Biological coupling material and its preparing method

Abstract

The invention is concerned with the organism coupling material, which is collagen, or the production of hydrolyze material and carbodiimide after imperfective coupling reaction. The coupling material is with fluidity and conglutination, which can be use for antiseep and anti-conglutination processing in surgery. The coupling material of the invention is imperfective coupling when it is using, which continues reaction to finish coupling during the process, it can adhere to the organic surface by coupling reaction in order to prevent organic conglutination and body fluid effusion of the wound surface.

Description

technical field The invention relates to a biological coupling material, in particular to a coupling material formed by utilizing biological macromolecules under the action of carbodiimide and a preparation method thereof. The coupling material can be used for anti-leakage and anti-adhesion treatment in operations . Background technique Surgical adhesions are a common problem after abdominal, cardiovascular, spinal, and tendon surgery. Surgical adhesions can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation and the potential risk of further complications. The causes of adhesion are complex and can be summarized as follows: (1) surgical trauma; (2) local ischemia; (3) foreign body retention; (4) bleeding and exposed wound surface; (5) bacterial infection. At present, there are two main ways to prevent adhesions: adjusting surgical techniques and using adjuvants. T...

AI Technical Summary

Problems solved by technology

In short, the current physical diaphragm method still has the following problems in clinical application: the diaphragm is not fluid, and it is not easy to coat; it is only a physical process, and it is difficult to ensure its combination with the tissue; it is difficult to ensure the coverage quality of the dead corner when the solid film covers the wound.

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