Injectable hydrogel hemostatic based on marine-derived gelatin as well as application and application method of hemostatic

A technology of hydrogel hemostatic agent and injection water, which can be applied in applications, pharmaceutical formulations, surgical adhesives, etc. It can solve problems such as sealing failure, mechanical property decline, and surrounding tissue damage, and achieves small curing swelling deformation and short curing time , The effect of fast hemostasis

Active Publication Date: 2020-09-08
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides an injectable hydrogel hemostatic agent based on marine source gelatin and its application and application method, aiming to solve the problems of decreased mechanical properties, sealing failure, At least one problem such as additional damage to surrounding tissues

Method used

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  • Injectable hydrogel hemostatic based on marine-derived gelatin as well as application and application method of hemostatic
  • Injectable hydrogel hemostatic based on marine-derived gelatin as well as application and application method of hemostatic
  • Injectable hydrogel hemostatic based on marine-derived gelatin as well as application and application method of hemostatic

Examples

Experimental program
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Embodiment 1

[0063] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0064] (1). Synthesis of chemically modified marine source gelatin:

[0065] Dissolve 5.0g of marine fish skin gelatin in 200mL of deionized water and heat to dissolve at 60°C;

[0066] Cool down to 50°C, add 1.0 mL of methacrylic anhydride dropwise, and adjust the pH value to about 8.6 with 2 mol / L sodium hydroxide solution; stir for 2 hours;

[0067] After the reaction was completed, the reaction solution was added to 1000 mL of absolute ethanol to precipitate, the precipitate was collected by centrifugation and dissolved in deionized water, and the solution was dialyzed in deionized water for 3 days, and freeze-dried to obtain marine source fish skin gelatin modified with methacrylic anhydride , collected for later use.

[0068] (2). Synthesis of PF127-DA:

[0069] Dissolve 12.6g of Pluronics F127 in 100mL of anhydrous dichloromethane, ...

Embodiment 2

[0087] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0088] (1). The synthesis of chemically modified marine source gelatin, PF127-DA and PF127-DF is the same as that in Example 1, except that in the chemically modified marine source gelatin, the marine source gelatin is derived from marine source fish scale gelatin.

[0089] (2). Preparation of injectable hydrogel hemostatic agent based on marine gelatin:

[0090] Add 100 mg of methacrylic anhydride-modified marine fish phosphogelatin, 100 mg of PF127-DA, 50 mg of PF127-DF and 2.5 mg of phenyl(2,4,6-trimethylbenzoyl)phosphate lithium salt into 750 μL of PBS buffer solution (pH=7.4), vortex until fully dissolved, and store away from ultraviolet light.

Embodiment 3

[0092] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0093] (1). The synthesis of chemically modified marine gelatin, PF127-DA and PF127-DF is the same as in Example 1.

[0094] (2). Preparation of injectable hydrogel hemostatic agent based on marine gelatin:

[0095]Add 100 mg of methacrylic anhydride-modified marine fish skin gelatin, 100 mg of PF127-DA, 100 mg of PF127-DF and 5 mg of phenyl(2,4,6-trimethylbenzoyl)phosphate lithium salt into 695 μL of normal saline , vortex until fully dissolved, and store away from ultraviolet light.

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Abstract

The invention relates to the technical field of hemostatics, and particularly provides an injectable hydrogel hemostatic based on marine-derived gelatin as well as application and application method of the hemostatic. According to the weight percentage of 100%, the injectable hydrogel hemostatic based on the marine-derived gelatin is prepared from the following components in percentage by weight:0.1%-10% of chemically-modified marine-derived gelatin, 10%-20% of a photo-crosslinking gelator, 0.1%-15% of a tissue adhesion factor, 0.1%-0.5% of a photoinitiator, and a dissolved amount of solvent.The injectable hydrogel hemostatic disclosed by the invention has a rapid and good hemostatic effect, has no extra trauma to surrounding tissues in a hemostatic process, has a degradable characteristic, and can be widely applied to hemostasis of human or animal tissues, visceral accidental wounds or surgical wounds.

Description

technical field [0001] The invention belongs to the technical field of hemostatic agents, and in particular relates to an injectable hydrogel hemostatic agent based on marine source gelatin and its application and application method. Background technique [0002] Acute hemorrhage caused by accidental trauma and surgical operation is a major medical problem that the world generally faces, and they will seriously threaten the life and health of patients. Among them, human organs such as the liver and spleen are the worst, because both the liver and the spleen are rich in vascular tissue. When suffering from trauma or performing related surgical operations, acute bleeding from the wound is not only very common but also very troublesome. How to find a quick and effective hemostasis treatment method is already the best strategy to reduce the mortality of patients. [0003] For acute bleeding caused by visceral rupture and irregularly shaped and deep narrow bleeding wounds, the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/10A61L24/04
CPCA61L24/0031A61L24/0042A61L24/001A61L24/104A61L24/046A61L2400/04A61L2400/06C08L71/02
Inventor 赵晓丽边少荃潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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