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Chitosan-based polyelectrolyte composite hemostatic sponge, preparation method and application

A technology of chitosan-based polymerization and hemostatic sponge, applied in the application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of undiscovered patent publications, etc., and achieve the advantages of large-scale quantitative production, good hemostatic effect, and prevention of wound infection. Effect

Inactive Publication Date: 2021-06-01
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Chitosan-based polyelectrolyte composite hemostatic sponge, preparation method and application
  • Chitosan-based polyelectrolyte composite hemostatic sponge, preparation method and application
  • Chitosan-based polyelectrolyte composite hemostatic sponge, preparation method and application

Examples

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preparation example Construction

[0036] The preparation method of the above-mentioned chitosan-based polyelectrolyte composite hemostatic sponge, the steps are as follows:

[0037] (1) Preparation of chitosan-sodium alginate polyelectrolyte complex;

[0038] ⑵Preparation of chitosan-based polyelectrolyte composite hemostatic sponge.

[0039] Preferably, said step (1) specifically includes the following steps:

[0040] Get chitosan and join in deionized water, add the acetic acid solution that volume percent is 1% again, stir until chitosan is all dissolved, be mixed with the chitosan solution of 2% (w / v); Dissolve sodium in deionized water and prepare 2% (w / v) sodium alginate solution; mix and stir the prepared chitosan solution and sodium alginate solution at a volume ratio of 1:10 to 10:1 Uniform, that is, polyelectrolyte complexes with different proportions.

[0041] Preferably, said step (2) specifically includes the following steps:

[0042] Take genipin and dissolve it in deionized water to prepare ...

Embodiment 1

[0045] Embodiment 1: Preparation of chitosan-based polyelectrolyte composite hemostatic sponge

[0046] specific method:

[0047] (1) Get described chitosan and join in deionized water, then add volume percent and be 1% acetic acid solution, stir until chitosan is all dissolved, be mixed with 2% (w / v) chitosan solution; get the same sodium alginate and dissolve it in deionized water to prepare 2% (w / v) sodium alginate solution; prepare chitosan solution and sodium alginate solution at a ratio of 1:3 , 2:3, 1:1 volume ratio and mix well to obtain polyelectrolyte complexes in different proportions.

[0048] (2) Take the genipin and make it dissolve in deionized water to prepare 0.05% genipin aqueous solution; also take the hyaluronic acid and make it dissolve in deionized water to prepare 1% hyaluronic acid solution; the prepared genipin solution (M CS :M Ge =1:5) and hyaluronic acid solution (M CS :M HA =2:1) ​​Add in the polyelectrolyte complex obtained in step (1), use ...

Embodiment 2

[0049] Example 2: Observation of the microscopic morphology of the composite hemostatic sponge prepared in Example 1

[0050] The microscopic morphology of the composite sponges with three different component ratios was observed by scanning electron microscopy (SEM). Such as figure 2 Shown are the surface and cross-sectional microscopic morphology diagrams of CAHS1, CAHS2, and CAHS3 prepared in Example 1 at 400 times. It can be seen from the figure that all three materials can form a structure with certain pores, and the surface and cross section are almost the same, which proves that the surface and interior of the material are relatively uniform. In comparison, the surface and cross-section of CAHS2 are obviously more uniform than CAHS1 and CAHS3, and have a finer and denser pore-like structure, which plays a vital role in the absorption of body fluids and blood at the wound, and also to a certain extent. affect the mechanical properties of the material. The structures o...

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Abstract

The invention relates to a chitosan-based polyelectrolyte composite hemostatic sponge. The composite hemostatic sponge comprises chitosan, sodium alginate, hyaluronic acid and genipin. According to the invention, a series of chitosan-based electrolyte composite sponges are obtained through a freeze-drying method by utilizing the shape characteristics of polyelectrolyte, and the apparent structure, water absorption, mechanical properties, biocompatibility and wound healing effect of the sponges are measured and evaluated; the result shows that the screened composite hemostatic sponge has good mechanical property, liquid absorption property and biocompatibility, and can obviously accelerate the wound healing process. An effective method is provided for the development of hemostatic materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a chitosan-based polyelectrolyte composite hemostatic sponge, a preparation method and application. Background technique [0002] Wound healing is a dynamic process, which mainly includes four stages such as blood stasis, inflammation, proliferation and extracellular matrix (ECM) remodeling. These four healing phases involve interactions between different types of cells, bioactive factors, and a support platform (usually the native ECM secreted by cells). The accumulation of wound secretions such as blood and body fluids can promote bacterial growth, which in turn can cause infection and lead to a delay in the wound healing process. Millions of people suffer from skin damage every year due to excessive physicochemical factors or diseases. Followed by wound infection and severe tissue necrosis, endangering human life. [0003] At present, there are many kinds of he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L15/42A61L15/46A61L15/28
CPCA61L24/0036A61L24/043A61L24/0015A61L24/001A61L15/425A61L15/46A61L15/42A61L15/28A61L2400/04A61L2300/404A61L2300/232C08L5/08C08L5/04
Inventor 孟欣卢阳刘涛高颖
Owner TIANJIN UNIV OF SCI & TECH
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