Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

627 results about "Skull bone" patented technology

Brain-computer interface module, digital skull implant and integration method and related application thereof

The embodiment of the invention relates to the technical field of brain-computer interfaces, in particular to a brain-computer interface module, a digital skull implant and an integration method and related application of the digital skull implant. The digital skull implant comprises a skull prosthesis and a brain-computer interface module, wherein the brain-computer interface module and the skull prosthesis are integrated; the brain-computer interface module comprises an ultrasonic transducer used for sending ultrasonic signals to the brain and collecting brain echo signals. The brain-computer interface module comprises an ultrasonic transducer used for sending ultrasonic signals to the brain and collecting brain echo signals. The brain-computer interface module is configured to be integrated with a skull or a skull prosthesis. In this way, the implantation structure integrating the brain-computer interface module in the skull form can have good mechanical strength and biocompatibility, complete implantation and wireless design can be achieved, and ultrasonic waves penetrate through the skull to conduct precise stimulation on the brain area.
Owner:GESTALT (CHENGDU) TECHNOLOGY CO LTD

Method, device, equipment, product and storage medium for identifying skull defect by constructing characteristic spectrum through nuclear magnetic image

Belongs to the technical field of biomedical engineering, and discloses a method, a device, equipment, a product and a storage medium for identifying skull defects by constructing a characteristic spectrum through a nuclear magnetic image to solve the problem that a defect area is mistakenly divided into skull areas in existing automatic skull segmentation. Converting the human brain nuclear magnetic image to an anatomical space based on the plurality of anatomical points, and implementing preliminary segmentation to obtain a primary segmentation region of the skull; calculating coordinates of voxel points in the primary segmentation region in an anatomical point coordinate system, establishing a matrix, calculating a plurality of nuclear magnetic gray statistical characteristics of the primary segmentation region, and drawing a characteristic spectrum; and performing multi-condition feature threshold judgment on the feature map to obtain a logic binary map, and extracting a region of which a connected domain is greater than a specified threshold as a skull defect region. According to the method provided by the invention, a plurality of gray features are utilized, the misrecognition of the skull in the prior art is effectively corrected, the method can be further used for judging the filling tissue of the skull defect area, and the skull defect recognition capability can be improved.
Owner:XIAN NEURODOME MEDICAL TECHNOLOGY CO LTD

Transcranial magnetic stimulation positioning system based on deep effect brain region

The invention discloses a transcranial magnetic stimulation positioning system based on a deep effect brain region, and the system comprises the steps: obtaining the data of a tested magnetic resonance image, which comprises a resting state functional image and a high-resolution T1 structure image; performing data preprocessing on the function image and the structure image, and establishing an individual space; the deep effect brain region template is converted to an individual space through nonlinear registration, and a target region of interest is defined; calculating functional connections between voxels of the deep effect brain region and the cortical region by adopting a Granger causality analysis method based on wavelet transformation; and screening Top block masses according to the functional connection strength, calculating the gravity centers of the Top block masses, and determining individualized stimulation targets in combination with the skull surface distance. According to the method, spontaneous brain activity function variation of the brain of an individual and the brain signal propagation direction are fully considered, accurate positioning of different individual levels is achieved, relatively stable cortex stimulation targets are obtained, and therefore the clinical curative effect of TMS is optimized.
Owner:HANGZHOU NORMAL UNIVERSITY

Multi-modal fusion-based nuclear magnetic resonance image auxiliary diagnosis method and system

PendingCN120809168AImage enhancementMedical data miningInversion recoveryT1 weighted
The invention relates to the technical field of medical image auxiliary diagnosis, in particular to a nuclear magnetic resonance image auxiliary diagnosis method and system based on multi-modal fusion. The method comprises the following steps: step 1, synchronously acquiring a three-dimensional T1 weighted structure image, a T2 weighted fluid attenuation inversion recovery image and diffusion weighted imaging data of a subject, carrying out spatial registration by taking the T1 weighted image as a reference, and executing skull stripping and gray scale standardization; 2, individualized brain region segmentation is carried out based on a brain anatomical map, the lesion sensitivity weight of each modal is calculated for each segmented brain region, and the weight is obtained by quantifying the following parameters; step 3, extracting multi-modal image features in each brain region; and 4, inputting the fusion features of the whole brain region into a multi-task classifier. The standardization and alignment of the multi-mode MRI image in the space and gray level are realized, and the problems of space mismatch and feature interference among different modes are effectively solved.
Owner:GUANGDONG SUNNICO MEDICAL TECH CO LTD

Milk-derived pentapeptide for promoting calcium mineral absorption and application thereof

ActiveCN120623307APeptide/protein ingredientsSkeletal disorderOD - Optical densitySkull bone
The invention belongs to the technical field of biology, and particularly relates to milk-derived pentapeptide for promoting calcium mineral absorption and application of the milk-derived pentapeptide. The CPP containing the high-activity peptide fragment is obtained by optimizing a process, and the influence of the CPP on mineral absorption is verified by utilizing a zebra fish model. Then, the pentapeptide GPFPI with calcium absorption promoting activity is screened out from the CPP in combination with peptidomics and a molecular docking technology, functional verification is carried out, it is found that the pentapeptide presents a dose-dependent trend on Ca < 2 + > transport, the Ca < 2 + > transport amount is remarkably increased by 23.23% at 10 mu M, and meanwhile, zebra fish experiments show that intervention of the GPFPI effectively reverses accumulated optical density value reduction caused by dexamethasone, and the effect of inhibiting calcium absorption is achieved. Compared with a manufacturing module, the skull accumulative optical density value of a GPFPI (2-20 mu M) processing group is remarkably increased. It is shown that the synthetic peptide GPFPI can effectively promote Ca < 2 + > transfer and absorption, improve the osteoporosis symptom of zebra fish and increase deposition of calcium in bones.
Owner:HANGZHOU KANGYUAN FOOD SCI & TECH +1

Head model generation method and device, equipment, storage medium and program product

The invention discloses a method, device and equipment for generating a head model, a storage medium and a program product. The method is characterized by comprising the following steps of: receiving and verifying original three-dimensional T1 weighted image data and an original three-dimensional grid model; performing tissue segmentation based on the verified three-dimensional T1 weighted image data and the original three-dimensional T1 weighted image data to obtain a cerebral grey matter mask, a cerebral white matter mask, a scalp mask and a skull mask; performing topological structure repair on the brain grey matter mask and the brain white matter mask to obtain a brain mask; respectively converting the scalp mask, the skull mask and the brain mask into a scalp mesh model, a skull mesh model and a brain mesh model; calculating and applying a spatial transformation matrix from the verified three-dimensional grid model to the scalp grid model, and performing spatial registration and fusion on the scalp grid model, the skull grid model and the brain grid model to obtain a head model; the method has the advantages that the efficiency, precision and robustness of head model generation are effectively improved, and the method has good cross-platform deployment capability.
Owner:GUOCI CLOUD DIGITAL (DEQING) TECHNOLOGY CO LTD

Bone cement injection device for skull repair

The invention relates to a bone cement injection device for skull repair. The bone cement injection device comprises an outer sheath tube, a separate injection structure and an outer push rod, a pushing channel extending in the axial direction is formed in the outer sheath tube, the tube wall of the outer sheath tube is provided with a first hole group and a second hole group which are symmetrically distributed by 180 degrees in the circumferential direction, and each hole group comprises a plurality of via holes arranged at equal intervals in the axial direction; the two symmetrically-arranged separated injection structures are arranged corresponding to the first hole set and the second hole set respectively, each separated injection structure comprises a separated injection pipe, the separated injection pipe is inserted into the pushing channel, a perfusion channel extending in the axial direction is arranged in the separated injection pipe, the near end of the perfusion channel is through, and the far end of the perfusion channel is closed; the rigid contact pins are arranged at equal intervals in the axial direction of the separate injection pipe and penetrate through the side wall of the separate injection pipe at the same circumferential angle, and the inner end of each contact pin is communicated with the perfusion channel. The repairing block can be effectively filled with bone cement, and the effect after skull repairing is improved.
Owner:XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI

Brain image region label generation method based on standard space inverse deformation reflection

The invention discloses a brain image area label generation method based on standard space inverse deformation reflection, and relates to the technical field of medical image processing and computer vision. The method comprises the following steps: performing skull stripping and resampling preprocessing on an individual space target brain image, performing rigid, affine and nonlinear cascade registration on the preprocessed brain image and a standard space template, and solving a forward deformation field and an inverse deformation field; calling an inverse deformation field to reversely propagate standard space anatomical atlas labels to an individual space, and resolving label conflicts to obtain an initial label graph; generating each modal coarse label graph through the registration matrix, and performing weighted fusion according to a confidence coefficient weight to obtain a consistent coarse label set; quality control is executed based on anatomy prior, an individualized label is obtained after topological repair, and finally a label, metadata and an uncertainty evaluation report are exported. According to the method, automation and standardization of brain image tag generation are realized, and the accuracy, consistency and generalization ability of tags are improved.
Owner:CHONGQING UNIV OF TECH

Brain-computer interface signal enhancement and evaluation method fusing physical information

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Craniofacial restoration method based on diffusion model

PendingCN120543750AImage enhancementImage analysisCraniofacialSkull bone
The invention discloses a craniofacial restoration method based on a diffusion model, and the method comprises the steps: S1, collecting a three-dimensional medical image of a head, carrying out the standardization processing and biological information labeling of the three-dimensional medical image, and obtaining a skull-craniofacial data set; s2, training a PiPNet network by using the craniofacial image marked with the craniofacial key structure mark points to obtain a craniofacial mark point recognition network; s3, constructing a craniofacial restoration network, and training the craniofacial restoration network by using the skull-craniofacial data set to obtain a craniofacial restoration model; and S4, inputting the skull image and the corresponding biological information into the craniofacial restoration model, and outputting a restored craniofacial image. According to the method, personal identity features are comprehensively captured by integrating multi-modal information; a diffusion model is used as a backbone network, the dependence of a traditional method on training data distribution is broken through, and the quality of a recovery result is remarkably improved. And meanwhile, an editable text prompt mechanism is introduced, so that the uncertainty of skull-face mapping is effectively reduced.
Owner:SICHUAN UNIV

Splicing skull repairing system

The utility model relates to the technical field of skull repairing, in particular to a splicable skull repairing system which comprises a first skull repairing piece, a second skull repairing piece and a plurality of connecting assemblies used for connecting the first skull repairing piece and the second skull repairing piece to the skull of the human body, and the first skull repairing piece and the second skull repairing piece are arranged in an up-down spaced mode. The first skull repairing piece comprises a plurality of first splicing strips which are arranged side by side in an abutting mode, the second skull repairing piece comprises a plurality of second splicing strips which are arranged side by side in an abutting mode, and the arrangement direction of the second splicing strips and the arrangement direction of the first splicing strips are staggered; a plurality of convex tongues are arranged on the second skull repairing sheet in an array mode, and a plurality of clamping grooves are formed in the first skull repairing sheet in an array mode; and the second skull repairing sheet is connected with the first skull repairing sheet through the clamping matching of the convex tongue and the clamping groove. The skull repair block has the advantages that the risk that the skull repair block collapses when bearing impact is reduced, the strength of the spliced skull repair block is improved, a patient is protected, the operation time is shortened, and the cost and the postoperative infection rate are reduced.
Owner:HUNAN JINBAIWEI MEDICAL TECH CO LTD +1

Bone surface bidirectional three-dimensional reconstruction and editing method and device, computer equipment and medium

The invention relates to the technical field of three-dimensional shape modeling and reconstruction, and discloses a bone surface bidirectional three-dimensional reconstruction and editing method and device, computer equipment and a medium, the method comprises the following steps: obtaining a plurality of multi-modal facial skull three-dimensional data, and obtaining a three-dimensional facial grid and a three-dimensional skull grid based on the multi-modal facial skull three-dimensional data, then, a dense ray matching technology of face-skull topological consistent registration is adopted to obtain a dense control point corresponding relation and a topological consistent face grid; based on a preset face-skull structure mapping relation, mapping the face grid and the three-dimensional skull grid which are topologically consistent, and establishing a dense tissue thickness vector field; on the basis of the dense control points and the dense tissue thickness vector field, a bone surface-tissue joint deformable model is constructed to conduct bone surface bidirectional three-dimensional reconstruction, finally bone surface bidirectional three-dimensional editing is conducted on the basis of a bone surface bidirectional three-dimensional reconstruction result, and the precision and individuation level of three-dimensional bone surface reconstruction are remarkably improved.
Owner:INST OF AUTOMATION CHINESE ACAD OF SCI

Guided ultrasound transcranial focusing method and device based on combination of k-space pseudo-spectrum method and angular spectrum method

The invention discloses a guided ultrasound transcranial focusing method and device based on the combination of a k-space pseudo-spectrum method and an angular spectrum method, and relates to the field of transcranial focused ultrasound simulation, and the method comprises the steps: obtaining a CT image of a target skull; calculating acoustic parameters of the CT image of the target skull; according to the CT image and the acoustic parameters of the target skull, applying a k-space pseudo-spectrum method to simulate propagation of ultrasonic waves before the ultrasonic waves enter the target skull, and obtaining initial ultrasonic field distribution before the ultrasonic waves enter the skull; according to the initial ultrasonic field distribution, applying an angular spectrum method to simulate propagation of ultrasonic waves before the ultrasonic waves enter the target skull, and obtaining target ultrasonic field distribution passing through the skull. According to the method, the k-space pseudo-spectrum method and the angular spectrum method are innovatively combined, and the calculation efficiency of transcranial ultrasonic simulation is improved while the focusing precision of the transcranial ultrasonic simulation is ensured.
Owner:BEIHANG UNIV

Antibacterial bioactive glass composite material for skull defect repair and preparation method thereof

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.
Owner:HUBEI SHUANGXING PHARMA CO LTD

Fine-grained segmentation method and system for three-dimensional CBCT skull image

The invention discloses a fine-grained segmentation method and system for a three-dimensional CBCT skull image. The method comprises the following steps: firstly, constructing a first training data set; thirdly, in combination with the first training data set, training the secondary segmentation neural network model to obtain a trained secondary segmentation neural network model; then, segmenting a to-be-processed three-dimensional CBCT skull image by using the trained secondary segmentation neural network model to obtain a segmentation result of each structure of the skull; and finally, segmenting the bone cortex and cancellous bone of the upper and lower jawbones by using an improved region growing method to obtain a bone cortex and cancellous bone segmentation result corresponding to the upper and lower jawbones, thereby completing fine-grained segmentation of the three-dimensional CBCT skull image. According to the method provided by the invention, fine-grained areas of the oral maxillofacial region can be separated, and the fine-grained areas comprise intact skull, upper and lower jawbone, teeth, bone cortex, cancellous bone, neural tubes, maxillary sinus, incisor canals and other structures.
Owner:HANGZHOU MEIQI TECH CO LTD

Casein-source heptapeptide for promoting absorption and utilization of calcium and application of casein-source heptapeptide

The invention belongs to the technical field of biology, and particularly relates to casein source heptapeptide for promoting calcium absorption and utilization and application of the casein source heptapeptide. The CPP containing the high-activity peptide fragment is obtained through an optimization process, and the influence of the CPP on mineral absorption and conversion is evaluated by utilizing a mineral deficiency rat model; then, heptapeptide with calcium absorption promoting activity is screened out from the CPP in combination with peptiomics and molecular docking technologies, functional verification is carried out, it is found that when the VAPFPEV is 2 mu M, the Ca < 2 + > transport amount is remarkably increased by 25.25%, meanwhile, zebra fish experiments show that intervention of the VAPFPEV effectively reverses reduction of an accumulated optical density value caused by dexamethasone, and compared with a module making set, the VAPFPEV has the advantages that the VAPFPEV has the advantages that the VAPFPEV has the advantages that the VAPFPEV has the advantages that the VAPFPEV has the advantages that the VAPFPEV has the The skull accumulative optical density value of a VAPFPEV (1-20 [mu] M) processing group is obviously increased. It is shown that VAPFPEV can effectively promote Ca < 2 + > transfer and absorption, improve the osteoporosis symptom of zebra fish and increase deposition of calcium in bones.
Owner:HANGZHOU KANGYUAN FOOD SCI & TECH +1

User-configurable mounting system

Example implementations relating to mounting assemblies are disclosed herein, including in one example a skull mount having a substantially longitudinal bracing member and an engaging member comprising a curved portion configured to engage a portion of an animal skull such as a base of the brain cavity. One or more adjusting members adjustably position and secure the bracing member and the engaging member to securely engage and retain a skull of an animal therebetween by engaging the curved portion of the engaging member with at least a portion of the skull such as the brain cavity. A base assembly attached to a mounting surface is coupled to a connecting assembly removably coupling the bracing member and engaging member assembly to the base assembly, the connecting assembly comprising a pivot rod and a sleeve configured to receive and removably retain the pivot rod.
Owner:CUSTOM RANGE FABRICATION LLC

Intelligent skull drilling device and method based on force-position feedback control

The invention relates to the technical field of skull drilling equipment, in particular to an intelligent skull drilling device and method based on force-position feedback control, and the intelligent skull drilling device based on force-position feedback control comprises a shell which is provided with an equipment cavity; the supporting assembly comprises a plurality of supporting mechanisms, an adsorption mechanism and a vibration reinforcing mechanism, and the supporting mechanisms are arranged around the shell; the drilling assembly comprises a driving mechanism, a feeding mechanism and a drill bit; and the brake assembly comprises a photoelectric detection mechanism and a brake mechanism. According to the invention, the organic combination of stable support, accurate control and active protection is realized, and the operation error and intraoperative risk are effectively reduced.
Owner:CHANGSHU INSTITUTE OF TECHNOLOGY +1

Ultrasonic transducer positioning apparatus, ultrasonic transducer positioning program, and ultrasonic transducer positioning artificial-intelligence implementation method

The present invention relates to an ultrasonic transducer position setting device, an ultrasonic transducer position setting program, and a method for implementing ultrasonic transducer position setting artificial intelligence. The ultrasonic transducer position setting device includes: an input / output unit for allowing a user to input data, and outputting the data in a form that is recognizable by the user; a memory for storing an ultrasonic transducer position setting program; and a control unit for executing the ultrasonic transducer position setting program to derive result data according to the data input through the input / output unit, wherein, when a focal point position of ultrasound, which is set to a region where a brain is positioned inside a skull in a living body, is input, the control unit outputs position data of an ultrasonic transducer, which allows the ultrasound to be applied to the input focal point position of the ultrasound.
Owner:KOREA UNIV RES & BUSINESS FOUND

Multi-mode mouse virtual reality and nerve recording integrated system based on skull anchoring

The invention belongs to the technical field of mouse neuroscience research, and relates to a multi-modal mouse virtual reality and nerve recording integrated system based on skull anchoring, which comprises a skull anchoring basic support, a binocular miniature VR display module, a multi-modal fixed expansion frame and a behavior and power supply platform. According to the invention, the skull screw is used as a unique space reference, accurate limiting of the head is realized through rapid butt joint of the MMA and the external fixing rod, and rapid plugging and coordinate multiplexing of equipment for two-photon imaging, optical genetic stimulation and the like are realized in combination with an M2 anchoring hole preset in the MMA; the total mass of the whole machine is strictly controlled within 3.2 g; the optical system provides panoramic visual stimulation with a horizontal field angle of 140 degrees, completely covers a key binocular vision area on the top of the mouse head, and supports high-order cognitive task paradigms such as complex ecological visual navigation, spatial memory and social interaction.
Owner:EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV

Intraventricular hydrops drainage device

The invention relates to an instrument for transferring cerebrospinal fluid in a ventricle into a body cavity of other parts of a human body, and particularly discloses an intraventricular hydrops drainage device which comprises a base used for being attached to a bone window of a skull, a confluence cavity and a liquid outlet connector communicated with the confluence cavity are arranged on the base, and the liquid outlet connector is provided with a liquid inlet and a liquid outlet. The flow guide hose is connected to the liquid outlet joint; a tip axially remote from the base; the drainage main body component is used for guiding cerebrospinal fluid in the ventricle to the confluence cavity; the drainage main body component comprises a plurality of micro-catheters; the near end and the far end of each micro catheter are attached to the base and the end respectively, and the near end of the micro central hole of each micro catheter is communicated with the confluence cavity; the micro-conduits are arranged in a plurality of circles in the circumferential direction and the radial direction; a micro drainage structure communicated with the micro central hole is arranged on the tube wall of each micro catheter, and the micro drainage structures are arranged in the circumferential direction and the axial direction of the tube wall of the micro catheter so as to allow cerebrospinal fluid to enter the micro central hole through the tube wall of the micro catheter.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Intelligent skull defect area segmentation method based on medical image

The invention relates to the technical field of image processing, in particular to a skull defect area intelligent segmentation method based on a medical image. The method comprises the following steps: acquiring a to-be-analyzed image and a template image of the brain; constructing a window by taking each pixel point as a center; obtaining a difference evaluation index of two windows with the same positions of the to-be-analyzed image and the template image; acquiring a skeleton line in the template image, acquiring pixel points corresponding to the pixel points in the template image on the skeleton line, and then obtaining included angles of the pixel points in the to-be-analyzed image; acquiring a neighborhood window of each window of the to-be-analyzed image, and judging whether each window is an initial abnormal window or not; judging whether each initial abnormal window is a suspected skull defect window or not; judging whether the suspected skull defect window is an abnormal window or not according to the gray level change condition of the pixel points in the suspected skull defect window; and segmenting the to-be-analyzed image according to the abnormal window to obtain a skull defect area. According to the method, the craniocerebral defect area can be effectively segmented.
Owner:XIAN NEURODOME MEDICAL TECHNOLOGY CO LTD

Photocuring bio-ink, digital light processing 3D printing product, preparation method of digital light processing 3D printing product and application of digital light processing 3D printing product in preparation of skull repair material

The invention provides light-cured bio-ink, a digital light processing 3D printing product, a preparation method of the digital light processing 3D printing product and application of the digital light processing 3D printing product in preparation of a skull repair material, and belongs to the technical field of biological medicine. The material provided by the invention can continuously release HO under different environmental conditions. Particularly, in a simulated in-vivo environment, the GHDP hydrogel keeps stable HO release for a long time, so that a signal channel related to angiogenesis is continuously activated, and in the skull defect repair process, the GHDP hydrogel can promote neovascularization and osteogenic differentiation by regulating and controlling the HO level, so that the skull defect repair effect is improved. And a new strategy and thought are provided for promoting tissue regeneration by utilizing redox signal regulation and control.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Methods and systems for confirming focus of ultrasound beams

Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,v<sub2>i < / sub2>for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,v<sub2>i< / sub2>.
Owner:CORDANCE MEDICAL INC

Transcranial ultrasonic simulation method and device based on RS diffraction integral and angular spectrum method

The invention discloses a transcranial ultrasonic simulation method and device based on an RS diffraction integral and angular spectrum method, and relates to the field of transcranial focused ultrasound simulation, and the method comprises the steps: obtaining a CT image of a target skull; calculating acoustic parameters of the CT image of the target skull; according to the CT image and the acoustic parameters of the target skull, an RS diffraction integral method is applied to simulate propagation of ultrasonic waves before the ultrasonic waves enter the target skull, and initial ultrasonic field distribution before the ultrasonic waves enter the skull is obtained; according to the initial ultrasonic field distribution, applying an angular spectrum method to simulate propagation of ultrasonic waves before the ultrasonic waves enter the target skull, and obtaining target ultrasonic field distribution passing through the skull. According to the method, the RS diffraction integral method and the angular spectrum method are innovatively combined, and the calculation efficiency of transcranial ultrasonic simulation is improved while the focusing precision of the transcranial ultrasonic simulation is ensured.
Owner:BEIHANG UNIV

Surgical instrument for building traumatic brain injury mouse model

The invention belongs to the technical field of medical instruments, and discloses a surgical instrument for building a traumatic brain injury mouse model.The surgical instrument comprises a tube blade, a limiter, a holding piece and a vacuum device, the tube blade is used for rotationally cutting into brain tissue of a mouse, the limiter is movably installed on the tube blade in the axial direction of the tube blade, and the vacuum device is arranged on the holding piece; the limiting device is used for abutting against the skull of the mouse, the holding piece is provided with an airflow channel, one end of the holding piece is connected with the pipe blade, one end of the airflow channel is communicated with the pipe blade, and the vacuum device is connected to the other end of the holding piece and connected with the other end of the airflow channel. According to the surgical instrument for building the traumatic brain injury mouse model, the problems that an injury area is uncontrollable and a focus area is difficult to quantify and unify in the current traumatic brain injury mouse model building process can be solved, so that the success rate and efficiency of model building are improved to the maximum extent.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

A low-intensity focused ultrasound transducer positioning and control method, device and equipment

The application discloses a low-intensity focused ultrasound transducer positioning regulation method, device and equipment, belongs to the technical field of transcranial focused ultrasound nerve regulation, and comprises the following steps: acquiring a head CT image of a PACS system; setting a skull layer HU threshold value and performing segmentation and extraction, reconstructing a three-dimensional skull contour model based on the segmentation and extraction result; screening transducer center point arrays outside the three-dimensional skull contour model; performing simulation selection of ultrasonic sound pressure and transducer positioning; performing focused ultrasound stimulation based on the transducer positioning result, checking the effects of the ultrasonic sound field and the spatial sound field of the positioned transducer point in the target area; and constructing a thermal effect temperature field under the focused ultrasound stimulation based on the sound field analysis of the corresponding target area, and verifying the safety of the positioned transducer. The application can calculate an optimal ultrasonic action path according to multiple ultrasonic frequencies, intensities, duty cycles and pulse repetition intervals required, and meets the needs of clinical use.
Owner:SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT

Histotripsy therapy systems and methods for the treatment of brain tissue

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.
Owner:THE RGT UNIV OF MICHIGAN

Skull traction operation auxiliary device and control method thereof

The invention relates to the technical field of orthopedic medical instruments, in particular to a skull traction operation auxiliary device and a control method thereof. The traction bed body provides a lying position / prone position for a patient, the skull traction bow is fixed to the head of the patient and used for traction, and the flexible traction arm is arranged on one side of the traction bed body and used for being connected with the skull traction bow. The flexible traction arm is provided with a connecting rod used for installing the skull traction bow, and the connecting rod is provided with an intelligent control stopwatch used for being matched with the skull traction bow. The auxiliary device for the skull traction operation has the advantages that the situation that the cervical curvature is inconvenient to adjust in the operation is improved, and the operation convenience of the auxiliary device for the skull traction operation is improved.
Owner:NINGBO FIRST HOSPITAL

Bone conduction hearing aid

ActiveCN223729915UDeaf-aid setsFacial boneSkull bone
The utility model discloses a bone conduction hearing aid which comprises a host, one end of the host is fixedly connected with a supporting column, the top end of the supporting column is fixedly connected with a connecting sleeve, one end of the host is fixedly connected with an adjusting mechanism, the connecting sleeve is sleeved on the end portion of a spectacle frame, and the bone conduction hearing aid is limited and fixed through the spectacle frame. The main machine and the spectacle frame cannot clamp and extrude each other, the ear pain problem is avoided, meanwhile, the bone conduction sound transmission device can be smoothly attached to the skull or the facial bone through the downward concave part, normal work of the bone conduction sound transmission device is guaranteed, and the sound transmission efficiency is improved. The position of the bone conduction sound conducting device in the vertical direction can be adjusted through the connecting column, meanwhile, the position of the bone conduction sound conducting device in the horizontal direction can be adjusted under the action of the rotating shaft, the bone conduction sound conducting device can be adjusted to the proper position through the two different adjusting modes, and therefore the use requirements of different patients are met; the use by different patients is convenient.
Owner:SHENZHEN HUIBANG MEDICAL & HEALTH CARE IND CO LTD