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Trauma hemostatic sponge and preparing method and application thereof

A hemostatic sponge, trauma technology, applied in the field of hemostasis

Active Publication Date: 2019-07-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, how to achieve effective regulation of zeolite heat release while maintaining the hemostatic properties of zeolites remains a challenge.

Method used

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  • Trauma hemostatic sponge and preparing method and application thereof
  • Trauma hemostatic sponge and preparing method and application thereof
  • Trauma hemostatic sponge and preparing method and application thereof

Examples

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Effect test

preparation example Construction

[0035] The present invention also provides a preparation method of the trauma hemostatic sponge described in the above technical solution, comprising the following steps:

[0036] Freeze-drying the zeolite-graphene oxide composite hydrogel to obtain the zeolite-graphene composite aerogel;

[0037] The zeolite-graphene composite airgel is sequentially subjected to microwave expansion and high temperature treatment to obtain a trauma hemostatic sponge.

[0038] In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0039] The invention freeze-dries the zeolite-graphene oxide hydrogel to obtain the zeolite-graphene composite airgel.

[0040] In the present invention, the preparation method of the zeolite-graphene oxide composite hydrogel comprises the following steps: mixing a graphene oxide solution, a crosslinking agent and zeolite, and performing a crosslinking reaction to...

Embodiment 1

[0057] Mix 100mg of zeolite powder, 20mL of graphene oxide solution (5mg / mL) and 0.2mL of ethylenediamine (0.90g / mL) and react at 96°C for 6h to obtain a zeolite-graphene oxide composite hydrogel ;

[0058] Freeze-dry the zeolite-graphene composite hydrogel at -45°C for 48 hours, wash the freeze-dried product with ethanol in a Soxhlet extractor for 48 hours, and dry it at 25°C for 48 hours to obtain the zeolite-graphene gas gel;

[0059] The zeolite-graphene airgel was expanded with 800W microwave for 10s, and treated at 100°C for 1 hour to obtain a trauma hemostatic sponge (the mass ratio of zeolite powder and graphene was 7:20), which could be directly used for trauma hemostasis;

[0060] The described trauma hemostatic sponge is carried out SEM test, test result is as follows figure 1 Shown (Figure B is a 100-fold magnification of Figure A), by figure 1 It can be seen that the graphene in the trauma hemostatic sponge of the present invention has a three-dimensional cross...

Embodiment 2

[0062] Mix 200mg zeolite powder, 20mL graphene oxide solution (5mg / mL) and 0.2mL ethylenediamine (0.90g / mL) and react at 96°C for 6h to obtain zeolite-graphene oxide composite hydrogel ;

[0063] Freeze-dry the zeolite-graphene composite hydrogel at -45°C for 48 hours, wash the freeze-dried product with ethanol in a Soxhlet extractor for 48 hours, and dry it at 25°C for 48 hours to obtain the zeolite-graphene gas gel;

[0064] The zeolite-graphene airgel was expanded by 800W microwave for 20s, and treated at 100°C for 2 hours to obtain a trauma hemostatic sponge (the mass ratio of zeolite powder to graphene was 7:3), which could be directly used for trauma hemostasis.

[0065] The SEM test results of the trauma hemostatic sponge are similar to the examples.

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Abstract

The invention relates to the technical field of hemostasis, in particular to a trauma hemostatic sponge and a preparing method thereof. The trauma hemostatic sponge comprises zeolite and graphene; thegraphene is of a three-dimensional crosslinking structure; the zeolite is dispersed in the three-dimensional crosslinking structure; the mass ratio of the zeolite to the graphene is 1:(0.2-5). The trauma hemostatic sponge has a distinctive hemostasis mechanism and excellent hemostasis performance. According to records of the embodiment, the trauma hemostatic sponge has a high hemostasis speed, amild exothermic reaction and high biological safety.

Description

technical field [0001] The invention relates to the technical field of hemostasis, in particular to a trauma hemostatic sponge and its preparation method and application. Background technique [0002] As we all know, bleeding is not only the direct cause of death in accidents, rapid control of bleeding in the early stage of bleeding is of great significance for saving lives, reducing pain and preventing complications. [0003] Zeolite is one of the most classic hemostatic agents and has been widely used since FDA approval in 2002. Zeolite has the property of rapidly absorbing water. After contacting the wound, it can quickly absorb blood plasma, enrich blood cells and other components to achieve the purpose of rapid control of bleeding; at the same time, the inert composition of zeolite will not cause toxicity to organisms. However, application of bare zeolites can result in severe thermal injury and necrosis of surrounding tissue. Z-Medica has developed a prehydrated zeol...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02
CPCA61L24/001A61L24/0036A61L24/02A61L2400/04
Inventor 王兴梁玉平
Owner BEIJING UNIV OF CHEM TECH
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