Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber and preparation method thereof

A technology of hydroxyethyl and modified cotton, applied in the fields of polymer chemistry and medical materials, can solve the problems of inability to effectively stop bleeding on the wound surface, achieve the effect of long molecular chain, not easy to agglomerate, and improve viscosity and adhesion

Inactive Publication Date: 2010-06-02
郑明义
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an absorbable hydroxyethyl modified cotton fiber hemostatic micropowder and a preparation method thereof, which mainly solves the problem that existing hemostatic materials cannot effectively stop bleeding on the wound surface caused by minimally invasive surgery

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Refined absorbent cotton 300g, immersed in 20% NaoH aqueous solution, alkalized at 10°C for 1 hour, and centrifuged to remove the liquid until the weight of alkalized cotton was 600g. Put the centrifuged alkalized cotton in a 10L rotary reactor, add 3500ml of 95% isopropanol, vacuumize to -0.008MPa, slowly add 520ml of ethylene oxide dropwise, after 20h, control the reaction temperature to less than 28°C. After 24 hours of reaction, 95ml of acetic acid was added, neutralized for 2 hours, washed three times with 90% isopropanol, centrifuged to discharge, and dried at 70°C. Obtain 405g of hydroxyethyl modified cotton.

[0055] Cut the dried hydroxyethyl modified cotton into fiber clusters with a diameter of less than 20 mm, put them into a superfine powder machine, and grind them at a temperature of 10-15 °C for 20 minutes to obtain 384 g of 300-mesh micropowder.

Embodiment 2

[0057]Refined absorbent cotton 450g, immersed in 23% NaoH aqueous solution, alkalized at 18°C ​​for 1.5h, centrifuged and deliquified until the weight of alkalized cotton was 810g. Put the centrifuged alkalized cotton in a 10L rotary reactor, add 5000ml of 95% isopropanol, vacuumize to -0.008MPa, slowly add 792ml of ethylene oxide dropwise, after 21 hours, control the reaction temperature to less than 30°C. After 24 hours of reaction, 126ml of acetic acid was added, neutralized for 2 hours, washed 3 times with 90% isopropanol, centrifuged, and dried at 60°C. Obtain 680 g of hydroxyethyl modified cotton.

[0058] Cut the dried hydroxyethyl modified cotton into fiber clusters with a diameter of less than 20mm, put them into a superfine powder machine and grind them at a temperature of 10-15°C, and process them for 20 minutes to obtain 646g of 200-mesh micropowder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides an absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber and a preparation method thereof, mainly solving the problem that the present hemostatic materials can not effectively stanch the wound caused by minimally invasive surgery. The particle size of the absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber is between 50mu m and 100mu m. The preparation method of the absorptivity hemostatic micropowder of hydroxyethyl modified cotton fiber comprises the main steps of alkalization treatment of cotton fiber, modification treatment of cotton fiber, supermicro grinding, crosslink sterilization and the like. The hemostatic micropowder made from hydroxyethyl modified cotton fiber can be directly applied to the wound of minimally invasive surgery in human body, and can be directly absorbed by human body without toxic or side effect, thus improving wound stanching speed and avoiding the problem of easy agglomeration in the process of micropowder storage.

Description

technical field [0001] The invention relates to a hemostatic micropowder and a preparation method thereof, in particular to a human body-absorbable hemostatic micropowder made of hydroxyethyl modified cotton fiber and a preparation method thereof, belonging to the technical fields of polymer chemistry and medical materials. Background technique [0002] At present, the hemostatic materials used in medical treatment are roughly divided into four categories: [0003] The first category is traditional Chinese medicine, such as Panax notoginseng, etc. Among them, Sanqi has a strong hemostatic effect, and it shows obvious hemostatic effect on different animals, different administration routes, and different preparations; the second category is natural polysaccharides, Such as cellulose, starch derivatives, etc.; the third category is animal-derived substances, such as gelatin, fibrin glue, etc.; the fourth category is minerals, such as zeolite. [0004] However, among the above-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/64A61L15/62A61L15/42
Inventor 郑明义
Owner 郑明义
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com