Preparing method of hemostasis repair hydrogel

A technology for repairing water and gel, applied in pharmaceutical formulation, application, medical science and other directions, can solve problems such as poor adhesion between hemostatic materials and bleeding wounds, no repair function, etc., and achieve excellent biocompatibility and hemostasis effect. , high biosafety effect

Inactive Publication Date: 2018-06-15
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to propose a hemostatic repair hydrogel to solve the technical problems that the existing hemostatic materials have poor adhesion to bleeding wounds and have no repair function

Method used

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  • Preparing method of hemostasis repair hydrogel
  • Preparing method of hemostasis repair hydrogel

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preparation example Construction

[0026] The present invention provides a method for preparing a hemostatic repair hydrogel. In a specific embodiment, the method includes the following steps: weighing 10-40 parts of snail mucus, 90-60 parts of silk protein sol containing hemostatic Chinese medicine and natural crosslinking agent 0.1-0.5 parts, reacted at 25-40°C for 3-24 hours, freeze-dried to obtain the hemostatic repair hydrogel, the above parts are all parts by mass.

[0027] Wherein, the snail mucus can be purchased in the market, or can be obtained by extracting from fresh white jade snails.

[0028] In some preferred embodiments, the method for extracting snail mucus includes the following steps:

[0029] S1. Take more than 20 grams of fresh white jade snails, wash the snails with clean water, and place them to dry naturally at room temperature;

[0030] S2. Take out the snail in the environment below 28℃, shock the foot of the snail instantly with electricity, and leave at one touch, repeat 2-4 times, no-load v...

Embodiment 1

[0045] 1. Extraction of snail mucus

[0046] S1. Take 50Kg of fresh white jade snails of more than 20 grams, wash the snails with clean water, and place them to dry naturally at room temperature;

[0047] S2. Take out the snail in an environment below 28°C, shock the snail's foot with electricity instantly, and leave with one touch, repeat 3 times, no-load voltage> 1000V, load current <3mA;

[0048] S3. Take the mucus secreted by the foot glands of the snail with a utensil. The snail after the mucus extraction needs to be supplemented with water and concentrated feed for 6 days before the mucus can be extracted again;

[0049] S4. Quickly freeze the extracted mucus in an environment of 0~5℃ for 8h;

[0050] S5. Repeatedly grind through a rubber mill in a working environment below 28°C until the mucus is broken;

[0051] S6. Filter the ground mucus with a filter screen of 450 mesh or more in a working environment below 10°C, and then centrifuge it for more than 12 minutes through a centri...

Embodiment 2

[0060] The difference between this example and Example 1 is that the amount of notoginseng powder is 1 Kg.

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Abstract

The invention discloses a preparing method of hemostasis repair hydrogel, and belongs to the field of hemostasis hydrogel. The preparing method comprises the following steps of weighing, by mass, 10-40 parts of snail mucus, 60-90 parts of silk protein sol containing hemostasis traditional Chinese medicine and 0.1-0.5 part of natural cross-linking agent, conducting a reaction at 25-40 DEG C for 3-24 h and conducting freezing and drying to obtain the hemostasis repair hydrogel. By compounding the natural cross-linking agent, the snail mucus, silk protein and the hemostasis traditional Chinese medicine, the hemostasis speed of the hemostasis repair hydrogel can be effectively increased, the repair performance to a wound can be effectively improved, and meanwhile, the attaching performance between the hemostasis repair hydrogel and the skin can be improved.

Description

Technical field [0001] The invention relates to a hemostatic hydrogel, in particular to a hemostatic hydrogel with a repair function. Background technique [0002] Among the accidental injuries caused by emergencies, death caused by uncontrolled bleeding has always been a problem that is difficult to solve in various wars and operations. When the blood loss of the injured reaches 20%, shock may occur at about 800 mL. The symptoms can even be life-threatening. How to solve the problem of hemorrhage has attracted more and more attention. Traffic injuries, natural disasters, etc. are often unpredictable. Large wounds or arterial injuries caused by accidents, high blood pressure, blood ejection, massive bleeding in a short time, and low rescue success rate. Sudden bleeding is not only a test for the injured, but also a test for medical research and development. How to avoid shock or death caused by bleeding has become a difficult problem for scientists. Hemostasis is completed wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0031A61L24/108A61L2300/30A61L2300/418A61L2400/04C08L89/00
Inventor 苏伟汤建新袁朝辉李文
Owner HUNAN UNIV OF TECH
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