Hydrogel prepared by using grafted modified material as well as preparation method and application of hydrogel

A graft modification, hydrogel technology, applied in medical science, bandages, etc., can solve problems such as poor mechanical properties, and achieve the effects of excellent antibacterial properties, good antibacterial properties, and strong mechanical properties

Active Publication Date: 2018-09-04
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings and deficiencies of the poor mechanical properties of polylysine hydrogel medical materials in the prior art, and provide a hydrogel with strong mechanical properties and suitable tissue adhesion

Method used

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  • Hydrogel prepared by using grafted modified material as well as preparation method and application of hydrogel
  • Hydrogel prepared by using grafted modified material as well as preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0034] The present embodiment provides a hydrogel, which is obtained by the following preparation method:

[0035] Weigh 5g of polylysine (molecular weight: 3000-5000) into a container, add 100ml of deionized water, stir to dissolve, add 0.125g of EDC and 0.125g of NHS, and react for 4h. The solution is taken out, dialyzed, and the solution in the dialysis bag is freeze-dried to obtain modified polylysine. Weigh 2g of modified polylysine into a container, add 10ml of deionized water, stir to dissolve, add 2g of acrylamide monomer to the container, stir to dissolve. Add 0.01g of ammonium persulfate photoinitiator and 0.01g of N,N'-methylenebisacrylamide into the container, and continue to stir for 30min. The solution was poured into a vessel and irradiated overnight with a 365nm ultraviolet light generator. The pH was adjusted to 8 using sodium borate buffer solution. After standing still for 30 minutes, a polylysine-polyacrylamide grafted gel-like polymer with a graft rate ...

Embodiment 2

[0037] This embodiment provides a kind of hydrogel, and this hydrogel is obtained by following preparation method:

[0038]Weigh 1.5g of polylysine (molecular weight: 3000-5000) into a container, add 60ml of purified water, stir to dissolve, add 0.25g of EDC and 1.25g of NHS, and react for 8 hours. The solution is taken out, dialyzed, and the solution in the dialysis bag is freeze-dried to obtain modified polylysine. Weigh 2g of modified polylysine into a container, add 20ml of deionized water, stir to dissolve, add 10g of acrylamide monomer into the container, stir to dissolve. Add 0.05g of ammonium persulfate photoinitiator and 0.05g of N,N'-methylenebisacrylamide into the container, and continue to stir for 1h. The solution was poured into a vessel and irradiated overnight with a 350nm ultraviolet light generator. The pH was adjusted to 10 using sodium borate buffer solution. After standing still for 30 minutes, a polylysine-polyacrylamide grafted gel-like polymer with a...

Embodiment 3

[0040] This embodiment provides a kind of hydrogel, and this hydrogel is obtained by following preparation method:

[0041] Weigh 5g of polylysine (molecular weight: 3000-5000) into a container, add 50ml of ultrapure water to dissolve it, add 0.25g of EDC and 0.5g of NHS, and react for 6h. The solution is taken out, dialyzed, and the solution in the dialysis bag is freeze-dried to obtain modified polylysine. Weigh 2g of modified polylysine into a container, add 15ml of deionized water, stir to dissolve, add 0.5g of acrylamide monomer to the container, stir to dissolve. Add 0.025g of ammonium persulfate photoinitiator and 0.025g of N,N'-methylenebisacrylamide into the container, and continue to stir for 2h. The solution was poured into a vessel and irradiated overnight with a 370nm ultraviolet light generator. The pH was adjusted to 9 using sodium borate buffer solution. After standing still for 30 minutes, a polylysine-polyacrylamide grafted gel polymer with a graft rate of...

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Abstract

The invention relates to hydrogel prepared by using a grafted modified material as well as a preparation method and the application of the hydrogel. The hydrogel is formed by polylysine grafted polyacrylamide and has an interpenetrating network structure. The hydrogel provided by the invention not only has a high mechanical property, proper wound adhesivity and excellent antibacterial property, but also has high saturated water absorbing rate and can be used for preparing wound repair products. The preparation method of the hydrogel, which is provided by the invention, is simple in process andhigh in yield.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and more specifically relates to a hydrogel prepared by grafting modified materials, a preparation method and application thereof. Background technique [0002] Hydrogel medical wound accessories are a new type of wound accessories developed in recent years. Compared with traditional excipients, hydrogel can promote better wound healing, relieve pain of patients, improve the microenvironment of the wound, and inhibit the growth of bacteria. [0003] In 1977, Japanese scholars extracted a homomonomer polymer containing 25 to 30 lysine residues from the culture filtrate of actinomycetes. This lysine polymer is formed by linking lysine residues through amide bonds formed by α-carboxyl groups and ε-amino groups, so it is called ε-polylysine. As a natural polymer, ε-polylysine is used in the preparation of hydrogels, and its advantages lie in the following aspects: First, there are a large...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F283/04C08F220/56C08F222/38C08F2/48A61L26/00C08L77/04
CPCA61L26/0019A61L26/0061A61L26/008C08F2/48C08F283/04C08J3/075C08J2377/04C08F220/56C08F222/38C08L51/08
Inventor 林丽敏邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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