Iron oxide/nano kaolin-containing composite hemostatic and preparation method thereof

A nano-kaolin and iron oxide technology, which is applied in the direction of drug combination, surgical adhesives, medical preparations containing active ingredients, etc., can solve the problems of high content of natural mineral impurities, complex processing procedures, and low safety in use, and achieve High biocompatibility, high safety performance, high safety effect

Active Publication Date: 2017-09-29
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Red stone fat and ochre have obvious hemostatic effect in the historical records of traditional Chinese medicine in my country, and have been used in the pharmaceutical market as the main ingredients of medicines. They contain hemostatic ingredients, but red stone fat, ocher and other natural mineral impurities are high in content, requiring complicated treatment process, poor biocompatibility, and low safety in use
At present, there is no relevant report on the preparation of composite hemostatic agents by loading iron oxide micro-nano materials on kaolin

Method used

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  • Iron oxide/nano kaolin-containing composite hemostatic and preparation method thereof
  • Iron oxide/nano kaolin-containing composite hemostatic and preparation method thereof

Examples

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Embodiment 1

[0042] This embodiment provides a kind of preparation of nano-kaolin, prepared according to the following method:

[0043] Weigh 4g of kaolin, add 10g of potassium acetate, grind for about 30min until it becomes a paste, add 10% deionized water, transfer it to a beaker, and let it stand at room temperature for three days. Wash with ethanol, filter, and dry at 60°C for 24h. Potassium acetate was intercalated with kaolin, added to deionized water, ultrasonically treated for 30 minutes, washed, filtered and dried. Tagged as Kaolin KAc .

Embodiment 2

[0045] This example provides the preparation of a polymeric hydroxy iron ion, which is prepared according to the following method: Weigh 2.4 g of sodium hydroxide, add 150 mL of water, and prepare a 0.4 mol / L sodium hydroxide solution. Weigh 10.8g FeCl 3 .6H 2O, add 100mL deionized water to prepare 0.4mol / L FeCl 3 solution. Slowly add 150 mL of 0.4 mol / L NaOH solution dropwise into 100 mL of 0.4 mol / L FeCl under vigorous stirring in a water bath at 70°C 3 solution, after the dropwise addition, take it out and slowly lower the temperature to obtain a stable reddish-brown transparent iron polymer solution for future use. Labeled Polymerized Hydroxyferric Ion Solution.

Embodiment 3

[0047] This example provides an iron oxyhydroxide / nano-kaolin composite hemostatic agent, which is prepared according to the following method:

[0048] Weigh 5g of kaolin after potassium acetate intercalation treatment, and add it into 250mL of 0.4M polyhydroxyferric ion solution. The pH of the reaction system was adjusted to 5 with 5M NaOH solution. Heated to 60°C in a water bath and stirred magnetically for 72h. Wash, separate, and dry at 60°C for 24h. Keep airtight in a desiccant with color-changing silica gel placed at the bottom for later use. Tagged FeOOH-Kaolin KAc .

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Abstract

The invention discloses an iron oxide / nano kaolin-containing composite hemostatic and a preparation method thereof. The composite hemostatic consists of nano kaolin and iron oxide, wherein the nano kaolin is adopted as a carrier; and the iron oxide is loaded on the surface of the nano kaolin. The composite hemostatic is prepared through a precipitation method, and has the advantages of being good in hemostatic effect, rapid in wound heal speed, free of conspicuous cytotoxicity, free of hemolysis, high in biocompatibility and the like.

Description

technical field [0001] The invention relates to a hemostatic agent, in particular to an iron oxide / nano kaolin composite hemostatic agent and a preparation method thereof, belonging to the technical field of external hemostatic dressings. Background technique [0002] Excessive blood loss is one of the main causes of traumatic death. The development of fast, stable and safe hemostatic agents is of great significance for emergency rescue of trauma, especially pre-hospital rescue of military wounds, car accidents and natural disasters. The research and development of hemostatic materials has always been a hot spot at home and abroad. The current hemostatic materials mainly include biological hemostatic agents such as thrombin, protease, etc., organic polymers such as chitosan and sodium alginate, inorganic substances such as silica, and natural Silicate mineral materials. Compared with other hemostatic materials, natural silicate mineral materials have the advantages of fast ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/0068A61L2300/102A61L2300/624A61L2400/04A61L2400/12A61L2300/412A61K33/26A61P7/04A61K35/02A61K33/06A61K2300/00
Inventor 杨华明张毅龙梅
Owner CENT SOUTH UNIV
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