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Preparation method of oxidized regenerated cellulose hemostatic material with micro-nano composite structure

A technology of micro-nano composite structure and regenerated cellulose, which can be applied to artificial filaments made of cellulose derivatives, wet spinning, medical science, etc. The effect of fast hemostasis, short hemostasis time and easy decomposition

Active Publication Date: 2013-02-06
WEIGAO HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of the existing hemostatic materials such as slow hemostatic speed, great impact on the environment and difficulty in decomposing, thereby providing an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and a preparation method thereof

Method used

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  • Preparation method of oxidized regenerated cellulose hemostatic material with micro-nano composite structure
  • Preparation method of oxidized regenerated cellulose hemostatic material with micro-nano composite structure
  • Preparation method of oxidized regenerated cellulose hemostatic material with micro-nano composite structure

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specific Embodiment approach 1

[0013] Specific Embodiment 1: A method for preparing an oxidized regenerated cellulose-based hemostatic material with a micro-nano composite structure according to this embodiment is implemented in the following steps:

[0014] 1. Raise the temperature of the ionic liquid to 95-115°C, then dissolve the cellulose in the ionic liquid and keep it warm, and stir once every 5-20 minutes. When the cellulose is completely dissolved, the cellulose solution is obtained, and the cellulose solution is cooled to 80-80 90°C, and keep it in a static state for later use; wherein, the mass fraction of cellulose in the ionic liquid is 2% to 6%;

[0015] 2. Put the cellulose solution prepared in step 1 into the syringe of the electrospinning machine for spinning, and the nanofibers obtained by spinning are coagulated in deionized water at 15-25°C for 10-30min, and then filtered to take the filtrate for further processing. Rinse, put the filtrate after rinsing into deionized water, stir evenly t...

specific Embodiment approach 2

[0019] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the ionic liquid in Step 1 is 1-allyl-3-methylimidazole. Other steps and parameters are the same as those in Embodiment 1.

[0020] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in step 1, the cellulose needs to be dried in a vacuum oven at 60-80°C for 0.5-1.5 hours before use. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

specific Embodiment approach 4

[0021] Specific Embodiment 4: The difference between this embodiment and one of specific embodiments 1 to 3 is that the rinsing in Step 2 and the rinsing in Step 4 are performed with medical ethanol. Other steps and parameters are the same as those in Embodiments 1 to 3.

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Abstract

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

Description

technical field [0001] The invention relates to a preparation method of an oxidized regenerated cellulose hemostatic material. Background technique [0002] Oxidized regenerated cellulose (ORC), due to its good biocompatibility and degradability, can be used as a hemostatic material in the medical field. Around the oxidized regenerated cellulose, a lot of research work at home and abroad is also going on, mainly including the preparation and modification of oxidized regenerated cellulose. Absorbable hemostatic gauze Surgicel, also known as "quick gauze", is currently widely used clinically. The "Suji Yarn" currently used is an imported product, the price is relatively expensive, and the "Suji Yarn" has a small specific surface area and slow hemostasis. It takes 2 to 8 minutes to achieve hemostasis. It is more suitable for wounds with a small amount of bleeding, but for bleeding Severe parts cannot effectively stop bleeding in time. [0003] Freon-113 was developed in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28D04H1/4258D01D5/06D01F2/24
Inventor 黄玉东程玮璐贺金梅李大龙高山李永刚
Owner WEIGAO HLDG
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