Manufacturing method of chitosan hemostatic membrane with high water-absorbing swelling performance

A technology of water absorption and swelling and production method, which is applied in absorbent pads, medical science, bandages, etc., can solve problems such as poor wound adhesion, and achieve the effects of improving water absorption, improving mechanical strength, and accelerating hemostasis.

Inactive Publication Date: 2011-04-27
ZHEJIANG HAIZHI INVESTMENT MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a method for making a chitosan hemostatic film with high water absorption and swelling properties, and aims to solve the problem of poor wound adhesion of existing chitosan dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: A kind of preparation method of chitosan hemostatic film with high water absorption and swelling performance

[0034] (1) Take 2g of chitosan with a deacetylation degree of 95% and a molecular weight of 100,000, put it into a 250ml three-necked flask, add 200ml of 2% dilute acetic acid solution, stir at room temperature until completely dissolved, and prepare a 1% (m / v) shell (2) Filter the above solution to obtain a clarified chitosan solution; (3) Inject the above chitosan solution into a mold (petri dish) and cover it with a layer of unidirectional osmosis Membrane, put the mold into the 5% NaOH precipitation solution with a mass concentration of 0.5% overnight, until the chitosan is completely precipitated to form a chitosan gel, and rinse with a large amount of deionized water to neutral pH=6.0-8.0; (4) Add dimethyl sulfoxide solution of succinic anhydride in a closed reactor (3g succinic anhydride dissolved in 40ml dimethyl sulfoxide), heat to 60°C, ...

Embodiment 2

[0035] Embodiment 2: A kind of preparation method of chitosan hemostatic film with high water absorption and swelling performance

[0036] (1) Take 4g of chitosan with a deacetylation degree of 85% and a molecular weight of 200,000, put it into a 250ml three-necked flask, add 200ml of 2% dilute acetic acid solution, stir at room temperature until completely dissolved, and prepare a 2% (m / v) shell (2) Filter the above solution to obtain a clarified chitosan solution; (3) Inject the above chitosan solution into the mold, cover it with a one-way permeable membrane, and put the mold Put in 5% NaOH precipitation solution overnight, until the chitosan is completely precipitated to form a chitosan gel, rinse with a large amount of deionized water to neutral pH = 6.0-8.0; (4) add butane in the closed reactor Dimethyl sulfoxide solution of acid anhydride (3g succinic anhydride dissolved in 40ml dimethyl sulfoxide), heated to 60°C, put the above neutral chitosan gel into a closed contai...

Embodiment 3

[0037] Embodiment 3: A kind of preparation method of chitosan hemostatic film with high water absorption and swelling performance

[0038](1) Take 6g of chitosan, deacetylation degree 65%, molecular weight 500,000, put it into a 250ml three-necked flask, add 200ml 2% dilute acetic acid solution, stir at room temperature until completely dissolved, and prepare a 3% (m / v) shell (2) Filter the above solution to obtain a clarified chitosan solution; (3) Inject the above chitosan solution into the mold, cover it with a one-way permeable membrane, and put the mold Put 5% NaOH precipitation solution overnight until chitosan is completely precipitated to form chitosan gel; (4) Add chloroacetic acid and isopropanol (m / m=1:10) in a closed reactor, Heat to 60-80°C, put the above-mentioned chitosan gel into an airtight container to react for 30 minutes, take it out, and wash it repeatedly with enough ethanol for 5-6 times; (6) Soak the above-mentioned partially carboxylated chitosan gel ...

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PUM

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Abstract

The invention discloses a manufacturing method of a chitosan hemostatic membrane with high water-absorbing swelling performance. The method comprises the following steps of: dissolving chitosan with the deacetylation degree of between 55 and 99 percent and the molecular weight of between 100,000 and 500,000 in an appropriate amount of dilute solution of methanoic acid, acetic acid or hydrochloric acid, preparing 0.5 to 5 percent (m / v) chitosan solution, standing and defoaming; injection the solution into a mold, covering a layer of one-way permeable membrane on the mold, soaking the mold in an alkali medium, preparing chitosan gel by a one-way penetration and neutralization method and washing the gel with a large amount of deionized water until the gel is neutral; performing N-position or O-position carboxylation, soaking the gel in 1 to 5 percent CaCl2 dilute solution for a short period of time, crosslinking appropriately, taking the gel out and washing; soaking the gel in 1 to 10 percent (m / v) glycerol solution for 1 hour, taking the gel out and draining; and drying and molding at the temperature of 60 DEG C so as to obtain the hemostatic membrane. Chitosan has excellent hemostatic effect and Ca2+ is one of blood coagulation factors and has the effect of promoting blood coagulation, so that hemostasis is promoted under the synergism of the chitosan and the Ca2+.

Description

technical field [0001] The invention relates to a preparation method of a surgical hemostatic dressing, in particular to a preparation method of a chitosan hemostatic film with high water absorption and swelling performance. Background technique [0002] Chitosan (Chitosan), scientific name (1,4)-2-amino-2-deoxy-β-D-glucose, is composed of chitin (N-acetyl-2-acetylamino-D-glucose with 1-4 glycoside bonded) a biopolymer obtained after deacetylation reaction, its molecular chain usually contains two structural units of N-acetylglucose and N-glucosamine, the ratio of which varies with the degree of deacetylation different from each other. [0003] The excellent hemostatic properties of chitosan have been recognized by people, and many literatures have reported that chitosan has excellent hemostatic properties and studied its hemostatic mechanism. The literature "Effects of chitin and chitosan on blood coagulation" (Carbohydrate Polymers) reported that both chitin and chitosan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
Inventor 胡巧玲孙永富施建基
Owner ZHEJIANG HAIZHI INVESTMENT MANAGEMENT
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