64 results about "Granulation tissue" patented technology

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The present application relates to the technical field of medical devices, and provides a drainage tube and a drainage apparatus. The drainage tube comprises a drainage portion, a porous loose structure, and a granulation tissue blocking structure. The drainage portion is provided with a first drainage channel, and is further provided with a first drainage hole. The first drainage hole is in communication with the first drainage channel. The porous loose structure is wrapped around the drainage portion. The granulation tissue blocking structure is wrapped around the porous loose structure and is provided with a second drainage hole. The second drainage hole, the porous loose structure, the first drainage hole, and the first drainage channel are in communication. By providing the granulation tissue blocking structure, the drainage tube can, while satisfying negative pressure suction, prevent granulation tissue from growing into the porous loose structure, thereby reducing bleeding of granulation tissue and improving the therapeutic effect of negative pressure drainage.

The present application relates to the technical field of clinical nursing, and specifically discloses a clinical nursing wound cleaning device, which comprises a negative pressure wound therapy instrument, and further comprises a negative pressure adsorption mechanism arranged on the negative pressure wound therapy instrument and used for adsorbing and cleaning a wound surface of a patient, and has at least the following beneficial effects: the negative pressure adsorption mechanism can be closely attached to the wound surface by means of an attached cover, thereby avoiding negative pressure leakage, improving adsorption efficiency and debridement effect, and using a negative pressure pump can efficiently adsorb and collect wound secretions and necrotic tissues, ensure complete debridement, and replace traditional mechanical debridement with negative pressure adsorption, which causes less damage to the wound surface and newly generated granulation tissue, significantly reduces the pain of the patient, and balances debridement effect and nursing safety, thereby meeting the fine cleaning requirements of various wounds in clinical practice.

The invention provides a burn medicine formula and a preparation method thereof, and relates to the technical field of burn medicines, the burn medicine formula comprises a first component medicine and a second component medicine, the first component medicine comprises 45-50 parts of Eurya camara; 30 to 45 parts of platycarya strobilacea bark; 5-15 parts of rice skin; 5 to 15 parts of aloe; 5-15 parts of June cold; the second component medicine comprises tung catalpa or sesame. Eurya emarginata, platycarya strobilacea bark, rice peel, aloe, June herb and other components are mixed to prepare a first medicine, tung catalpa or sesame is squeezed to form a second medicine, the first medicine and the second medicine are uniformly stirred and mixed to be smeared to the wound of a patient in the use process, and all the components cooperate and promote each other, so that the effect of treating the wound is achieved. And the liquid medicine can quickly permeate into the deep layer of the skin, soften the skin, dredge nerves and blood vessels, prevent adhesion and inflammation, gradually soften the wounded part, achieve the effects of clearing away fire, promoting blood circulation, relieving pain, astringing, promoting granulation and accelerating normal growth of tender granulation, the recovery process is intact, and scars and lumps are not easy to remain.

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

The application discloses application of miR-30a-5p in preparation of a product for treating airway stenosis. The application finds that miR-30a-5p plays an important regulatory role between airway basal stem cells and airway fibroblasts, and through the carrying of extracellular vesicles, miR-30a-5p is transmitted from the airway basal stem cells to the airway fibroblasts, targets and regulates the expression of a key gene FAP, inhibits the activation of the airway fibroblasts, reduces the collagen gel contraction ability of the airway fibroblasts, improves the extracellular matrix remodeling of the airway fibroblasts, can effectively stabilize the tracheal granulation tissue, prevents the recurrence of airway stenosis, and has application value for treating airway stenosis.

This application relates to the fields of biomedicine and wound repair technology, and particularly to the application of platelet exosomes in the treatment of diabetic wound healing. This application discloses the use of platelet exosomes in the preparation of products having one or more of the following functions: 1) prevention and / or treatment of diabetic foot; 2) promotion of wound healing and / or tissue repair; 3) shortening wound healing time; 4) promoting granulation tissue growth; 5) enhancing wound angiogenesis; 6) alleviating inflammatory responses; 7) inhibiting the expression of pro-inflammatory factors; 8) promoting the expression of anti-inflammatory factors; 9) reducing MMP-9 expression; and 10) increasing MMP-2 expression. It is particularly suitable for the treatment of diabetic foot ulcers, delayed wound healing, and related complications, and also covers the use of this product in the preparation of diabetic foot treatment drugs and medical dressings.

The utility model relates to periodontal surgery technical field, especially a kind of periodontal surgery granulation tissue removal instrument set, including, placing tray, the placing tray is provided with the adaptation area that can place six appliances, the placing tray includes the square open-bottom portion with waist line type, and the limiting plate is set in its inner cavity two sides, the rotating handle is movably provided in the length direction both ends of placing tray;Six The appliance is bone defect granulation removal instrument and alveolar crypt granulation removal instrument respectively.The application scheme can effectively help doctor to realize the removal of granulation tissue in clinical process, reduce the influence of residual granulation tissue on periodontal tissue and bone regeneration, reduce the muscle fatigue of doctor, improve the debridement efficiency and regeneration success probability.

This utility model discloses a protective anal tube for rectal anastomosis after surgery, relating to the field of medical device technology. It solves the initial problem of the need to develop a protective anal tube for rectal anastomosis after surgery that has three-dimensional isolation, facilitates negative pressure drainage, and has a biological barrier function. The utility model includes a tube body with two support members on it for supporting the intestine. Both support members are capable of mechanical deformation, and the contact surfaces between the two support members and the intestine are annular, which can support both sides of the intestinal anastomosis. Thus, a cavity is formed between the two support members and the anastomotic segment of the intestine. The purpose is that the two support members form a physical barrier through the annular contact surfaces, completely preventing the leakage of intestinal contents into the anastomotic area, avoiding contamination of the wound by feces and digestive juices, maintaining a moist environment, and promoting the migration of epithelial cells and the growth of granulation tissue.

The invention provides a process for preparing a Biochanin A (BCA)-loaded hydroxypropyl methyl cellulose (HPMC) hydrogel aimed at promoting wound healing in diabetic patients. The hydrogel is prepared by dispersing HPMC in distilled water, followed by dissolving BCA into the mixture with continuous stirring, then storing under refrigeration. The therapeutic potential of Biochanin A (BCA) in promoting wound healing, is evaluated in rats induced with diabetes. The results showed that the BCA-loaded hydrogel accelerates diabetic wound repair by boosting antioxidant defenses via upregulating Nrf2 and related enzymes, suppressing inflammatory markers such as IL-1β, IL-6, TNF-α, COX-2, and TLR4, and stimulating angiogenesis through increased expression of TGF-β1, VEGF-A, and PDGFR. It promotes faster wound contraction, re-epithelialization, collagen deposition, granulation tissue formation, and neovascularization, potentially reducing the risk of complications like limb amputation. The invention offers a promising therapeutic approach for treating chronic diabetic wounds with improved healing outcomes.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.

The application discloses a kind of wound repair composite preparation based on FGF2 variant and its application, it is related to the technical field of skin wound repair biological preparation, the composite preparation is composed of active ingredient and matrix, the active ingredient is FGF2 mutant, the matrix is cream.The FGF2 mutant is NGF2 protein, the NGF2 protein is obtained by protein engineering technology to natural FGF2 is reformed;The NGF2 protein has high thermal stability and extended normal temperature half-life.The cream is preferably water cream (Basic Aquacream).In the application, NGF2 and water cream synergistically, extend the local action time of protein, realize the effect of reducing the frequency of smearing, enhance repair durability.Preparation can effectively promote wound granulation tissue formation, angiogenesis and collagen remodeling, improve healing quality and reduce scar, provide reliable scheme for the development of new generation wound repair biological preparation.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

The invention discloses a scald ointment for diminishing inflammation and swelling and promoting healing and a preparation method thereof. The emu oil is prepared from the following raw materials: peony seed oil, borage oil, evening primrose oil, perilla seed oil, shea butter, rose hip oil, emu oil, linseed oil, coconut oil, palm oil, horse oil, zedoary turmeric oil, safflower seed oil, pine needle oil, a paniculate spotflower herb alcohol extract, a paniculate spotflower herb water extract, lygodium japonicum, polygonatum polysaccharide, a blackberry lily extracting solution, a jerusalem artichoke extracting solution, a lavender extracting solution and a rhodiola rosea extracting solution. The formula comprises a radix zanthoxyli extracting solution, lanolin, methylparaben, granular paraffin and ethanol. The traditional Chinese medicine composition is natural and mild in components, small in skin irritation, safe to use, capable of deeply permeating, locking moisture, rapid in effect taking and capable of remarkably inhibiting inflammatory response, relieving tissue redness and swelling, shortening the healing period, providing a moist environment for tissue repair, continuously nourishing periinvasive tissue, promoting granulation tissue growth and accelerating the epithelization process, so that damaged skin is effectively repaired; good clinical application prospects and market potential are realized.

The invention discloses scald ointment with a superstrong healing function, and relates to the field of scald ointment. According to the scald ointment with the super-strong healing function, the honey can keep a wound moist, reduce pain and prevent infection; the garden burnet has the effects of astringing to stop bleeding, diminishing inflammation and detoxifying, and can relieve edema, relieve pain and promote granulation tissue growth when being used for scalds; the radix arnebiae seu lithospermi has the effects of clearing away heat and toxic materials and cooling and activating blood and can promote cell regeneration, diminish inflammation and repair damaged skin; the coptis chinensis has relatively strong antibacterial and anti-inflammatory effects and is suitable for preventing and controlling scald infection; scutellaria baicalensis has the effects of clearing heat, drying dampness, purging fire and removing toxin, and is cooperated with coptis chinensis to enhance the antibacterial and anti-inflammatory effects and relieve the heat toxin symptom caused by scald; borneolum syntheticum has the effects of cooling, relieving pain and diminishing inflammation, can immediately relieve pain and burning heat caused by scald, and promotes transdermal absorption of the medicine; all the components interact to remarkably improve the healing speed of the wound surface, and the formula adopts natural components and is small in side effect and rapid in comprehensive effect.

The invention discloses a burn wound negative pressure treatment and medicine perfusion combined drainage device which comprises a shell, a negative pressure mechanism, an infusion mechanism, a drainage opening, a supporting mechanism, a pressing mechanism and an adsorption mechanism, a rotating ring is installed at the top of the shell, and a guide column is arranged on the inner wall of the rotating ring; the supporting mechanism is fixed in the shell and provided with a supporting channel, and the negative pressure mechanism penetrates through the supporting channel. A drainage opening is formed in the surface of the shell; the negative pressure mechanism comprises a connecting port, a negative pressure pipeline and a protruding block, and the connecting port is formed in the top of the negative pressure pipeline. Therefore, negative pressure treatment of the wound surface and medicine perfusion can be carried out synergistically, and wound surface infection can be controlled in time; a negative pressure system does not need to be disassembled and assembled in each time of perfusion, operation is greatly simplified, medical care burden is relieved, frequent operation on a wound surface is reduced, damage to new granulation tissue is avoided, pain of a patient is relieved, and the risk of secondary pollution caused by repeated exposure of the wound surface is reduced.

The utility model relates to the technical field of medical instruments, and provides an oral cavity alveolar nest granulation tissue separator which comprises a holding cylinder, an adjusting column is movably inserted into the inner side of the holding cylinder, a fixing plate is fixed to the edge of one side wall of the adjusting column, a fixing disc is fixed to the edge of one side wall of the fixing plate, and a connecting ring is movably inserted into the outer side of the fixing disc. A cutter is fixed to the outer wall of the connecting ring, a moving groove is formed in the other edge of one side wall of the adjusting column, and a containing groove is formed in the middle of the inner wall of one side of the moving groove. The adjusting column can move on the inner side of the holding cylinder to adjust the overall length, the connecting ring can rotate between the fixed plate and the movable plate to adjust the angle of the cutter, and therefore a doctor can conveniently operate and cut alveolar fossa granulation at different positions in the oral cavity of a patient, the connecting ring can be conveniently detached, and operation is convenient. The cutter is prevented from being abraded due to long-time use, the service life is prolonged, and the use cost is reduced.

The application relates to the technical field of medical devices, and particularly discloses a nursing auxiliary device for a general surgery department, which comprises a rack, a water receiving hopper is fixedly connected to the middle part of the top left side of the rack, a flushing assembly is arranged at the right side of the water receiving hopper on the top of the rack, the flushing assembly comprises a fixing frame fixedly connected to the top of the rack and located at the right side of the water receiving hopper, a fixing cylinder is fixedly connected to the middle part of the fixing frame, a flexible pipeline is arranged at the bottom of the fixing cylinder, a water spraying cover is fixedly connected to the end of the flexible pipeline away from the fixing cylinder, through cooperation of the above structure, the flow rate can be conveniently adjusted, the pressure during flushing does not change because the physiological saline flows out by gravity, damage to the wound bed caused by excessive flushing pressure is avoided, especially for fragile tissues or newly formed granulation tissues, and the influence on the nursing effect is reduced, meanwhile, convenient adjustment of the flow rate can avoid excessive flow rate during cleaning, and physiological saline is prevented from being wasted.

The application relates to the technical field of nanofiber membrane technology, and particularly relates to an electrospun nanofiber membrane loaded with seaweed polysaccharide and application of the electrospun nanofiber membrane as a skin wound dressing, which comprises the following steps: dissolving polyvinyl alcohol powder in deionized water, heating and stirring until complete dissolution to form a transparent glue solution, adding carboxymethyl agarose and sodium alginate in proportion, adding CaSO4, MgCl2 and ZnCl2 to prepare a hydrogel precursor solution; blending the hydrogel precursor solution with a modified polyurethane solution to obtain a blended solution, adding silver nitrate solution into artemisia extract to obtain a mixed solution, mixing the blended solution with the mixed solution to obtain a spinning solution, and obtaining the electrospun nanofiber membrane loaded with seaweed polysaccharide through an electrospinning technology. After the prepared electrospun nanofiber membrane loaded with seaweed polysaccharide absorbs exudate, a soft hydrogel is formed on the side in contact with the wound, so that adhesion with new granulation tissue is avoided.

The hydrophilic and hydrophobic Janus membrane comprises a hydrophobic fiber layer and a hydrophilic fiber layer loaded with metal-ellagic acid nanoparticles, and the metal-ellagic acid nanoparticles comprise ellagic acid and metal ions which are connected through coordinate bonds. Metal-ellagic acid nanoparticles are synthesized through a self-assembly reaction, the particles are loaded on a hydrophilic fiber layer through a high-voltage electrostatic spinning technology, the hydrophilic and hydrophobic Janus membrane which can continuously release ellagic acid and has antioxidant, antibacterial and directional drainage and seepage functions is obtained, bacterial growth can be inhibited, the free radical level can be reduced, and the antibacterial effect can be improved. Meanwhile, wound exudate is led out. In addition, the Janus membrane loaded with the metal-ellagic acid nanoparticles can effectively promote the repair of granulation tissues, the deposition of wound collagen and the acceleration of the crawling of epithelium, and can inhibit the expression of MMP-9 at the wound of diabetes mellitus.

The invention discloses an oral and maxillofacial infection drainage device for tumor patient nursing, and relates to the technical field of postoperative drainage nursing. The application is fixed to the bottom end of the fixing base and used for being attached to a wound surface; the drainage tube is connected to the fixed seat in a sliding manner and can be axially drawn and pulled; the liquid filling bag is coaxially arranged in the drainage tube; the liquid suction pipe is fixed to the fixing base, and a liquid suction cavity is formed in the liquid suction pipe; the piston is arranged in the liquid suction cavity; and a barrier sheet. When the oral and maxillofacial infection drainage device for tumor patient nursing is used, an operator does not need to respectively operate an anti-blocking device, and only needs to observe and rotate a knob according to a healing stage to enable a piston to be aligned with a corresponding scale, so that suction pressure can be adjusted according to a disease course; granulation tissues are prevented from growing and being adhered to the drainage tube, so that the traction pain of a patient when the drainage tube is pulled out is reduced.

The invention relates to the technical field of medical care instruments, and discloses a wound surface flushing device of a pre-filled flexible porous catheter and a flushing method thereof.The wound surface flushing device of the pre-filled flexible porous catheter comprises a supporting plate, a needle cylinder is fixedly connected to the bottom of the supporting plate, a liquid outlet pipe is fixedly connected to the bottom of the needle cylinder, and the liquid outlet pipe is fixedly connected to the bottom of the needle cylinder; a soft guide pipe is fixedly connected to the bottom of the liquid outlet pipe, a round guide head is fixedly connected to the end, away from the liquid outlet pipe, of the soft guide pipe, side holes are evenly formed in the end, close to the round guide head, of the soft guide pipe, a protection cover is arranged on the outer wall of the end, close to the round guide head, of the soft guide pipe, and a supporting assembly is installed on one side of the supporting plate. The pre-filling type design is adopted for the needle cylinder, the steps of liquid preparation and liquid extraction are omitted, the rounded guide head cannot puncture granulation tissue, impact pain caused by water flow to a wound surface is avoided through the side holes, the soft catheter can go deep into a deep sinus tract or a sneaking cavity which cannot be reached by a traditional instrument, and the situation of accidental injection is effectively avoided through the supporting assembly.

The invention relates to the technical field of biological antibacterial drugs, in particular to application of polylactic acid and berberine in preparation of microneedles for preventing or treating acnes, biodegradable polylactic acid (PLA) has good biocompatibility and film-forming property and is used as a drug delivery carrier. Berberine serving as a Chinese herbal medicine active ingredient is proved to have multiple effects of broad-spectrum antibiosis, anti-inflammation and healing promotion as a natural alkaloid. Berberine and PLA are compounded to construct an intelligent collaborative treatment system; a PLA nano-carrier can realize controllable and slow release of berberine on a wound surface, and the action time is prolonged; the combination of the two can not only efficiently resist bacterial infection and relieve inflammatory response, but also jointly promote granulation tissue growth and epithelial regeneration, and provides a new direction with a great prospect for developing green wound dressing for replacing or reducing use of antibiotics.

The invention belongs to the technical field of wound nursing, and discloses a wound nursing guidance system for remote synchronous video recognition, which comprises a video acquisition module, an AR measurement module, a dual-channel calculation module, a data fusion module and a specified suggestion generation module, the video acquisition module is used for performing video data acquisition work; the AR measurement module can dynamically superpose a preset virtual scale template in a corrected video image frame, and the dual-channel calculation module is used for calculating a wound necrosis regression rate and a granulation growth slope through dynamic indexes and quantifying a wound change trend, a sneaking depth and a flaccid paralysis node through a parallel processing mechanism. The AR measurement module augmented reality overlaps a virtual scale, the length, width, area, volume, sneaking, sinus tract and flaccidity duct parameters of a wound are accurately marked in a real-time video stream, meanwhile, the wound necrosis regression rate and the granulation growth slope are calculated through the two-channel calculation module, the wound change trend, sneaking depth and flaccidity duct nodes are quantified, and the wound necrosis regression rate and the granulation growth slope are calculated through the two-channel calculation module. The rate evolution track of the wound of the patient can be conveniently monitored.

The invention belongs to the technical field of biomedical material preparation, and particularly relates to a preparation method and application of dendrobium officinale combined multifunctional ion hydrogel. The invention particularly relates to a preparation method of multifunctional conductive, antibacterial, anti-inflammatory and antioxidant drug sustained-release ionized water gel prepared by combining a main chain of modified sodium alginate loaded with dendrobium officinale with a main chain of polyionic liquid with amino, and application of the multifunctional conductive, antibacterial, anti-inflammatory and antioxidant drug sustained-release ionized water gel in drugs for promoting healing of wounds infected with diabetes mellitus. The dendrobium officinale ion hydrogel OP (at) DO disclosed by the invention shows a treatment effect which is far superior to that of a commercial 3M TegadermTM film on wound healing rate, granulation tissue thickness, tissue and blood vessel regeneration condition and growth factor content in treatment of a diabetes wound surface infected skin injury model.

The invention discloses an agilawood combined extract and application of the agilawood combined extract in oral care, and belongs to the technical field of oral care. 15%-20% of a lavender extract; 15%-25% of a pseudo-ginseng root extract; 15%-25% of a radix scutellariae extract; 5%-8% of a surfactant; 0.5%-1% of a soothing anti-allergy agent and the balance of a water-based matrix component. Through scientific compatibility of four plant extracts of agilawood, lavender, pseudo-ginseng and scutellaria baicalensis, the agilawood and lavender exert anti-inflammatory, analgesic and soothing effects; pseudo-ginseng has the effects of promoting blood circulation to remove blood stasis, improving ulcer local microcirculation and promoting granulation tissue growth; scutellaria baicalensis has a strong broad-spectrum antibacterial and antiviral effect and controls secondary infection, the four components cooperate, a plurality of links of inflammation diminishing, pain easing, antibacterial and healing promoting act comprehensively, and the effect is superior to that of a single component or a simple compound aiming at the complex pathological mechanism of oral ulcer.

The invention provides a biological dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: thawing in still water; unhairing and degreasing; cutting and segmenting; fine trimming and punching; performing iodophor soaking treatment; soaking in purified water; soaking in a mixed solution of protease and alkali metal hydroxide; soaking in purified water; antibacterial agent brushing treatment is carried out; and packaging and irradiating. The product obtained by the invention can be used for purifying, cleaning and protecting wound surfaces, promoting granulation tissue growth, covering granulation wound surfaces, chronic ulcers and bedsores, shortening the healing time and improving the healing effect.

The invention relates to the technical field of medical equipment, and provides a micro-aerobic pressurization negative pressure wound therapy device which comprises a wound mask body which comprises a covering face and an upper end face, the covering face is concaved inwards to form a micro-aerobic therapy cavity, and an oxygen supply port, a negative pressure port and a cleaning port are formed in the outer wall of the wound mask body; the oxygen supply port, the negative pressure port and the cleaning port are all communicated with the micro-aerobic treatment chamber; an oxygen supply mechanism, a negative pressure mechanism and a cleaning fluid pumping mechanism are arranged on the oxygen supply main machine, and the oxygen supply mechanism, the negative pressure mechanism and the cleaning fluid pumping mechanism are detachably connected with the oxygen supply port, the negative pressure port and the cleaning port through pipelines respectively; a normally-closed one-way valve is arranged on the wound mask body, and the micro-aerobic treatment cavity is communicated towards the outside in a one-way mode through the normally-closed one-way valve. The micro-oxygen supply mode and the cleaning mode can alternately supply oxygen to and clean wounds of patients, granulation tissue growth and epithelization processes can be accelerated, the infection risk is reduced, and the healing efficiency and quality of chronic wounds can be remarkably improved.