Cryogel for stopping bleeding and carrying anti-cancer drug and preparation method thereof

An anti-cancer drug, crystal glue technology, applied in the direction of drug delivery, pharmaceutical formulation, application, etc., can solve the problems of lack of hemostatic articles, lack of inhibition and so on

Active Publication Date: 2021-06-11
XI AN JIAOTONG UNIV
View PDF19 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, and provide a crystal gel for hemostasis and carrying anticancer drugs and its preparation metho

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cryogel for stopping bleeding and carrying anti-cancer drug and preparation method thereof
  • Cryogel for stopping bleeding and carrying anti-cancer drug and preparation method thereof
  • Cryogel for stopping bleeding and carrying anti-cancer drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The invention discloses a crystal gel used for hemostasis and carrying anticancer drugs. The preparation method comprises the following steps:

[0040] (1) Synthesizing complex A through a double bond functionalization reagent and the first biomacromolecule;

[0041] (2) complex B is synthesized by polyphenolic compounds and second biomacromolecules;

[0042] (3) synthesis of nanoparticle C by anticancer substances, dopamine and ZIF-8;

[0043] (4) Preparation of crystal gel by compound A, compound B and nanoparticle C.

[0044] Preferably, in step 1, the first biomacromolecule is chitosan or its derivatives, gelatin or its derivatives, hyaluronic acid or its derivatives, alginate or its derivatives, dextran or its Derivatives, cellulose or derivatives thereof, polyvinyl alcohol or derivatives thereof, polyethylene glycol or derivatives thereof, or Pluronic F127 or derivatives thereof; when the first biomacromolecule is used, it is a or multiple combinations;

[004...

Embodiment 1

[0061] (1) Compound A, the synthesis of quaternized chitosan (QCSG) modified by glycidyl methacrylate;

[0062] In step (1), the preparation step of the quaternized chitosan modified by glycidyl methacrylate comprises:

[0063] (1A) 1g chitosan is suspended in 36mL deionized water to obtain a suspension of chitosan;

[0064] (1B) Add 180 μL of glacial acetic acid to the chitosan suspension obtained in step (1A), and stir at 55° C. for 30 min;

[0065] (1C) adding the chitosan-glacial acetic acid solution obtained in step (1B) under continuous stirring to GTMAC with a molar ratio of 2:1 to the amino groups on the chitosan skeleton, and stirring the reaction mixture at 55° C. for 15 hours;

[0066] (1D) After the reaction in step (1C) is completed, add GMA dropwise to the above reaction mixture under continuous stirring at 55°C, and fix the ratio of GMA and amino groups on the main chain of pure chitosan to 0.5:1.0. Reaction was carried out at 55° C. for 15 hours;

[0067] (1...

Embodiment 2

[0087] The difference from Example 1 is that QCSG, HA-DA and ZDH nanoparticles are prepared in 5wt%, 1.5wt% and 1wt% aqueous solutions or dispersions in step (4A), respectively. 600 μL of QCSG aqueous solution was mixed with 100 μL of ZDH aqueous dispersion and 200 μL of HA-DA aqueous solution, pre-cooled in an ice bath, and the corresponding prepared crystal gel was named QH10 / ZDH.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a cryogel for stopping bleeding and bearing an anti-cancer drug and a preparation method thereof, the preparation method comprises the following steps: a double bond is modified to a biomacromolecule, a polyphenolic compound is grafted onto the biomacromolecule, and the dopamine molecule and the Zn 2 + ion are coordinated to prepare dopamine-modified ZIF -8; and all the components are respectively prepared into aqueous solutions or dispersion solutions, and then under the action of an initiator, through double-bond polymerization, the multifunctional water/blood triggered shape memory cryogel l is formed at low temperature. According to the preparation method, polysaccharide and other biomacromolecules with good biocompatibility and degradation performance are taken as the basis, the process of chemical grafting of double-bond or polyphenol compounds also has the characteristics of low toxicity and no pollution, the used double-bond functionalized biomacromolecules are simple to prepare, the synthesis technology is mature, and the prepared product has good universality.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a crystal glue used for hemostasis and carrying anticancer drugs and a preparation method thereof. 【Background technique】 [0002] In the course of tumor treatment, surgical resection is still the first choice and the most effective method of cancer treatment. However, hemorrhage is unavoidable in the process of tumor resection, especially the resection of tumors with rich blood vessels, such as the resection of liver cancer, which makes hemostasis become particularly important. Although there are many reports or commercially available hemostatic agents, such as tissue adhesives, glutaraldehyde cross-linked hemostats, or gelatin hemostats, which have high hemostatic effect on superficial bleeding wounds, there is still a lack of evidence for complicated internal bleeding. an effective strategy. For example, the current clinical treatment of hemorrhage...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L24/04A61L24/08A61L24/10A61L24/00A61L26/00
CPCA61L24/0015A61L24/0036A61L24/0094A61L26/0095A61L26/0066A61L26/0085A61L2300/416A61L2400/04A61L2300/624A61L2300/602
Inventor 郭保林梁永平乔李鹏李勐黄颖
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap