Rapid hemostatic powder for injury and preparation method of rapid hemostatic powder

Abstract

The invention relates to the technical field of medical materials and particularly relates to rapid hemostatic powder for an injury and a preparation method of the rapid hemostatic powder. The rapid hemostatic powder for the injury comprises the following raw materials in parts by weight: 40-56 parts of chitosan quaternary ammonium salt, 28-36 parts of puffball extracts, 8-12 parts of sodium alginate, 1-5 parts of ramie root extracts, 1-5 parts of cirsium setosum extracts, 1-5 parts of madder extracts and 0.5-1.5 parts of carbonized hair extracts. The rapid hemostatic powder for the injury can take a hemostasis effect through various approaches and remarkably shorten the blood coagulation time, also has the effects of inhibiting and resisting bacteria, relieving pain and promoting wound healing and can be widely applied to rapid hemostasis, emergency treatment and treatment of skin scratch, injury and haemorrhoids and relief of scar formation.

Description

technical field

[0001] The invention relates to the technical field of medical materials, in particular to a quick hemostatic powder for trauma and a preparation method thereof. Background technique

[0002] Blood coagulation process is very complicated, and there are about 13 factors participating in the reaction, and calcium is one of them. There is a folk practice of burning eggshells to stop bleeding, the principle is the role of calcium. The hemostatic properties of chitosan have been reported in a large number of literatures. The hemostatic mechanism is that positively charged amino groups combine with negatively charged red blood cells and platelet surfaces to form mucoadhesive clots and activate the traditional coagulation pathway.

[0003] Chitosan is an alkaline polysaccharide obtained by deacetylation of chitin. Due to the amino group in chitosan molecule, it has many excellent properties such as biocompatibility, biodegradability, hemostasis, and inhibition. Ba...

Examples

Embodiment 1

[0079] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0080] Chitosan quaternary ammonium salt 40 parts

[0081] Puffball Extract 28 parts

[0082] Sodium alginate 8 parts

[0083] 1 part ramie root extract

[0084] 1 part thistle extract

[0085] 1 part madder extract

[0086] Blood remaining charcoal extract 0.5 part.

[0087] The chitosan quaternary ammonium salt is 92%-2-hydroxypropyltrimethylammonium chloride chitosan and 95% dimethyl diallyl chloride by quaternization degree. A mixture of ammonium chitosan with a weight ratio of 2.5:1.

[0088] The sodium alginate is a nano-scale ultrafine sodium alginate powder with a particle size of 10 nm produced by gas atomization powder making technology.

[0089] The trauma rapid hemostasis powder also includes 1 part of calcium salt, which is a mixture of calcium lactate, calcium malate and calcium citrate in a weight ratio of 0.8:1:1.5.

[0090] A p...

Embodiment 2

[0095] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0096] Chitosan quaternary ammonium salt 44 parts

[0097] Puffball Extract 30 parts

[0098] Sodium alginate 9 parts

[0099] Ramie root extract 2 parts

[0100] 2 parts thistle extract

[0101] Rubia extract 2 parts

[0102] Blood remaining charcoal extract 0.8 parts.

[0103] The chitosan quaternary ammonium salt is 93% 2-hydroxypropyltrimethylammonium chloride chitosan and 96% dimethyl diallyl ammonium chloride by quaternization degree A mixture of chitosan with a weight ratio of 2.8:1.

[0104] The sodium alginate is nano-scale ultrafine sodium alginate powder with a particle diameter of 30nm produced by gas atomization powder making technology.

[0105] A preparation method of quick hemostatic powder for trauma, comprising the steps of:

[0106] Step A, weighing: weigh the chitosan quaternary ammonium salt, puffball extract, sodium algina...

Embodiment 3

[0110] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0111] Chitosan quaternary ammonium salt 48 parts

[0112] Puffball Extract 32 parts

[0113] Sodium alginate 10 parts

[0114] Ramie root extract 3 parts

[0115] 3 parts thistle extract

[0116] Rubia extract 3 parts

[0117] Blood remaining charcoal extract 1 part.

[0118] The chitosan quaternary ammonium salt is 94% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 97% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 3:1.

[0119] The sodium alginate is a nano-scale ultrafine sodium alginate powder with a particle diameter of 50 nm produced by gas atomization powder making technology.

[0120] The trauma rapid hemostatic powder also includes 3 parts of calcium salt, which is a mixture of calcium lactate, calcium malate and calcium citrate in a weight ratio of 1:1:2.

[0121] A prepa...

technical field

[0001] The invention relates to the technical field of medical materials, in particular to a quick hemostatic powder for trauma and a preparation method thereof. Background technique

[0002] Blood coagulation process is very complicated, and there are about 13 factors participating in the reaction, and calcium is one of them. There is a folk practice of burning eggshells to stop bleeding, the principle is the role of calcium. The hemostatic properties of chitosan have been reported in a large number of literatures. The hemostatic mechanism is that positively charged amino groups combine with negatively charged red blood cells and platelet surfaces to form mucoadhesive clots and activate the traditional coagulation pathway.

[0003] Chitosan is an alkaline polysaccharide obtained by deacetylation of chitin. Due to the amino group in chitosan molecule, it has many excellent properties such as biocompatibility, biodegradability, hemostasis, and inhibition. Ba...

Examples

Embodiment 1

[0079] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0080] Chitosan quaternary ammonium salt 40 parts

[0081] Puffball Extract 28 parts

[0082] Sodium alginate 8 parts

[0083] 1 part ramie root extract

[0084] 1 part thistle extract

[0085] 1 part madder extract

[0086] Blood remaining charcoal extract 0.5 part.

[0087] The chitosan quaternary ammonium salt is 92%-2-hydroxypropyltrimethylammonium chloride chitosan and 95% dimethyl diallyl chloride by quaternization degree. A mixture of ammonium chitosan with a weight ratio of 2.5:1.

[0088] The sodium alginate is a nano-scale ultrafine sodium alginate powder with a particle size of 10 nm produced by gas atomization powder making technology.

[0089] The trauma rapid hemostasis powder also includes 1 part of calcium salt, which is a mixture of calcium lactate, calcium malate and calcium citrate in a weight ratio of 0.8:1:1.5.

[0090] A p...

Embodiment 2

[0095] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0096] Chitosan quaternary ammonium salt 44 parts

[0097] Puffball Extract 30 parts

[0098] Sodium alginate 9 parts

[0099] Ramie root extract 2 parts

[0100] 2 parts thistle extract

[0101] Rubia extract 2 parts

[0102] Blood remaining charcoal extract 0.8 parts.

[0103] The chitosan quaternary ammonium salt is 93% 2-hydroxypropyltrimethylammonium chloride chitosan and 96% dimethyl diallyl ammonium chloride by quaternization degree A mixture of chitosan with a weight ratio of 2.8:1.

[0104] The sodium alginate is nano-scale ultrafine sodium alginate powder with a particle diameter of 30nm produced by gas atomization powder making technology.

[0105] A preparation method of quick hemostatic powder for trauma, comprising the steps of:

[0106] Step A, weighing: weigh the chitosan quaternary ammonium salt, puffball extract, sodium algina...

Embodiment 3

[0110] A trauma quick hemostatic powder, the trauma quick hemostasis powder comprises the following raw materials by weight:

[0111] Chitosan quaternary ammonium salt 48 parts

[0112] Puffball Extract 32 parts

[0113] Sodium alginate 10 parts

[0114] Ramie root extract 3 parts

[0115] 3 parts thistle extract

[0116] Rubia extract 3 parts

[0117] Blood remaining charcoal extract 1 part.

[0118] The chitosan quaternary ammonium salt is 94% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 97% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 3:1.

[0119] The sodium alginate is a nano-scale ultrafine sodium alginate powder with a particle diameter of 50 nm produced by gas atomization powder making technology.

[0120] The trauma rapid hemostatic powder also includes 3 parts of calcium salt, which is a mixture of calcium lactate, calcium malate and calcium citrate in a weight ratio of 1:1:2.

[0121] A prepa...