55results about How to "Good tissue adhesion" patented technology

Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with / without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

The invention discloses a degradable medical hemostatic adhesion-resistant material and a preparation method thereof. The invention uses chitosan or derivatives thereof and transparent sodium hyaluronate as main raw materials, adopts methods, such as spray drying, self lamination assembly, and the like to prepare microspheric and gel-type hemostatic adhesion-resistant materials, and medicines and activated substances capable of stimulating hemostasis and antiphlogosis can be compounded and added in the preparation process. The material has high water absorption rate, can rapidly arrest bleeding to form an aquagel protective layer on a wound surface, has favorable tissue adhesiveness, adhesion resistance and bacterinertness, can suit a wound in an irregular shape, truly fully covers the wound surface to fully take the aims of arrest bleeding, resisting adhesion and stimulating wound surface healing, has remarkable postoperative hemostatic adhesion-resistant effects while being used for ear-nose-throat department operations, is convenient to use and brings little pain to patients.

Production of amphiphilic chitose derivative and its usage are disclosed. The process is carried out by taking chitose as raw material, alkalizing, reacting with 4-methyl bromoethyl acid in 2-propanol medium to obtain 6-0-carboxy-propyl-chitose, purifying, and reacting with long-chain fatty acyl chloride to obtain N-acyl-6-0-carboxy-propyl-chitose. In chemical formula, R=-(CH) n, n=8, 10, 12, 14, 16 and 18. It has excellent biological compatibility and degradation, good tissue adhesion and mechanical strength. It can improve wound heal and have styptic and adhesion-preventing functions.

The invention discloses a preparation method of a conductive double-layer hydrogel for integral regeneration of bone and cartilage by electrical stimulation. The preparation method comprises the following steps: step 1, dispersing conductive particles and dopamine monomers in water to form a suspension liquid, adding a calcium hydroxide solution to adjust the suspension liquid to be alkalescent, and carrying out a full reaction to generate a calcium hydroxide solution A containing dopamine-modified conductive particles; step 2, preparing a polyvinyl alcohol solution B, adding the polyvinyl alcohol solution B into the solution A to obtain a mixed solution C; step 3, dropwise adding phosphoric acid into the mixed solution C for a reaction, then carrying out forming, and carrying out freeze-thawing circulation to obtain a lower-layer hydrogel; step 4, dissolving polyvinyl alcohol, natural macromolecules and dopamine in deionized water to form a mixed solution, and carrying out a completereaction under a weak alkaline condition to obtain a solution D; and step 5, placing the solution D on the lower-layer hydrogel, and carrying out freeze-thawing circulation to obtain the required double-layer hydrogel. The double-layer hydrogel disclosed by the invention is good in tissue adhesion and electrical stimulation response capability.

The invention provides a hemostatic material as well as a preparation method and application thereof. The hemostatic material is prepared from nanofiber clusters; the nanofiber clusters are derived from a crosslinked nanofiber material and have dimensions within a range of 5mu m to 500mu m in any direction of a three-dimensional space by taking a geometric center of the nanofiber clusters as a starting point; and / or, the dimensions, represented by a median particle size D50, of the nanofiber clusters in the hemostatic material are in a range of 100mu m to 500mu m; the nanofiber clusters respectively have a porous structure, and the nanofiber clusters respectively have a staggered structure formed by overlapping multiple short nanofibers; the diameters of the short nanofibers are in a rangeof 1nm to 1000nm, and the lengths of the short nanofibers are1000mu m or less; the porosity of the hemostatic material is 50-90%. The hemostatic material provided by the invention has excellent tissue adhesion property and a remarkable hemostatic effect; the excellent tissue adhesion property can enable the material to closely adhere to a wound surface during hemostasis, so that the material is prevented from being washed away by blood, the hemostatic effect is significantly improved, and the mutual fusion process of the material and tissues is promoted.

The invention provides composite antibiotic hydrogel based on controlled release of aminoglycoside antibiotics and ornidazole. The composite antibiotic hydrogel is obtained by crosslinking an oxidizednatural polysaccharide polymer, the aminoglycoside antibiotics and the ornidazole through an acid-sensitive Schiff base bond, wherein the ornidazole is modified by a first-generation polyamidoamine dendrimer with an amino terminal. The Schiff base bond is broken in an acidic environment caused by bacterial infection, so that gel degradation is caused, and the on-demand release of the antibioticsis realized. The composite antibiotic hydrogel is easy to prepare and low in cost. According to the prepared controlled-release composite antibiotic hydrogel, the strength, morphology and degradationof the gel, the release rate of drugs and the like can be controlled based on the content of antibiotics, the composite antibiotic hydrogel has broad-spectrum high-efficiency antibacterial properties,and the bacteriostatic effect is superior to that of various kinds of commercial antibacterial gel on the market. The hydrogel is expected to be prepared into external dressings, ointment preparations, implants, coatings on medical apparatuses and instruments and the like and used for resisting infection caused by Gram-negative bacteria, Gram-positive bacteria, anaerobic bacteria and the like.

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with / without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

The invention discloses a multifunctional tissue adhesion cryogel dressing as well as a preparation method and application thereof. The multifunctional tissue adhesion cryogel dressing is characterized in that amino-containing polysaccharide and a polysaccharide derivative with blood coagulation promoting capability are used as base materials, and polydopamine formed by dopamine oxidative polymerization is used for crosslinking the amino-containing polysaccharide and the polysaccharide derivative in a cryogel system. so that the hemostatic and wound healing promoting properties of the cryogelcan be further enhanced, and the cryogel is endowed with good oxidation resistance and good photo-thermal properties. A hemostatic adhesive tape has good biocompatibility, bacterium resistance, oxidation resistance, tissue adhesion and other properties, and has better blood cell and platelet adhesion, enrichment, activation and blood coagulation capabilities than medical gauze and gelatin sponge.The multifunctional tissue adhesion cryogel dressing is suitable for hemostasis of various different types of human wounds.

The invention provides a hemostasis fibrous membrane, a preparation method of the hemostasis fibrous membrane and a hemostasis product adopting the hemostasis fibrous membrane. The hemostasis fibrousmembrane comprises microfibers; the microfibers are derived from a cross-linked nanofiber material; the microfibers have a diameter of 0.1mm to 1mm and a length of 20mm or below; the microfibers havea staggered structure formed by mutually overlapping a plurality of nano short fibers; the nano short fibers have a diameter of 1nm to 1,000nm and a length of 10mm or below. The hemostasis fibrous membrane provided by the invention has a high specific surface area and water absorption and meanwhile, has an excellent tissue adhesion property and an obvious hemostasis effect. Further, the hemostasisfibrous membrane provided by the invention is simple and convenient to operate in the using process, and can rapidly separate materials according to an actual dosage demand. Moreover, the surface ofthe hemostasis fibrous membrane has a microcosmic and / or macroscopic concave-convex structure, so that the hemostasis fibrous membrane is better attached to tissue surfaces and meanwhile, the specificsurface area is also higher.

Single cohesiveness or dispersivity cannot simultaneously satisfy different needs in the whole cataract surgery. Chitosan and sodium hyaluronate respectively belong to natural polycation and polyanion polysaccharides. Through charge interaction between chitosan and sodium hyaluronate, a polyelectrolyte complex is formed and the polyelectrolyte complex is processed to form the viscoelastic agent with cohesiveness and dispersivity. Medical chitosan gel has thermolability and after moist heat sterilization, the molecular weight of the chitosan gel is reduced and dispersivity is improved so that the chitosan gel can prevent corneal tissue mechanical damage. After positive and negative charge interaction, ionic crosslinked compound gel still has good cohesiveness, still has typical non-Newton rheological behavior and can be removed easily and reduce residual in eyes. Cohesiveness and dispersivity guarantees that a single product can satisfy demands in different stages in the whole cataract surgery and has a wide clinical application prospect.

The invention relates to hydrogel prepared by using a grafted modified material as well as a preparation method and the application of the hydrogel. The hydrogel is formed by polylysine grafted polyacrylamide and has an interpenetrating network structure. The hydrogel provided by the invention not only has a high mechanical property, proper wound adhesivity and excellent antibacterial property, but also has high saturated water absorbing rate and can be used for preparing wound repair products. The preparation method of the hydrogel, which is provided by the invention, is simple in process andhigh in yield.

The invention discloses a cryogel for stopping bleeding and bearing an anti-cancer drug and a preparation method thereof, the preparation method comprises the following steps: a double bond is modified to a biomacromolecule, a polyphenolic compound is grafted onto the biomacromolecule, and the dopamine molecule and the Zn 2 + ion are coordinated to prepare dopamine-modified ZIF -8; and all the components are respectively prepared into aqueous solutions or dispersion solutions, and then under the action of an initiator, through double-bond polymerization, the multifunctional water / blood triggered shape memory cryogel l is formed at low temperature. According to the preparation method, polysaccharide and other biomacromolecules with good biocompatibility and degradation performance are taken as the basis, the process of chemical grafting of double-bond or polyphenol compounds also has the characteristics of low toxicity and no pollution, the used double-bond functionalized biomacromolecules are simple to prepare, the synthesis technology is mature, and the prepared product has good universality.

The invention discloses an injectable biological adhesive, a preparation method and application thereof, and belongs to the technical field of high polymer materials and biological materials. According to the preparation method, saccharide macromolecules, namely glucan and chitosan oligosaccharide, with good biocompatibility are selected as matrixes and mixed and dispersed in an aqueous solution with dopamine and an oxidative cross-linking agent, and rapid gelatinization is performed to obtain the multi-cross-linked biological adhesive. The biological adhesive material obtained by the invention has the advantages of injectability, convenience in practical application and operation, capability of being applied to skin tissues, capability of being injected to the required amount according tothe required adhesion size and the like, high mechanical strength, no cytotoxicity and excellent tissue adhesion performance, can be applied to adhesion of various materials such as animal epidermis,in-vivo tissues and organs, glass, metals and oxides thereof, sealants, plastics and the like in clinical operations, and has wide application prospects in the fields of tissue adhesion and repair, hemostasis, packaging, sealing and the like in clinical medicine.

The invention discloses a biodegradable cryogel dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. Amino compounds are selected as main components, and the selected amino compounds have good biocompatibility and can be degraded in organisms. Therefore, the amidation reaction of amino and carboxyl in the amino compound is catalyzed by EDC hydrochloride and NHS to form a basic network structure of the cryogel. The cryogel dressing is holes communicating with each other in a free state, compared with the cryogel dressing in a shape free state, the cryogel dressing in a shape fixed state is a collapsed and closed hole, but a cryogel dressing sample still keeps an undamaged network structure. The preparation method disclosed by the invention is simple and low in cost, the biodegradable cryogel dressing is easy to carry and biodegradable, and the prepared cryogel dressing can be used for quickly stopping bleeding andhas huge potential in serving as a novel hemostatic for promoting wound healing.

The invention discloses a preparation method of PEGDA-mussel adhesive protein-collagen composite hydrogel with strong adhesion and high mechanical strength, belonging to the technical field of hydrogel. In order to improve the mechanical strength and tissue adhesion of a collagen hydrogel, the invention discloses the preparation method for the PEGDA-mussel adhesive protein-collagen composite hydrogel with strong adhesion and high mechanical strength. The method comprises the following steps: dissolving mussel adhesive protein into an acetic acid solution to obtain an acetic acid solution of the mussel adhesive protein; dissolving a collagen solid in the acetic acid solution of the mussel adhesive protein to obtain a mussel adhesive protein-collagen solution; carrying out alkali neutralization until a pH value is in a range of 5-9, and adding a PEGDA solid until the solid is completely dissolved; and adding a photoinitiation factor, and carrying out ultraviolet crosslinking to form thePEGDA-mussel adhesive protein-collagen composite hydrogel. The preparation method is simple in process and easy to operate, and has wide application prospects in the fields of tissue engineering, medicine and the like.

The invention provides a hemostatic dressing which comprises starch-based composite hydrogel and a diluent, and the starch-based composite hydrogel comprises a fiber network structure and a network structure which is inserted and attached to the interior of the fiber network structure; the fiber network structure comprises a composite high-molecular compound, and the composite high-molecular compound comprises a hydroxyl succinimide ester modified group; the net-shaped structure comprises starch paste. The hemostatic dressing not only has excellent tissue adhesion capability and can resist blood flow impact so as to be stably attached to a wound part, but also has strong liquid absorption capability and swelling capability, and the volume of the hemostatic dressing can be expanded after absorbing body fluid so as to block a damaged blood vessel, so that rapid and simple hemostasis is realized. The invention further provides a preparation method of the hemostatic dressing.

The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.

The invention discloses an adhesion-non-adhesion integrated hydrogel as well as a preparation method and application thereof in wound repair. The integrated hydrogel comprises two kinds of hydrogel with tissue adhesion and two kinds of hydrogel with non-tissue adhesion. When the hydrogel is prepared, an adhesive or non-adhesive monomer is dissolved in a polysaccharide polymer solution in advance, firstly, an adhesive or non-adhesive hydrogel solution is injected into a specified position, and after the hydrogel is formed, a hydrogel solution with a monomer with the opposite property is injected into the specified position; after the two parts are self-healed into a whole hydrogel, free radical polymerization is initiated, and the adhesion-non-adhesion integrated hydrogel is formed. The non-adhesion part can be in direct contact with a wound, damage to new granulation tissue in daily replacement is avoided, the adhesion part can be adhered to normal tissue near the wound, and therefore the hydrogel is fixed to the wound and does not fall off. The adhesive-non-adhesive integrated hydrogel has bactericidal performance, can promote wound repair, and can be used as a wound dressing.

The invention discloses slow-release disinfection gel, a preparation method and application thereof, and belongs to the technical field of biomedical materials. High-purity hypochlorous acid water is prepared by imitating a generation mode of hypochlorous acid in human neutrophil, and the hypochlorous acid hydrogel is prepared by taking the hypochlorous acid water as a main raw material, taking a mixture of sodium magnesium fluosilicate and magnesium fluosilicate as gel, taking hydrochloric acid or alkaline electrolyzed water as a pH regulator and taking acetic acid and sodium acetate as pH buffering agents. If necessary, sodium chloride can be added as an isotonic agent, sodium hyaluronate can be added as a humectant, and poloxamer can be added as a hemostatic. According to the gel disclosed by the invention, the high-purity hypochlorous acid water is taken as a main raw material, particularly the mixture of the sodium magnesium fluosilicate and the magnesium fluosilicate is taken as the gel agent, and the invention has good tissue adhesion, biocompatibility and swelling property and has the advantages of long-acting slow-release bacterium killing, adjustable formula and wide application range.

The invention particularly relates to an injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as a preparation method and application of the injectable hydrogel dressing. The hydrogel compound dressing is prepared from the following raw materials in percentage by mass: 3-30% of an antibacterial high-molecular compound, 3-30% of a natural polyphenol compound, 3-30% of an inorganic gallium compound and deionized water. The hydrogel auxiliary material has good injectable performance, antibacterial performance, hemostatic performance and antioxidant effect, and can significantly improve the wound healing effect in a mouse full-thickness skin wound simulation model.

The invention relates to the field of biomedicine, especially to a drug-loaded tissue adhesive film and a preparation method thereof. The invention provides a drug-loaded tissue adhesive film, which comprises alternately superimposed cationic layers and anionic layers, at least one layer of the cationic layers and anionic layers is a drug layer, or at least one layer of the cationic layers and anionic layers contains a charged drug. The drug-loaded tissue adhesive film provided by the invention has good tissue adhesiveness, good biocompatibility and degradable absorbability, and good stability, and the physical and chemical properties of the drug-loaded tissue adhesive film can be adjusted by regulating the material composition.

The invention relates to a chitosan-based polyelectrolyte composite hemostatic sponge. The composite hemostatic sponge comprises chitosan, sodium alginate, hyaluronic acid and genipin. According to the invention, a series of chitosan-based electrolyte composite sponges are obtained through a freeze-drying method by utilizing the shape characteristics of polyelectrolyte, and the apparent structure, water absorption, mechanical properties, biocompatibility and wound healing effect of the sponges are measured and evaluated; the result shows that the screened composite hemostatic sponge has good mechanical property, liquid absorption property and biocompatibility, and can obviously accelerate the wound healing process. An effective method is provided for the development of hemostatic materials.

The invention discloses an in-situ rapid prototyping magnetic hydrogel for urinary system repair and a preparation method thereof. The magnetic hydrogel is double-network hydrogel, and comprises monomer acrylamide, a cross-linking agent and a photoinitiator of a first network, and carboxymethyl chitosan and magnetic nanoparticles gamma-Fe2O3 of a second network; the preparation method of the in-situ rapid prototyping magnetic hydrogel comprises the following steps: in-situ injecting a hydrogel precursor solution into a urinary system injury part of a human body, such as bladder and vaginal fistula, and rapidly prototyping the hydrogel precursor solution for 5 seconds under blue light of 405 nanometers to form the hydrogel adapting to the shape of the inner wall of the bladder and vaginal fistula. The magnetic hydrogel has the properties of in-situ rapid prototyping, high swelling rate, traceability and the like, and meanwhile, can promote cell adhesion, so that the repair of the injurypart is accelerated. The preparation process of the in-situ rapid prototyping magnetic hydrogel is simple and convenient, surgical operation is simple and convenient, and large-scale production is facilitated from the perspective of industrialization.

The invention discloses a biomimetic mechanical active hydrogel adhesive and a preparation method thereof. The preparation method comprises the following steps: firstly, dissolving N-isopropylacrylamide, sodium alginate, HKUST-1 nanoparticles, a cross-linking agent, an initiator and an initiator into deionized water, and reacting at low temperature to prepare cross-linked interpenetrating network hydrogel; the preparation method comprises the following steps: carrying out coupling reaction on amino on chitosan and carboxyl in 3, 4-dihydroxyphenylpropionic acid to prepare chitosan-g-catechol with a catechol structure on a branched chain; and uniformly coating the chitosan-g-catechol solution on the surface of the hydrogel to obtain the product. According to the invention, poly (N-isopropylacrylamide) is used as a first network of the hydrogel, so that a temperature-sensitive volume phase transformation effect is realized; meanwhile, the chitosan-g-catechol is used for improving the adhesion of the hydrogel in the form of bridging polymer. Under the synergistic effect, the skin tissue around the wound surface is promoted to shrink, and the wound healing is accelerated.

The invention relates to the field of biological medicine, in particular to a polysaccharide medicine loading tissue adhesion film and a preparing method thereof. The polysaccharide medicine loading tissue adhesion film comprises cationic layers and anionic layers, wherein the cationic layers and the anionic layers are stacked alternately. At least one layer in the cationic layers and the anionic layers is a medicine layer, or at least one layer in the cationic layers and the anionic layers contains medicine with charges, and polysaccharide medicine serves as the medicine. The polysaccharide medicine loading tissue adhesion film has good tissue adhesion and high biological compatibility, degradation absorbability and stability, and the physical performance and the chemical performance of the polysaccharide medicine loading tissue adhesion film can be adjusted by adjusting the constitution of materials.

The invention provides a high-stability self-linking MXene nanosheet, and a preparation method and application thereof, and particularly provides a surface-modified MXene nanosheet. The MXene nanosheet is provided with Na ions and a sulfonic acid intercalation layer, and meanwhile, the surface of the MXene nanosheet is also provided with a polydopamine layer and a polyethylene dioxythiophene layer; the polydopamine layer and the polyethylene dioxythiophene layer are arranged in sequence; and specifically, firstly, a polydopamine layer is polymerized on the surface of an MXene nanosheet with Na ions and a sulfonic acid intercalation layer, and then a polyethylene dioxythiophene layer is polymerized in situ. Various modifications of the MXene nanosheet interact, and various properties such as physical and chemical stability, film-forming ability and biocompatibility of the MXene nanosheet in a living body are enhanced, so that the MXene nanosheet can be used as an electrode modification material, a peripheral nerve cell repair material, a wire of a neural electrode, a site of a central nerve electrode and the like.