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Injectable hydrogel hemostatic agent based on marine source gelatin and application and application method

A technology for injecting water and hemostatic agents, which is applied in applications, medical formulations, surgical adhesives, etc., can solve the problems of surrounding tissue damage, mechanical property decline, and sealing failure, etc., and achieve small curing swelling deformation, short curing time, and hemostasis speed fast effect

Active Publication Date: 2021-12-14
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides an injectable hydrogel hemostatic agent based on marine source gelatin and its application and application method, aiming to solve the problems of decreased mechanical properties, sealing failure, At least one problem such as additional damage to surrounding tissues

Method used

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  • Injectable hydrogel hemostatic agent based on marine source gelatin and application and application method
  • Injectable hydrogel hemostatic agent based on marine source gelatin and application and application method
  • Injectable hydrogel hemostatic agent based on marine source gelatin and application and application method

Examples

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Embodiment 1

[0063] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0064] (1). Synthesis of chemically modified marine source gelatin:

[0065] Dissolve 5.0g of marine fish skin gelatin in 200mL of deionized water and heat to dissolve at 60°C;

[0066] Cool down to 50°C, add 1.0 mL of methacrylic anhydride dropwise, and adjust the pH value to about 8.6 with 2 mol / L sodium hydroxide solution; stir for 2 hours;

[0067] After the reaction was completed, the reaction solution was added to 1000 mL of absolute ethanol to precipitate, the precipitate was collected by centrifugation and dissolved in deionized water, and the solution was dialyzed in deionized water for 3 days, and freeze-dried to obtain marine source fish skin gelatin modified with methacrylic anhydride , collected for later use.

[0068] (2). Synthesis of PF127-DA:

[0069] Dissolve 12.6g of Pluronics F127 in 100mL of anhydrous dichloromethane, ...

Embodiment 2

[0087] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0088] (1). The synthesis of chemically modified marine gelatin, PF127-DA and PF127-DF is the same as in Example 1, except that in the chemically modified marine gelatin, the marine gelatin is derived from marine fish scale gelatin.

[0089] (2). Preparation of injectable hydrogel hemostatic agent based on marine gelatin:

[0090] Add 100 mg of methacrylic anhydride-modified marine fish phosphogelatin, 100 mg of PF127-DA, 50 mg of PF127-DF and 2.5 mg of phenyl(2,4,6-trimethylbenzoyl)phosphate lithium salt into 750 μL of PBS buffer solution (pH=7.4), vortex until fully dissolved, and store away from ultraviolet light.

Embodiment 3

[0092] A preparation method of an injectable hydrogel hemostatic agent based on marine source gelatin, comprising the following steps:

[0093] (1). The synthesis of chemically modified marine gelatin, PF127-DA and PF127-DF is the same as in Example 1.

[0094] (2). Preparation of injectable hydrogel hemostatic agent based on marine gelatin:

[0095]Add 100 mg of methacrylic anhydride-modified marine fish skin gelatin, 100 mg of PF127-DA, 100 mg of PF127-DF and 5 mg of phenyl(2,4,6-trimethylbenzoyl)phosphate lithium salt into 695 μL of normal saline , vortex until fully dissolved, and store away from ultraviolet light.

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Abstract

The invention relates to the technical field of hemostatic agents, and specifically provides an injectable hydrogel hemostatic agent based on marine gelatin and its application and application method. According to 100% by weight, the injectable hydrogel hemostatic agent based on marine gelatin comprises the following components: chemically modified marine gelatin 0.1% to 10%; photocrosslinking gel factor 10% ~ 20%; tissue adhesion factor 0.1% ~ 15%; photoinitiator 0.1% ~ 0.5%; and the solvent of the dissolved amount. The injectable hydrogel hemostatic agent of the present invention has fast and good hemostatic effect, and there is no additional trauma to surrounding tissues during the hemostatic process, and has degradable properties, and can be widely used in human or animal body tissues, accidental trauma to organs, or surgery The wound is bleeding.

Description

technical field [0001] The invention belongs to the technical field of hemostatic agents, and in particular relates to an injectable hydrogel hemostatic agent based on marine source gelatin and its application and application method. Background technique [0002] Acute hemorrhage caused by accidental trauma and surgical operation is a major medical problem that the world generally faces, and they will seriously threaten the life and health of patients. Among them, human organs such as the liver and spleen are the worst, because both the liver and the spleen are rich in vascular tissue. When suffering from trauma or performing related surgical operations, acute bleeding from the wound is not only very common but also very troublesome. How to find a quick and effective hemostasis treatment method is already the best strategy to reduce the mortality of patients. [0003] For acute bleeding caused by visceral rupture and irregularly shaped and deep narrow bleeding wounds, the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/10A61L24/04
CPCA61L24/0031A61L24/0042A61L24/001A61L24/104A61L24/046A61L2400/04A61L2400/06C08L71/02
Inventor 赵晓丽边少荃潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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