Hemostasis fibrous membrane, preparation method of hemostasis fibrous membrane and hemostasis product adopting hemostasis fibrous membrane

Abstract

The invention provides a hemostasis fibrous membrane, a preparation method of the hemostasis fibrous membrane and a hemostasis product adopting the hemostasis fibrous membrane. The hemostasis fibrousmembrane comprises microfibers; the microfibers are derived from a cross-linked nanofiber material; the microfibers have a diameter of 0.1mm to 1mm and a length of 20mm or below; the microfibers havea staggered structure formed by mutually overlapping a plurality of nano short fibers; the nano short fibers have a diameter of 1nm to 1,000nm and a length of 10mm or below. The hemostasis fibrous membrane provided by the invention has a high specific surface area and water absorption and meanwhile, has an excellent tissue adhesion property and an obvious hemostasis effect. Further, the hemostasisfibrous membrane provided by the invention is simple and convenient to operate in the using process, and can rapidly separate materials according to an actual dosage demand. Moreover, the surface ofthe hemostasis fibrous membrane has a microcosmic and/or macroscopic concave-convex structure, so that the hemostasis fibrous membrane is better attached to tissue surfaces and meanwhile, the specificsurface area is also higher.

Description

technical field [0001] The invention relates to a hemostatic fiber membrane, a preparation method thereof and a hemostatic product, belonging to the field of biomedical materials. Background technique [0002] Biomedical materials are a class of high-tech materials developed in the past 30 years, among which hemostatic materials have gradually attracted the attention of the medical community with the increase in accidents such as traffic accidents, severe burns, and major disasters. With the rapid development of modern science and technology, the research on hemostatic materials has made very rapid progress, and various new hemostatic materials have emerged continuously, and their performance has also been greatly improved. Currently, commonly used local hemostatic materials include fibrin glue, thrombin powder, gelatin sponge, collagen sponge, chitosan sponge, oxidized cellulose, microfibrillar collagen, alginate fiber, zeolite, cyanoacrylate, plant polysaccharide powder W...

AI Technical Summary

Problems solved by technology

Generally, the hemostatic effect of the film-like hemostatic materials prepared by these two methods is not satisfactory, and cannot meet the needs of clinical use.

Among them, the fibrous membrane prepared directly by electrospinning has poor conformability and adhesion to the wound surface, and its liquid absorption capacity is not high, while the hemostatic membrane material obtained by directly drying the solution into a film has poor air permeability. The speed of liquid absorption is also slow, and the effect of fast and efficient hemostasis cannot be achieved

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