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Hemostasis fibrous membrane, preparation method of hemostasis fibrous membrane and hemostasis product adopting hemostasis fibrous membrane

A technology of hemostatic fibers and microfibers, which is used in medical science, absorbent pads, bandages, etc., can solve the problems of unsatisfactory hemostatic effect of film-like hemostatic materials, inability to achieve fast and efficient hemostasis, poor adherence and adhesion, etc. Excellent tissue adhesion, significant hemostatic effect, high water absorption effect

Active Publication Date: 2018-03-23
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally, the hemostatic effect of the film-like hemostatic materials prepared by these two methods is not satisfactory, and cannot meet the needs of clinical use.
Among them, the fibrous membrane prepared directly by electrospinning has poor conformability and adhesion to the wound surface, and its liquid absorption capacity is not high, while the hemostatic membrane material obtained by directly drying the solution into a film has poor air permeability. The speed of liquid absorption is also slow, and the effect of fast and efficient hemostasis cannot be achieved

Method used

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  • Hemostasis fibrous membrane, preparation method of hemostasis fibrous membrane and hemostasis product adopting hemostasis fibrous membrane
  • Hemostasis fibrous membrane, preparation method of hemostasis fibrous membrane and hemostasis product adopting hemostasis fibrous membrane
  • Hemostasis fibrous membrane, preparation method of hemostasis fibrous membrane and hemostasis product adopting hemostasis fibrous membrane

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Effect test

no. 1 approach

[0055] The first embodiment of the present invention provides a hemostatic fibrous membrane. The hemostatic fiber membrane includes microfibers, and the microfibers have an interlaced structure formed by overlapping short nanofibers. The microfibers are derived from crosslinked nanofibrous material.

[0056] Wherein, the crosslinked nanofiber material can be obtained by performing crosslinking modification on the nanofiber material.

[0057]

[0058] The nanofibrous material of the present invention can be derived from a biocompatible and biodegradable polymer material, more preferably a hydrophilic polymer material. For example, the polymer material may include one or a combination of two or more of collagen (Collagen), chitosan (Chitosan), hyaluronic acid (HA), alginate, cellulose and derivatives thereof.

[0059] The nanofibrous material of the present invention can be formed by interweaving fiber filaments. Preference is given to nanofibrous materials produced using e...

no. 2 approach

[0078] The second embodiment of the present invention provides a method for preparing a hemostatic fibrous membrane, comprising the following steps:

[0079] Electrospinning step: preparing the nanofiber material by electrospinning;

[0080] Crosslinking step: performing crosslinking treatment on the nanofiber material in the presence of a crosslinking agent to obtain a crosslinked nanofiber material;

[0081] Shearing step: performing shearing treatment on the cross-linked nanofiber material to obtain microfibers;

[0082] Forming step: using a mold to press the microfibers to obtain a molded body.

[0083] The "cross-linking" and "cross-linking modification" described herein have the same or similar meanings, and in the process of "cross-linking", some characteristics of "modification" can be attached. For the sake of simplicity, in the present invention, Use "cross-linked" instead of "cross-linked modification".

[0084]

[0085] In the electrospinning step, the fiber ...

no. 3 approach

[0114] The third embodiment of the present invention also provides a hemostatic product, including the hemostatic fibrous membrane according to the first embodiment of the present invention, or the hemostatic fibrous membrane prepared according to the method for preparing the hemostatic fibrous membrane according to the second embodiment of the present invention.

[0115] The hemostatic product of the present invention can be used for hemostasis and repair when tissue oozes, capillary hemorrhage, arteriole hemorrhage, and lacunar ooze, and / or, for hemostasis and repair of burns, wounds, and surgical wounds. application prospects. When it is used for hemostasis and repair when the cavity oozes, it can be applied to the oozing of the cavity and other parts with the help of auxiliary equipment, or the doctor can use this product in combination with other commercially available products based on experience, such as Hemostatic sponge, hemostatic gauze and other products to achieve ...

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Abstract

The invention provides a hemostasis fibrous membrane, a preparation method of the hemostasis fibrous membrane and a hemostasis product adopting the hemostasis fibrous membrane. The hemostasis fibrousmembrane comprises microfibers; the microfibers are derived from a cross-linked nanofiber material; the microfibers have a diameter of 0.1mm to 1mm and a length of 20mm or below; the microfibers havea staggered structure formed by mutually overlapping a plurality of nano short fibers; the nano short fibers have a diameter of 1nm to 1,000nm and a length of 10mm or below. The hemostasis fibrous membrane provided by the invention has a high specific surface area and water absorption and meanwhile, has an excellent tissue adhesion property and an obvious hemostasis effect. Further, the hemostasisfibrous membrane provided by the invention is simple and convenient to operate in the using process, and can rapidly separate materials according to an actual dosage demand. Moreover, the surface ofthe hemostasis fibrous membrane has a microcosmic and / or macroscopic concave-convex structure, so that the hemostasis fibrous membrane is better attached to tissue surfaces and meanwhile, the specificsurface area is also higher.

Description

technical field [0001] The invention relates to a hemostatic fiber membrane, a preparation method thereof and a hemostatic product, belonging to the field of biomedical materials. Background technique [0002] Biomedical materials are a class of high-tech materials developed in the past 30 years, among which hemostatic materials have gradually attracted the attention of the medical community with the increase in accidents such as traffic accidents, severe burns, and major disasters. With the rapid development of modern science and technology, the research on hemostatic materials has made very rapid progress, and various new hemostatic materials have emerged continuously, and their performance has also been greatly improved. Currently, commonly used local hemostatic materials include fibrin glue, thrombin powder, gelatin sponge, collagen sponge, chitosan sponge, oxidized cellulose, microfibrillar collagen, alginate fiber, zeolite, cyanoacrylate, plant polysaccharide powder W...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L15/64A61L15/60A61L15/42
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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