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Traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, preparation method and capsule quality control method thereof

A composition and technology of traditional Chinese medicine, applied in the direction of blood diseases, drug combinations, diseases, etc., can solve the pain of patients and other problems

Active Publication Date: 2010-12-22
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Regarding the treatment of anovulatory DUB, Western medicine mainly uses hormone therapy and hemostatic drugs. If the effect is not good, further surgery and curettage or even hysterectomy can be taken, which has caused great pain to the patient.

Method used

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  • Traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, preparation method and capsule quality control method thereof
  • Traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, preparation method and capsule quality control method thereof
  • Traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, preparation method and capsule quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 The preparation of the Chinese medicine composition capsule of the present invention for the treatment of gynecological dysfunction

[0067] (1) Weigh 1000g of Radix Paeoniae Rubra, 1000g of Motherwort, 300g of Panax notoginseng, 1000g of Agrimony, 600g of Burnet charcoal, and 600g of Puhuang charcoal, and set aside.

[0068] (2) Take Radix Paeoniae Rubra and Panax notoginseng and grind them into coarse powder, add 6 times the amount of 80% ethanol, reflux extraction twice, the first time for 2 hours, and the second time for 1 hour, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure. The clear paste with a relative density of 1.05-1.10 (60°C) is centrifuged (3000 rpm, 5 minutes), concentrated to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside.

[0069] (3) Take motherwort and other four flavors, add water to decoct twice, add 10 times the amount of water each time, decoct for 1 hour, combi...

Embodiment 2

[0070] Embodiment 2 The preparation method of the present invention for the treatment of gynecological dysfunctional Chinese medicine composition tablet

[0071] (1) Weigh 1000g of Radix Paeoniae Rubra, 1000g of Motherwort, 300g of Panax notoginseng, 1000g of Agrimony, 600g of Burnet charcoal, and 600g of Puhuang charcoal, and set aside.

[0072] (2) Take Radix Paeoniae Rubra and Panax notoginseng and grind them into coarse powder, add 6 times the amount of 80% ethanol, reflux extraction twice, the first time for 2 hours, and the second time for 1 hour, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure. The clear paste with a relative density of 1.05-1.10 (60°C) is centrifuged (3000 rpm, 5 minutes), concentrated to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside.

[0073] (3) Take motherwort and other four flavors, add water to decoct twice, add 10 times the amount of water each time, decoct for 1 hour, comb...

Embodiment 3

[0074] Embodiment 3 The preparation method of the traditional Chinese medicine composition granule for the treatment of gynecological dysfunction of blood of the present invention

[0075] (1) Weigh 1000g of Radix Paeoniae Rubra, 1000g of Motherwort, 300g of Panax notoginseng, 1000g of Agrimony, 600g of Burnet charcoal, and 600g of Puhuang charcoal, and set aside.

[0076] (2) Take Radix Paeoniae Rubra and Panax notoginseng and grind them into coarse powder, add 6 times the amount of 80% ethanol, reflux extraction twice, the first time for 2 hours, and the second time for 1 hour, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure. The clear paste with a relative density of 1.05-1.10 (60°C) is centrifuged (3000 rpm, 5 minutes), concentrated to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside.

[0077](3) Take motherwort and other four flavors, add water to decoct twice, add 10 times the amount of water each tim...

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Abstract

The invention relates to a traditional Chinese medicine combination for treating gynecologic functional uterine bleeding diseases, which comprises the following raw medicinal materials in portions by weight: 900-1100 portions of red paeonia, 900-1100 portions of motherwort, 200-400 portions of pseudo-ginseng, 900-1100 portions of agrimony, 500-700 portions of charred radix sanguisorbae and 500-700 portions of charred pollen typhae. The preparation method of the traditional Chinese medicine combination comprises the following steps: extracting from the red paeonia and the pseudo-ginseng with 80% ethanol, extracting from the motherwort, the agrimony, the charred radix sanguisorbae and the charred pollen typhae with water, and finally preparing the traditional Chinese medicine combination byan appropriate process. The invention also relates to a capsule quality control method of the traditional Chinese medicine combination, which comprises an identification step and a content determination step, wherein in the identification step, identification is carried out by using red paeonia control medicinal materials, paeoniflorin controls, pseudo-ginseng control medicinal materials, agrimony control medicinal materials, motherwort control medicinal materials and stachydrine hydrochloride controls based on a thin-layer chromatography; and in the content determination step, the content ofthe red paeonia should be not less than 12.0mg per capsule (measured by penoniflorin, C23H28O11 and determined by the red paeonia). The traditional Chinese medicine combination has the advantages of high hemostasis speed, good effect and the like. The capsule quality control method can conveniently and visually identify the preparation and can well ensure the effect of the traditional Chinese medicine combination.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating gynecological dysfunctional blood diseases, a preparation method and a quality control method thereof. Background technique [0002] Metrorrhagia refers to menstrual cycle, menstrual period, and menstrual flow are seriously disordered, and menstrual blood is violently or continuously dripping. It is a frequently-occurring and difficult disease in gynecology. According to some statistics, about 1 / 3 of gynecological clinics see a doctor for metrorrhagia. This disease is equivalent to functional uterine bleeding in Western medicine, and it is especially similar to anovulatory DUB. [0003] Dysfunctional uterine bleeding is abnormal uterine bleeding caused by dysfunction of the neuroendocrine system, referred to as "gong blood", which is one of the common diseases in obstetrics and gynecology....

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P15/00A61P7/04G01N30/36G01N30/90
Inventor 刘建武
Owner ZHUZHOU QIANJIN PHARMA
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