Zeolite hemostatic dressings and preparation method and application thereof

The technology of hemostatic dressing and zeolite is applied in the field of high exchange degree Ca-A type zeolite hemostatic dressing and its preparation, which can solve the problems such as the undisclosed synthetic zeolite process, the pharmacological effect and the function disclosure, and achieve no sensitization reaction, no cell Toxic, non-skin irritating effects

Active Publication Date: 2011-06-22
深圳泰明嘉业药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The zeolite used in this patent application can be natural zeolite, also can be synthetic zeolite, but does not disclose the technology of concrete synthetic zeolite
At the same time, the patent application did not make any disclosure about its pharmaceutical effects and functions.

Method used

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  • Zeolite hemostatic dressings and preparation method and application thereof
  • Zeolite hemostatic dressings and preparation method and application thereof
  • Zeolite hemostatic dressings and preparation method and application thereof

Examples

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preparation example Construction

[0039] One embodiment of the present invention relates to the preparation method of described zeolite hemostatic dressing, described method comprises the following steps:

[0040] 1) Mix 4A zeolite, binder, lignin and optional molecular sieve activated powder together to produce seeds and granulate, polish, and then sieve the particles with a particle size of 0.2-1.0mm;

[0041] 2) After the particles obtained in step 1) are dried, they are activated and roasted at about 300-800°C;

[0042] 3) reacting the calcined particles with an alkali solution at about 50-150°C for a suitable period of time, followed by washing;

[0043] 4) Repeatedly exchanging the particles obtained in step 3) with a solution containing calcium ions, followed by repeated washing with deionized water and drying;

[0044] 5) The particles obtained in step 4) are activated and calcined for the second time at about 300-800°C.

[0045] Step 1) can be granulated using granulation techniques well known to th...

Embodiment 1

[0054] The preparation of embodiment 1 zeolite hemostatic dressing

[0055] The zeolite used in the present invention is 4A zeolite provided by China Kaolin Co., Ltd. The crystal form of the zeolite was tested by X-ray diffractometer in the detection laboratory of Zhengzhou Light Metal Research Institute, and the measured spectrum was consistent with the standard A-type zeolite spectrum, and the zeolite was determined to be A-type zeolite. X-ray diffraction pattern see attached figure 1 .

[0056] In gained 1000g zeolite, add 400g kaolin (product of Chinese kaolin company), 40g lignin (Jilin Chenning Paper Industry Co., Ltd.) and add 120g molecular sieve activation powder as dispersant, spray sodium carboxymethyl cellulose in the pelletizing machine The solution is made into spherical particles, sieved into 0.2-1.0mm particles with a 0.2mm sieve and a 1.0mm sieve, and then activated and roasted at 600°C.

[0057] The product obtained by activation roasting was reacted in a ...

Embodiment 2

[0059] Embodiment 2 Composition test of hemostatic powder

[0060] The testing laboratory of Zhengzhou Light Metal Research Institute is responsible for the test, and the composition of the zeolite hemostatic dressing is tested by X-fluorescence spectrometer. The analytical result of X-fluorescent spectrometer shows, zeolite hemostatic dressing of the present invention mainly consists of Al 2 o 3 About 25%~35%, SiO 2 About 30% to 40%, and CaO about 10% to 18%.

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Abstract

The invention relates to the high degree of exchange Ca-A type zeolite hemostasis dressing and the preparation method and the purpose. The zeolite hemostasis dressing of the invention containing the zeolite has fast hemostasis speed, and has no bacterium, no pyrogen, no cell toxicity, no hypersensitive reaction and no skin irritation, the using is convenient and the cost is low.

Description

technical field [0001] The invention relates to the field of hemostatic dressings. More specifically, the present invention relates to a high-exchange Ca-A zeolite hemostatic dressing and its preparation method and application. Background technique [0002] Blood is a liquid tissue that contains plasma and red blood cells, white blood cells, particles, and platelets dispersed in the plasma. Plasma also contains water, acids, lipids, soluble electrolytes, and proteins. A special protein suspended in the blood plasma is fibrinogen, its function is that in the case of bleeding, it can react with water and thrombin to form blood-insoluble fibrin and further polymerize to form a clot to stop bleeding. Under normal circumstances, when the animal body (including the human body) is injured and bleeding, the fibrinogen in the blood can exert the above-mentioned function and play the role of hemostasis. [0003] Generally speaking, the bleeding caused by small wounds can be suppress...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18
Inventor 古鸿雁窦桂芳欧阳茂海周旭
Owner 深圳泰明嘉业药业有限公司
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