362 results about "Granulation tissue" patented technology

A laminated negative pressure wound dressing system and method is described. The wound dressing is disposed in the wound in layers including at least one bioabsorbable layer that contacts the wound bed, a bioabsorbable fluid communicating layer, an atmospheric barrier layer, and a tube for applying a negative pressure to the wound bed. Ingrowth of granulation tissue into the bioabsorbable wound bed layer does not need to be inhibited as the bioabsorbable material need not be removed during dressing changes. A kit containing the components of the wound dressing system is also disclosed as well as a method for applying the dressing.

A wound closure apparatus having a porous pad adapted to be fluidly connected to a vacuum pump. The pad is placed over or within a tissue site, and the vacuum pump may be activated to draw air and exudates from the tissue site. The pad contains multiple pore sizes to prevent granulation tissue from migrating into the pad as reduced pressure treatment is applied. The pad has an outer surface adjacent the wound with pore sizes of a diameter of approximately 100 microns or less to prevent tissue from growing into the pad and is treated for biocompatibility.

An apparatus, system, and method are disclosed for medializing the middle turbinate following sinus surgery, thus preventing synacheiae, granulation tissue, and other complications of the prior art. The apparatus utilizes a fastening device configured to attach the middle turbinate to the nasal septum, a prong comprising a slender wand portion and a fastening module, and a handle configured to trigger deployment of the fastening means by activating the fastening module. The fastening device may be a staple, rivet, glue, or another similar device.

This invention relates to a periodontal instrument and curettage method for separating and removing calculus and diseased granulation tissue from the tooth surface and periodontal cavity in deep pockets greater than 10 mm. The invention is comprised of a straight shaft, a distal portion in parallel orientation with and terminating in a spoon-shaped blade with a rounded tip and continuous sharp edge. The approximate 90 degree angle orientation between the distal and proximal shank portions, rounded blade tip, and parallel alignment of the blade face relative to the distal shank portion enhance maneuverability, accessibility, and efficiency and minimize tissue trauma during periodontal curettage.

A rotatable tissue removing instrument having a tissue engaging member. The tissue engaging member includes one or more prongs or barbs, or both, which grab the strands of granulation tissue and cause the tissue to be wrapped around the tissue engaging member. The granulation tissue continues to be wrapped around the tissue engaging member until pulled free from both the tooth and the bone.

The invention discloses a medical composite chitosan gel containing medicines promoting wound healing. The medical composite chitosan gel comprises the following compositions in parts by weight: 0.5-10 parts of chitosan high-molecular material, 0.1-8 parts of a medicine promoting wound healing, 0-10 parts of a thickening agent, 1-25 parts of a moisturizing agent, 0-30 parts of a co-solvent / solubilizer, 17-98.4 parts of purified water. The medical composite chitosan gel containing medicines promoting wound healing is capable of effectively keeping the wet environment of a wound, promoting generation of granulation tissue, accelerating wound healing and alleviating wound pain. By employing the chitosan high-molecular material as a matrix and the medicine promoting wound healing as an auxiliary material, the wound dressing combines the advantages that the chitosan high-molecular material is capable of absorbing moisture, keeping moisture, inhibiting bacteria, stopping bleeding and the like and the effect that the medicine promoting wound healing is capable of promoting generation of granulation tissue, accelerating wound healing and alleviating pain, and the gel with excellent performances is prepared.

The invention belongs to the technical field of biology and particularly relates to a miRNA145-5p-modified umbilical cord mesenchymal stem cell exosome and preparation and application of the miRNA145-5p-modified umbilical cord mesenchymal stem cell exosome. The invention provides a preparation method of the highly-miRNA145-5p-expressed umsc-exosome (umbilical cord mesenchymal stem cell exosome) and application of various biological preparations for accelerating full-thickness skin defect healing and antagonizing scar contracture. The preparation method of the exosome includes (1), adopting fresh umbilical cords to culture human umbilical cord mesenchymal stem cells; (2) preparing mesenchymal stem cells highly expressed in miRNA145-5p; (3), storing conditional media; (4) performing exosome extraction and purification. The highly-miRNA145-5p-expressed umbilical cord mesenchymal stem cell exosome is transferred into a full-thickness wound model of rat backs by serving as a biological preparation, so that skin granulation tissue proliferation can be promoted effectively, wound healing is accelerated and scar contracture can be antagonized; novel approaches and novel methods are provided for wound treatment.

A wound closure device has internal and external components designed to close, shrink or approximate an open wound. The internal component preferably comprises sachets filled with highly absorbent material such as carboxymethylcellulose, disposed at the surface of the wound bed to absorb exudate from the wound. The external components preferable include paddles that adhere to the skin, and form part of, or have a mechanism to couple to an elastic tensioning fabric. The internal component is placed between the open wound and the elastic tensioning fabric, such that expansion of the internal component applies pressure on the wound base. It is contemplated that the two components will work synergistically together to create ‘micro-deformation’ forces that stimulate granulation tissue.

As a wound dressing that includes a perforated material having through-holes, in which the perforated material can be coated with a low-adhesive resin without closing the through-holes, and that has excellent adhesion prevention properties to wounds, provided is a wound dressing 1 that includes a sheet-shaped perforated material 11 having through-holes 111 and a low-adhesive resin 12 with which at least one face of the perforated material 11 is coated without closing the through-holes 111, the perforated material 11 is a knitted fabric or a woven fabric formed of a multifilament, and the perforated material 11 has an average opening area of the through-holes 111 of 0.02 to 1.2 mm2 and an average number of through-holes of 40 to 220 cm−2. By designing the opening area of the through-hole 111 and the number of through-holes 111 in the perforated material 11 within the particular numerical ranges, such a wound dressing can be prevented from adhering to granulation tissues that invade the through-holes 111 and can ensure sufficient permeation properties of exudate through the through-holes 111.

The invention relates to a supporting frame capable of being taken out. In the invention, a sandwich structure that a support is arranged between an inner membrane and an outer membrane is adopted; the connection part of the inner membrane and the outer membrane is opposite to a mesh of the supporting frame; and the supporting frame can freely wriggle in the space formed by the disconnection part of the inner membrane and the outer membrane, therefore, the supporting frame capable of being taken out, provided by the invention, has particularly good flexibility; a full covering membrane structure is adopted to ensure that granulation tissues cannot grow into the supporting frame; and a detachable design is adopted to ensure that the supporting frame can be conveniently taken out. The supporting frame capable of being taken out can be used for inducing and promoting the growth of a neonatal cavity tube, the covering and the epithelization of a mucous membrane, can be conveniently taken out and detached under the direct vision of an endoscopy after the mucous membrane of the neonatal cavity tube is epithelized and the organization is stable, and can be used for a temporary support under the situations of esophagus rebuilding and injury repairing, trachea rebuilding and injury repairing, urethra rebuilding and injury repairing, esophagus-esophagus anastomosing, intestine-intestine anastomosing, nasal cavity rebuilding and injury repairing, external auditory canal rebuilding and injury repairing and the like.

The invention discloses an easy-to-stick skin and soft tissue wound attracting and lavaging device which comprises a medical sponge block, build-in tubes and a sticking membrane. The sticking membrane enwraps the whole medical sponge block from the back. The lower surface of the sponge block is a region which is in contact with the wound. The sticking membrane forms a circle of an enclosed blending surface on the periphery of the lower surface to be blended with skin. The build-in tubes which are provided with a plurality of lateral holes are inserted in the sponge block, eduction ends of which are provided with atomseal ports at sticking membrane piercing out parts for maintaining the subpressure in the sponge during the attracting process. The product can carry out the vacuum sealing drainage on the wound and the enclosed lavage on infective wounds, has the advantages of lightness and using convenience and can relieve trivial works of repeated wound cleaning and change dressing of medical staff by one-time operation and achieve cleaning and draining effects better than repeated dressing changes, thereby promoting the infection control on the infective wounds and the rapid growth of granulation tissues.

The invention discloses new dihydroiso-coumarin glucoside compounds shown in a formula I, which are extracted and separated from Periplaneta americanna medicinal materials. Through mouse auricle swelling tests, rat granulation tissue hyperblastosis tests and the like, results show that the compounds have effects of resisting inflammation, promoting wounds to heal and the like; and the compounds can be used for preparing medicines for treating inflammation, ulcers, wounds, incised wounds, fistula, burn, scalding and the like, particularly medicines for preventing and treating diseases related to inflammation resistance, promotion of granulation tissue hyperblastosis, wound healing and the like, and have high clinical application value. The invention provides a preparation method for the compounds shown in the formula I.

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

Provided is a new bionic skin material with multiple functions and a high efficacy. With a compound microporous fibre net structure, the material imitates a skin barrier function, has anti-fouling properties, hygroscopic properties, moisture retention properties, air permeability, flexibility and adhesiveness, and can effectively absorb wound exudate and residues for rapid painless autolysis and debridement, ensure sufficient drainage by bidirectional regulation, maintain a semi-closed, local physiological wet environment favorable for the reparative metabolism and physiological healing of a wound, inhibit inflammation, reduce exudation, benefit the response inside and outside of cells, promote the migration of fibroblasts and epithelial cells of the body itself and the regeneration of granulation tissue and epithelial cells of the wound, accelerate the physiological healing and recovery of the wound, and reduce recurrences. It has been clinically proved that the dressing material can accelerate the healing of acute skin injuries and chronic ulcer wounds, achieve a high healing quality, avoid or reduce traumatic skin grafting to the greatest extent, reduce the pain of patients and the production of scars, and restore the physiological function and appearance of the body.

The invention discloses a silicosis treatment aerosol containing a human mesenchymal stem cell exosome extract and a preparation method thereof, wherein the main component of the aerosol is the high-concentration mesenchymal stem cell exosome extract. The mesenchymal stem cells can secrete various cell factors in the culture process, and the cell factors can penetrate into the basal layer of an inner membrane, promote tissue differentiation of the inner membrane, angiogenesis and growth of granulation tissues, promote regeneration and repair of damaged skin tissue structures, reduce generation of scar connective tissues and reduce bacterial infection and inflammatory reaction of wound surface tissues. According to the aerosol and the preparation method thereof, a method of continuous starvation of the mesenchymal stem cells is adopted, a high-concentration human mesenchymal extract can be obtained in a short period of time, and a big amount of stem cell exosomes can be separated from the mesenchymal extract by an exosome extractor. The aerosol containing the high-concentration mesenchymal stem cell exosome extract disclosed by the invention is suitable for the restoration and treatment of silicosis.

An antipruritic for treating the itch caused by wound scab and prickly heat, and non-ulcer frostbite contains the medical oil prepared from menthol, camphor, thymol, borneol and holly oil, glyoxyldiureide, and matrix.

The invention discloses a personalized airway stent manufacturing technology.A personalized airway stent is manufactured by utilizing a CT image to reestablish an airway stenosis model of a patient, expanding the stenosis of the airway model in three-dimensional numerical model reestablishment software by 20%-40% and then outwards expanding the wall face of the outmost side of the processed airway model by 10% to form the outer wall of the stent.A three-dimensional numerical model of the personalized airway stent is designed through the processing.Finally, the personalized airway stent model is imported into a 3D printer, and silicone and other medical biological materials are injected to manufacture the personalized stent conforming to the airway structure of the patient.Three-dimensional modeling is performed according to airway stenosis of different patients, the personalized airway stents are designed, and the shortcomings and defects that existing commercial airway stents difficultly fit the airways of the patients and granulation tissue proliferation is easily caused are overcome.

The invention provides an external periplaneta americana preparation and a preparation method thereof. The external periplaneta americana preparation can be used for obviously increasing the preservation of periplaneta americana extracts in skins, thus adding granulation tissues and better accelerating wound healing. The external periplaneta americana preparation is used for the surfaces of incised wounds, traumas, ulcers, fistulas, burns, scalds and bedsores as well as inflammations and ulcers of eyes, oral cavities, nasal cavities and vaginal mucosas.

An artificial collagen gel skin is prepared from ox tendon collagen dispersing liquid 80 portions, DMEM culture liquid 10, glutamine solution 1, dicarbonate solution 6 and fetal calf serum 12 through proportionally mixing, adding human embryo skin fibroblast suspension, and external culture.

The present invention is one kind of dermatosis treating medicine and its preparation process. The dermatosis treating medicine is prepared with Chinese goldthread, phellodendron bark, climbing groundsel, gromwell, aloe, vaseline, glycerin and sesame oil in certain proportion. The medicine of the present invention has the functions of diminishing inflammation, relieving pain, drying wetness, astringing, promoting granulation, etc. The medicine has obvious curative effect on baby's napkin area dermatitis, bedsore and scalds,

The invention discloses a skin care composition and a preparation thereof. The skin care composition comprises, by weight, 4%-20% of a chitosan derivative, 4%-20% of trehalose, and 60-92% of glycerol. The skin care composition provided by the invention is broad-spectrum antibacterial, has high moisture retention, provides the growth environment of granulation tissues, protects wound surfaces, promotes the growth of bacteria regulating microecological balance of the human body, facilitates breeding of beneficial bacteria, accelerates wound surface healing, and is low in cost.

The invention discloses a degradable airway stent and application thereof. The degradable airway stent contains 80 percent to 99.5 percent of magnesium element in percentage by weight and at least one of aluminium element, manganese element, zinc element, zirconium element, rare earth element, lithium element, calcium element or silver element. The degradable airway stent can be quickly degraded, thus meeting the requirement of the airway on the degradation rate of the stent, and moreover, because the magnesium alloy stent has excellent biocompatibility, the degradable airway stent has less irritation on tissues and high anti-infection capability. Because the surface of the magnesium alloy stent is processed or coated with degradable material and therapeutic medicine, fibrous tissues cannot grow inwards to form granulation tissues, or tumor cells can be prevented from proliferating to block the airway. In addition, the magnesium alloy stent is porously processed, so that the degradation rate of the magnesium alloy stent can be increased. Consequently, the degradable airway stent can be widely applied in airways.

The invention discloses injectable modified HA (hyaluronic acid), a preparation method for the same and a composition. -OH in -COOH in an HA structural unit is partially substituted by a group shown in the original document, and the substitution rate is not lower than 40 percent. The modified HA can be directly reacted with chitosan to form hydrogel without chemical cross-linking reaction and damage to the structure of the HA. Rheodynamic experiments show that AHA-CS can be prepared into injection, and the formed hydrogel is stable in structure. Animal experiments show that the AHA-CS hydrogel has the effects of accelerating the healing of wounds and promoting cell proliferation and keratinocyte migration. Histological detection for the wounds treated by the hydrogel also proves that the hydrogel has the effect of promoting the formation of granulation tissues and capillaries. The expression of MRNA (messenger ribose nucleic acid) such as a VEGF-A (vascular endothelial growth factor), an SDF-1 (stromal-derived factor-1) and MMPs (matrix metalloproteinases) at the wounds treated by the hydrogel is increased or upregulated. Significantly, new hair follicles are found on the wounds treated by the hydrogel.

The present invention relates to a compound preparation for effectively curing epithelial erosion. Said compound preparation includes 0.05-15% of aloe yellow juice dried product, immunological competent substance, bactericidal / bacteriostatic agent and biological adhesive or mucosal adhesive carrier, in which the described immunological competent substance is freeze-dried aloe gel product or aloe gel spray-dried product, the described bactericidal / bacteriostatic agent is one kind of chlorhexidine digluconate, chlorhexidine acetate and new benzalkonium chloride or several kinds of them, and the described biological adhesive or mucosal adhesive carrier includes one of hydroxypropyl methyl cellulose, carbomer, alginate, pectine, xylose polyglucosan and polycarbophil or several kinds of them. Said invention also provides its correspondent preparation method, and said compound preparation can be used for effectively curing the diseases of female genital viral and bacterial infection and cervical erosion, etc.

The invention provides a continuous negative-pressure drainage device capable of intermittently inflating and flushing and belongs to the technical field of medical instruments in the orthopedics department. The device is used for continuous negative-pressure drainage, that is, inflating and flushing are intermittently conducted on the surface of a wound. The device is characterized in that a negative-pressure drainage pipe is connected with an inflating pipe and a flushing water pipe, an air inlet end of the inflating pipe and an water inlet end of the flushing water pipe are connected with an oxygen delivery pipe and a flushing water pipeline respectively, the inflating pipe and the flushing water pipe are provided with electric control valves respectively, and the electric control valves are connected with a programmable controller respectively. According to the device, oxygen and physiological saline are supplied intermittently, anaerobic bacteria infection can be inhibited, exudate and contaminated tissue can be cleared away, repeated debridement is avoided, when oxygen supply and flushing are conducted, a continuous negative pressure environment can be created, exudate and necrotic tissue of the wound can be timely cleared away and drained, the local microcirculation is improved, relieving of edema of soft tissue is promoted, the growth of granulation tissue is stimulated, wound healing is accelerated, a good condition is provided for the follow-up treatment, and the treatment process is sped up.

The invention relates to a wound-protecting product with disposable negative pressure drainage, which mainly comprises a sponge block (1) and a drainage tube (2), wherein the sponge block adopts carboxymethyl chitosan / polyvinyl alcohol compound sponge; the drainage tube is at least one; a body of each drainage tube is provided with a plurality of drainage holes (3); and parts of drainage holes ofthe drainage tube are inserted into the sponge block along the horizontal direction of the sponge block. The wound-protecting product is clinically matched with a special negative pressure pump for use, has the advantages of fast wound surface healing, low infection rate, less times of exchanging dressing, little use of antibacterial drug, reduced medical cost and the like compared with the conventional open-type drug exchanging, and is mainly used for body surface wounds, burns, granulation tissues and the like clinically.

The invention discloses a medicine for external application for treating pyogenic type contaminated wounds, which is characterized by comprising the following raw materials in the proportion by weight: 20-60 of catechu, 15-45 of dragon blood, 25-60 of prepared frankincense, 25-60 of prepared myrrh, 50-150 of calcined dragon bone, 60-200 of calcined gypsum, 20-60 of red halloysite, 40-80 of pearl, 0.5-1.0 of musk, 2-5 of borneol and 2-5 of calomel. The medicine for external application has the efficacies of diminishing inflammation and relieving pain, removing necrosis and promoting granulation, promoting discharge of venom, increasing the amount of blood supply, activating cell growth, accelerating growth of granulation tissue and promoting wounds to heal quickly. The medicine for external application is used for treating various pyogenic type contaminated wounds of dermis, fat, muscle, aponeurosis and periosteum. After clinical application for many years, the medicine for external application has good treating effect, and the healing rate reaches 90 percent. The course of treatment is generally ten days to two months, the healed wounds have unobvious scars, and patients have slight or no functional disorder.

The invention provides an optical wound therapy apparatus comprising light sources, a controller body, a PCB, a top cover, a bottom cover, a radiator and other related structural components. The therapy apparatus is internally equipped with blue (400nm to 490nm), red (600nm to 690nm) and near-infrared (780nm to 970nm) low-power laser lamps or ultra-bright LED light sources, and adopts a mode of comprehensive radiation therapy. The therapy apparatus has the effect of infection clearing, bacteria inhibiting, inflammatory absorption promoting and pain alleviating, and can improve blood circulation, promote granulation tissue maturing, make skin cells grow at the rate of 3-5 times and significantly improve the healing rate of injured tissues. The therapy apparatus has a lighting regulation function, and appropriate lighting parameters can be chosen flexibly to illuminate injured tissue parts according to different biological organisms or different statuses and different symptoms of organisms to affect the biological system. Thus, the work intensity of the nursing staff is lightened greatly, and the workload is reduced.

The invention relates to ointment for treating sore and ulcer and a preparation method of the ointment. The ointment for treating the sore and ulcer is prepared from the following raw materials in parts by weight: 15 to 17 parts of radix angelicae dahuricae, 30 to 35 parts of liquorice root, 30 to 35 parts of Chinese angelica, 6 to 8 parts of radix lithospermi, 3 to 4 parts of sanguis draconis, 3 to 4 parts of calomel, 500 parts of sesame oil and 32 to 35 parts of bee wax. The preparation method of the ointment comprises the following steps: sufficiently soaking the radix angelicae dahuricae, the liquorice root, the Chinese angelica and the radix lithospermi into the sesame oil; heating until black smoke coms out and the surface of the radix angelicae dahuricae becomes black; stopping heating and filtering to remove medicine dreg, so as to obtain medicine liquid; adding the bee wax into the medicine liquid when the medicine liquid is hot and dissolving; after cooling, adding sanguis draconis powder and calomel powder, and uniformly mixing. The ointment provided by the invention can be used for effectively inhibiting reproduction of harmful bacteria on wounds and promoting the growth of granulation tissues on the wounds; the ointment can be used for burns, scalds and various injury skin infection, can also be used for deep skin tissue ulcer which is not healed after being treated for long time, has a high healing rate and can be stored for long time.

The present invention relates to a Chinese medicine for curing colitis and its preparation method. Said medicine is an oral preparation made up by using 18 Chinese medicinal materials of drynaria root, phellodendron bark, white peony root, ovate atractylodes root, solidago, lindera root, condonopsis root, copperleaf and others through the processes of pulverizing, extraction with ethyl alcohol, decocting, concentration, vacuum drying and pulverizing, and the pharmacodynamic tests show that said medicine has the functions of regulating immunity, resisting inflammation, regulating bowel movement and stopping pain.