Biomimetic mechanical active hydrogel adhesive and preparation method thereof

A biomimetic machine, active water technology, used in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of lack of skin tissue adhesion properties, complex preparation process, strong cytotoxicity, etc., to increase structural stability and mechanical properties, Simple synthesis method and the effect of improving tissue adhesion
CN114470313AActive Publication Date: 2022-05-13SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2022-05-13

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Abstract

The invention discloses a biomimetic mechanical active hydrogel adhesive and a preparation method thereof. The preparation method comprises the following steps: firstly, dissolving N-isopropylacrylamide, sodium alginate, HKUST-1 nanoparticles, a cross-linking agent, an initiator and an initiator into deionized water, and reacting at low temperature to prepare cross-linked interpenetrating network hydrogel; the preparation method comprises the following steps: carrying out coupling reaction on amino on chitosan and carboxyl in 3, 4-dihydroxyphenylpropionic acid to prepare chitosan-g-catechol with a catechol structure on a branched chain; and uniformly coating the chitosan-g-catechol solution on the surface of the hydrogel to obtain the product. According to the invention, poly (N-isopropylacrylamide) is used as a first network of the hydrogel, so that a temperature-sensitive volume phase transformation effect is realized; meanwhile, the chitosan-g-catechol is used for improving the adhesion of the hydrogel in the form of bridging polymer. Under the synergistic effect, the skin tissue around the wound surface is promoted to shrink, and the wound healing is accelerated.
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Description

technical field

[0001] The invention relates to a medical hydrogel dressing that can be used for wound healing, in particular to a biomimetic mechanically active hydrogel adhesive and a preparation method thereof. The biomimetic mechanically active hydrogel adhesive is used as a medical hydrogel dressing. Background technique

[0002] Wound healing is a continuous and complex process that can be temporally divided into four phases: (i) coagulation and hemostasis; (ii) inflammation; (iii) cellular proliferation; and (iv) wound remodeling. In the process of cell proliferation, the wound is filled with granulation tissue composed of newly formed capillaries and connective tissue, in which fibroblasts, as the main cells in the proliferation phase, migrate from the surrounding tissue to the wound site for reproduction, among which fibroblasts have contractile properties Specialized fibroblasts, called myofibrils, promote wound shrinkage by contracting the wound. The process of w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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