6results about How to "Good tissue adhesion" patented technology

The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.

The invention relates to the technical field of medical biological materials, and discloses a mussel mucin-chondroitin sulfate composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a mussel mucin aqueous solution and a chondroitin sulfate aqueous solution; the mass volume concentration of the mussel mucoprotein aqueous solution is 1%-10%, the mass volume concentration of the chondroitin sulfate aqueous solution is 1%-10%, the mass ratio of the mussel mucoprotein to the chondroitin sulfate is 3: 1-1: 3, the two solutions are mixed and stirred or oscillated under the conditions that the temperature is 4-37 DEG C and the pH value is 7.0-9.0, a cross-linking reaction is conducted, and hydrogel is formed; the cross-linking mode is physical cross-linking, chemical cross-linking or physical-chemical dual cross-linking; according to the invention, excellent tissue adhesion, injectability, self-healing property and biodegradability are realized, cell adhesion and proliferation can be effectively promoted, and the gel is suitable for various medical beauty scenes such as skin filling, wound repairing and anti-aging nursing.

This invention relates to a myocardial repair patch based on multi-material printing, its preparation, and its application, belonging to the field of bio-3D printing and regenerative medicine technology. The invention uses PLCL and GelMA hydrogel loaded with active cardiomyocytes as bio-inks, and introduces gelatin gel as a heat buffer material. An orthogonal network structure is constructed using multi-material bio-3D printing technology to prepare a myocardial repair patch with excellent dynamic adaptability to the myocardial interface and good biocompatibility. The myocardial injury repair patch prepared by this invention achieves a structure-function integrated design through the synergistic effect of the three materials, significantly overcoming the limitations of single materials in terms of mechanical properties, biological function, or thermal compatibility. The mechanical properties of the myocardial injury repair patch prepared by this invention can precisely match those of natural myocardium, while possessing high cell activity, effectively inhibiting fibrosis, improving myocardial function, and achieving true active repair. Furthermore, the process conditions are controllable, demonstrating good translational potential.

The invention discloses a medical flushing glue solution and a preparation method thereof, and relates to the technical field of flushing glue solutions, and the medical flushing glue solution is prepared by adding 0.15% by weight of sodium methyl cellulose, 0.8% by weight of sodium chloride and 99.05% by weight of medical purified water. According to the application, the content ratio of sodium carboxymethyl cellulose to sodium chloride is accurately matched with the requirement of a medical flushing scene, and meanwhile, the dosage of sodium carboxymethyl cellulose can enable the glue solution to have good flowability and moderate tissue adhesiveness, so that smooth flushing in clinical operation can be realized, a continuous moist protective layer can be formed on the surface of tissue, and the medical flushing effect is improved. The cleaning and protecting effects are effectively achieved; the dosage of sodium chloride can accurately simulate physiological osmotic pressure to ensure that the glue solution is compatible with the human tissue environment, in addition, the glue solution under the formula is excellent in stability, has no layering and precipitation phenomena within 6 months under the storage condition of 4 DEG C, and can meet the stability requirements of long-term storage and clinical use.

The present application relates to a kind of injectable compound for soft tissue repair and its preparation method and application, the injectable compound includes: temperature-sensitive medium;Pre-crosslinked, water-insoluble hydrophilic polymer gel microparticles dispersed in the temperature-sensitive medium, content is 5-23% of the total mass of injectable compound;And acellular matrix microparticle dispersed in the temperature-sensitive medium, content is 6-12% of the total mass of injectable compound;Wherein, the network phase formed by the hydrophilic polymer gel microparticle gelatinization with the temperature-sensitive medium at body temperature is combined, constitutes the support framework of enhancing the structural stability of the injectable compound.The injectable compound involved in the present application is flowable viscous gel when injection, rapidly converted into non-flowing semi-solid at physiological temperature, forms tissue-conforming repair layer.Among them, gelatinous particle, temperature-sensitive medium, acellular matrix microparticle three synergistically promote tissue repair.

The invention relates to multifunctional in-situ repair hydrogel based on a modified dermal matrix as well as a preparation method and application of the hydrogel. The hydrogel is formed by crosslinking a first polymer precursor and a second polymer precursor through dynamic covalent bonds of boric acid ester, the first polymer precursor is carboxymethyl chitosan grafted with a phenylboronic acid group and an epsilon-polylysine chain segment; the second polymer precursor is a soluble acellular dermal matrix which is grafted with a 3, 4-dihydroxyphenyl propionic acid group and is subjected to enzymolysis treatment. The hydrogel disclosed by the invention has good biocompatibility, moldability and potential self-healing capability.