Medical absorbable skeletal wound hemostatic material and preparation method thereof

A hemostatic material and wound surface technology, applied in the field of medicine, can solve the problems of non-degradable bone wax and affecting the healing of bone tissue, and achieve reliable safety and clinical promotion value, good hemostatic effect, and good biocompatibility

Inactive Publication Date: 2012-10-17
ZHUHAI ORTUS BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The first purpose of the present invention is to solve the problem in the prior art that bone wax cannot be degraded in the human body or animal body and affect the healing of bone tissue, and to provide a wax that is completely degradable in the human body or animal body and can promote bone tissue healing. It is a material that can replace bone wax and does not change the doctor's habit of hemostasis on bone wounds and promotes bone tissue healing

Method used

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  • Medical absorbable skeletal wound hemostatic material and preparation method thereof
  • Medical absorbable skeletal wound hemostatic material and preparation method thereof
  • Medical absorbable skeletal wound hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The carboxymethyl cellulose is washed with alcohol and then dried into powder, and maltose is added into distilled water to dissolve and filtered, and then concentrated into maltose syrup with a cured product ≥ 75%.

[0044] Put 23g of medical glycerin, 3g of Tween 80 and 10g of olive oil into the reaction kettle, seal it and vacuum it to a degree of 10KPa, heat it up to 50°C, keep it warm and stir for 30 minutes; then put 38g of carboxymethyl Base cellulose and 26g of maltose syrup in terms of maltose were put into a reaction kettle, sealed and vacuumed, heated to 80°C and kept at a vacuum of 10KPa, and continuously stirred at a low speed for 2 hours. The paste in the reaction kettle was taken out and poured into polytetrafluoroethylene molds and quickly placed in a refrigerator at 4°C for 120 minutes. A solid block (sample A) that can be shaped arbitrarily and has certain mechanical strength is prepared. Finally, the obtained products are sealed and packaged separate...

Embodiment 2

[0046] Wash the hydroxypropyl starch with alcohol and dry it into powder, add sucrose into distilled water to dissolve and filter to remove impurities, and dry it into powder. Put 12g of glycerin, 0.5g of polysorbate and 7.5g of refined corn oil into the reaction kettle, seal and evacuate, the vacuum degree is 20KPa, heat up to 30°C, keep warm and stir for 120 minutes; then put 63g of hydroxypropyl starch and Put 17g of sucrose into the reaction kettle, seal and vacuumize, raise the temperature to 40°C and keep the vacuum at 20KPa, and stir continuously at low speed for 6 hours. The paste in the reaction kettle was taken out and poured into polytetrafluoroethylene molds, and quickly placed in a refrigerator at 2°C for 90 minutes. A solid block (sample B) that can be shaped arbitrarily and has a certain mechanical strength is prepared. Finally, the obtained products are sealed and packaged separately, and sterilized by ethylene oxide.

Embodiment 3

[0048] Carboxymethyl starch was washed with alcohol and dried into powder. Put 31g of glycerin, 2g of Tween 80 and 9g of soybean oil into the reaction kettle, seal and evacuate, the vacuum degree is 30KPa, heat up to 30°C, keep warm and stir for 60 minutes; then put 58g of carboxymethyl starch into the reaction kettle , sealed and evacuated, the temperature was raised to 50° C. and the vacuum was maintained at 30 KPa, and the mixture was continuously stirred at a low speed for 4.5 hours. Take out the paste in the reaction kettle and pour it into a polytetrafluoroethylene mold, and quickly place it in a refrigerator at 0°C for 30 minutes. A solid block (sample C) that can be shaped arbitrarily and has a certain mechanical strength is prepared. Finally, the obtained products are sealed and packaged separately, and sterilized by ethylene oxide.

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Abstract

The invention relates to a medical absorbable skeletal wound hemostatic material with accelerating wound healing and a preparation method thereof. The absorbable skeletal wound hemostatic material comprises 40-95 wt% of matrix material and 5-60 wt% of auxiliary material, wherein the matrix material comprises oligosaccharide, polysaccharide or a mixture of oligosaccharide and polysaccharide, and the auxiliary material comprises (1) one or more of polyhydroxy alcohols, (2) one or more of plant oil, and (3) one or more of emulsifiers. The preparation method comprises the following steps: carrying out chemical blending and latex blending on the matrix material and the auxiliary material with the prescribed dose, cooling to form solid clumps, packaging, and then conducting disinfection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an absorbable material for hemostasis and healing of bone wounds and a preparation method thereof. Background technique [0002] Medical sterile bone wax is an indispensable auxiliary material for hemostasis of spongy bone in orthopedics, thoracic surgery and neurosurgery in medical treatment. It mainly relies on its unique hardness, toughness and viscosity to achieve the purpose of hemostasis by mechanical packing. At present, many hospitals in China are self-produced and used for their own use. There is no unified formula and standard. Most of them use beeswax and vaseline, beeswax, refined sesame oil and salicylic acid, beeswax, peanut oil and aspirin. Most of them can not achieve the ideal hardness, toughness and viscosity, and the hemostatic effect is poor. The main products in the domestic market are the medical bone wax produced by Johnson & Johnson in the Un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/64A61L15/20A61L15/26A61L15/28A61L15/40
CPCA61L24/0042A61L2430/02A61K47/40A61L2400/04A61K47/36A61L24/08A61L24/0005A61P7/04
Inventor 杨鹏邢飞宋祥锐沈楠
Owner ZHUHAI ORTUS BIOTECH
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