Antibacterial hydrogel dressing for promoting healing of diabetic wounds and preparation method thereof
By using the combination of nano-silver antibacterial peptide coupling and adenovirus in hydrogel dressings, the problem of poor antibacterial effect of existing hydrogel dressings is solved, and effective healing of diabetic wounds is achieved.
CN119971125APending Publication Date: 2025-05-13CHONGQING MEDICAL UNIVERSITY +1
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Patent Information
- Application Number
- CN202510179319.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-18
- Publication Date
- 2025-05-13
AI Technical Summary
Technical Problem
Existing hydrogel dressings have poor antibacterial effects when treating diabetic wounds, resulting in slow wound healing.
Method used
Complex hydrogels were prepared by combining nano-silver antibacterial peptide coupling with adenovirus as active ingredients, using a combination of specific proportions with chitosan and glutaraldehyde to form dressings with antibacterial and healing effects.
Benefits of technology
The hydrogel dressing significantly improves the antibacterial effect, promotes the rebirth of microvascular and collagen, improves the cell ratio of new granulation tissues, and significantly accelerates the healing process of diabetic wounds.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides an antibacterial hydrogel dressing for promoting healing of diabetic wounds and a preparation method of the antibacterial hydrogel dressing. The hydrogel is prepared by taking a combination of a specific amount of nano-silver and antibacterial peptide conjugate and adenovirus as an active component, the toxicity of silver ions is eliminated, the stability of antibacterial peptide is enhanced, meanwhile, the advantages of high replication capacity, stability, long-term expression and the like of the adenovirus are achieved, and the obtained hydrogel can remarkably promote microangiogenesis and has a good application prospect. The collagen regeneration is promoted, the cell proportion of new granulation tissues is improved, and the effect of repairing the diabetic wound is good. The preparation method is simple and suitable for industrial production.
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