122 results about "Granulation tissue" patented technology

The invention relates to the technical field of medical health assessment information, in particular to a construction method and system based on an anorectal surgery postoperative nursing rehabilitation assessment model. The method comprises the following steps: acquiring postoperative health data of an anorectal surgery patient; performing postoperative wound morphological image scanning on the postoperative health data of the anorectal surgery patient to obtain a wound morphological structure image; performing postoperative wound area measurement and calculation on the wound morphological structure image to generate postoperative wound area data; and performing granulation tissue feature recognition on the wound morphological structure image according to the postoperative wound area data to obtain granulation tissue feature data. According to the method, through a data processing technology, a feature mapping technology and a mode recognition technology, an anorectal surgery postoperative nursing rehabilitation evaluation model is constructed based on granulation tissue growth information, step number fatigue evaluation data and postoperative defecation index data; the comprehensive functional index postoperative nursing rehabilitation evaluation of the patient is realized, so that the evaluation accuracy is improved.

The embodiment of the invention provides a drainage tube and a drainage device, and relates to the technical field of medical instruments. The drainage tube comprises a drainage part, a porous loose structure and a granulation blocking structure, the drainage part is provided with a first drainage channel, the drainage part is provided with a first drainage hole, and the first drainage hole is communicated with the first drainage channel; the porous loose structure wraps the drainage part, the granulation blocking structure wraps the porous loose structure, and second drainage holes are formed in the granulation blocking structure; and the second drainage holes, the porous loose structure, the first drainage holes and the first drainage channels are communicated. According to the drainage tube, by arranging the granulation blocking structure, granulation can be blocked from growing into the porous loose structure while negative pressure adsorption is met, so that the condition of granulation tissue bleeding is reduced, and the treatment effect of negative pressure drainage is improved.

The invention relates to the technical field of medical instruments, in particular to a multi-layer ultra-light hernia patch which comprises a large-mesh electrostatic spinning tissue ingrowth layer, a mesh woven base material layer and an anti-adhesion layer which are sequentially connected in a stacked mode. Wherein after the large-mesh electrostatic spinning tissue ingrowth layer is implanted into a human body, a cell microenvironment can be better simulated, cell adhesion, differentiation and migration are facilitated, uniform distribution of newborn cells in the fiber direction of an electrospinning membrane is promoted, granulation tissues uniformly ingrow in a defect part, and the electrospinning fiber membrane and the tissues are cooperatively repaired; secondly, the middle layer can provide supporting performance and mechanical performance of the patch in the early stage for the patch, the defects of the electrospinning fiber membrane in the supporting performance and the mechanical performance are overcome, the long-term implantation amount of the patch after later degradation is greatly reduced, and the foreign body sensation is obviously reduced; the anti-adhesion layer also adopts the electrostatic spinning technology, and the anti-adhesion effect is achieved by selecting materials and regulating and controlling the porosity, the aperture and the fiber diameter of the electrospun fiber membrane.

The invention relates to the technical field of peek skull defect repair, in particular to a skull defect repair structure based on structural reconstruction of a peek skull repair material, which comprises a repair patch, a plurality of hourglass-shaped pore channels are formed in the surface of the repair patch, the diameter of the port of a horn-shaped concave groove is larger than that of the tail of the horn-shaped concave groove, the diameter of the port is 1.5 mm, the diameter of the tail of the horn-shaped concave groove is 0.05 mm, and the diameter of the hourglass-shaped pore channels is 1.5 mm. The hourglass-shaped hole channel is designed to be in an hourglass shape with two wide ends and a slender channel, the contact area between the two ends of the hole channel and healthy skull tissue is increased, growth, climbing and combination of granulation tissue are facilitated, meanwhile, attachment, adhesion and healing of soft tissue inside and outside a growth promoting layer repairing material are facilitated, the integration degree of the implant is further improved, and the survival rate of the implant is increased. And the outer surface of the PEEK is covered with the convex structures, so that the contact area between the PEEK material and tissues can be increased, the growth and combination of the tissues are facilitated, and individualized design conforming to aesthetic plastic surgery, thickening design for supplementing temporal muscle atrophy space and mutual embedding of the PEEK material and the skull are carried out.

The present invention relates to the field of medical health assessment information technology, and in particular to a construction method and system based on anorectal surgery postoperative nursing rehabilitation assessment model. The method comprises the following steps: obtaining postoperative health data of anorectal surgery patients; scanning postoperative wound morphology images of postoperative health data of anorectal surgery patients to obtain wound morphology structure images; measuring postoperative wound area of ​​wound morphology structure images to generate postoperative wound area data; identifying granulation tissue features of wound morphology structure images according to postoperative wound area data to obtain granulation tissue feature data. The present invention constructs anorectal surgery postoperative nursing rehabilitation assessment model based on granulation tissue growth information, step fatigue assessment data and postoperative defecation index data through data processing technology, feature mapping technology and pattern recognition technology; realizes postoperative nursing rehabilitation assessment of patients based on comprehensive functional indicators, thereby improving the accuracy of the assessment.

The utility model provides a curettage tool for apical surgery, which comprises a handle, a neck part and a curettage head, the handle is connected with the curettage head through the neck part, the neck part is bent by 80-100 degrees, the curettage head is shovel-shaped, and one end of the curettage head far away from the neck part is provided with a tip. Through the shovel-shaped design of the digging spoon head, the digging spoon can extend into the position where tooth roots are difficult to scrape, and the problem that the included angle between the root tip lesion lingual side and the tooth surface is an acute angle and is difficult to scrape thoroughly is solved. By means of the specially designed angle, diseased tissues right behind and behind the tooth root can be scraped more effectively, residues of granulation tissues can be reduced, the healing speed of root apex bone defects is increased, and the operation efficiency is improved.

The utility model discloses an intracavity negative pressure device for treating upper digestive tract fistula, which comprises a drainage catheter, and two ends of the drainage catheter are respectively a suction end and a negative pressure end connected with the negative pressure device; a liquid suction hole adjacent to the suction end is formed in the side wall of the drainage catheter, and a sponge body wrapping the liquid suction hole is arranged on the outer wall of the drainage catheter. The sponge body comprises a first sponge body and a second sponge body with the aperture larger than that of the first sponge body, the first sponge body wraps the suction end, and the second sponge body is arranged between the first sponge body and the negative pressure end. The two cavernous bodies with different pore diameters are arranged in a partitioned mode, the first cavernous body with the small pore diameter absorbs effusion at the wound of the upper digestive tract fistula in time, granulation tissue hyperplasia is promoted, recovery of a patient is facilitated, and the treatment period is shortened; the second sponge body with the large hole diameter enables secretions with large viscidity to be adsorbed in time, the sponge body and the drainage catheter are not prone to being blocked, the service life of the negative pressure device is prolonged, and the replacement frequency of the device is reduced.

The invention provides an antibacterial hydrogel dressing for promoting healing of diabetic wounds and a preparation method of the antibacterial hydrogel dressing. The hydrogel is prepared by taking a combination of a specific amount of nano-silver and antibacterial peptide conjugate and adenovirus as an active component, the toxicity of silver ions is eliminated, the stability of antibacterial peptide is enhanced, meanwhile, the advantages of high replication capacity, stability, long-term expression and the like of the adenovirus are achieved, and the obtained hydrogel can remarkably promote microangiogenesis and has a good application prospect. The collagen regeneration is promoted, the cell proportion of new granulation tissues is improved, and the effect of repairing the diabetic wound is good. The preparation method is simple and suitable for industrial production.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention relates to the field of biological dressings, and discloses an artificial dermis dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: adding water into a container, and freezing until the water is frozen; then adding a collagen A solution, freezing and standing; continuing to add collagen B liquid, freezing and standing; continuing to add collagen A liquid, freezing and then freeze-drying; and cross-linking in a glutaraldehyde solution, and cleaning to obtain the artificial dermis dressing. The dressing provided by the invention can provide a good stent effect and promote cell migration and proliferation, and the healing rate is close to 100% after wound making. In the wound healing process, the dressing can inhibit collagen deposition, relieve inflammatory response, inhibit abnormal hyperplasia of blood vessels, inhibit excessive proliferation of fibroblasts and excessive formation of granulation tissues, and effectively prevent scar formation. The dressing can also effectively inhibit abnormal vascular hyperplasia in a wound area, and fibrosis and scar hyperplasia caused by excessive vascular hyperplasia are prevented.

The invention discloses a curcumin-containing polyurethane hydrogel for promoting healing of scalded wounds. The hydrogel is prepared by a one-step method under the condition of no solvent and no catalyst. The raw materials comprise biodegradable polyester polyol, polyethylene glycol, bio-based diisocyanate, an acidic response chain extender, a zwitterionic chain extender, curcumin, a biodegradable cross-linking agent and a notoginsenoside aqueous solution. The hydrogel disclosed by the invention has the effect of promoting healing of scalded wounds; in a hemostasis stage, the hydrogel can quickly stop bleeding and construct a physical barrier; in the inflammation stage, the quaternary ammonium salt in the hydrogel and the physically loaded curcumin have a synergistic effect to effectively kill bacteria; in wound remodeling and hyperplasia stages, notoginsenoside slowly released by the hydrogel can regulate inflammatory response, improve collagen deposition and promote granulation tissue hyperplasia and neovascularization. The hydrogel has good biocompatibility, controllable degradation performance and multifunctional biological activity, and can be used as an efficient special dressing for scalded wounds.

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

A wound assessment method is provided. The wound assessment method includes receiving an image that includes an L-shaped color calibration card and a wound; performing an image preprocessing on the image, based on the L-shaped color calibration card, to obtain an adjusted image, where the image preprocessing includes a distortion correction and a color calibration; obtaining a wound image excluding the L-shaped color calibration card, based on the adjusted image, where the wound image includes a plurality of regions; and classifying each of the plurality of regions of the wound image into one of wound tissue types, to obtain a wound tissue type distribution of the wound, where the wound tissue types include a granulation tissue, a slough tissue, and an eschar tissue.

The invention relates to the field of new biological materials, in particular to a high-packaging-dose antibacterial slow-release biological patch obtained by packaging at least two antibiotics with an acellular matrix material. The acellular matrix material is derived from any two of small intestinal submucosa, peritoneum, dermis, bladder basement membrane and pericardium; the antibiotics comprise hydrophobic antibiotics and hydrophilic antibiotics, and the hydrophobic antibiotics are selected from one or more of Beta-lactam antibiotics, rifamycin and macrolide antibiotics; the hydrophilic antibiotics are tetracycline antibiotics. The coating-free drug-loaded sustained-release system based on a lamination process kills bacteria in a short period, prevents colonization and reproduction of bacteria in a wound / patch, realizes synergistic and continuous release of antibiotics along with a wound healing process, guides tissue regeneration and synchronously realizes degradation, is applied to a high-incidence infection period of a surgical operation, reduces adhesion, and has a good application prospect. The abdominal wall strength is enhanced, and the growth of wound granulation tissues is promoted.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The invention provides a pressure sore staging judgment method and device based on image recognition, and the method comprises the steps: segmenting a pressure sore image from a collected image of an affected part; identifying pressure sore features from the pressure sore image; wherein the pressure sore characteristics comprise pressure sore color, tissue type and area and skin integrity; the tissue types at least comprise spots, serous vesicles, granulation tissues, fat, slough, eschar, fascia muscles, tendons, ligaments, cartilages and bones; and determining stages of the pressure sores according to the identified features of the pressure sores. According to the invention, the pressure sore staging can be automatically identified based on the pressure sore features in the pressure sore image, and the accuracy and efficiency of pressure sore staging identification are improved.

The present application relates to the technical field of medical devices, and provides a drainage tube and a drainage apparatus. The drainage tube comprises a drainage portion, a porous loose structure, and a granulation tissue blocking structure. The drainage portion is provided with a first drainage channel, and is further provided with a first drainage hole. The first drainage hole is in communication with the first drainage channel. The porous loose structure is wrapped around the drainage portion. The granulation tissue blocking structure is wrapped around the porous loose structure and is provided with a second drainage hole. The second drainage hole, the porous loose structure, the first drainage hole, and the first drainage channel are in communication. By providing the granulation tissue blocking structure, the drainage tube can, while satisfying negative pressure suction, prevent granulation tissue from growing into the porous loose structure, thereby reducing bleeding of granulation tissue and improving the therapeutic effect of negative pressure drainage.

The present application relates to the technical field of clinical nursing, and specifically discloses a clinical nursing wound cleaning device, which comprises a negative pressure wound therapy instrument, and further comprises a negative pressure adsorption mechanism arranged on the negative pressure wound therapy instrument and used for adsorbing and cleaning a wound surface of a patient, and has at least the following beneficial effects: the negative pressure adsorption mechanism can be closely attached to the wound surface by means of an attached cover, thereby avoiding negative pressure leakage, improving adsorption efficiency and debridement effect, and using a negative pressure pump can efficiently adsorb and collect wound secretions and necrotic tissues, ensure complete debridement, and replace traditional mechanical debridement with negative pressure adsorption, which causes less damage to the wound surface and newly generated granulation tissue, significantly reduces the pain of the patient, and balances debridement effect and nursing safety, thereby meeting the fine cleaning requirements of various wounds in clinical practice.

The invention provides a burn medicine formula and a preparation method thereof, and relates to the technical field of burn medicines, the burn medicine formula comprises a first component medicine and a second component medicine, the first component medicine comprises 45-50 parts of Eurya camara; 30 to 45 parts of platycarya strobilacea bark; 5-15 parts of rice skin; 5 to 15 parts of aloe; 5-15 parts of June cold; the second component medicine comprises tung catalpa or sesame. Eurya emarginata, platycarya strobilacea bark, rice peel, aloe, June herb and other components are mixed to prepare a first medicine, tung catalpa or sesame is squeezed to form a second medicine, the first medicine and the second medicine are uniformly stirred and mixed to be smeared to the wound of a patient in the use process, and all the components cooperate and promote each other, so that the effect of treating the wound is achieved. And the liquid medicine can quickly permeate into the deep layer of the skin, soften the skin, dredge nerves and blood vessels, prevent adhesion and inflammation, gradually soften the wounded part, achieve the effects of clearing away fire, promoting blood circulation, relieving pain, astringing, promoting granulation and accelerating normal growth of tender granulation, the recovery process is intact, and scars and lumps are not easy to remain.

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

The utility model discloses an alveolar fossa granulation tissue clamp which comprises two clamp bodies (1) which are connected in a hinged mode, clamp handles (2) are arranged at the tail ends of the clamp bodies (1), bending rods (4) are arranged at the ends of the clamp bodies (1), fixing pieces (5) are arranged at the ends of the bending rods (4), connecting rods (3) are arranged at the front ends of the clamp bodies (1), and round holes (6) are formed in the front fixing pieces (5) of the connecting rods (3). And a tong head (7) is arranged at the end part of the fixing sheet (5). According to the utility model, granulation tissues can be stably clamped, and meanwhile, the rotatable forceps heads can be used for clamping granulation tissues in alveolar sockets with different shapes, so that the use flexibility is improved.

The application discloses application of miR-30a-5p in preparation of a product for treating airway stenosis. The application finds that miR-30a-5p plays an important regulatory role between airway basal stem cells and airway fibroblasts, and through the carrying of extracellular vesicles, miR-30a-5p is transmitted from the airway basal stem cells to the airway fibroblasts, targets and regulates the expression of a key gene FAP, inhibits the activation of the airway fibroblasts, reduces the collagen gel contraction ability of the airway fibroblasts, improves the extracellular matrix remodeling of the airway fibroblasts, can effectively stabilize the tracheal granulation tissue, prevents the recurrence of airway stenosis, and has application value for treating airway stenosis.

This application relates to the fields of biomedicine and wound repair technology, and particularly to the application of platelet exosomes in the treatment of diabetic wound healing. This application discloses the use of platelet exosomes in the preparation of products having one or more of the following functions: 1) prevention and / or treatment of diabetic foot; 2) promotion of wound healing and / or tissue repair; 3) shortening wound healing time; 4) promoting granulation tissue growth; 5) enhancing wound angiogenesis; 6) alleviating inflammatory responses; 7) inhibiting the expression of pro-inflammatory factors; 8) promoting the expression of anti-inflammatory factors; 9) reducing MMP-9 expression; and 10) increasing MMP-2 expression. It is particularly suitable for the treatment of diabetic foot ulcers, delayed wound healing, and related complications, and also covers the use of this product in the preparation of diabetic foot treatment drugs and medical dressings.

The utility model relates to periodontal surgery technical field, especially a kind of periodontal surgery granulation tissue removal instrument set, including, placing tray, the placing tray is provided with the adaptation area that can place six appliances, the placing tray includes the square open-bottom portion with waist line type, and the limiting plate is set in its inner cavity two sides, the rotating handle is movably provided in the length direction both ends of placing tray;Six The appliance is bone defect granulation removal instrument and alveolar crypt granulation removal instrument respectively.The application scheme can effectively help doctor to realize the removal of granulation tissue in clinical process, reduce the influence of residual granulation tissue on periodontal tissue and bone regeneration, reduce the muscle fatigue of doctor, improve the debridement efficiency and regeneration success probability.

This utility model discloses a protective anal tube for rectal anastomosis after surgery, relating to the field of medical device technology. It solves the initial problem of the need to develop a protective anal tube for rectal anastomosis after surgery that has three-dimensional isolation, facilitates negative pressure drainage, and has a biological barrier function. The utility model includes a tube body with two support members on it for supporting the intestine. Both support members are capable of mechanical deformation, and the contact surfaces between the two support members and the intestine are annular, which can support both sides of the intestinal anastomosis. Thus, a cavity is formed between the two support members and the anastomotic segment of the intestine. The purpose is that the two support members form a physical barrier through the annular contact surfaces, completely preventing the leakage of intestinal contents into the anastomotic area, avoiding contamination of the wound by feces and digestive juices, maintaining a moist environment, and promoting the migration of epithelial cells and the growth of granulation tissue.

The invention discloses schizophyllan, which has two components with molecular weights of 1.54 * 10 < 7 > Da and 1.85 * 10 < 4 > Da respectively, and consists of glucose, mannose, galactose and fucose, and the molar ratio of glucose to mannose to galactose to fucose is 86: 8: 5: 1. The schizophyllan is a heterogeneous polysaccharide with glucose as a main component, and can promote proliferation of HaCaT cells and HUVEC cells. Meanwhile, the schizophyllan can remarkably promote the healing speed of a full-thickness skin wound model mouse wound and has excellent effects in the aspects of epithelium reformation, granulation tissue formation and tissue remodeling, and when 4 mg / mL of schizophyllan is used for treating the mouse wound, the healing rate reaches 96.65%.

The invention discloses a bi-crosslinked chitosan derivative antioxidant hydrogel as well as a preparation method and application thereof. The structure of the hydrogel comprises chitosan modified by 2, 3-dihydroxybenzoic acid and phosphate, and the chitosan modified by 2, 3-dihydroxybenzoic acid and the phosphate are combined through electrostatic interaction; and in the hydrogel, a crystalline region exists in at least partial region of the 2, 3-dihydroxybenzoic acid modified chitosan. The hydrogel provided by the invention is excellent in biocompatibility, high in antioxidant stability and remarkable in blood coagulation activity, has multiple free radical scavenging ability, can inhibit macrophage M1 type polarization activity, promote angiogenesis and regulate granulation tissue regeneration, and finally realizes the effect of promoting chronic wound healing. The composition is applied to the field of chronic wound treatment, and can promote regeneration of granulation tissues of chronic wounds and angiogenesis by removing ROS (reactive oxygen species) on the wounds and regulating and controlling the oxidative stress level of the wounds, so that the healing process of the chronic wounds is accelerated.

The invention provides a process for preparing a Biochanin A (BCA)-loaded hydroxypropyl methyl cellulose (HPMC) hydrogel aimed at promoting wound healing in diabetic patients. The hydrogel is prepared by dispersing HPMC in distilled water, followed by dissolving BCA into the mixture with continuous stirring, then storing under refrigeration. The therapeutic potential of Biochanin A (BCA) in promoting wound healing, is evaluated in rats induced with diabetes. The results showed that the BCA-loaded hydrogel accelerates diabetic wound repair by boosting antioxidant defenses via upregulating Nrf2 and related enzymes, suppressing inflammatory markers such as IL-1β, IL-6, TNF-α, COX-2, and TLR4, and stimulating angiogenesis through increased expression of TGF-β1, VEGF-A, and PDGFR. It promotes faster wound contraction, re-epithelialization, collagen deposition, granulation tissue formation, and neovascularization, potentially reducing the risk of complications like limb amputation. The invention offers a promising therapeutic approach for treating chronic diabetic wounds with improved healing outcomes.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.