efficiency is improved, and the postoperative recovery time and complication risk of the patient are reduced.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

This invention relates to the field of facial acne repair technology, and more particularly to a computer vision-based system and method for assessing facial acne atrophic scars. The system includes: analyzing the intensity of facial pollution behaviors caused by the patient's daily activities based on patient daily behavior data and scar location distribution data; predicting the patient's risk of stress response in the scar area under future environmental conditions by combining environmental status data with epidermal morphology data of the patient's facial acne atrophic scar area; assessing the risk of scar recovery deterioration during the patient's scar repair process based on the results of the facial pollution behavior intensity analysis and the predicted risk of stress response in the scar area; and providing early warning for medical follow-up examinations based on the results of the scar recovery deterioration risk assessment. This system can accurately assess the state of acne atrophic scars, dynamically monitor the risk of recovery deterioration, and promptly trigger follow-up examination warnings, effectively improving the scar repair effect and the accuracy of medical intervention.

The present disclosure relates to the field of medical and healthcare instruments, specifically relates to an pelvic floor muscle repair device that includes a body and a variable diameter structure sleeved around the body, wherein the body is a strip-shaped structure, and the variable diameter structure is connected to the body and configured to change a diameter of the body. The present disclosure can choose bodies with different diameters according to a user's situation, and gradually reduce an overall diameter of the body as a repair process progresses to better suit the user, and also can reduce production costs and be convenient storage.

The invention relates to the field of biological medicine, in particular to a composition for repairing skin mucosa. The composition takes the cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser (PO3H2) and the vitamin B12 as active ingredients, the repair process of skin mucosa is remarkably promoted, including acceleration of epithelial cell migration, enhancement of barrier protein expression, inhibition of inflammatory response and promotion of wound healing, and compared with a traditional skin mucosa repair agent, the composition has higher repair efficiency and better treatment effect.

The present application relates to the field of biological medicine, and particularly relates to a composition for skin mucosa repair. The composition takes a cyclic peptide of Dap-Abu-Pro-Thz-Asp-Nva-Ser(PO3H2) and vitamin B12 as active ingredients, significantly promotes the repair process of skin mucosa, including accelerating epithelial cell migration, enhancing barrier protein expression, inhibiting inflammatory reaction and promoting wound healing, and has higher repair efficiency and better treatment effect compared with traditional skin mucosa repair agents.

The present invention belongs to the technical field of healthcare instruments, and specifically relates to a pelvic floor muscle repair apparatus. The apparatus comprises a repair body and a diameter-varying structure. The repair body is in the shape of a strip, the diameter-varying structure is connected to the repair body, and the diameter-varying structure is configured to change the diameter of the repair body. The present application allows for the selection of repair bodies of different diameters on the basis of the situations of users and also enables the overall diameter of the repair body to be gradually reduced as the repair process proceeds, so as to be better suitable for the users. The present application also offers the advantages of reducing production costs and facilitating storage.

The invention relates to the technical field of oral biomedical materials, in particular to an oral restoration membrane material and a preparation method thereof. In order to improve the antibacterial performance of the oral cavity repairing film, the prepared oral cavity repairing film material adopts a multi-layer composite film structure, a back film in contact with an external oral cavity environment is made of a film prepared from PLGA, and gelatin-based hydrogel with an antibacterial function is used as an inner layer material of the oral cavity repairing film inside, so that the antibacterial performance of the oral cavity repairing film is improved, and the antibacterial performance of the oral cavity repairing film is improved. The porphyromonas gingivalis prepared from porphyromonas gingivalis, which contains thiophene and imidazole groups, and can generate antibacterial activity on common periodontal pathogenic bacteria, so that the alveolar bone can be prevented from being invaded by the porphyromonas gingivalis in the repairing process, and the repairing process is accelerated.

The invention discloses a preparation method of a 3D printing PEEK network stent for repairing large-scale defects of lower jawbone, and belongs to the field of biomedical engineering and mouth rehabilitation, and the preparation method comprises the following steps: reversely deducing the elastic modulus required by the stent in a specific area according to local stress distribution by introducing a mechanical calculation formula, further optimizing the microstructure of the stent, and obtaining the 3D printing PEEK network stent for repairing the large-scale defects of the lower jawbone. And the stent can dynamically meet the growth requirement of bone tissues in the whole repair process, so that the regeneration of endogenous bones and blood vessels is effectively promoted.

The application discloses arginase 2 inhibiting peptides and application thereof in wound healing. The arginase 2 inhibiting peptide has an amino acid sequence as shown in SEQ ID No. 1 or a mutant sequence thereof. It is found through research of the application at a cell level and in a mouse skin wound model that MUT4-short peptide and MUT5-short peptide can effectively improve the viability and migration ability of keratinocytes under high-sugar conditions in vitro and in a metabolic abnormality model in vivo, reduce the intracellular reactive oxygen level, and promote the repair process of skin wounds, wherein the MUT4-short peptide shows more significant in promoting the recovery of cell functions and accelerating wound healing, and has a good application prospect in promoting skin wound healing, especially in the treatment of difficult-to-heal wounds related to metabolic diseases such as diabetes.

The invention discloses a preparation technology of a silk protein bone nail with a porous structure and biological activity, and particularly relates to the technical field of biomedical engineering.The preparation technology comprises the following steps that S1, a silk protein raw material is provided, and a regenerated silk protein solution is prepared through degumming, dissolving and purifying treatment; s2, uniformly mixing the silk protein solution obtained in the step S1 with a pore-foaming agent to prepare mixed slurry with proper viscosity; and S3, transferring the mixed slurry obtained in the step S2 into three-dimensional printing equipment, and performing extrusion printing according to a preset bone nail three-dimensional model. According to the preparation technology of the silk protein bone nail with the porous structure and the biological activity, the silk protein bone nail with the mutually-communicated porous structure is prepared through the synergistic effect of the three-dimensional printing technology and the pore-foaming agent, and the overall porosity is 60%-85%. The porous structure effectively improves the problem of poor connectivity of pore channels formed by traditional methods such as salt dissolution pore forming and the like, and is beneficial to cell migration, blood vessel ingrowth and nutrient substance transmission, so that the bone defect repair process is accelerated.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.

The utility model discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof, the engineering construction composite artificial bone comprises a bioactive material and a mechanical support bracket, the bioactive material is used as a main body, the mechanical support bracket is contained in the bioactive material, and the bioactive material and the mechanical support bracket are tightly combined to form an artificial bone tissue complex. The mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. According to the utility model, the osseointegration performance and the mechanical property of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

The invention discloses a BBB repairing agent evaluation method and system based on an ischemia reperfusion injury model, and relates to the technical field of biologication.The method comprises the following specific steps that the ischemia reperfusion injury model is built, and a sample is collected, specifically, an animal ischemia reperfusion injury model is built, and experimental animals are divided into an experimental group and a control group; brain tissue and blood samples of the two groups of animals are collected at a plurality of preset time nodes, and behavioral evaluation is carried out at the same time to obtain score data; according to the method, the deep learning model fused with the dynamic attention mechanism is constructed, the weights of different time nodes and different modal data on BBB repair effect evaluation after ischemia reperfusion injury can be automatically identified, the problems that early signals are ignored and key time node evaluation is deviated due to fixed static data weights in a traditional evaluation method are solved, and the accuracy of BBB repair effect evaluation is improved. The model can flexibly adjust the weight of each modal data according to the dynamic change characteristics of the BBB repair process, and a more reliable basis is provided for research, development and application of a repair agent.

This invention provides a tissue repair and filling composite gel, its preparation method, and its application, relating to the field of biomedical materials technology. The composite gel is mainly prepared by freeze-thaw physical cross-linking of hyaluronic acid and biodegradable microspheres, wherein: the hyaluronic acid has a molecular weight of 800,000 to 3,000,000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair and filling composite gel of this application consists of a hyaluronic acid matrix with a porous three-dimensional network structure obtained by freeze-thaw physical cross-linking and uniformly dispersed hydroxyapatite microspheres. During the filling and repair process, the hyaluronic acid provides an immediate filling effect, while the hydroxyapatite microspheres stimulate collagen regeneration. This tissue repair and filling composite gel effectively alleviates the technical problems of poor safety associated with existing hyaluronic acid gels obtained by cross-linking agents for in vivo filling, and the inconvenience of injecting regenerated microsphere fillers.

A method for treating muscular dystrophy of a subject comprising administrating a N-formyl peptide receptor (FPR) agonist to the subject and compositions therefore. An FPR agonist may be used to target the FPR2-mediated pro-resolving pathway, thus facilitating the clearance of inflammation, reducing inflammatory response, enhancing repair processes, enhancing regenerative capacity in muscles, and otherwise improving prognosis of muscular dystrophy.

The invention discloses a three-dimensional patch for esophageal hiatus hernia repair, and relates to the technical field of human life necessities. A three-dimensional patch for esophageal hiatus hernia repair comprises a patch body and an esophagus lower end connecting piece, the esophagus lower end connecting piece is in a U shape and is connected and sewn with the lower end of an esophagus, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is made of a silk collagen material, and the silk collagen material has the slow absorbable characteristic; the patch body is gradually degraded into carbon dioxide and water within about two years, the process is matched with the natural repairing process of esophageal pore tissue, meanwhile, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is matched with the U-shaped esophageal lower end connecting piece, the complex anatomical structure of the esophageal pore and surrounding tissue can be precisely matched, and the repairing effect is good. The arc-shaped end conforms to the bending form of the connecting part of the esophagus and the stomach, and the U-shaped esophagus lower end connecting piece is attached to the diaphragm radian around the esophageal crack hole, so that the patch is tightly attached to the tissue, and the repairing effect is improved.

The application relates to the field of medical devices, in particular to a repair system, which at least comprises a double-puncture structure, a catching device and a repair unit connected with the double-puncture structure, the double-puncture structure is used for guiding the repair unit, and the double-puncture structure can pass through the tissue to be repaired back and forth in the repair process; the catching device is arranged on the side of the starting point of the first puncture of the double-puncture structure in the repair process and is abutted against the tissue, so that the tissue for the second puncture of the double-puncture structure is provided with a supporting force, and thus the tissue for the second puncture is provided with the supporting force and the puncture force from the proximal end and the distal end directions respectively, the double-puncture structure can smoothly puncture at the target position, the accuracy of the puncture point is guaranteed, and the catching device is also responsible for catching the repair unit after the second puncture.

The invention discloses a preparation method and application of an anti-inflammatory and vascularization-promoting sequential drug release composite fiber dressing, the dressing is loaded with functionalized core-shell structure nanoparticles NGR1-cMSN-coated CMOFs, and the nanoparticles are loaded with a vascularization-promoting drug notoginsenoside R1 by taking carboxylated mesoporous silica (cMSN) in an inner layer as a core; the metal organic framework ZIF-8 on the outer layer is used as a shell, and an anti-inflammatory drug curcumin is loaded. Through the exquisite core-shell structure design, sequential release of drugs in the wound repair process is achieved: the ZIF-8 layer firstly responds to the subacid environment of the wound to be rapidly degraded, and curcumin is released for early-stage anti-inflammation; then, the notoginsenoside R1 is slowly released by the mesoporous silicon dioxide core, and later angiogenesis is promoted. The synergistic effect mechanism of first anti-inflammation and then blood vessel promotion can effectively overcome the healing disorder of the diabetic wound and significantly accelerate the wound repair process. The dressing prepared by the invention has good biocompatibility and repairing function, and has wide application prospect in the field of chronic wound treatment.

The invention relates to the technical field of biological materials and tissue engineering, and discloses a 3D printed gradient layered anisotropic bionic cartilage scaffold and a preparation method thereof. On the macroscopic level, the 3D-printed porous structure with gradient change is provided, so that the pore size of each layer can be properly regulated and controlled, and the space structure of surrounding primary cartilage tissue can be properly matched after the 3D-printed porous structure is implanted into a body. And secondly, on the microscopic level, the cartilage tissue culture medium has different-layer anisotropic orientation structures for template freezing, and can guide directional differentiation and functional expression of cartilage cells at different layers, so that the regeneration and repair process of cartilage tissues is accelerated. Therefore, the bionic cartilage scaffold disclosed by the invention can fully simulate the microenvironment of natural cartilage, and plays an important role in repairing and regenerating damaged cartilage tissues.

The invention provides temperature-sensitive hydrogel loaded with nitric oxide nanoparticles and fat extract and application of the temperature-sensitive hydrogel in diabetes wound treatment, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: mixing egg yolk lecithin and dichloromethane, carrying out rotary evaporation until a lipid membrane is formed, and adding a phosphate buffer solution to obtain a liposome suspension; adding perfluorobromooctane into the liposome suspension, carrying out emulsification treatment to obtain a liposome wrapped with perfluorobromooctane, and loading NO gas in a closed space to obtain a liposome loaded with NO; and adding F-127 powder, dissolving the F-127 powder, and adding the fat extract FE to obtain the temperature-sensitive hydrogel loaded with the nitric oxide nanoparticles and the fat extract. The gel is a flowable liquid at normal temperature, can form a stable gel structure at the body temperature of 37 DEG C, and synergistically promotes the repair processes of angiogenesis, fibroblast migration, collagen deposition and the like; the closure of the diabetic wound surface is accelerated.

The invention provides a scaffold material for promoting vascularized bone tissue regeneration and a preparation method thereof, the scaffold material for promoting vascularized bone tissue regeneration is a biological scaffold material based on traditional Chinese medicine active micromolecule gentiopicroside modification, and aims to solve the problem that the biological scaffold material in bone repair is insufficient in vascular regeneration capacity. The core of the strategy is that the GPD is utilized to modify the biological scaffold, and the revascularization in the bone repair process is remarkably promoted, so that the dependence on poor-stability and expensive vascular growth factors (such as VEGF (vascular endothelial growth factor), PDGF-BB (PDGF-BB) and the like) is avoided. Therefore, the gentiopicroside shows a huge application prospect in the field of bone repair, especially in the aspect of large-area bone defect vascular regeneration.

The invention provides a nano-adhesion-mediated induced bone regeneration hydrogel barrier membrane, which is prepared by the following steps: dissolving N-isopropylacrylamide and dimethylaminoethyl methacrylate in deionized water to form a hydrogel matrix, adding polyethylene glycol diacrylate and phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate, and stirring to form the hydrogel barrier membrane, thereby obtaining the nano-adhesion-mediated induced bone regeneration hydrogel barrier membrane. The preparation method comprises the following steps: uniformly stirring and mixing, performing ultraviolet light illumination, performing crosslinking to obtain composite hydrogel, spraying a nano-particle aqueous solution with the mass concentration of 10-15% on the surface of the composite hydrogel, and drying to obtain the nano-adhesion-mediated induced bone regeneration hydrogel barrier membrane, the bone regeneration barrier membrane is high in adhesion, does not swell at the temperature of 37 DEG C, can be applied to the bone defect repairing process in the biomedical field, and solves the problems that in the prior art, a guided bone regeneration barrier membrane needs to be fixed through a bone nail, cannot be completely attached to a wound surface and needs to be removed through a secondary operation.

The application relates to the technical field of medical devices, and discloses an absorbable door opening maintainer for cervical vertebra canal plasty, wherein the maintainer body is integrally formed by using high-strength absorbable material, a hollow bone ingrowth matrix is arranged in the maintainer body in the axial direction, the maintainer body comprises a spiral coupler structure and a zero-cut trace cable structure, and the spiral coupler structure and the zero-cut trace cable structure are both hollow structures. In the application, the whole maintainer is made of high-strength absorbable material, is matched with absorbable sutures of the same type, the degradation periods of the two are mutually adapted, the degradation process is synchronized with the bone growth period, secondary surgery for removal is not needed, secondary damage to bone and soft tissues is avoided, the multi-dimensional bone ingrowth channel is beneficial to the migration, proliferation and angiogenesis of bone cells, biological fusion between the maintainer and the host bone is promoted, and the bone repair process is accelerated.

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