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Silicate clay modified hemostatic material and preparation method thereof

A hemostatic material and silicate technology, applied in pharmaceutical formulations, surgical adhesives, medical science and other directions, can solve the problems of limited adhesion of hemostatic materials, difficulty in subsequent treatment, and reduced hemostatic ability, etc. The effect of reducing shrinkage and hemostasis is fast

Active Publication Date: 2019-11-19
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned hemostatic gauze has the following problems: the adhesion amount of the hemostatic material is limited, and the particles adhering to the substrate are easy to fall off, which will lead to the reduction of its hemostatic ability and the difficulty of subsequent treatment

Method used

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  • Silicate clay modified hemostatic material and preparation method thereof
  • Silicate clay modified hemostatic material and preparation method thereof
  • Silicate clay modified hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Preparation of halloysite nanotubes:

[0041] Weigh 5.0 g of raw halloysite that has been ground, washed and centrifuged, add 500 mL of deionized water and ultrasonically crush it at 1500 W for 2 hours to obtain halloysite nanorods with an average size below 1 μm.

[0042] (2) Preparation of halloysite-modified hemostatic material:

[0043] Dissolve 1.0 g of polyvinylpyrrolidone in 10 mL of absolute ethanol, add 1.50 g of halloysite nanorods, and stir in a water bath at room temperature for 36 hours; perform electrospinning and set the drum speed to 500 r / min, and the distance between the needle and the drum (receiving distance) is 21cm, the liquid flow rate is 0.05mL / min, the positive electrode voltage is 10kV, and the negative electrode voltage is 2kV, the haemostatic material modified by halloysite is prepared, and the SEM map is as followsfigure 1 Shown: Halloysite groups in the halloysite-modified hemostatic material are distributed in the 3D network structure ...

Embodiment 2

[0047] (1) Preparation of halloysite nanotubes:

[0048] Weigh 5.0 g of raw halloysite that has been ground, washed and centrifuged, add 500 mL of deionized water and ultrasonically crush it at 1500 W for 2 hours to obtain halloysite nanorods with an average size below 1 μm.

[0049] (2) Preparation of halloysite-modified hemostatic material:

[0050] Dissolve 1.0 g of polyvinylpyrrolidone in 10 mL of absolute ethanol, add 0.50 g of halloysite nanorods, and stir in a water bath at room temperature for 36 hours; perform electrospinning and set the drum speed to 500 r / min, the distance between the needle and the drum to 21 cm, and the liquid The speed is 0.05mL / min, the positive electrode voltage is 10kV, and the negative electrode voltage is 2kV to prepare halloysite-modified hemostatic material.

[0051] (3) Hemostasis experiment:

[0052] Rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (0.3ml / 100g), fixed in the supine position, and disinfected. A...

Embodiment 3

[0054] (1) Preparation of attapulgite nanorods:

[0055] Weigh 5.0 g of raw ore attapulgite after grinding, washing and centrifugation, add 500 mL of deionized water and ultrasonically crush it at 1500 W for 2 hours to obtain attapulgite nanorods with an average length of less than 2 μm.

[0056] (2) Preparation of hemostatic material modified by attapulgite:

[0057] Dissolve 1.0 g of polyvinylpyrrolidone in 10 mL of absolute ethanol, add 1.50 g of attapulgite nanorods, and stir in a water bath at room temperature for 36 hours; perform electrospinning by setting the drum speed to 500 r / min, and the distance between the needle and the drum to 21 cm. The speed is 0.05mL / min, the positive voltage is 10kV, and the negative voltage is 2kV. The hemostatic material modified by attapulgite is obtained, and the SEM spectrum is as follows figure 2 As shown: the hemostatic material has a rough surface film structure, and the film is composed of attapulgite after partial rod crystal b...

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Abstract

The invention provides a silicate clay modified hemostatic material and a preparation method thereof. The hemostatic material is composed of silicate clay and a high polymer by electrostatic spinning;the mass ratio of the silicate clay and the high polymer is (0.5 to 2.5):1; the silicate clay includes kaolinite, halloysite, attapulgite or montmorillonite; part of silicon hydroxyl of the silicateclay combines with hydrogen bond of the high polymer, and the rest of silicon hydroxyl plays the role of hemostasis and hydrophilicity on the surface of the hemostatic material. The preparation methodincludes the following steps that first, the silicate clay is pretreated and broken by ultrasound and then mixed with a high polymer ethanol solution to obtain an electrostatic spinning solution, andfinally the electrostatic spinning is conducted to obtain the silicate clay modified hemostatic material. The hemostatic material has the advantages of fast hemostasis, convenient use, wound healingfacilitation, good biocompatibility and low cost.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a silicate clay-modified hemostatic material and a preparation method thereof. Background technique [0002] The research and application of new hemostatic materials is an important topic in the field of global medicine and biomaterial science. Whether it is a clinical surgical operation or a variety of sudden accidents that cause massive bleeding in the human body, efficient hemostatic materials are of great significance for saving lives. Currently, there are different types of hemostatic materials commonly used clinically, such as oxidized cellulose, gelatin sponge, and fibrin glue. The hemostatic effects of these commonly used hemostatic materials vary greatly, and the application conditions are different, which cannot fully meet the needs of all emergency situations. [0003] Silicate clay minerals are widely distributed and various in nature, and are a valuabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/02A61L24/06A61L2400/04A61L2400/12C08L39/06
Inventor 唐爱东崔龑张毅杨华明
Owner CENT SOUTH UNIV
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