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Post-surgery functional barrier film and method for preparing the same

An isolation membrane and functional technology, which is applied in the field of biodegradable polymer anti-adhesion membranes, can solve the problems of not taking into account the reduction of tissue fluid penetration and tissue healing, the inability to achieve the time release of various drugs, and the unsatisfactory anti-adhesion effect. Achieve the effect of preventing peridural fibrosis and adhesion, reducing tissue fluid infiltration, and reducing organ infection

Inactive Publication Date: 2008-09-03
蒋婧 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The postoperative anti-adhesion films mentioned above have some problems: the anti-adhesion effect is not ideal, the wound is difficult to heal, and some postoperative complications such as tissue infection
These two patents considered compounding drugs on the anti-adhesion membrane, but they only compounded anti-inflammatory, analgesic, neurotrophic drugs, and chemotherapy drugs, and did not simultaneously consider functions such as reducing interstitial fluid penetration, inhibiting fibrin deposition, and promoting tissue healing.
And carrying different drugs can only be released at the same time, which cannot achieve the release of various drugs at the required time

Method used

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  • Post-surgery functional barrier film and method for preparing the same
  • Post-surgery functional barrier film and method for preparing the same
  • Post-surgery functional barrier film and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 10 grams of poly D with a molecular weight of 400,000, L-lactic acid and 0.2 grams of cortisone into 100 ml of ethyl acetate, fully dissolve and mix well, then pour it into a flat container to form a film, and make the ethyl acetate fully volatilize to form a thick film. It is a 0.04 mm film, cut into 4×6 (mm), 10×20 (mm) and 50×80 (mm) sheets, and after disinfection and sterilization, it is vacuum-sealed and protected from light for future use.

Embodiment 2

[0025] Take 10 grams of D, L-lactic acid, glycolic acid and caprolactone copolymer with a molecular weight of 150,000 and add it to 100 ml of acetone. After fully dissolving, add 0.15 g of gentamicin and 0.15 g of dexamethasone, mix well, and pour into Form a film in a flat container, make acetone fully volatilize to make a film with a thickness of 0.08 mm, cut into 4×6 (mm), 10×20 (mm) and 50×80 (mm) sheets, and disinfect and sterilize After processing, vacuum seal and store away from light for later use.

Embodiment 3

[0027] Take 5 grams of poly D with a molecular weight of 350,000, add 50 ml of ethyl acetate to L-lactic acid, add 0.15 g of hydrocortisone after fully dissolving, mix well, pour it into a flat container to form a film, and make the ethyl acetate fully volatilize An upper layer film having a thickness of 0.03 mm was prepared. Take 3 grams of D, L-lactic acid and glycolic acid copolymer with a molecular weight of 150,000, add 50 milliliters of ethyl acetate, add 0.15 grams of nifedipine after fully dissolving, mix well, pour it into a flat container to form a film, and make ethyl acetate The ester is fully volatilized to form a middle layer film with a thickness of 0.02 mm. Take 2 grams of poly D with a molecular weight of 50,000, L-lactic acid and polyethylene glycol copolymer and add it to 20 milliliters of acetone. After fully dissolving, add 0.15 grams of kanamycin, mix well, and pour it into a flat container to form a film. The acetone is fully volatilized to form a botto...

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Abstract

This invention is about a functional after-operation isolation membrane and method for making same. The functional after-operation isolation membrane is composed of the drugs taken by biodegradable isolation membrane host material, and the drugs contain antiphlogiston drugs, fibrin inhibitor drugs, calcium channel inhibitor drugs, anticoagulant drugs and antibiotics drugs or one or several kinds of Chinese patent drugs; while the isolation membrane host material is made of one or several kinds degradation rate differed materials, whose half-decay times are 1 week to 6 months. Alerting membrane materials kinds and charging amount, drugs kinds and charging amount and isolation membrane layers can make multifunctional, degradation rate different and drug-release characteristic different functional after-operation isolation membrane products, so as to adapt to different using demands. Experiments prove that this functional after-operation isolation membrane can effectively accelerate tissue healing after operation, diminish infection and prevent after-operation adhesions.

Description

technical field [0001] The invention belongs to a postoperative isolation film, in particular to a biodegradable polymer anti-adhesion film for preventing postoperative adhesion. Background technique [0002] The development of functional postoperative anti-adhesion films arose out of the medical community's concern for post-surgical adhesions. How to make surgical operations to treat diseases without causing serious tissue adhesions and infection complications is an urgent problem to be solved in today's medicine. There are nearly ten million cases of various types of surgery in the country every year, and almost all of them involve anti-adhesion between tissues and local anti-inflammation. It can not only cause serious complications, such as: adhesive ileus after abdominal and pelvic surgery, postoperative epilepsy after craniotomy, secondary recurrent laryngeal nerve injury after thyroid surgery, etc. One of the most important reasons for the significant increase in com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/00A61L31/14A61L31/04
Inventor 蒋婧张勇
Owner 蒋婧
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