Adhesive-non-adhesive integrated hydrogel as well as preparation method and application thereof in wound repair

A hydrogel, non-adhesive technology, used in medical science, bandages, etc., to achieve good mechanical properties, good application prospects, and good water absorption.

Active Publication Date: 2021-09-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems existing in the use of existing hydrogel dressings, the present invention provides an adhesion-non-adhesion integrated hydrogel and its preparation method

Method used

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  • Adhesive-non-adhesive integrated hydrogel as well as preparation method and application thereof in wound repair
  • Adhesive-non-adhesive integrated hydrogel as well as preparation method and application thereof in wound repair
  • Adhesive-non-adhesive integrated hydrogel as well as preparation method and application thereof in wound repair

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preparation example Construction

[0052] The present invention also provides a method for preparing an adhesion-non-adhesion integrated hydrogel, which specifically includes the following steps:

[0053] (1) Prepare the precursor solution of the hydrogel for the adhesion part, that is, prepare the base substance with a double bond containing 1 to 30% of the mass fraction, 1 to 50% of the monomer with a double bond, and 0.01 to 5% of the Mixed aqueous solution A of initiator, 0.005-0.5% cross-linking agent, 0.1-30% polysaccharide.

[0054] (2) Prepare the precursor solution of the non-adhesive part of the hydrogel, that is, prepare a monomer with a double bond with a mass fraction of 1 to 30%, a zwitterionic monomer with a double bond with a mass fraction of 1 to 50%, and 0.01 to 5% A mixed aqueous solution B of initiator, 0.005-0.5% cross-linking agent, and 0.1-40% polysaccharide.

[0055] (3) Inject the mixed solution A of step (1) into the mold, and stand still at 0-35° C. for 5-120 minutes to form a hydrog...

Embodiment 1

[0063] (1) Weigh 400mg of acrylamide, 100mg of acrylylated adenine, 25mg of ammonium persulfate, 0.5mg of N,N'-bisacrylamide, 5mg of chitosan, and 35mg of oxidized hyaluronic acid in a centrifuge tube, and add 2.5mL Distilled water, vortex at room temperature to dissolve, and ultrasonically remove air bubbles in the mixed solution. Transfer the mixed solution to the annular groove formed concentrically between the cylinder and the barrel, let it stand for 5 minutes, and take out the cylinder to form a ring-shaped hydrogel.

[0064] (2) Weigh 350mg acrylamide, 150mg 2-methacryloyloxyethyl phosphorylcholine, 25mg ammonium persulfate, 0.5mg N,N'-bisacrylamide, 20mg chitosan, 7mg oxidized hyaluronic acid in Add 2.5 mL of distilled water to the centrifuge tube, vortex to dissolve at room temperature, and remove air bubbles in the solution by ultrasonication. The mixed solution was poured inside the ring-shaped hydrogel of (1) in this embodiment, and left to stand for 5 minutes to ...

Embodiment 2

[0067] (1) Weigh 400mg of acrylamide, 100mg of acrylylated adenine, 25mg of ammonium persulfate, 0.5mg of N,N'-bisacrylamide, 15mg of carboxymethyl chitosan, and 35mg of oxidized dextran in a centrifuge tube, Add 2.5 mL of distilled water, vortex at room temperature to dissolve, and ultrasonically remove the air bubbles in the mixed solution. Transfer the mixed solution to the annular groove of the mold formed concentrically between the cylinder and the barrel, let it stand for 5 minutes, take out the cylinder, and form a ring-shaped hydrogel.

[0068] (2) Weigh 350mg of acrylamide, 150mg of 2-methacryloyloxyethyl phosphorylcholine, 25mg of ammonium persulfate, 0.5mg of N,N'-bisacrylamide, 40mg of carboxymethyl chitosan, 7mg of oxidized glucose Add 2.5 mL of distilled water to the polysaccharide in a centrifuge tube, vortex to dissolve at room temperature, and remove bubbles in the solution by ultrasonication. The mixed solution was poured inside the ring-shaped hydrogel of (...

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Abstract

The invention discloses an adhesion-non-adhesion integrated hydrogel as well as a preparation method and application thereof in wound repair. The integrated hydrogel comprises two kinds of hydrogel with tissue adhesion and two kinds of hydrogel with non-tissue adhesion. When the hydrogel is prepared, an adhesive or non-adhesive monomer is dissolved in a polysaccharide polymer solution in advance, firstly, an adhesive or non-adhesive hydrogel solution is injected into a specified position, and after the hydrogel is formed, a hydrogel solution with a monomer with the opposite property is injected into the specified position; after the two parts are self-healed into a whole hydrogel, free radical polymerization is initiated, and the adhesion-non-adhesion integrated hydrogel is formed. The non-adhesion part can be in direct contact with a wound, damage to new granulation tissue in daily replacement is avoided, the adhesion part can be adhered to normal tissue near the wound, and therefore the hydrogel is fixed to the wound and does not fall off. The adhesive-non-adhesive integrated hydrogel has bactericidal performance, can promote wound repair, and can be used as a wound dressing.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an adhesion-non-adhesion integrated hydrogel, a preparation method thereof and an application in skin wound repair. Background technique [0002] Hydrogel contains a large amount of water, and when used as a dressing, it can provide a moist environment for skin wounds, which is conducive to wound healing. However, the existence of a large amount of water makes the hydrogel lack of adhesion when it is attached to the skin tissue, and it is easy to fall off during use, so it is often necessary to supplement it with other medical adhesive materials to fix it on the wound, which is very inconvenient. To solve this problem, researchers have developed a variety of hydrogels with self-adhesive properties, which can be directly attached to the wound. For example, inspired by the fact that mussels can be firmly attached to rocks in nature and can withstand the impac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08L51/02
CPCA61L26/0023A61L26/008C08J3/075C08J2351/02C08L51/02
Inventor 罗祥林周良芹
Owner SICHUAN UNIV
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