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Biomimetic mechanical active hydrogel adhesive and preparation method thereof

A biomimetic machine, active water technology, used in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of lack of skin tissue adhesion properties, complex preparation process, strong cytotoxicity, etc., to increase structural stability and mechanical properties, Simple synthesis method and the effect of improving tissue adhesion

Active Publication Date: 2022-05-13
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong cytotoxicity of nano silver, it will cause damage to other tissue cells in the process of wound healing.
At the same time, due to the lack of good skin tissue adhesion properties, it is easy to cause slippage when this technology is applied to the wound, which is not conducive to fixing the hydrogel on the wound surface
In addition, this preparation method requires loading hydrogel microspheres and repeated freezing and thawing several times, and the preparation process is relatively complicated.

Method used

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  • Biomimetic mechanical active hydrogel adhesive and preparation method thereof
  • Biomimetic mechanical active hydrogel adhesive and preparation method thereof
  • Biomimetic mechanical active hydrogel adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of the present embodiment mechanically active hydrogel adhesive comprises the following steps:

[0039] 1) Dissolve 0.3g of copper acetate monohydrate in 4ml of deionized water, and dissolve 0.22g of 1,3,5-benzenetricarboxylic acid in 4ml of absolute ethanol. Add the copper acetate monohydrate solution dropwise to the 1,3,5-benzenetricarboxylic acid solution, then stir at room temperature at a speed of 300r / min for about 30min to obtain a dark turquoise suspension, and at a speed of 5000r / min The suspension was centrifuged for 8 min to separate HKUST-1 nanoparticles. The product was washed with 50% ethanol solution, and the washing was repeated three times to remove residual reactants. The collected samples were dried under vacuum and sealed and stored in a desiccator. figure 1 (1) is 1,3,5-benzenetricarboxylic acid and (2) is the FTIR spectrum of HKUST-1 nanoparticles, 1619cm -1 、1566cm -1 、1440cm -1 、1370cm -1 The asymmetric and symmetric vi...

Embodiment 2

[0044] The preparation method of the present embodiment mechanically active hydrogel adhesive comprises the following steps:

[0045] 1) Dissolve 0.3g of copper acetate monohydrate in 4ml of deionized water, and dissolve 0.22g of 1,3,5-benzenetricarboxylic acid in 4ml of absolute ethanol. Add the copper acetate monohydrate solution dropwise to the 1,3,5-benzenetricarboxylic acid solution, then stir at room temperature at a speed of 300r / min for about 30min to obtain a dark turquoise suspension, and at a speed of 5000r / min The suspension was centrifuged for 8 min to separate HKUST-1 nanoparticles. The product was washed with 50% ethanol solution, and the washing was repeated three times to remove residual reactants. The collected samples were dried under vacuum and sealed and stored in a desiccator.

[0046] 2) In a 50ml flask equipped with a magnetic stirring bar, dissolve 1.8g of N-isopropylacrylamide, 0.0036g of N,N-methylenebisacrylamide and 0.15g of sodium alginate at 25°C...

Embodiment 3

[0050] The preparation method of the present embodiment mechanically active hydrogel adhesive comprises the following steps:

[0051] 1) Dissolve 0.3g of copper acetate monohydrate in 4ml of deionized water, and dissolve 0.22g of 1,3,5-benzenetricarboxylic acid in 4ml of absolute ethanol. Add the copper acetate monohydrate solution dropwise to the 1,3,5-benzenetricarboxylic acid solution, then stir at room temperature at a speed of 300r / min for about 30min to obtain a dark turquoise suspension, and at a speed of 5000r / min The suspension was centrifuged for 8 min to separate HKUST-1 nanoparticles. The product was washed with 50% ethanol solution, and the washing was repeated three times to remove residual reactants. The collected samples were dried under vacuum and sealed and stored in a desiccator.

[0052] 2) In a 50ml flask equipped with a magnetic stirring bar, dissolve 1.8g of N-isopropylacrylamide, 0.0036g of N,N-methylenebisacrylamide and 0.15g of sodium alginate at 25°C...

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Abstract

The invention discloses a biomimetic mechanical active hydrogel adhesive and a preparation method thereof. The preparation method comprises the following steps: firstly, dissolving N-isopropylacrylamide, sodium alginate, HKUST-1 nanoparticles, a cross-linking agent, an initiator and an initiator into deionized water, and reacting at low temperature to prepare cross-linked interpenetrating network hydrogel; the preparation method comprises the following steps: carrying out coupling reaction on amino on chitosan and carboxyl in 3, 4-dihydroxyphenylpropionic acid to prepare chitosan-g-catechol with a catechol structure on a branched chain; and uniformly coating the chitosan-g-catechol solution on the surface of the hydrogel to obtain the product. According to the invention, poly (N-isopropylacrylamide) is used as a first network of the hydrogel, so that a temperature-sensitive volume phase transformation effect is realized; meanwhile, the chitosan-g-catechol is used for improving the adhesion of the hydrogel in the form of bridging polymer. Under the synergistic effect, the skin tissue around the wound surface is promoted to shrink, and the wound healing is accelerated.

Description

technical field [0001] The invention relates to a medical hydrogel dressing that can be used for wound healing, in particular to a biomimetic mechanically active hydrogel adhesive and a preparation method thereof. The biomimetic mechanically active hydrogel adhesive is used as a medical hydrogel dressing. Background technique [0002] Wound healing is a continuous and complex process that can be temporally divided into four phases: (i) coagulation and hemostasis; (ii) inflammation; (iii) cellular proliferation; and (iv) wound remodeling. In the process of cell proliferation, the wound is filled with granulation tissue composed of newly formed capillaries and connective tissue, in which fibroblasts, as the main cells in the proliferation phase, migrate from the surrounding tissue to the wound site for reproduction, among which fibroblasts have contractile properties Specialized fibroblasts, called myofibrils, promote wound shrinkage by contracting the wound. The process of w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F251/00C08F220/54C08F222/38
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/008A61L26/009A61L26/0019C08F251/00A61L2400/12A61L2300/102A61L2300/216A61L2300/232A61L2300/404C08F220/54C08F222/385C08L33/24C08L5/08C08L5/04C08L87/00
Inventor 彭晓宏黄晁康
Owner SOUTH CHINA UNIV OF TECH
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