120results about How to "Fast hemostasis" patented technology

The invention relates to the high degree of exchange Ca-A type zeolite hemostasis dressing and the preparation method and the purpose. The zeolite hemostasis dressing of the invention containing the zeolite has fast hemostasis speed, and has no bacterium, no pyrogen, no cell toxicity, no hypersensitive reaction and no skin irritation, the using is convenient and the cost is low.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

The invention discloses a preparation method of a medical hemostatic occlusion dressing. The preparation method comprises the following steps: (1), taking and pouring deionized water into a reactor, heating the reactor, slowly adding lemon peel pectin and gelatin, and mechanically stirring at the same time; (2), after the addition of the lemon peel pectin and gelatin, stirring continuously, then adding other components into the reactor, and carrying out mechanical stirring uniformly at the same time; (3), after the mixing of the materials, cooling hydrogel to be at a room temperature, so as to obtain the medical hemostatic occlusion dressing. The medical hemostatic occlusion dressing prepared through the method provided by the invention is high in bleeding stopping speed, has auxiliary functions of promoting wound surface healing, preventing adhesion and the like, is also better in biomechanics and air permeability, and has an important clinical application value; the preparation method provided by the invention has the advantages that the process is simple, requirements for equipment are relaxed, raw materials are low in cost and readily available, the cost is low, and industrialization is easy to realize.

The invention discloses a preparation method of a quick absorption saturation gelation seaweed hemostatic dressing. The method includes the steps of: soaking, rinsing and drying on calcium fiber textile or non-woven products containing alginate, and the carrying out cutting, packaging and sterilizing to obtain the quick absorption saturation gelation hemostatic dressing. The invention also discloses the application of the quick absorption saturation gelation seaweed hemostatic dressing prepared by the above method. The invention is applicable to rapid absorption and removal of a large amount of surgical diffusate in surgical operation process, so as to realize the effects of rapid hemostasis and operation wound clean; the hemostatic dressing is used for burn, scald and other acute and chronic wounds, can cover the wound and prevent moisture loss in body fluids, provide a positive moist environment for wound healing, prevent the wound from effusion and erosion, isolate bacterial infection, and play the effects of stopping bleeding, relieving pain, promoting wound healing, and reducing scar.

The invention provides a method for preparing bleeding stopping oxidized celluloses in ramie oxidation degumming procedures. The method includes smashing raw ramie to obtain short fibers and soaking the short fibers to sufficiently moisten the short fibers and allow the short fibers to sufficiently swell; mixing the pretreated raw ramie short fibers and degumming solution with one another to obtain mixtures, heating the mixtures, then preserving heat, sufficiently removing colloid in the raw ramie by the aid of oxidability of specific oxidizing agents and simultaneously oxidizing celluloses with active hydroxyl to obtain oxidized celluloses with a large quantity of carboxyl; soaking oxidized and treated fibers by the aid of organic solvent aqueous solution and removing the unreacted oxidizing agents; separating the oxidized celluloses from water and carrying out drying treatment on the oxidized celluloses to ultimately obtain the powdery bleeding stopping oxidized celluloses. The method has the advantages that processes are simple, the original two working procedures are combined into a single working procedure, accordingly, the total reaction time can be shortened, medicines and the cost can be saved, and the efficiency can be greatly improved; the bleeding stopping oxidized celluloses which are products prepared by the aid of the method are high in bleeding stopping speed and bleeding stopping efficiency and can be widely applied to quickly stopping bleeding under conditions of war wound, trauma and the like, and stable effects can be realized.

The invention relates to a traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, which comprises the following raw medicinal materials in portions by weight: 900-1100 portions of red paeonia, 900-1100 portions of motherwort, 200-400 portions of pseudo-ginseng, 900-1100 portions of agrimony, 500-700 portions of charred radix sanguisorbae and 500-700 portions of charred pollen typhae. The preparation method of the traditional Chinese medicine combination comprises the following steps: extracting from the red paeonia and the pseudo-ginseng with 80% ethanol, extracting from the motherwort, the agrimony, the charred radix sanguisorbae and the charred pollen typhae with water, and finally preparing the traditional Chinese medicine combination byan appropriate process. The invention also relates to a capsule quality control method of the traditional Chinese medicine combination, which comprises an identification step and a content determination step, wherein in the identification step, identification is carried out by using red paeonia control medicinal materials, paeoniflorin controls, pseudo-ginseng control medicinal materials, agrimony control medicinal materials, motherwort control medicinal materials and stachydrine hydrochloride controls based on a thin-layer chromatography; and in the content determination step, the content ofthe red paeonia should be not less than 12.0mg per capsule (measured by penoniflorin, C23H28O11 and determined by the red paeonia). The traditional Chinese medicine combination has the advantages of high hemostasis speed, good effect and the like. The capsule quality control method can conveniently and visually identify the preparation and can well ensure the effect of the traditional Chinese medicine combination.

The invention provides a blood protein responsive type gamma-PGA (polyglutamic acid) hydrogel hemostasis material as well as a preparation method and an application thereof. The hemostasis material isprepared from a PHPA and DA (dopamine) molecule functionalized gamma-PGA polymer, a solvent with water as a main body, horseradish peroxidase and hydrogen peroxide, the synergetic enhancement effectof gamma-PGA, PHPA and DA on integration of wet high-strength wound is realized and the efficient blocking and hemostasis effect is achieved through Fe<3+> in gamma-PGA complexing blood, adsorption and blood coagulation of blood protein under the inducing action of benzene ring hydrophobic functional groups in PHPA and gel forming through oxidation and crosslinking by catechol groups in DA. The provided gamma-PGA hydrogel hemostasis material can effectively overcome the limitation of conventional pressing hemostasis method in application fields, besides, the problems that numerous hemostasis materials have poor blood responsiveness, poor integration capability for the wet bleeding wound and the like at present are solved, and the blood protein responsive type gamma-PGA hydrogel hemostasismaterial has the advantages of being high in hemostasis efficiency, good in biocompatibility, capable of allowing orthotopic injection of matched complicated wound types and the like and has broad market application prospects.

The invention provides a method of preparing a natural polymer base composite polyelectrolyte hemostasis dressing. A natural polymer base composite polyelectrolyte solution with traces of thrombin is prepared by preparing polyanion and polycation solutions with different concentrations. The composite polyelectrolyte solution with the traces of thrombin is transferred to a liquid nitrogen refrigeration device and is enabled to be frozen in a liquid nitrogen environment. Under the conditions that the temperature is -80 DEG C and the vacuum degree is -1 pascal, freeze-drying treatment is conducted for more than 48 hours by a freezer dryer, and a high porosity composite polyelectrolyte fiber dressing with the traces of thrombin is obtained. The high porosity natural composite polyelectrolyte fiber dressing with the traces of thrombin has wide application values in aspects such as hemostasis, bacteriostat and wound healing promotion.

The invention relates to the technical field of hemostasis, in particular to a trauma hemostatic sponge and a preparing method thereof. The trauma hemostatic sponge comprises zeolite and graphene; thegraphene is of a three-dimensional crosslinking structure; the zeolite is dispersed in the three-dimensional crosslinking structure; the mass ratio of the zeolite to the graphene is 1:(0.2-5). The trauma hemostatic sponge has a distinctive hemostasis mechanism and excellent hemostasis performance. According to records of the embodiment, the trauma hemostatic sponge has a high hemostasis speed, amild exothermic reaction and high biological safety.

The invention relates to a preparation method and application of self-assembled thrombin esterified microporous hemostatic starch. The preparation method comprises the following steps: carrying out heating reaction on microporous starch and sodium trimetaphosphate under the alkaline condition to obtain esterified microporous starch with starch phospholipid on the surface; mixing the esterified microporous hemostatic starch with a thrombin aqueous solution and then carrying out low-temperature drying to obtain the self-assembled thrombin esterified microporous hemostatic starch. Firstly, the hemostatic starch in the invention has a larger surface area and a higher surface negative charge performance, and can be stably combined with a large amount of thrombin through hydrogen bonds. Secondly, the hemostatic starch in the invention can quickly and extensively suck blood, as well as aggregate and activate platelets so as to achieve a rapid hemostatic effect. Thirdly, the hemostatic starchin the invention has no biotoxicity and can be rapidly degraded and absorbed by tissue cells.

The invention discloses a preparation method of a modified loofah sponge fiber dressing with a cell regeneration function. The modified loofah sponge fiber dressing is prepared by molding modified loofah sponge fibers through a spunlace non-woven fabric technology, and compounding eggshell membrane powder. The preparation method comprises the following steps: firstly, performing plasma treatment on the surface of the loofah sponge fibers by selecting a proper discharging condition in order to improve the flexibility, skin fitness and adhesion of the dressing; secondly, loading calcium on the surface of the chemically-modified loofah sponge fibers by using waste egg shell calcified liquid in order to effectively prevent heavy metal poisoning and shorten the wound incrustation time; lastly, spraying the eggshell membrane powder on the surface of a non-woven fabric by using natural honey to improve the hygroscopicity of the dressing. The modified loofah sponge fiber dressing has the advantages of easiness in operation, adoption of simple, readily-available and environment-friendly raw materials, and high comfort and great convenience in use, and has the effects of activating blood, promoting cell regeneration, high hemostasis speed, and high anti-bacterial and anti-infection performance.

The invention relates to the technical field of medical materials, in particular to medical quick biological rhinal styptic powder and a preparation method thereof. The medical quick biological rhinal styptic powder is composed of, by weight, 65-85 parts of lasiosphaera seu calvatia extracts, 10-14 parts of sodium carboxymethylcellulose, 1-5 parts of cirsium japonicum extracts, 1-5 parts of lalang grass rhizome extracts, 1-5 parts of flos sophorae extracts, 1-5 parts of Indian mockstrawberry extracts and 0.5-1.5 parts of cacumen platycladi extracts. The medical quick biological rhinal styptic powder is capable of realizing stypticity by various means and evidently shortening blood clotting time, further has functions of bacteriostasis, antibiosis, analgesia and acceleration of wound healing and is widely applicable to postoperation quick hemostasis, pain relief and wound repair for nasal cavities, oral cavities and throats.

The invention provides an absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber and a preparation method thereof, mainly solving the problem that the present hemostatic materials can not effectively stanch the wound caused by minimally invasive surgery. The particle size of the absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber is between 50mu m and 100mu m. The preparation method of the absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber comprises the main steps of alkalization treatment of cotton fiber, modification treatment of cotton fiber, supermicro grinding, crosslink sterilization and the like. The hemostatic micropowder made from hydroxyethyl modified cotton fiber can be directly applied to the wound of minimally invasive surgery in human body, and can be directly absorbed by human body without toxic or side effect, thus improving wound stanching speed and avoiding the problem of easy agglomeration in the process of micropowder storage.

The invention discloses hydroxypropyl-beta-cyclodextrin hemostatic gauze. The hydroxypropyl-beta-cyclodextrin hemostatic gauze is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of luffa leaves, 1-2 parts of cacumen biotae, 1-2 parts of sangusis draconis, 1-2 parts of mock strawberry, 0.5-1 part of pine pollen, 6-8 parts of hydroxypropyl-beta-cyclodextrin, 6-8 parts of gelatin, 3-5 parts of sodium alginate, 0.1-0.2 part of polysorbate-80, 0.5-1 part of caprylic capric triglyceride, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of auxiliary materials, and 200-250 parts of water. The soluble hemostatic gauze disclosed by the invention is collaboratively prepared from natural high polymer materials of hydroxypropyl-beta-cyclodextrin and the like, is fast in hemostatic effect, is capable of effectively promoting wound healing, is good in antibacterial effect, is easily absorbed by human body, is good in biocompatibility, and is free from toxic or side effects; the soluble hemostatic gauze is capable of resisting bacteria in a broad spectrum, and diminishing inflammation and easing pain by extracting and compounding natural plant effective ingredients, has a controlled-release function, effectively prolongs the action time, and achieves a better use effect.

The invention provides wound dressing capable of stopping bleeding and resisting infection and a preparation method of the wound dressing, and belongs to the technical field of medical dressing. According to the wound dressing disclosed by the invention, N-alkylated chitosan of which the substitution degree is 8%-39% is used as a bleeding stopping material, so that the blood coagulation effect isnotable, and the bleeding stopping speed is high. Manuka honey is used as an antibacterial agent, so that the antibacterial efficacy is powerful, the activity is stable, and the Manuka honey is not liable to decompose at normal temperature and not liable to decompose by bioactive enzymes. According to the wound dressing, the N-alkylated chitosan and the Manuka honey are combined for use, and the wound dressing which can quickly and effectively stop bleeding, concurrently has the effects of restraining bacterial reproduction and preventing wound from being infected and is good in biocompatibility can be obtained.