Anti-adhesion medical material and method for producing same

A manufacturing method and anti-adhesion technology, applied in the fields of medical science, absorbent pads, surgical drugs, etc., can solve the problems of edema in the tissue, delayed tissue healing, unprepared bacterial infection, etc., and achieve the effect that harmful phenomena are not easy to achieve

Inactive Publication Date: 2014-04-16
DAINICHISEIKA COLOR & CHEM MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anti-adhesion materials in a state of high water content are known to have problems such as generation of edema in tissue, delay in tissue healing, and defense against bacterial infection (see Patent Document 4)

Method used

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  • Anti-adhesion medical material and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] 10 g of acid process gelatin (derived from pigskin, manufactured by Sigma Chemicals) was dissolved in water to make the total amount 100 g to prepare a 10% gelatin aqueous solution. 30 g of the prepared aqueous gelatin solution was dispensed onto a 15 cm×15 cm tray whose inner surface was coated with polytetrafluoroethylene. The tray was placed in a dryer (trade name "Program Incubator IN800", manufactured by Yamato Scientific Co., Ltd.) set at 32° C., and the dispensed aqueous gelatin solution was air-dried to obtain 3 g of a gelatin film. The obtained gelatin film was poured into water cooled to 5° C. to be hydrated, and then 20 kGy of γ-rays was irradiated to perform water insolubilization treatment on the gelatin film. The degree of swelling of the water-insolubilizing gelatin film was 600%, and the water elution rate was 3.5%. The gelatin film treated with water insolubilization was immersed in 50 mL of 5% glycerin aqueous solution for 3 times for 2 hours each tim...

Embodiment 2

[0099] Except having set the temperature of the dryer at 50° C., it was carried out in the same manner as in the above-mentioned Example 1, and a 3-g gelatin film was obtained. The obtained gelatin film was immersed in 100 mL of 5 volume % glutaraldehyde aqueous solution, and it was made to react at room temperature for 6 hours, and the gelatin film was water-insolubilized. The degree of swelling of the gelatin film treated with water insolubilization was 550%, and the water elution rate was 3.6%. After the gelatin film treated with water insolubilization was fully washed with water, it was immersed in 50 mL of 5% glycerin aqueous solution three times for 2 hours each time, so that the inside of the gelatin film retained 5% glycerin aqueous solution to obtain an anti-adhesion medical material. The obtained medical material for anti-adhesion had a glycerin content rate of 22.5%, and a glycerin retention rate of 0%.

Embodiment 3

[0101] In the same manner as in the aforementioned Example 1, a 3 g gelatin film was obtained. The obtained gelatin film was immersed in 100 mL of an ethanol solution containing 5% by volume of hexamethylene diisocyanate, and reacted at room temperature for 18 hours to perform a water-insolubilizing treatment on the gelatin film. The degree of swelling of the water-insolubilizing gelatin film was 450%, and the water-eluting rate was 4.0%. After the gelatin film treated with water insolubilization was thoroughly washed with ethanol, it was immersed in 50 mL of 5% glycerin aqueous solution three times for 2 hours each time, so that the inside of the gelatin film was kept in 5% glycerin aqueous solution to obtain an anti-adhesion medical material . The obtained medical material for anti-adhesion had a glycerin content rate of 17.5%, and a glycerin retention rate of 0%.

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Abstract

Provided is an anti-adhesion medical material in which a polyhydric alcohol or a polyhydric alcohol aqueous solution containing a polyhydric alcohol is retained in a bioabsorbable base material that contains a bioabsorbable material and has a degree of swelling of 200 to 3,000 mass% and a water elution rate of 10 mass% or lower, and in which the residual amount of polyhydric alcohol after three hours of immersion in 25 DEG C water 50 or more times the total mass of the polyhydric alcohol aqueous solution or the polyhydric alcohol aqueous solution and the bioabsorbable base material is 30 mass% or less of the amount of polyhydric alcohol prior to immersion.

Description

technical field [0001] The present invention relates to an anti-adhesion medical material capable of preventing adhesion or adhesion between a wounded part and its surrounding tissues or between originally separated internal organs, and a method for producing the same. Background technique [0002] Postoperative adhesion formation (postoperative adhesion) is known to occur in a large number of cases, causing various pathological conditions such as intestinal obstruction, infertility, abdominal pain, and pelvic pain (see, for example, Non-Patent Document 1). In general, the original purpose of treatment by surgery is achieved by bringing about repair of wounds after surgery. On the other hand, surgery may cause new bonding, that is, adhesion, between internal organs that should be separated. Due to the occurrence of such adhesions, serious problems such as intestinal obstruction and infertility often occur. In addition, when reoperation is required, if adhesions occurred in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00A61K31/047A61L15/00A61P41/00
CPCA61L31/045A61L31/044A61L31/148A61L31/042A61L31/141A61L31/047A61L31/145A61P41/00C08L1/286C08L5/08A61K31/047A61L15/00A61L31/00A61L2300/232
Inventor 野一色泰晴山南隆德礒野康幸金尾伸三伊藤博饭岛义彦
Owner DAINICHISEIKA COLOR & CHEM MFG CO LTD
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