A conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes

Abstract

The present invention relates to a conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes, comprising a drainage plate, a drainage body arranged on the drainage plate, a first drainage tube and a second drainage tube respectively connected to the drainage body, the drainage body is respectively provided with a liquid inlet and a liquid outlet, the drainage plate is provided with a reciprocating cabin base, the reciprocating cabin base is provided with a plug, the plug can move relative to the liquid inlet to open or close the liquid inlet, the second drainage tube is connected to the guide body, and the guide body is provided with at least one irrigation port. The surgical method of implanting the device of the present invention into the conjunctival sac on the ocular surface is feasible, the sterile aqueous humor can be drained to the ocular surface under reasonable automatic control to moisturize the ocular surface, there is no need to carry or use manually, and the aqueous humor is clean and sterile, the circulation time is short, and the source is sufficient, which solves the technical problem that there is no device implanted in the eye to effectively treat severe dry eyes.

Description

Technical Field

[0001] The invention relates to the field of medical technology, and in particular to a conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes. Background Art

[0002] The cavity between the back of the cornea and the iris and lens is called the anterior chamber, which is about 2.5mm to 3.0mm deep. The anterior chamber is filled with transparent aqueous humor, which comes from the plasma in the ciliary capillary network. The total amount of aqueous humor is about 0.25 to 0.3ml, and the generation rate is about 1.80 to 4.30μL / min. Its main component is water. In addition, there are proteins, electrolytes, lactic acid, glucose, which have stable physical and chemical properties, fast renewal cycle, clean and sterile, etc. It is continuously generated and updated about every 50 minutes.

[0003] At present, the non-drug treatment strategies for dry eyes in clinical practice mainly include the following aspects: ① Physical therapy such as eye massage and hot compress; ② Increasing local humidity of the eye and applying therapeutic corneal contact lenses such as wet chamber lenses; ③ Improving the ocular environment, such as feasible punctal embolization, to prolong the residence time on the ocular surface. The drug treatment strategies for dry eyes mainly include artificial, anti-inflammatory drugs, autologous serum, amniotic membrane extracts and other drugs (such as androgens, Chinese herbal medicines), etc., which are selected alone or in combination according to different types of dry eyes and the development of the disease. For patients who are ineffective with non-drug treatment, surgical treatment is usually adopted. Especially for patients with severe dry eyes who have no other options, eyelid suturing can be performed; for patients who do not respond to conventional treatment and may become blind, lip gland or submandibular gland transplantation can be performed.

[0004] There are many limitations in the current treatment options for patients with severe dry eyes: (1) Conventional physical means and wearing therapeutic contact lenses have little effect and cannot effectively improve the condition; (2) In drug treatment, the efficacy of different brands of artificial eye drops varies greatly from person to person, and patients need to carry them with them for frequent use. The storage conditions of some eye drops are relatively harsh, which brings inconvenience to the treatment; (3) Although autologous serum has a good effect on severe dry eyes, its use cycle is short, the process is complicated and cumbersome, the source of raw materials is limited, and it must be refrigerated and cannot be carried around for use; (4) When conventional treatment is ineffective, eyelid suture and related surgeries such as labial gland or submandibular gland transplantation are relatively complicated, with relatively limited clinical efficacy, and are likely to cause psychological and economic burdens on patients. Patients are not easy to accept and it is difficult to apply and promote. At present, there is no device implanted in the eye to effectively treat severe dry eyes. Summary of the invention

[0005] Therefore, in view of the above problems, the present invention proposes a conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes, which solves the technical problem that there is no device implanted in the eye to effectively treat severe dry eyes.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes, comprising a drainage plate, a drainage body arranged on the drainage plate, a first drainage tube and a second drainage tube respectively connected to the drainage body, a closed diversion cavity is formed between the drainage plate and the drainage body, a liquid inlet and a liquid outlet communicating with the diversion cavity are respectively provided on the drainage body, the first drainage tube is conductively connected to the liquid inlet, the second drainage tube is conductively connected to the liquid outlet, a reciprocating cabin base is provided on the drainage plate in the diversion cavity, a plug is provided on the reciprocating cabin base, the plug can move relative to the liquid inlet to open or close the liquid inlet, the second drainage tube is connected to the diversion body, and at least one irrigation port is provided on the diversion body.

[0008] Further:

[0009] A reciprocating cavity is provided on the reciprocating chamber base, the opening of the reciprocating cavity faces the liquid inlet, the plug can slide in the reciprocating cavity, an elastic device is provided on the reciprocating chamber base in the reciprocating cavity, and the elastic device is connected to the plug.

[0010] The elastic device is a pressure spring.

[0011] The plug is a retractable elastic silicone, one end of which is fixed to the base of the reciprocating cabin, and the other end of which can be pressed against and sealed at the liquid inlet.

[0012] The top of the base of the compound tank is fixedly and sealedly connected to the drainage body, and two drainage channels are formed between the two sides of the base of the compound tank and the drainage body. The two drainage channels are connected to the liquid collecting tank, which is triangular in shape and connected to the liquid outlet.

[0013] Each of the drainage channels is provided with a first one-way valve.

[0014] The drainage disc is provided with at least one suture hole.

[0015] The guiding body is in an ultra-thin micro-arch shape.

[0016] At least one second one-way valve is arranged on the liquid outlet.

[0017] By adopting the above technical solution, the beneficial effects of the present invention are:

[0018] The present invention allows a first drainage tube to enter the anterior chamber under the conjunctival sac, and the other end is connected to the drainage body. The drainage body is sutured and fixed on the sclera through a drainage disc and embedded in the conjunctival sac. The aqueous humor enters the liquid inlet through the first drainage tube. The elastic device connected to the plug on the liquid inlet is preset with a certain elastic value, which is usually set to 11mmHg to 13mmHg. When the aqueous humor pressure is lower than the set value, the plug abuts against the closed liquid inlet to prevent the aqueous humor from flowing in and prevent the intraocular pressure from being too low. When the aqueous humor pressure exceeds the set value, the aqueous humor pushes the plug to move, so that the liquid inlet is opened and enters the drainage body, and then enters the second drainage tube from the liquid outlet, flows out from the irrigation port of the drainage body, flows into the surface of the eyeball, and moistens the conjunctiva and cornea; further, the plug is pushed to move by the elastic device, and the elastic device is set; further, the plug is a retractable elastic silicone, and the aqueous humor pushes the plug to retract, The higher the aqueous humor intraocular pressure, the greater the compression of the plug. When the aqueous humor pressure exceeds the set value, the elastic silicone is compressed, the liquid inlet is opened, and the aqueous humor flows into the drainage body. This structure is simple and practical. Further, after entering the drainage body, it flows into the liquid collecting chamber from the drainage channels on both sides respectively. The inner walls of the liquid collecting chamber adopt a bevel design, which is conducive to flowing from the liquid collecting chamber to the liquid outlet and prevents it from being retained here. Further, the drainage plate can be sutured and fixed to the sclera through the suture hole. Further, the diversion body is ultra-thin and micro-arched, which can prevent the scarring of its own tissue from blocking the irrigation port. The diversion direction of the irrigation port is along multiple angles, and the coverage area of ​​the flow from the irrigation port is large, which is conducive to flowing to the outer surface of the eyeball and increasing the range of wetting the conjunctiva and cornea. The setting of the first one-way valve and the second one-way valve can ensure the flow direction of the liquid. The aqueous humor can only flow from the inside of the eye to the conjunctival sac in one direction, preventing the ocular surface contaminated liquid from flowing back into the eye. The device designed by this patent is implanted and buried in the conjunctival sac of the ocular surface. The sterile aqueous humor can be drained to the ocular surface under reasonable automatic control to moisturize the ocular surface. Its effect is better than conventional manual work. It does not need to be carried or used manually. The aqueous humor is clean and sterile, and carries electrolytes, cytokines and other components that are beneficial to the human body. Its renewal cycle time is short and the source is sufficient. It is acceptable to patients with severe dry eyes that threaten the health of the ocular surface. The surgical method of implanting the device on the ocular surface is feasible. After animal experiments and clinical trials have confirmed its feasibility and safety, it can be applied to patients with severe dry eyes who are difficult to respond to other methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of the present invention;

[0020] Figure 2 It is a schematic diagram of the cross-sectional structure of the drainage body of the first embodiment;

[0021] Figure 3 is another state structure schematic diagram of the first embodiment;

[0022] Figure 4 is a schematic diagram of the cross-sectional structure of the drainage body of Embodiment 2;

[0023] Figure 5 is a schematic diagram of another state structure of the second embodiment;

[0024] Figure 6 It is a schematic diagram of the cross-sectional structure of the flow conductor. DETAILED DESCRIPTION

[0025] The present invention will now be further described with reference to the accompanying drawings and specific implementation methods.

[0026] Embodiment 1:

[0027] refer to Figure 1 , Figure 2 , Figure 3 and Figure 6 The present embodiment provides a conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes, comprising a drainage plate 1, a drainage body 2 arranged on the drainage plate 1, a first drainage tube 3 and a second drainage tube 4 respectively connected to the drainage body 2, two suture holes 11 are arranged on the drainage plate 1, a closed diversion cavity 23 is formed between the drainage plate 1 and the drainage body 2, a liquid inlet 21 and a liquid outlet 22 are respectively arranged on the drainage body 2, the first drainage tube 3 is conductively connected to the liquid inlet 21, the second drainage tube 4 is conductively connected to the liquid outlet 22, a second one-way valve 221 is arranged on the liquid outlet 22, a reciprocating cabin base 26 is arranged on the drainage plate 1, a reciprocating cavity 261 is arranged on the reciprocating cabin base 26, the reciprocating cavity 261 opens toward the liquid inlet 21, a guide rail 262 is arranged on the reciprocating cabin base 26 in the reciprocating cavity 261, and a plug 6 is arranged in the reciprocating cavity 261, The plug 6 can slide along the guide rail 262 to open or close the liquid inlet 21. An elastic device is provided on the reciprocating chamber 261 on the base 26 of the reciprocating chamber. The elastic device is a pressure spring 61. The elastic device is connected to the plug 6. The outer wall of the plug 6 is sealed with the inner wall of the reciprocating chamber 261. The pressure spring 61 gives the plug 6 an elastic force to seal against the liquid inlet 21; the top of the reciprocating chamber base 26 is fixedly and sealedly connected to the drainage body 2, and two drainage channels 24 are formed between the two sides of the reciprocating chamber base 26 and the drainage body 2. Each drainage channel 24 is provided with a first one-way valve 241, and the two drainage channels 24 are connected to the liquid collecting chamber 25. The liquid collecting chamber 25 is triangular in shape, and the liquid collecting chamber 25 is connected to the liquid outlet 22; the second drainage tube 4 is connected to the guide body 5. The guide body 5 is ultra-thin and slightly arched, which fits the shape of the eyeball, and the guide body 5 is provided with five irrigation ports 51.

[0028] One end of the first drainage tube 3 is in an oblique pointed shape and enters the anterior chamber under the conjunctival sac, thereby increasing the area for water inflow.

[0029] The number of the irrigation ports 51 can be one, two, three or even more, depending on the specific situation.

[0030] The above-mentioned suture hole 11 can be one, two, three or even more. Usually, the number of suture holes 11 is two, which can play a good fixing role. Usually, the two suture holes 11 are arranged on the side close to the first drainage tube 3 to facilitate the operation. If the suture hole 11 is arranged on the side close to the second drainage tube 4, the surgical operation is more difficult. The specific setting depends on the situation.

[0031] Usually, the liquid inlet direction of the above-mentioned first drainage tube 3 and the liquid outlet direction of the above-mentioned second drainage tube 4 are set at 90 degrees, and the liquid is drained from the side and irrigated from the fornix above the temporal part, which is beneficial to the irrigation of the eyeball. Therefore, the above-mentioned second drainage tube 4 can be set as a drainage tube with a 90-degree bend. The liquid outlet direction of the above-mentioned second drainage tube 4 has a difference of 180 degrees between the left and right eyes. The liquid inlet direction of the first drainage tube 3 and the liquid outlet direction of the above-mentioned second drainage tube 4 can also be at other angles, which can be set according to the specific situation.

[0032] The length of the above-mentioned first drainage tube 3 is usually 15 mm, and the length can be trimmed and adjusted according to the situation during the operation. The length of the above-mentioned drainage plate 1 is usually 15 mm, the width of the above-mentioned drainage plate 1 is usually 12 mm, and the total length of the above-mentioned second drainage tube 4 is usually 12 mm, wherein the length of the above-mentioned second drainage tube 4 along the length direction is 2 mm, and the length along the width direction is 10 mm. The length of the above-mentioned first drainage tube 3, the length and width of the above-mentioned drainage plate 1, and the total length of the above-mentioned second drainage tube 4 can be other values, which are set according to the specific situation.

[0033] The first one-way valve 241 may not be provided on the drainage channel 24, and may be provided according to specific circumstances.

[0034] The above-mentioned pressure spring 61 can be made of memory-type biomaterials with excellent stretchability, such as silicone and other materials. These are well-known materials and will not be described here. According to needs, by setting the elastic force of the pressure spring 61, when the aqueous humor pressure exceeds 11mmHg~13mmHg, the plug 6 is pushed to move, so that the liquid inlet 21 is opened.

[0035] The above elastic force value is set according to the user's situation, usually 11mmHg to 13mmHg. It can also be adjusted in a small range according to the user's actual average intraocular pressure, achieving a trace, continuous, slow and safe effect.

[0036] The top of the above-mentioned complex cabin base 26 may be fixed to the drainage body 2 or may not be sealed. In this structure, the liquid in the drainage body 2 flows in the entire diversion cavity 23, which may easily lead to chaotic liquid flow and may cause part of the liquid to remain in the diversion cavity 23 for too long, which is not conducive to the treatment of dry eye.

[0037] The drainage body 2, drainage plate 1, plug, reversing cabin base 26, and guide body 5 of the present invention can be made of silica gel material, which is a well-known material and will not be described in detail here.

[0038] The first drainage tube 3 and the second drainage tube 4 can be made of materials with good biocompatibility such as silicone, hydrogel or polymethyl methacrylate.

[0039] The guide rail 262 may be made of polymethyl methacrylate, which is not easily biodegradable and has good biocompatibility. The guide rail 262 can maintain the stability of the linear motion of the plug 6 after the plug has reciprocated multiple times.

[0040] The first one-way valve 241 and the second one-way valve 221 are both well-known technologies, and reference can be made to patent application number: CN 201821594264.4. The principle of the one-way check valve mentioned in the patent is similar, and will not be repeated here.

[0041] The working method of the first embodiment is:

[0042] Through surgery, the oblique tip of the first drainage tube 3 is inserted into the anterior chamber under the conjunctival sac, and the other end is connected to the drainage body 2. The drainage body 2 is sutured and fixed on the sclera through the drainage disk 1 and embedded in the conjunctival sac. The aqueous humor enters the liquid inlet 21 through the first drainage tube 3. When the aqueous humor pressure in the anterior chamber is lower than the preset elastic value of the pressure spring 61, which is usually set to 11mmHg~13mmHg, the plug 6 abuts against the sealed liquid inlet 21 to prevent the liquid from flowing in. When the aqueous humor pressure exceeds the set value, the plug 6 is pushed to move, so that The liquid inlet 21 is opened, the aqueous humor enters the drainage body 2, and then enters the second drainage tube 4 from the liquid outlet 22, flows out from the multiple irrigation ports 51 of the drainage body 5, flows into the surface of the eyeball, and moistens the conjunctiva and cornea; the sterile aqueous humor of the device designed by this patent can be drained to the ocular surface under reasonable automatic control to moisturize the conjunctiva and cornea, and its effect is better than that of conventional manual drainage, and it does not need to be carried or used manually. The aqueous humor is clean and sterile, its renewal cycle time is short, and the source is sufficient. The implantation surgery of the device on the ocular surface is also relatively simple, and patients can easily accept it.

[0043] Embodiment 2:

[0044] refer to Figures 1 to 6 The difference between the second embodiment and the first embodiment is that the plug 7 of the second embodiment is a retractable elastic silicone, one end of the plug 7 is fixed to the base 26 of the reciprocating chamber, and the other end of the plug 7 is retractably against the liquid inlet 21. The plug 7 is a retractable elastic silicone, and the aqueous humor pushes the plug 7 to retract. The higher the aqueous humor pressure, the greater the compression of the plug 7. When the aqueous humor pressure exceeds the set value, the elastic silicone is compressed, and the liquid inlet 21 is opened, so that the aqueous humor flows into the drainage body 2. This structure is simple and practical. Guide seats 71 can be set on both sides of the plug 7 of the second embodiment, so that the plug 7 can perform telescopic movement along a straight line.

[0045] The guide seat 71 of the second embodiment can be made of silicone material or polymethyl methacrylate material. The guide seat 71 can maintain the stability of the linear motion of the plug 7 after the plug 7 has reciprocated multiple times.

[0046] In the second embodiment, a first one-way valve may also be provided on the drainage channel 24 .

[0047] The number of the second one-way valves 221 of the liquid outlet 22 can be one, two, three or even more. Usually, one or two are provided to prevent the liquid from flowing back, which is simple and practical.

[0048] A one-way valve may also be provided on the liquid inlet 21, or at other locations where the aqueous humor passes through the device. The valves may be provided according to the specific situation. The provision of multiple one-way valves allows the aqueous humor to flow from the eye to the conjunctival sac in one direction, thereby effectively preventing the conjunctival sac liquid from flowing back into the eye.

[0049] Although the present invention has been specifically shown and described in conjunction with the preferred embodiments, it should be understood by those skilled in the art that various changes may be made to the present invention in form and details without departing from the spirit and scope of the present invention as defined by the appended claims, all of which are within the scope of protection of the present invention.

Claims

1. A conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes, characterized in that: The invention comprises a drainage plate, a drainage body arranged on the drainage plate, a first drainage tube and a second drainage tube respectively connected to the drainage body, a closed drainage cavity is formed between the drainage plate and the drainage body, a liquid inlet and a liquid outlet communicating with the drainage cavity are respectively arranged on the drainage body, the first drainage tube is conductively connected to the liquid inlet, the second drainage tube is conductively connected to the liquid outlet, a reciprocating cabin base is arranged on the drainage plate in the drainage cavity, a plug is arranged on the reciprocating cabin base, and the plug can move relative to the liquid inlet to open The liquid inlet is opened or closed, the second drainage pipe is connected to the guide body, and the guide body is provided with at least one irrigation port; the top of the base of the compound cabin is fixedly and sealedly connected to the drainage body, and two drainage channels are formed between the two sides of the base of the compound cabin and the drainage body, and the two drainage channels are connected to the liquid collecting tank, which is triangular in shape, and the liquid collecting tank is connected to the liquid outlet; each of the drainage channels is provided with a first one-way valve, and the liquid outlet is provided with at least one second one-way valve, and one end of the first drainage pipe is obliquely pointed.

2. The conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes according to claim 1, characterized in that: A reciprocating cavity is provided on the reciprocating chamber base, the opening of the reciprocating cavity faces the liquid inlet, the plug can slide in the reciprocating cavity, an elastic device is provided on the reciprocating chamber base in the reciprocating cavity, and the elastic device is connected to the plug.

3. The conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes according to claim 2, characterized in that: The elastic device is a pressure spring.

4. The conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes according to claim 1, characterized in that: The plug is a retractable elastic silicone, one end of which is fixed to the base of the reciprocating cabin, and the other end of which can be pressed against and sealed at the liquid inlet.

5. The conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes according to claim 1, characterized in that: The drainage disc is provided with at least one suture hole.

6. The conjunctival sac drainage aqueous humor micro-irrigation device for treating severe dry eyes according to claim 1, characterized in that: The guiding body is in an ultra-thin micro-arch shape.

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