90 results about "Granulation tissue" patented technology

The embodiment of the invention provides a drainage tube and a drainage device, and relates to the technical field of medical instruments. The drainage tube comprises a drainage part, a porous loose structure and a granulation blocking structure, the drainage part is provided with a first drainage channel, the drainage part is provided with a first drainage hole, and the first drainage hole is communicated with the first drainage channel; the porous loose structure wraps the drainage part, the granulation blocking structure wraps the porous loose structure, and second drainage holes are formed in the granulation blocking structure; and the second drainage holes, the porous loose structure, the first drainage holes and the first drainage channels are communicated. According to the drainage tube, by arranging the granulation blocking structure, granulation can be blocked from growing into the porous loose structure while negative pressure adsorption is met, so that the condition of granulation tissue bleeding is reduced, and the treatment effect of negative pressure drainage is improved.

The utility model provides a curettage tool for apical surgery, which comprises a handle, a neck part and a curettage head, the handle is connected with the curettage head through the neck part, the neck part is bent by 80-100 degrees, the curettage head is shovel-shaped, and one end of the curettage head far away from the neck part is provided with a tip. Through the shovel-shaped design of the digging spoon head, the digging spoon can extend into the position where tooth roots are difficult to scrape, and the problem that the included angle between the root tip lesion lingual side and the tooth surface is an acute angle and is difficult to scrape thoroughly is solved. By means of the specially designed angle, diseased tissues right behind and behind the tooth root can be scraped more effectively, residues of granulation tissues can be reduced, the healing speed of root apex bone defects is increased, and the operation efficiency is improved.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention relates to the field of biological dressings, and discloses an artificial dermis dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: adding water into a container, and freezing until the water is frozen; then adding a collagen A solution, freezing and standing; continuing to add collagen B liquid, freezing and standing; continuing to add collagen A liquid, freezing and then freeze-drying; and cross-linking in a glutaraldehyde solution, and cleaning to obtain the artificial dermis dressing. The dressing provided by the invention can provide a good stent effect and promote cell migration and proliferation, and the healing rate is close to 100% after wound making. In the wound healing process, the dressing can inhibit collagen deposition, relieve inflammatory response, inhibit abnormal hyperplasia of blood vessels, inhibit excessive proliferation of fibroblasts and excessive formation of granulation tissues, and effectively prevent scar formation. The dressing can also effectively inhibit abnormal vascular hyperplasia in a wound area, and fibrosis and scar hyperplasia caused by excessive vascular hyperplasia are prevented.

A wound assessment method is provided. The wound assessment method includes receiving an image that includes an L-shaped color calibration card and a wound; performing an image preprocessing on the image, based on the L-shaped color calibration card, to obtain an adjusted image, where the image preprocessing includes a distortion correction and a color calibration; obtaining a wound image excluding the L-shaped color calibration card, based on the adjusted image, where the wound image includes a plurality of regions; and classifying each of the plurality of regions of the wound image into one of wound tissue types, to obtain a wound tissue type distribution of the wound, where the wound tissue types include a granulation tissue, a slough tissue, and an eschar tissue.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The present application relates to the technical field of medical devices, and provides a drainage tube and a drainage apparatus. The drainage tube comprises a drainage portion, a porous loose structure, and a granulation tissue blocking structure. The drainage portion is provided with a first drainage channel, and is further provided with a first drainage hole. The first drainage hole is in communication with the first drainage channel. The porous loose structure is wrapped around the drainage portion. The granulation tissue blocking structure is wrapped around the porous loose structure and is provided with a second drainage hole. The second drainage hole, the porous loose structure, the first drainage hole, and the first drainage channel are in communication. By providing the granulation tissue blocking structure, the drainage tube can, while satisfying negative pressure suction, prevent granulation tissue from growing into the porous loose structure, thereby reducing bleeding of granulation tissue and improving the therapeutic effect of negative pressure drainage.

The present application relates to the technical field of clinical nursing, and specifically discloses a clinical nursing wound cleaning device, which comprises a negative pressure wound therapy instrument, and further comprises a negative pressure adsorption mechanism arranged on the negative pressure wound therapy instrument and used for adsorbing and cleaning a wound surface of a patient, and has at least the following beneficial effects: the negative pressure adsorption mechanism can be closely attached to the wound surface by means of an attached cover, thereby avoiding negative pressure leakage, improving adsorption efficiency and debridement effect, and using a negative pressure pump can efficiently adsorb and collect wound secretions and necrotic tissues, ensure complete debridement, and replace traditional mechanical debridement with negative pressure adsorption, which causes less damage to the wound surface and newly generated granulation tissue, significantly reduces the pain of the patient, and balances debridement effect and nursing safety, thereby meeting the fine cleaning requirements of various wounds in clinical practice.

The invention provides a burn medicine formula and a preparation method thereof, and relates to the technical field of burn medicines, the burn medicine formula comprises a first component medicine and a second component medicine, the first component medicine comprises 45-50 parts of Eurya camara; 30 to 45 parts of platycarya strobilacea bark; 5-15 parts of rice skin; 5 to 15 parts of aloe; 5-15 parts of June cold; the second component medicine comprises tung catalpa or sesame. Eurya emarginata, platycarya strobilacea bark, rice peel, aloe, June herb and other components are mixed to prepare a first medicine, tung catalpa or sesame is squeezed to form a second medicine, the first medicine and the second medicine are uniformly stirred and mixed to be smeared to the wound of a patient in the use process, and all the components cooperate and promote each other, so that the effect of treating the wound is achieved. And the liquid medicine can quickly permeate into the deep layer of the skin, soften the skin, dredge nerves and blood vessels, prevent adhesion and inflammation, gradually soften the wounded part, achieve the effects of clearing away fire, promoting blood circulation, relieving pain, astringing, promoting granulation and accelerating normal growth of tender granulation, the recovery process is intact, and scars and lumps are not easy to remain.

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

The utility model discloses an alveolar fossa granulation tissue clamp which comprises two clamp bodies (1) which are connected in a hinged mode, clamp handles (2) are arranged at the tail ends of the clamp bodies (1), bending rods (4) are arranged at the ends of the clamp bodies (1), fixing pieces (5) are arranged at the ends of the bending rods (4), connecting rods (3) are arranged at the front ends of the clamp bodies (1), and round holes (6) are formed in the front fixing pieces (5) of the connecting rods (3). And a tong head (7) is arranged at the end part of the fixing sheet (5). According to the utility model, granulation tissues can be stably clamped, and meanwhile, the rotatable forceps heads can be used for clamping granulation tissues in alveolar sockets with different shapes, so that the use flexibility is improved.

The application discloses application of miR-30a-5p in preparation of a product for treating airway stenosis. The application finds that miR-30a-5p plays an important regulatory role between airway basal stem cells and airway fibroblasts, and through the carrying of extracellular vesicles, miR-30a-5p is transmitted from the airway basal stem cells to the airway fibroblasts, targets and regulates the expression of a key gene FAP, inhibits the activation of the airway fibroblasts, reduces the collagen gel contraction ability of the airway fibroblasts, improves the extracellular matrix remodeling of the airway fibroblasts, can effectively stabilize the tracheal granulation tissue, prevents the recurrence of airway stenosis, and has application value for treating airway stenosis.

This application relates to the fields of biomedicine and wound repair technology, and particularly to the application of platelet exosomes in the treatment of diabetic wound healing. This application discloses the use of platelet exosomes in the preparation of products having one or more of the following functions: 1) prevention and / or treatment of diabetic foot; 2) promotion of wound healing and / or tissue repair; 3) shortening wound healing time; 4) promoting granulation tissue growth; 5) enhancing wound angiogenesis; 6) alleviating inflammatory responses; 7) inhibiting the expression of pro-inflammatory factors; 8) promoting the expression of anti-inflammatory factors; 9) reducing MMP-9 expression; and 10) increasing MMP-2 expression. It is particularly suitable for the treatment of diabetic foot ulcers, delayed wound healing, and related complications, and also covers the use of this product in the preparation of diabetic foot treatment drugs and medical dressings.

The utility model relates to periodontal surgery technical field, especially a kind of periodontal surgery granulation tissue removal instrument set, including, placing tray, the placing tray is provided with the adaptation area that can place six appliances, the placing tray includes the square open-bottom portion with waist line type, and the limiting plate is set in its inner cavity two sides, the rotating handle is movably provided in the length direction both ends of placing tray;Six The appliance is bone defect granulation removal instrument and alveolar crypt granulation removal instrument respectively.The application scheme can effectively help doctor to realize the removal of granulation tissue in clinical process, reduce the influence of residual granulation tissue on periodontal tissue and bone regeneration, reduce the muscle fatigue of doctor, improve the debridement efficiency and regeneration success probability.

This utility model discloses a protective anal tube for rectal anastomosis after surgery, relating to the field of medical device technology. It solves the initial problem of the need to develop a protective anal tube for rectal anastomosis after surgery that has three-dimensional isolation, facilitates negative pressure drainage, and has a biological barrier function. The utility model includes a tube body with two support members on it for supporting the intestine. Both support members are capable of mechanical deformation, and the contact surfaces between the two support members and the intestine are annular, which can support both sides of the intestinal anastomosis. Thus, a cavity is formed between the two support members and the anastomotic segment of the intestine. The purpose is that the two support members form a physical barrier through the annular contact surfaces, completely preventing the leakage of intestinal contents into the anastomotic area, avoiding contamination of the wound by feces and digestive juices, maintaining a moist environment, and promoting the migration of epithelial cells and the growth of granulation tissue.

The invention discloses a bi-crosslinked chitosan derivative antioxidant hydrogel as well as a preparation method and application thereof. The structure of the hydrogel comprises chitosan modified by 2, 3-dihydroxybenzoic acid and phosphate, and the chitosan modified by 2, 3-dihydroxybenzoic acid and the phosphate are combined through electrostatic interaction; and in the hydrogel, a crystalline region exists in at least partial region of the 2, 3-dihydroxybenzoic acid modified chitosan. The hydrogel provided by the invention is excellent in biocompatibility, high in antioxidant stability and remarkable in blood coagulation activity, has multiple free radical scavenging ability, can inhibit macrophage M1 type polarization activity, promote angiogenesis and regulate granulation tissue regeneration, and finally realizes the effect of promoting chronic wound healing. The composition is applied to the field of chronic wound treatment, and can promote regeneration of granulation tissues of chronic wounds and angiogenesis by removing ROS (reactive oxygen species) on the wounds and regulating and controlling the oxidative stress level of the wounds, so that the healing process of the chronic wounds is accelerated.

The invention provides a process for preparing a Biochanin A (BCA)-loaded hydroxypropyl methyl cellulose (HPMC) hydrogel aimed at promoting wound healing in diabetic patients. The hydrogel is prepared by dispersing HPMC in distilled water, followed by dissolving BCA into the mixture with continuous stirring, then storing under refrigeration. The therapeutic potential of Biochanin A (BCA) in promoting wound healing, is evaluated in rats induced with diabetes. The results showed that the BCA-loaded hydrogel accelerates diabetic wound repair by boosting antioxidant defenses via upregulating Nrf2 and related enzymes, suppressing inflammatory markers such as IL-1β, IL-6, TNF-α, COX-2, and TLR4, and stimulating angiogenesis through increased expression of TGF-β1, VEGF-A, and PDGFR. It promotes faster wound contraction, re-epithelialization, collagen deposition, granulation tissue formation, and neovascularization, potentially reducing the risk of complications like limb amputation. The invention offers a promising therapeutic approach for treating chronic diabetic wounds with improved healing outcomes.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.

The application discloses a kind of wound repair composite preparation based on FGF2 variant and its application, it is related to the technical field of skin wound repair biological preparation, the composite preparation is composed of active ingredient and matrix, the active ingredient is FGF2 mutant, the matrix is cream.The FGF2 mutant is NGF2 protein, the NGF2 protein is obtained by protein engineering technology to natural FGF2 is reformed;The NGF2 protein has high thermal stability and extended normal temperature half-life.The cream is preferably water cream (Basic Aquacream).In the application, NGF2 and water cream synergistically, extend the local action time of protein, realize the effect of reducing the frequency of smearing, enhance repair durability.Preparation can effectively promote wound granulation tissue formation, angiogenesis and collagen remodeling, improve healing quality and reduce scar, provide reliable scheme for the development of new generation wound repair biological preparation.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

The invention discloses a scald ointment for diminishing inflammation and swelling and promoting healing and a preparation method thereof. The emu oil is prepared from the following raw materials: peony seed oil, borage oil, evening primrose oil, perilla seed oil, shea butter, rose hip oil, emu oil, linseed oil, coconut oil, palm oil, horse oil, zedoary turmeric oil, safflower seed oil, pine needle oil, a paniculate spotflower herb alcohol extract, a paniculate spotflower herb water extract, lygodium japonicum, polygonatum polysaccharide, a blackberry lily extracting solution, a jerusalem artichoke extracting solution, a lavender extracting solution and a rhodiola rosea extracting solution. The formula comprises a radix zanthoxyli extracting solution, lanolin, methylparaben, granular paraffin and ethanol. The traditional Chinese medicine composition is natural and mild in components, small in skin irritation, safe to use, capable of deeply permeating, locking moisture, rapid in effect taking and capable of remarkably inhibiting inflammatory response, relieving tissue redness and swelling, shortening the healing period, providing a moist environment for tissue repair, continuously nourishing periinvasive tissue, promoting granulation tissue growth and accelerating the epithelization process, so that damaged skin is effectively repaired; good clinical application prospects and market potential are realized.

The invention discloses scald ointment with a superstrong healing function, and relates to the field of scald ointment. According to the scald ointment with the super-strong healing function, the honey can keep a wound moist, reduce pain and prevent infection; the garden burnet has the effects of astringing to stop bleeding, diminishing inflammation and detoxifying, and can relieve edema, relieve pain and promote granulation tissue growth when being used for scalds; the radix arnebiae seu lithospermi has the effects of clearing away heat and toxic materials and cooling and activating blood and can promote cell regeneration, diminish inflammation and repair damaged skin; the coptis chinensis has relatively strong antibacterial and anti-inflammatory effects and is suitable for preventing and controlling scald infection; scutellaria baicalensis has the effects of clearing heat, drying dampness, purging fire and removing toxin, and is cooperated with coptis chinensis to enhance the antibacterial and anti-inflammatory effects and relieve the heat toxin symptom caused by scald; borneolum syntheticum has the effects of cooling, relieving pain and diminishing inflammation, can immediately relieve pain and burning heat caused by scald, and promotes transdermal absorption of the medicine; all the components interact to remarkably improve the healing speed of the wound surface, and the formula adopts natural components and is small in side effect and rapid in comprehensive effect.

The utility model provides a curettage auxiliary instrument for an apical operation. The curettage auxiliary instrument comprises a clamping body and a working head. The clamping body comprises a first clamping arm and a second clamping arm, the number of the working heads is two, one end of each working head is provided with a neck part, the two working heads are connected with the first clamping arm and the second clamping arm through the neck parts respectively, the bending angle of the neck parts is 90-110 degrees, and scratching blades are arranged on the edges of the working heads. In the using process, fiberous granulation tissue can be removed through a clamping method, the fiberous granulation tissue is cut through the scratching blade on the edge of the working head by operating the clamping body, the clamping efficiency is better improved, the use is more flexible through the bending design of the neck, the surrounding tissue is not prone to being scratched, and the practicability is high. And the operation safety and efficiency are improved.

The present application provides an iodine-containing disinfectant based on keratin and a preparation method thereof. The iodine-containing disinfectant comprises elemental iodine, keratin, a stabilizer and water. The preparation method of the iodine-containing disinfectant comprises: step 1): dissolving elemental iodine and a first stabilizer in water, then adding keratin, and then adjusting the pH to obtain a mixed solution A; step 2): adding a second stabilizer to the mixed solution A, mixing, and obtaining the iodine-containing disinfectant. In the iodine-containing disinfectant of the present application, by combining elemental iodine, a stabilizer and keratin, the iodine-containing disinfectant not only has a good bactericidal effect, but also can promote the growth of granulation tissue and accelerate wound healing.

The invention discloses a burn wound negative pressure treatment and medicine perfusion combined drainage device which comprises a shell, a negative pressure mechanism, an infusion mechanism, a drainage opening, a supporting mechanism, a pressing mechanism and an adsorption mechanism, a rotating ring is installed at the top of the shell, and a guide column is arranged on the inner wall of the rotating ring; the supporting mechanism is fixed in the shell and provided with a supporting channel, and the negative pressure mechanism penetrates through the supporting channel. A drainage opening is formed in the surface of the shell; the negative pressure mechanism comprises a connecting port, a negative pressure pipeline and a protruding block, and the connecting port is formed in the top of the negative pressure pipeline. Therefore, negative pressure treatment of the wound surface and medicine perfusion can be carried out synergistically, and wound surface infection can be controlled in time; a negative pressure system does not need to be disassembled and assembled in each time of perfusion, operation is greatly simplified, medical care burden is relieved, frequent operation on a wound surface is reduced, damage to new granulation tissue is avoided, pain of a patient is relieved, and the risk of secondary pollution caused by repeated exposure of the wound surface is reduced.

The present invention relates to the technical field of medical devices. An airway stent includes a stent body and a covering film provided on the stent body; the stent body includes a waist stent segment and a dense mesh bare stent segment provided at an end portion of the waist stent segment; the covering film is provided on the waist stent segment; the mesh density of the dense mesh bare stent segment is higher than the mesh density of the waist stent segment. According to the airway stent in the present invention, the stimulation of the airway stent to the inner wall of the trachea can be reduced, thereby effectively avoiding the growth of granulation tissue, and preventing the airway lumen from being narrowed again.

The utility model relates to the technical field of medical instruments, and provides an oral cavity alveolar nest granulation tissue separator which comprises a holding cylinder, an adjusting column is movably inserted into the inner side of the holding cylinder, a fixing plate is fixed to the edge of one side wall of the adjusting column, a fixing disc is fixed to the edge of one side wall of the fixing plate, and a connecting ring is movably inserted into the outer side of the fixing disc. A cutter is fixed to the outer wall of the connecting ring, a moving groove is formed in the other edge of one side wall of the adjusting column, and a containing groove is formed in the middle of the inner wall of one side of the moving groove. The adjusting column can move on the inner side of the holding cylinder to adjust the overall length, the connecting ring can rotate between the fixed plate and the movable plate to adjust the angle of the cutter, and therefore a doctor can conveniently operate and cut alveolar fossa granulation at different positions in the oral cavity of a patient, the connecting ring can be conveniently detached, and operation is convenient. The cutter is prevented from being abraded due to long-time use, the service life is prolonged, and the use cost is reduced.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, a preparation method and application of the traditional Chinese medicine composition to preparation of medicine for preventing or treating diabetic foot. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from leech, caulis spatholobi, lumbricus, radix paeoniae rubra, garden balsam stem, radix cyathulae, cassia twig, frankincense, myrrh, radix aconiti lateralis praeparata, angelica sinensis, rheum officinale, coptis chinensis and astragalus membranaceus. All the medicines are combined to play roles in promoting blood circulation and enriching blood, dredging channels and collaterals, improving nerve and blood vessel functions of lower limbs and promoting growth of local granulation tissues, so that the traditional Chinese medicine composition can be used for preventing or treating diabetic foot or complications thereof, and the complications comprise diabetic peripheral vasculopathy or diabetic peripheral neuropathy.

The application relates to the technical field of medical devices, and particularly discloses a nursing auxiliary device for a general surgery department, which comprises a rack, a water receiving hopper is fixedly connected to the middle part of the top left side of the rack, a flushing assembly is arranged at the right side of the water receiving hopper on the top of the rack, the flushing assembly comprises a fixing frame fixedly connected to the top of the rack and located at the right side of the water receiving hopper, a fixing cylinder is fixedly connected to the middle part of the fixing frame, a flexible pipeline is arranged at the bottom of the fixing cylinder, a water spraying cover is fixedly connected to the end of the flexible pipeline away from the fixing cylinder, through cooperation of the above structure, the flow rate can be conveniently adjusted, the pressure during flushing does not change because the physiological saline flows out by gravity, damage to the wound bed caused by excessive flushing pressure is avoided, especially for fragile tissues or newly formed granulation tissues, and the influence on the nursing effect is reduced, meanwhile, convenient adjustment of the flow rate can avoid excessive flow rate during cleaning, and physiological saline is prevented from being wasted.