Preparation method of an infrared-responsive high-strength hydrogel for articular cartilage repair

Abstract

The invention discloses a preparation method of an infrared-responsive high-strength hydrogel for cartilage repair. The main operation is to modify polysaccharides or proteins with double bonds through methacrylic acid, methacrylic anhydride, and methacrylate substances, so that the side chains have double bond groups and can be polymerized to form hydrogels; Under the action of initiator and cross-linking agent, N-isopropylacrylamide, double bond modified polysaccharide or protein polymerize in situ to form double network high-strength hydrogel. The infrared-responsive high-strength hydrogel prepared by the method has good biocompatibility and excellent mechanical properties, and has good application prospects in the field of articular cartilage repair.

Description

technical field

[0001] The invention relates to a preparation method of an infrared response high-strength intelligent hydrogel for articular cartilage repair. Background technique

[0002] Hydrogel has a soft and elastic three-dimensional network structure, which can provide a microenvironment closer to the natural cartilage extracellular matrix for cell proliferation and differentiation, and is an ideal material for cartilage tissue repair.

[0003] In the process of promoting cartilage repair, the growth factors traditionally loaded in hydrogels cannot be released in a controlled manner according to the repair requirements, which is an important problem that restricts the application of hydrogels in cartilage repair. In recent years, light-responsive hydrogels have attracted more and more attention because of their intelligence in sensing changes in the external environment and in the release of external stimuli-response control factors. However, the existing light-respo...