Preparation method of porous hydrogel coating on surface of polypropylene patch

A surface-porous, polypropylene technology, applied in coatings and other directions, can solve the problems of reducing the mechanical strength of PP materials, reducing the mechanical properties of the body, and complicated preparation processes, so as to improve the hydrophilic properties, keep the mechanical properties from reducing, and promote The effect of abdominal wall repair

Pending Publication Date: 2022-03-08
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the grafting of hydrophilic monomers on the surface of PP by chemical modification, initiator initiation, photoinitiation, plasma treatment and other methods can improve the hydrophilicity of the PP surface, but this method is easy to cause damage to PP and lead to bulk mechanical problems. The performance is reduced, and the preparation process is complicated and difficult to control
Existing PVA is grafted on the surface of polypropylene material through chemical reaction. Although it improves the hydrophilicity, it also reduces the mechanical strength of the PP material itself and reduces the utilization rate of the material.

Method used

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  • Preparation method of porous hydrogel coating on surface of polypropylene patch
  • Preparation method of porous hydrogel coating on surface of polypropylene patch
  • Preparation method of porous hydrogel coating on surface of polypropylene patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Place the PP material net in ethanol, stir and wash three times, 20mL each time, for three hours, and dry at 40°C for 24 hours;

[0031] (2) Add 4g of polyvinyl alcohol, with a degree of polymerization of 1750, into 40mL of deionized water, and stir to dissolve at 80°C;

[0032] (3) 0.8g sodium bicarbonate is dissolved in the polyvinyl alcohol solution in step (2), slowly stirred to dissolve;

[0033] (4) Add 0.027g of ferric chloride hexahydrate into 10mL of deionized water, and dissolve at room temperature to obtain a 0.01mol / L ferric chloride solution;

[0034] (5) Add 0.9 mL of ferric chloride hexahydrate solution in step (4) to the polyvinyl alcohol solution in step (3), and mix well;

[0035] (6) With the PP material net treated in step (1), its surface is coated with the mixed solution of polyvinyl alcohol and ferric chloride hexahydrate dissolved in step (5);

[0036] (7) Freeze the processed PP material web obtained in step (6) by non-directional freezing...

Embodiment 2

[0039] (1) Place the PP material net in dichloromethane, stir and wash three times, 20mL each time, for three hours, and dry at 25°C for 30 hours;

[0040] (2) Add 16g of polyvinyl alcohol, with a degree of polymerization of 1700, into 360mL of deionized water, and stir to dissolve at 80°C;

[0041] (3) 0.8g sodium bicarbonate is dissolved in the polyvinyl alcohol solution in step (2), slowly stirred to dissolve;

[0042] (4) Add 0.27g of ferric chloride hexahydrate into 10mL of deionized water, and dissolve at room temperature to obtain a 0.1mol / L ferric chloride solution;

[0043] (5) Add 0.9 mL of ferric chloride hexahydrate solution in step (4) to the polyvinyl alcohol solution in step (3), and mix well;

[0044] (6) With the PP material net treated in step (1), its surface is coated with the mixed solution of polyvinyl alcohol and ferric chloride hexahydrate dissolved in step (5);

[0045] (7) Freeze the treated PP material web obtained in step (6) by non-directional fr...

Embodiment 3

[0048] (1) Place the PP material net in dichloromethane, stir and wash three times, 20mL each time, for three hours, and dry at 30°C for 25 hours;

[0049] (2) Add 8g of polyvinyl alcohol, with a degree of polymerization of 1800, into 180mL of deionized water, and stir to dissolve at 80°C;

[0050] (3) 0.8g sodium bicarbonate is dissolved in the polyvinyl alcohol solution in step (2), slowly stirred to dissolve;

[0051] (4) 0.135g of ferric chloride hexahydrate was added to 10mL of deionized water, and dissolved at room temperature to obtain a 0.05mol / L ferric chloride solution;

[0052](5) Add 0.9 mL of ferric chloride hexahydrate solution in step (4) to the polyvinyl alcohol solution in step (3), and mix well;

[0053] (6) With the PP material net treated in step (1), its surface is coated with the mixed solution of polyvinyl alcohol and ferric chloride hexahydrate dissolved in step (5);

[0054] (7) Freeze the treated PP material web obtained in step (6) for 15 hours at ...

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Abstract

The invention discloses a preparation method of a porous hydrogel coating on the surface of a polypropylene patch. The preparation method comprises the following steps: ultrasonically cleaning and drying a polypropylene material; putting sodium bicarbonate into the polyvinyl alcohol solution, and slowly stirring until the sodium bicarbonate is completely dissolved; preparing a ferric chloride solution, mixing the ferric chloride solution with the solution, and fully and uniformly stirring to prepare a mixed solution; coating the surface of the dried polypropylene material with the prepared mixed solution, and freezing the polypropylene material at low temperature; finally, the frozen polypropylene material is taken out, unfrozen at room temperature and soaked in deionized water, and the polypropylene material with the porous hydrogel coating on the surface is obtained. The modification method is simple, mild in condition and easy to control. The modified material can keep the mechanical property of a polypropylene body not reduced, and the surface hydrophilicity and anti-inflammatory property of PP can be improved.

Description

technical field [0001] The invention belongs to the surface modification of a medical polypropylene patch material, in particular to a preparation method of a porous hydrogel coating on the surface of a polypropylene patch. Background technique [0002] Polypropylene material (PP) has the advantages of stable chemical properties, high physical strength, and good resistance to infection, and has been widely used as a medical device material, such as a hernia repair material in hernia surgery. But postoperatively, the PP patch material tends to adhere to organs and cause related inflammation. In order to make up for the postoperative adhesion caused by PP monofilament patch, it is imperative to modify it to improve hydrophilicity and anti-pollution. Polyvinyl alcohol hydrogel (PVA) has been used in drug delivery devices, artificial organs, wound dressings, and contact lenses due to its non-toxicity, high hydrophilicity, good biocompatibility, biodegradability, and high mechan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/056C08L23/12C09D129/04C09D7/61
CPCC08J7/056C08J2323/12C08J2429/04C08K3/16
Inventor 张天柱魏丹丹
Owner SOUTHEAST UNIV
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