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Anti-adhesion flushing fluid for operation

An anti-adhesion and irrigating liquid technology, applied in the field of surgical irrigating liquid, can solve problems such as unsatisfactory effect and unsatisfactory effect

Active Publication Date: 2013-09-04
山东益洲生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, researchers have conducted a large number of experimental and clinical studies, and have adopted various methods and measures to prevent postoperative adhesions, such as improving surgical techniques, applying mechanical barriers or solution barriers to isolate the serosal surface, using fibrinolytic drugs or anti-inflammatory drugs, etc. Blood coagulation drugs interfere with fiber formation, anti-adhesion with integrated traditional Chinese and Western medicine, etc., but the effect is not ideal, and there are certain side effects
At present, the commonly used surgical irrigating fluids such as mannitol irrigating fluid, glycine irrigating fluid and normal saline irrigating fluid have certain effects in cleaning the surgical site and improving the clarity of the surgical field of view, but the effect of preventing postoperative adhesions is not ideal.
Clinically, there is still a lack of surgical cleaning solutions that have both good surgical cleaning effects and good postoperative adhesion prevention effects

Method used

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  • Anti-adhesion flushing fluid for operation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of surgical cleaning solution containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid

[0013] The formula is as follows:

[0014] 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid 0.5g

[0015] Sodium chloride 3g

[0016] Water for injection 1000ml

[0017] The preparation method is as follows:

[0018] Weigh the prescribed amount of sodium chloride and 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid, add to 1000 ml water for injection, stir to dissolve, and sterilize with damp heat at 121°C , the surgical cleaning fluid containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid was obtained.

Embodiment 2

[0019] Example 2 Preparation of surgical cleaning solution containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid

[0020] The formula is as follows:

[0021] 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid 10g

[0022] Sodium chloride 8g

[0023] Water for injection 1000ml

[0024] The preparation method is as follows:

[0025] Weigh the prescribed amount of sodium chloride and 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid, add to 1000 ml water for injection, stir to dissolve, and sterilize with damp heat at 121°C , the surgical cleaning fluid containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid was obtained.

[0026]

Embodiment 3

[0027] Example 3 Preparation of surgical cleaning solution containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid

[0028] The formula is as follows:

[0029] 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid 35g

[0030] Sodium chloride 42g

[0031] Water for injection 1000ml

[0032] The preparation method is as follows:

[0033] Weigh the prescribed amount of sodium chloride and 1,4,5,6-tetrahydro-2-methyl-5-hydroxy-4-pyrimidinecarboxylic acid, add to 1000 ml water for injection, stir to dissolve, and sterilize with damp heat at 121°C , the surgical cleaning fluid containing 1,4,5,6-tetrahydro-2-methyl-5-hydroxyl-4-pyrimidinecarboxylic acid was obtained.

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Abstract

The invention discloses operation flushing fluid and particularly relates to an anti-adhesion flushing fluid for preventing operation adhesion. The anti-adhesion flushing fluid mainly comprises 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid, sodium chloride and water for injection. In the anti-adhesion flushing fluid for an operation, concentration of 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid is 0.1 to 40 g / L and concentration of sodium chloride is 1 to 50 g / L. The operation flushing fluid disclosed by the invention also can be added with a pH buffer. The inventor of the invention makes a series of animal experiments and researches to show that the human operation flushing fluid disclosed by the invention has an excellent operation cleaning effect and also has an excellent effect of preventing postoperative adhesion.

Description

technical field [0001] The invention relates to an operation flushing liquid, in particular to an operation flushing liquid for preventing surgical adhesion. Background technique [0002] After normal tissue suffers from various injuries and causes inflammatory exudate, bleeding, etc., abnormal adhesions will occur in adjacent septal tissues, which will restrict the movement of the injured area or cause varying degrees of dysfunction. Surgical adhesions often occur after abdominal, cardiovascular, spinal, joint, and tendon surgery. According to literature reports (Liakakos T, Thomaskos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Digestive Surgery. 2001;18(4):260-273 ; Menzies D, Ellis H. Intestinal obstruction from adhesions--how big is the problem? Annals of The Royal College of Surgeons of England. 1990;72(1):60-63.), tissue adhesion after abdominal and pelvic s...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K31/505A61P41/00
Inventor 厉保秋李娜厉凌子高继友
Owner 山东益洲生物科技有限公司
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