Medical absorbable oxycellulose material and preparation method thereof

A technology of oxidizing cellulose and activating cellulose, applied in the field of biomedical materials, can solve the problems of polluted environment, waste gas, waste liquid recycling difficulty, high NO2 price, etc., and achieves the effects of easy degradation, sufficient raw material source and low price

Active Publication Date: 2014-07-30
HEBEI AINENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome NO 2 In the system method, it is difficult to recycle waste gas and waste liquid, pollute the environment, and NO 2 expensive flaw

Method used

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  • Medical absorbable oxycellulose material and preparation method thereof
  • Medical absorbable oxycellulose material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031]Take 50g of natural doffing, soak in -30°C liquid ammonia for 0.5h, put in 5°C 25% NaOH aqueous solution, soak and swell for 24h, remove the alkali solution to obtain activated cellulose.

[0032] Preparation of oxidant solution: TEMPO2.5g, NaBr25g, NaClO solution 1100ml, Na 2 B 4 o 7 10H 2 O25g, add activated cellulose, react at -2°C, keep the pH value of the reaction solution at about 11.5 with 5% NaOH solution, add NaClO solution and Na 2 B 4 o 7 10H 2 O was added once every 1 hour to terminate the reaction. Take out the gauze and put it in absolute ethanol, and wash it 3 times. Take out the gauze and put it in 70% ethanol concentrated hydrochloric acid solution, soak for 1 hour. The gauze was taken out, washed 5 times with pure water, and dried at 40°C to obtain a medical absorbable oxidized cellulose material with an oxidation degree of 19%. The material is implanted into the abdominal cavity of rabbits and can be completely absorbed within 14 days.

Embodiment 2

[0034] Take 50g of natural absorbent cotton gauze, soak it in 35% NaOH aqueous solution at 0°C, and swell it for 4 hours, wash with water to remove all the strong alkali solution, put it into -30°C ammonia water, soak it for 20 minutes, remove ammonia, and dry to obtain activated fibers white.

[0035] Preparation of oxidant solution: TEMPO2.0g, NaBr20g, NaClO solution 1050ml, Na 2 B 4 o 7 10H 2 O15g, put into activated cellulose, react at -10°C, add NaClO solution and NaClO solution in 5 times 2 B 4 o 7 10H 2 O, add once every 1 hour, continue to react for 2 hours after adding. To terminate the reaction, take out the gauze and put it in absolute ethanol, and wash it 3 times. Take out the gauze and put it in 70% ethanol concentrated hydrochloric acid solution, soak for 1 hour. Take out the gauze, wash it with pure water until neutral, and dry it at 40°C to obtain a medical absorbable oxidized cellulose material. The degree of oxidation is 18.5%. The material is impl...

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Abstract

The invention belongs to the technical field of a biologically medical material, and concretely relates to a medical absorbable oxycellulose material and a preparation method thereof. The material has dual functions of stopping bleeding and restoring wound. The material takes natural cellulose as a raw material, and is oxidized by an oxidation system under certain technology condition, the obtained product is subjected to acid treatment, washing by water and drying to prepare the medical absorbable oxycellulose material. The oxidation system has the advantages of strong selectivity, mild and controllable condition, and environmental protection of preparation technology. The prepared material has the advantages of rapidly stopping bleeding and rapidly being absorbed, has wound restoration function, can promote the healing of wound, and has wide application value on medical science.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a medical absorbable oxidized cellulose material and a preparation method thereof. Background technique [0002] Oxidized cellulose is a cellulose derivative in which the C6 hydroxyl group in the cellulose molecule is oxidized to a carboxyl group. Because of its good biocompatibility and degradability, it can be used as medical suture or hemostatic gauze. Among them, SURGICEL, developed by Johnson & Johnson Medical Devices Company of the United States with regenerated cellulose as a raw material, has been widely used in clinical practice as an absorbable hemostatic gauze. Hemostasis, its degradation time in vivo is 10-20 days. [0003] At present, no domestic patent reports on the preparation of oxidized cellulose from natural cellulose have been retrieved. Oxidized regenerated cellulose is now available clinically. It uses regenerated cellulose as raw material to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/02
Inventor 李素哲王新光高明李鹏达张志宝程志李璟刘媞刘俊英
Owner HEBEI AINENG BIOTECH CO LTD
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